[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"residual-limb-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:residual-limb-pain":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,89],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":4},"100626681","post-amputation-stump-infection-as-a-predictor-of-persistent-residual-limb-pain-a-prospective-cohort-study-100626681",false,"NCT07438795","Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study","INF-STUMP-PAIN","Inclusion Criteria:\n\n* Traumatic upper or lower limb amputation\n* Enrollment within 4 weeks after surgery\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Pre-existing chronic pain in the affected limb\n* Severe cognitive impairment\n* Terminal illness limiting follow-up\n* Refusal or inability to complete follow-up assessments","ALL","18 Years","60 Years",{"count":20,"type":21},150,"ESTIMATED","6 Months","OBSERVATIONAL","Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and long-term pain persistence. This prospective cohort study aims to determine whether early post-amputation stump infection independently predicts persistent clinically significant residual limb pain at 3 and 6 months after surgery.",[26,27,28,29,30],"Residual Limb Pain","Stump Pain","Post-Amputation Pain","Surgical Site Infection","Phantom Limb Pain (PLP)",[32,33,34,35,36,37,38],"Traumatic amputation","stump infection","residual limb pain","chronic pain","surgical site infection","blast injury","neuropathic pain","NOT_YET_RECRUITING","2026-06-01",{"date":42,"type":43},"2026-06-03","ACTUAL",{"date":45,"type":21},"2026-06-23",{"date":47,"type":21},"2026-12-23",{"name":49,"class":50},"Ukrainian Society of Regional Anesthesia and Pain Therapy","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":59,"enrollmentInfo":60,"targetDuration":62,"studyType":23,"phases":4,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":88},"100625250","evaluation-of-rpni-for-symptomatic-neuromas-in-lower-limb-amputees-100625250","NCT07420192","Evaluation of RPNI for Symptomatic Neuromas in Lower Limb Amputees","The Effect of Regenerative Peripheral Nerve Interface (RPNI) Surgery on Neuropathic Pain and Functional Outcomes in Major Lower Extremity Amputations","RPNI-AMPUTEE","Inclusion Criteria:\n\n* Age: Adults aged 18 to 70 years.\n* Amputation Status: Unilateral major lower extremity amputation (Transtibial, Transfemoral, or Knee Disarticulation).\n* Radiological Baseline: Absence of Heterotopic Ossification (HO) in the residual limb, confirmed by pre-operative X-rays (Walter Reed Classification Grade 0).\n* Diagnosis: Confirmed diagnosis of \"Symptomatic Neuroma\" validated by the Clinical Triad:\n\n  1. Neuropathic Pain: DN4 Questionnaire score ≥ 4.\n  2. Pain Intensity: Numeric Rating Scale (NRS) score ≥ 4.\n  3. Physical Exam: Positive Tinel's sign or palpation tenderness at a specific trigger point.\n  4. Radiology: Diagnostic Ultrasound visualization of the neuroma bulb.\n* Surgical Indication: Scheduled for RPNI surgery as part of the routine standard of care treatment protocol due to prosthesis intolerance or severe pain.\n* Consent: Willing and able to provide informed consent and attend follow-up visits.\n\nExclusion Criteria:\n\n* CRPS: Diagnosis of Complex Regional Pain Syndrome (CRPS Type 1 or 2).\n* Concurrent Bone Surgery: Patients requiring simultaneous stump revision surgery (e.g., bone shortening, osteotomy, spur excision) or having existing HO (Walter Reed Grade \\> 0).\n* Systemic Conditions: Uncontrolled diabetes mellitus (HbA1c \\> 8.5%) or severe peripheral arterial disease compromising wound healing.\n* Cognitive Status: Cognitive impairment or psychiatric conditions preventing reliable completion of patient-reported outcome measures (PEQ, DN4).\n* History: Previous RPNI surgery at the same site (Recurrent RPNI cases).","70 Years",{"count":61,"type":21},20,"24 Months","This prospective, observational cohort study evaluates the long-term outcomes of Regenerative Peripheral Nerve Interface (RPNI) surgery in patients with major lower extremity amputations suffering from symptomatic neuromas. RPNI is a surgical technique where the transected nerve end is implanted into a free autologous muscle graft to serve as a physiological target for reinnervation. The study aims to objectively assess the reduction in mechanical hypersensitivity using Pressure Pain Threshold (PPT) measurements via a digital algometer. Additionally, it monitors subjective neuropathic pain levels, functional mobility, and prosthesis satisfaction over a 24-month follow-up period compared to pre-operative baselines.",[65,66,26,67,68],"Symptomatic Neuroma","Phantom Limb Pain After Amputation","Neuropathic Pain","Lower Extremity Amputations",[70,71,72,73,74,75,76,77],"RPNI","Regenerative Peripheral Nerve Interface","Pressure Pain Threshold","PPT","Algometry","Prosthesis Satisfaction","Viscero-Somatic Convergence","Phantom Motor Execution","RECRUITING","2026-02-12",{"date":81,"type":43},"2026-02-19",{"date":83,"type":43},"2026-01-20",{"date":85,"type":21},"2030-03",{"name":87,"class":50},"Saglik Bilimleri Universitesi",1,{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":115},"100439984","surgical-treatments-for-postamputation-pain-100439984","NCT05009394","Surgical Treatments for Postamputation Pain","Inclusion Criteria:\n\n* The participant must have a major limb amputation.\n* The participant is ≥ 18 years old at the time of consent.\n* The participant must be in generally good health to undergo a surgical intervention, as per the clinical investigator's opinion.\n* Time since the last amputation must be over a year at the time of consent.\n* The participant must have an average residual limb pain score equal or greater than 4 on the Numerical Rating Scale (NRS, 0-10) after the baseline period.\n* If the participant has been prescribed pharmacological treatments for pain, there must be no variations in dosage (steady consumption) for at least 1 month before the screening visit.\n* If the participant has been prescribed non-pharmacological treatments for pain, such as spinal cord stimulation, transcutaneous electrical nerve stimulation, and mirror therapy, the treatment must have ended at least 1 month before the screening visit.\n* The participant must have a stable prosthetic fitting for at least a month before the screening visit.\n* The participant has a sufficient understanding of the language in which the assessments will be conducted, as per the clinical investigator's opinion.\n\nExclusion Criteria:\n\n* Neurological or other conditions that affect nerve regeneration for the nerve to be treated.\n* Active infection in the residual limb.\n* Prior RPNI or TMR surgery of the nerve to be treated (with painful neuroma) to address postamputation pain.\n* Mental disorders (e.g., schizophrenia, paranoia, psychosis, etc.), reluctance, or language difficulties that result in difficulty understanding the meaning of study participation.\n* Ongoing participation in a clinical study that the clinical investigator deems detrimental to participation in this study.",{"count":96,"type":21},110,"INTERVENTIONAL",[99],"NA","This is a double-blind randomised controlled trial (RCT) which compares the effectiveness of three surgical techniques for alleviating residual limb pain (RLP), neuroma pain and phantom limb pain (PLP). The three surgical treatments are Targeted Muscles Reinnervation (TMR), Regenerative Peripheral Nerve Interface (RPNI), and an active control (neuroma excision and muscle burying). Patients will be follow-up for 4 years.",[26,102,103,104,105],"Amputation Neuroma","Phantom Limb Pain","Pain, Neuropathic","Pain, Nerve","2025-01-07",{"date":108,"type":43},"2025-01-09",{"date":110,"type":43},"2023-06-20",{"date":112,"type":21},"2029-06",{"name":114,"class":50},"Prometei Pain Rehabilitation Center",9]