[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"resistance-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:resistance-training":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,49,98,121,154,194,219,249,276,311],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100539857","prehabilitation-with-resistance-exercise-training-for-breast-cancer-neoadjuvant-therapy-100539857",false,"NCT06309290","Prehabilitation With Resistance-exercise Training for Breast Cancer Neoadjuvant Therapy","Prehabilitation Based on Resistance-exercise Training in Women With Breast Cancer Undergoing Neoadjuvant Therapy: From Molecular Mechanism to Clinical Benefits","NEO STRONG","Inclusion Criteria:\n\n* Postmenopausal women with breast cancer in stages I, II and III with luminal breast tumor, HER2+ or TNBC\n* Indication for neoadjuvant chemotherapy\n* Candidates for curative breast surgery\n* Body mass index: 18.5 \\\u003CBMI \\\u003C30 kg\u002Fm2\n* Sedentary (does not perform scheduled or planned physical activity ≥ 2 times a week)\n* Willingness to participate in the study and follow the proposed prehabilitation scheme.\n\nExclusion Criteria:\n\n* Present comorbidities that interact with the metabolism and mobility of the muscles of the body and that do not allow the (safe) performance of strength exercises (e.g., debilitating arthritis, all neurological disorders, paralysis, among others).\n* Severe or uncontrolled cardiovascular disease, cardiac ejection fraction less than 50%\n* Previous antineoplastic treatment\n* Use of nutritional supplements (leucine, glutamine, casein, whey protein, fatty acids and creatine).",true,"FEMALE",{"count":20,"type":21},68,"ESTIMATED","INTERVENTIONAL",[24],"NA","Breast cancer stands as the foremost cause of cancer-related deaths among women worldwide, with the highest incidence of any cancer type. The choice of therapeutic interventions hinges upon factors like cancer stage, cell subtype, and tumor size. Consequently, individuals with more aggressive tumors, such as HER+2 and Triple Negative, or larger tumors often undergo neoadjuvant chemotherapy before breast surgery. However, these anticancer treatments come with side effects like cancer-related fatigue, reduced functional capacity, and changes in body composition, notably skeletal muscle atrophy. Skeletal muscle loss correlates with heightened mortality rates, cardiotoxicity, and diminished quality of life, underscoring the need for early therapeutic interventions. One such promising strategy is prehabilitation, which involves resistance-exercise training aimed at bolstering skeletal muscle mass from the outset of the disease, even preceding breast surgery. Resistance-exercise training has shown favorable effects on women undergoing adjuvant therapy or survivors of breast cancer, however, its molecular and clinical effects in women with breast cancer undergoing neoadjuvant therapy are unknown.",[27,28,29,30],"Prehabilitation","Breast Cancer","Postmenopause","Resistance Training",[27,32,33,34,35],"Breast neoplasm","Strength Training","Skeletal muscle","Muscle strength","RECRUITING","2026-06-10",{"date":39,"type":40},"2026-06-12","ACTUAL",{"date":42,"type":40},"2025-01-01",{"date":44,"type":21},"2026-12",{"name":46,"class":47},"Universidad de La Frontera","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":69,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":97},"100643710","effects-of-dietary-supplementation-with-omega3-fatty-acids-fish-oil-and-progressive-resistance-training-on-skeletal-muscle-status-in-gynaecological-gastrointestinal-and-urological-cancer-patients-100643710","NCT07643558","Effects of Dietary Supplementation With omega3-fatty Acids (Fish Oil) and Progressive Resistance Training on Skeletal Muscle Status in Gynaecological, Gastrointestinal and Urological Cancer Patients","SUPPORT-Study = Effects of a Dietary SUPPlementation With Omega3-fatty Acids\u002F Fish Oil and Progressive Resistence Training on Skeletal Muscle Status in Gynaecological, Gastrointestinal, and Urological Cancer Patients","SUPPORT","Inclusion Criteria:\n\n* Patients with malignant tumors undergoing curative or palliative treatment, including breast, ovarian, esophageal, pancreatic, gastric, colon, rectal, and prostate cancer, across all UICC stages\n* Women and men aged 18 years or older\n* ECOG performance status 0-2\n\nExclusion Criteria:\n\n* Patients younger than 18 years\n* Bone metastases or skeletal involvement associated with a high risk of fracture\n* Pregnant or breastfeeding women\n* Patients with psychiatric disorders that raise concerns regarding decision-making capacity or ability to provide informed consent\n* Participation in other exercise and\u002For nutritional intervention studies within the previous 3 months\n* Current use of fish oil supplements\n* Severe cardiovascular disease, NYHA class IV","ALL","18 Years",{"count":60,"type":21},288,[24],"Cancer cachexia is a common and prognostically relevant complication of advanced malignancies, characterized by systemic inflammation, increased catabolism, and reduced nutritional intake, leading to a progressive loss of skeletal muscle mass, physical performance, and quality of life. Muscle wasting negatively affects the tolerability and efficacy of oncological therapies and exacerbates distressing symptoms such as fatigue. Consequently, international guidelines recommend combined nutritional and exercise interventions as key components of supportive cancer care. However, due to treatment-related limitations, conventional exercise programs are often difficult to implement, highlighting the need for feasible, time-efficient, and individually adaptable training concepts suitable for daily life.\n\nIn addition, adequate protein-rich nutrition is essential and may be supported by targeted nutritional supplementation. Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have demonstrated anti-inflammatory effects and beneficial influences on nutritional status, quality of life, and potentially skeletal muscle mass.\n\nThe aim of the present project is to investigate, in a randomized, placebo-controlled trial, whether the combination of progressive resistance training (twice-weekly TheraBand-based exercise) and omega-3 supplementation (daily intake of 2 g EPA and 1 g DHA administered as fish oil capsules) can improve muscle status, physical performance, and patient-relevant outcomes such as quality of life, appetite, and fatigue in cancer patients at high risk of developing cancer cachexia.",[64,65,30,66,67,68],"Cancer Cachexia","Omega 3","Cancer","Muscle Wasting","Systemic Inflammation",[70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87],"Resistance training","Progressive resistance exercise","Exercise therapy","Supportive cancer care","Nutritional intervention","Protein-rich nutrition","Nutritional supplementation","Omega-3 fatty acids","Eicosapentaenoic acid (EPA)","Docosahexaenoic acid (DHA)","Fish oil supplementation","Physical performance","Quality of life","Fatigue","Appetite","Patient-reported outcomes","Randomized placebo-controlled trial","Cachexia risk","2026-06-08",{"date":90,"type":40},"2026-06-11",{"date":92,"type":40},"2026-01-01",{"date":94,"type":21},"2029-10",{"name":96,"class":47},"University of Erlangen-Nürnberg Medical School",1,{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":17,"sex":57,"minAge":104,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":111,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":97},"100602811","mechanisms-of-resistance-exercise-training-for-improved-muscle-insulin-sensitivity-100602811","NCT07128368","Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity","Inclusion Criteria:\n\n* Sedentary (≤30min of physical activity on ≤1 day\u002Fweek)\n* Weight stable for ≥3 months prior to study\n\nExclusion Criteria:\n\n* Active coronary artery disease or heart failure.\n* Participation in a structured exercise program \\> 1 day\u002Fweek.\n* A known medical condition that in the judgment of the investigator might interfere with the completion of the protocol such as the following examples:\n\n  * Abnormal liver function test results (Transaminase \\>2 times the upper limit of normal)\n  * Abnormal renal function test results (calculated GFR \\\u003C60 mL\u002Fmin\u002F1.73m2); If on antihypertensive, thyroid, anti-depressant or lipid lowering medication, lack of stability on the medication for the past 2 months prior to enrollment in the study\n  * Uncontrolled thyroid disease (TSH undetectable or \\>10 mlU\u002FL); testing required within three months prior to admission for subjects with a goiter, positive antibodies, or who are on thyroid hormone replacement, and within one year otherwise\n  * Abuse of alcohol or recreational drugs\n  * Active tobacco usage\n  * Infectious process not anticipated to resolve prior to study procedures (e.g. meningitis, pneumonia, osteomyelitis).\n  * Uncontrolled arterial hypertension (Resting diastolic blood pressure \\>90 mmHg and\u002For systolic blood pressure \\>160 mmHg) at the time of screening.\n  * A recent injury to body or limb, muscular disorder, use of any medication, any carcinogenic disease, or other significant medical disorder if that injury, medication or disease in the judgment of the investigator will affect the completion of the protocol\n  * Active pregnancy\n  * Menopause (defined as absence of menstruation for 12 consecutive months)\n  * Restrictions on Use of Other Drugs or Treatments:\n\n    * Any other medication believed to be a contraindication to the subject's participation.","30 Years","50 Years",{"count":107,"type":21},16,[24],"To uncover the underlying mechanisms of resistance exercise training benefits on glucose metabolism and insulin sensitivity in muscle.",[30],"NOT_YET_RECRUITING","2025-12-09",{"date":114,"type":40},"2025-12-12",{"date":116,"type":21},"2026-09-01",{"date":118,"type":21},"2028-10-31",{"name":120,"class":47},"Mayo Clinic",{"id":122,"slug":123,"hasResults":11,"nctId":124,"briefTitle":125,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":57,"minAge":128,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":22,"phases":131,"briefSummary":132,"conditions":133,"keywords":138,"overallStatus":111,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":97},"100595037","frailty-intervention-in-postoperative-hip-fracture-inpatients-100595037","NCT07027241","Frailty Intervention in Postoperative Hip Fracture Inpatients","Multicomponent Exercise and Nutrition Based Frailty Intervention in Postoperative Hip Fracture Inpatients","Inclusion Criteria:\n\n* Older adults \\>\u002F= 65\n* Clinical Frailty Score 4-6 (This includes patients with very mild, mild and moderate frailty. This would be in keeping with literature quoting frailty interventions where patients who are 'pre-frail' and frail are included)\n* Post fragility hip fracture (including subtrochanteric fracture)\n* Post hip fracture surgery (all types including total hip replacement, hemiarthroplasty, IM nailing)\n* Medically stable postoperatively\n* No weightbearing restriction\n* Mobile pre-admission (including aids and max assist of 1 person)\n\nExclusion Criteria:\n\n* Medically unstable (NEWS \\>3, unless a higher cutoff is stipulated by the primary medical researcher)\n* Non fragility hip fracture (fracture from non osteoporotic aetiology, pathologic fracture)\n* Hip surgery for other aetiology (prosthetic joint infection, arthritis, implant loosening, avascular necrosis, periprosthetic fracture)\n* Polytrauma\n* Delirium or severe cognitive impairment (as defined by inability to follow instructions and unable to provide informed consent)\n* Pre-existing neurologic or cardiovascular disorders that would affect participation\u002F compliance with exercise intervention\n* Open hip fracture\n* Other lower limb orthopaedic disorders that affect participation\u002F compliance with exercise intervention\n* Terminal illness with \\\u003C\u002F= 6 months to live\n* Active treatment for cancer (systemic chemotherapy or radiotherapy, patients on oral chemotherapeutic agents\u002F checkpoint inhibitors will be eligible for inclusion)\n* Nursing Home Resident\n* Severe lower limb pain post-op\n* Severe skin issues\u002F ulcers in non-operated lower limb that would preclude utilisation of ankle weights\n* Swallowing disorders\u002F difficulty\n* Renal impairment with eGFR \\\u003C30\n* Hepatic failure\n* Patients with a dairy\u002F soy allergy","65 Years",{"count":130,"type":21},50,[24],"Hip fracture is a big health concern in older adults, and can lead to increased risk of death, reduced level of independence \\& mobility, reduced quality of life, and higher likelihood of admission to nursing homes. Frailty is a medical condition associated with ageing that results in a reduced ability to do daily tasks. A frail older adult is also less able to recover well from conditions that may affect their wellbeing (for example, infections, falls resulting in injuries or hospital admissions). Frailty is common in older adults with hip fractures.\n\nThere has been increasing research showing that frailty can be slowed down and improved by a combination of nutritional supplementation and exercise. However, most of the research in this area has been in frail older adults living at home or in nursing homes. The exercise or nutritional programs in these studies tend to be carried out over weeks or months. There are very few studies looking at older adults in hospital and how exercise and nutrition help with frailty over shorter periods of time, even more so in patients who have sustained an injury.\n\nThere is, however, very little research in hospital based frailty programs in older patients who have suffered major trauma. It is well known that standing up and starting to walk soon after a hip fracture improves time to recovery, reduces hospital length of stay and death. Hence, physiotherapy on the first day after hip fracture surgery is now recommended. However, there needs to be more research to aid in developing physiotherapy and exercise programs that are safe and doable in the care of hip fracture patients despite limited resources in our healthcare system.\n\nSimilarly, although malnutrition is common in frail older adults with hip fractures, the benefits of nutritional supplementation in these patients is not fully understood. It is known that having a hip fracture puts a person at risk of muscle breakdown and increasing protein intake is recommended to help reduce this risk. Research on exercise and nutrition based frailty programs specific to hip fracture patients is strongly needed, specifically the development of that are doable and safe in the hospital setting that can help improve outcomes in hip fracture patients after surgery.\n\nThe investigators believe that a multicomponent exercise and nutrition based frailty program will be safe, doable and acceptable in frail older adults after hip fracture surgery.",[134,135,33,30,136,137],"Hip Fractures (ICD-10 72.01-72.2)","Frailty at Older Adults","Exercise Training","Protein Supplementation",[139,140,141,142,143,144],"Hip fracture","Exercise","Nutrition","Protein supplementation","Strength and resistance training","Frailty","2025-06-16",{"date":147,"type":40},"2025-06-18",{"date":149,"type":21},"2025-08-01",{"date":151,"type":21},"2026-02",{"name":153,"class":47},"Royal College of Surgeons, Ireland",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":11,"sex":57,"minAge":128,"maxAge":4,"enrollmentInfo":161,"targetDuration":4,"studyType":22,"phases":163,"briefSummary":164,"conditions":165,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":48},"100493872","the-save-project-sarcopenia-and-vertigo-in-aging-patients-with-colorectal-cancer-100493872","NCT05710809","The SaVe Project-Sarcopenia and Vertigo in Aging Patients With Colorectal Cancer","SaVe","Inclusion Criteria:\n\n* Meet the criteria of the oncological departments of receiving neoadjuvant, adjuvant or first line palliative chemotherapy for colorectal cancer\n* ≥65 years of age at the time of signing the informed consent form\n* Able to speak and read Danish, and to provide a signed informed consent form\n* Have an Eastern Cooperative Oncology Group (ECOG) performance status score of ≤2\n\nExclusion Criteria:\n\n* Chemotherapy treatment within two years and sequelae of neuropathy, or symptoms of dizziness or vertigo, or balance disturbance\n* Severe physical disability that hinders physical exercise\n* Dementia, psychotic disorders, or other cognitive diseases or conditions that hinder participation in a clinical exercise-based trial\n* Inability to sign informed content\n* Patients who have had a consultation in the geriatric outpatient clinic within the past six months",{"count":162,"type":21},150,[24],"The goal of this clinical trial is to learn about the cause of dizziness and decline in walking ability in in older adults ≥65 years during chemotherapy treatment for colorectal cancer. Another goal is to investigate if a comprehensive geriatric assessment and three months' specialized physical group-based exercise three times\u002Fweek can counteract muscle weakness, vertigo, instability, impaired walking balance, and neuropathy",[166,167,168,169,170,171,172,66,173,140,174,175,176,177,178,179,30,180,181,182,183,184],"Colorectal Cancer","Oncologic Complications","Comprehensive Geriatric Assessment","Vestibular Rehabilitation","Geriatric Oncology","Sarcopenia","Vertigo","Rehabilitation","Geriatric","Elderly","Frail","Older Adults","Chemotherapy","Chemotherapy-induced Peripheral Neuropathy","Balance Training","Postural Stability","Pragmatic Trial","Personal Medicine","Individualised","2025-04-02",{"date":187,"type":40},"2025-04-06",{"date":189,"type":40},"2023-02-20",{"date":191,"type":21},"2027-09",{"name":193,"class":47},"Rigshospitalet, Denmark",{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":17,"sex":57,"minAge":58,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":22,"phases":204,"briefSummary":205,"conditions":206,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":97},"100574915","exercise-induced-hypoalgesia-differences-between-upper-and-lower-limbs-resistance-training-interventions-100574915","NCT06765486","Exercise-Induced Hypoalgesia Differences Between Upper and Lower Limbs Resistance Training Interventions","Exercise-Induced Hypoalgesia Differences at Proximal and Distal Regions After Applying a Lower Limb Resistance Training or an Upper Limb Resistance Training Protocol: A Randomized Controlled Trial in Healthy Participants","Inclusion Criteria:\n\n* Asymptomatic subjects aged between 18 and 64 years.\n\nExclusion Criteria:\n\n* Cardiovascular, respiratory, metabolic, neurological, or osteomuscular signs or pathologies.\n* History of epilepsy.\n* Pregnant.\n* Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 12 weeks.","64 Years",{"count":203,"type":21},90,[24],"This randomized controlled trial with healthy subjects aims to compare exercise-induced hypoalgesia among three groups: one utilizing a lower limb resistance training intervention, another using an upper limb resistance training, and a control group. The exercise protocol involves 3 sets of 5 repetitions of resistance exercises (brachial biceps curl and leg extensions). Exercise-induced hypoalgesia will be assessed by measuring pressure pain thresholds in the thigh and elbow, comparing exercise interventions with the control group. Additionally, a secondary objective is to compare the lower limb and upper limb resistance training groups in terms of their effects on pressure pain thresholds in the thigh and elbow. Thus, the study anticipates observing differences in local and distal hypoalgesia based on the trained region.",[207,208,30,209],"Local Hypoalgesia","Distal Hypoalgesia","Pressure Pain Thresholds","2025-02-25",{"date":212,"type":40},"2025-02-26",{"date":214,"type":40},"2025-02-15",{"date":216,"type":21},"2025-06-01",{"name":218,"class":47},"Centro Universitario La Salle",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":4,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":226,"minAge":58,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":229,"briefSummary":230,"conditions":231,"keywords":233,"overallStatus":111,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":97},"100579723","feasibility-of-a-remotely-delivered-resistance-training-program-for-cognitive-function-in-men-living-with-and-beyond-prostate-cancer-100579723","NCT06828003","Feasibility of a Remotely-Delivered Resistance Training Program for Cognitive Function in Men Living With and Beyond Prostate Cancer","A Remotely-Delivered Resistance Training Program for Cognitive Function in Men Living With and Beyond Prostate Cancer: A Feasibility Study","Inclusion Criteria:\n\n* ≥18 years of age\n* localized or asymptomatic metastatic primary prostate cancer (i.e., androgen receptor axis agents \\[ARATs\\] including conventional ADT, abiraterone, enzalutamide)\n* a history of ADT treatment\n* not currently undergoing radiation\n* no neurological or musculoskeletal co-morbidity inhibiting exercise\n* mild cognitive impairment as determined by the TICS-M \\[scores between 21-24 to separate individuals with mild cognitive impairment and normal cognition (\\>24)\\]\n* not physically active (self-report \\\u003C90 minutes of MVPA\u002Fweek and \\\u003C2 days of RT\u002Fweek)\n* physician clearance to participate\n* access to a webcam and internet\n* able to complete the study in English.\n\nExclusion Criteria:\n\n* a medical condition that prevents unsupervised exercise\n* presence of other primary or recurrent invasive cancer\n* have experienced a fall in the last 12 months\n* use a gait aid device\n* current participation in other exercise programs\u002Ftrials\n* colour-blind since the objective cognitive tests require participants to distinguish between colours.","MALE",{"count":228,"type":21},30,[24],"Prostate cancer and its treatment are associated with many long-term adverse effects including cancer-related cognitive impairment. Specifically, androgen deprivation therapy has been shown to negatively impact cognitive function. Combined aerobic and resistance training has been shown to improve cognitive function in men treated with androgen deprivation therapy, but limited research has observed its impact into survivorship. Additionally, existing study designs are limited to supervised, combined aerobic and resistance training interventions. Remotely-delivered resistance training programs could enhance exercise participation by overcoming commonly reported barriers in men living with and beyond prostate cancer such as transportation, distance to facility, and timing of programs. Alongside the needs to address cancer-related cognitive impairments due to androgen deprivation therapy, resistance training may serve to manage functional deficits, losses in bone mineral density and muscle mass and increases in cardiometabolic risk factors. This study will assess the feasibility of an 8-week remotely-delivered resistance training program to improve cognitive function in men living with and beyond prostate cancer who have a history of androgen deprivation therapy treatment.",[232,30],"Prostate Cancer",[234,235,236,237,238,239],"cancer survivorship","cognitive function","prostate cancer","remote delivery","feasibility","resistance training","2025-02-10",{"date":242,"type":40},"2025-02-14",{"date":244,"type":21},"2025-03-01",{"date":246,"type":21},"2026-01",{"name":248,"class":47},"University of Toronto",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":57,"minAge":58,"maxAge":256,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":260,"conditions":261,"keywords":265,"overallStatus":111,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":97},"100568419","hospital-based-and-home-based-resistance-training-in-adult-congenital-heart-disease-100568419","NCT06680973","Hospital-Based and Home-Based Resistance Training in Adult Congenital Heart Disease","Comparison of the Effects of Hospital-Based and Home-Based Resistance Training in Individuals with Adult Congenital Heart Disease","Inclusion Criteria:\n\n* Diagnosis of congenital heart disease\n* Aged between 18 and 45 years\n* Being informed about the study and providing written consent to participate\n* Clinical stability has been achieved in the patients\n* No changes in ongoing medication treatment that negatively affect clinical stability\n\nExclusion Criteria:\n\n* Having additional cardiovascular, neurological, orthopedic, or any other systemic diseases\n* Being classified as high risk (severe systolic dysfunction, moderate\u002Fsevere elevated pulmonary artery pressure, significant arrhythmic burden, malignant arrhythmia, etc.)\n* Not suitable for cognitive, psychological, and mental assessments\n* Undergoing a surgery other than heart surgery","45 Years",{"count":258,"type":21},33,[24],"Congenital heart disease (CHD) is defined as functional or anatomical abnormalities of the heart and major intrathoracic vessels present at birth. Impaired responses to exercise in individuals with CHD reduce exercise capacity and increase long-term mortality risk. Today, the growing population of adults with congenital heart disease (ACHD) faces chronic issues stemming from congenital abnormalities, along with muscle strength loss and a decline in activities of daily living. Once the planned treatments in this project proposal are implemented and data are obtained (especially if these data support the hypotheses), the treatment protocols applied in this study and their effects will be considered alongside the current treatment plans for individuals with CHD who experience muscle strength loss and disease-related impairment. With new treatment programs, this study aims to reduce disease-related muscle strength loss, improve disease-related outcomes, and enhance quality of life.",[262,30,263,264],"Congenital Heart Diseases","Muscle Strength","Functional Capacity",[262,70,35,266],"Functional capacity","2024-11-07",{"date":269,"type":40},"2024-11-08",{"date":271,"type":21},"2025-01-05",{"date":273,"type":21},"2025-11-05",{"name":275,"class":47},"Hacettepe University",{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":282,"eligibilityCriteria":283,"healthyVolunteers":17,"sex":18,"minAge":58,"maxAge":4,"enrollmentInfo":284,"targetDuration":4,"studyType":22,"phases":286,"briefSummary":287,"conditions":288,"keywords":297,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":97},"100568305","impact-of-menstrual-cycle-based-resistance-training-on-neuromuscular-performance-in-female-athletes-100568305","NCT06679491","Impact of Menstrual Cycle-Based Resistance Training on Neuromuscular Performance in Female Athletes","Effects of Menstrual Cycle-based Undulating Periodized Resistance Training in Women's Neuromuscular Abilities","MENSES","Inclusion Criteria:\n\n* Female athletes with natural menstrual cycles (eumenorrheic): Participants must have regular menstrual cycles lasting between 21 and 35 days, with at least 9 cycles per year.\n* Women using a low-dose monophasic estrogen-progestin oral contraceptive.\n* Age 18 or older: Participants must be legal adults.\n* Body Mass Index (BMI) between 18 and 30 kg\u002Fm².\n* No medical contraindications to high-level physical training or exercise.\n* Physically active: Engages in at least 3 hours of physical activity per week.\n* Informed consent: Provides written, informed consent to participate in the study.\n* Affiliation with a social security system (if applicable by local regulations).\n\nExclusion Criteria:\n\n\\-",{"count":285,"type":21},60,[24],"The goal of this clinical trial is to assess the impact of menstrual cycle-based resistance training on neuromuscular function in female athletes.\n\nThe primary questions it aims to answer are :\n\n* Does varying resistance training intensity according to menstrual phases improve maximal knee extensor strength?\n* How do different training protocols affect voluntary activation, rate of force development, muscle stiffness, and vertical jump height?\n\nResearchers will compare natural menstrual cycle groups with an oral contraceptive control group to determine if menstrual phase-specific training influences neuromuscular adaptations.\n\nParticipants will:\n\n* Undergo 2 weekly resistance training sessions over 13 weeks with intensity adjustments based on menstrual phase\n* Complete periodic neuromuscular assessments across three menstrual phases: early follicular, late follicular, and mid-luteal before and after resistance training intervention",[289,30,290,291,292,293,294,295,296],"Menstrual Cycle","Neuromuscular Function","Female Athlete","Women Health","Oral Contraceptive Pill","Muscle Strenght","Hormones","Periodized Training",[289,70,298,299,300,295,301,302],"Periodized training","neuromuscular function","Female athlete","oral contraceptive pill","women health","2024-11-05",{"date":267,"type":40},{"date":306,"type":21},"2024-11-01",{"date":308,"type":21},"2027-12-31",{"name":310,"class":47},"Universite de La Reunion",{"id":312,"slug":313,"hasResults":11,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":17,"sex":226,"minAge":318,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":22,"phases":322,"briefSummary":323,"conditions":324,"keywords":327,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":97},"100557337","effects-of-high-load-strength-training-with-and-without-tissue-specific-planter-facia-stretching-with-planter-fasciitis-100557337","NCT06536803","Effects of High Load Strength Training With and Without Tissue Specific Planter Facia Stretching With Planter Fasciitis","Effects of High Load Strength Training With and Without Tissue Specific Planter Facia Stretching Exercise on Pain Range of Motion and Functional Disability Among the Athletes With Planter Fasciitis","Inclusion Criteria:\n\n* Only Male Athletes\n* Prediagnosed Patients suffering from Plantar fasciitis referred from Orthopedic.\n* History of inferior heel pain atleast 2 weeks before enrollement.\n* Pain on palpation of Medial calcaneal Tubercle\u002Fproximal Plantar Fascia.\n* All participants with in the age group between 20-35 yrs.\n* Patients who are willing to particiapate in the study.\n* Heel pain syndrome\n\nExclusion Criteria:\n\n* History of any systemic disease\n* Heel and skin infection\n* History of prior Surgery\n* Corticosteroid injection for Plantar fasciitis within previous 06 momths;\n* Any known malignancy \u002Fneoplasma involved side.\n* Diagnosed\u002Fknown psychiatric illness","20 Years","35 Years",{"count":321,"type":21},40,[24],"The rationale behind examining the synergistic impacts of high load strength training and tissues pecific plantar fascia stretching activities in athletes diagnosed with plantar fasciitis arises from an acknowledged deficiency in the existing body of scholarly research.Study design will be Randomized Control Trial. The study will be completed in 10 months after Synopsis Approval.The study will be carried in sports clubs of MOTH Mirpur AJK. Convenient Sampling will be used. Data Collection Tools will be used named as VAS, Functional foot index (FFI), and Goniometry used for Pain, functional disability and range of motion will be measured respectively before and after the intervention",[325,30,326],"Plantar Fascitis","Muscle Stretching Exercises",[328],"plantar heel pain,High-load strength training,","2024-08-02",{"date":331,"type":40},"2024-08-05",{"date":333,"type":40},"2024-06-26",{"date":335,"type":21},"2024-09-26",{"name":337,"class":47},"Riphah International University"]