[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiration-artificial\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiration-artificial":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,52,91,119,145,167,192,220],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100642479","ventilation-modalities-during-transport-of-postoperative-critically-ill-patients-to-the-icu-100642479",false,"NCT07646249","VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU","VENtilation Modalities During Transport of PostoperatIve CRITically Ill Patients to the ICU - A Multicenter Observational Study","VENTICRIT","Inclusion criteria\n\n* Intubated patients undergoing general anesthesia for non-cardiac surgery\n* Requirement for postoperative IMV\n* Age ≥18 years\n* Obtained informed consent Exclusion criteria\n* Patients undergoing cardiac surgery\n* Patients receiving preoperative mechanical ventilation prior to surgery.","ALL","18 Years",{"count":20,"type":21},800,"ESTIMATED","OBSERVATIONAL","Patients undergoing major non-cardiac surgery may require postoperative mechanical ventilation and transfer from the operating room to the intensive care unit (ICU). This intra-hospital transport phase is critical, as patients may experience changes in respiratory and hemodynamic status, including alterations in oxygenation, ventilation, blood pressure, and heart rate.\n\nDuring transport, ventilatory support may be provided using different strategies, including manual ventilation with a bag-valve device or mechanical ventilation with a portable ventilator. Although both approaches are commonly used in clinical practice, there is limited evidence comparing their effects on respiratory function, gas exchange, and overall physiological stability during and after transport.\n\nThis multicenter, prospective observational study aims to describe current clinical practices in ventilatory support during intra-hospital transport in adult patients undergoing non-cardiac surgery who require ICU admission. The study will also evaluate changes in vital signs, arterial blood gas parameters, and respiratory mechanics, as well as the occurrence of adverse events during transport and postoperative pulmonary complications within the first five days after surgery.\n\nNo additional interventions or procedures beyond standard clinical care will be performed. All data will be collected as part of routine clinical practice. The results of this study are expected to improve the understanding of ventilation management during transport and to identify safer and more effective strategies for critically ill postoperative patients.",[25,26,27,28,29,30],"Respiration, Artificial","Positive-Pressure Respiration","Postoperative Complications (Cardiopulmonary)","Postoperative Complications","Critical Illness","Intensive Care Units",[32,33,34,25,26,35,28,36,29,30,37,38,39],"Intra-hospital Transport","Mechanical Ventilation","Manual Ventilation","Postoperative Care","Postoperative Pulmonary Complications","Endotracheal Intubation","General Anesthesia","Non-Cardiac Surgery","NOT_YET_RECRUITING","2026-06-09",{"date":43,"type":44},"2026-06-12","ACTUAL",{"date":46,"type":21},"2026-07-01",{"date":48,"type":21},"2027-10-01",{"name":50,"class":51},"Societa Italiana Anestesia Analgesia Rianimazione e Terapia Intensiva","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":60,"enrollmentInfo":61,"targetDuration":63,"studyType":22,"phases":4,"briefSummary":64,"conditions":65,"keywords":73,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":90},"100600524","a-new-tool-for-extubation-readiness-in-mechanically-ventilated-patients-readiness-for-extubation-score-100600524","NCT07098611","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score","A New Tool for Extubation Readiness in Mechanically Ventilated Patients: Readiness for EXtubation Score (REXs STUDY)","REXs","Inclusion Criteria:\n\n\\- Patients who are in the weaning process from mechanical ventilation after being connected to invasive mechanical ventilation in the intensive care unit.\n\nExclusion Criteria:\n\n* Patients without legal guardian consent.\n* Tracheostomized patients.\n* Patients enrolled in other studies.\n* Individuals with diaphragmatic pacers.\n* Pregnant patients.","89 Years",{"count":62,"type":21},470,"6 Weeks","Liberation from mechanical ventilation involves three steps: weaning, readiness assessment, and extubation. Readiness is determined using clinical criteria such as improvement of the underlying condition, hemodynamic stability, and adequate respiratory effort. Successful extubation is defined as not requiring invasive support within 48 hours. Due to the complexity of ICU patients, various clinical parameters and multi-component scores have been developed to predict extubation success. This study aims to develop and evaluate a multi-component score, the Readiness for EXtubation score (REXs), to predict extubation readiness in ICU patients under invasive mechanical ventilation.",[66,25,67,68,69,70,71,72],"Ventilator Weaning","Respiratory Failure","Extubation Readiness","Extubation Failure","Extubation Succeeded","Intensive Care Patients Invasively Ventilated","Weaning Invasive Mechanical Ventilation",[74,75,76,77,78,79],"mechanical ventilation","extubation","weaning","readiness","prediction","score","RECRUITING","2026-04-29",{"date":83,"type":44},"2026-05-05",{"date":85,"type":44},"2025-06-15",{"date":87,"type":21},"2026-12-30",{"name":89,"class":51},"Medipol University",7,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":17,"minAge":98,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":101,"phases":102,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":116,"locationsCount":118},"100559220","optimal-timing-for-spontaneous-breathing-trials-100559220","NCT06561295","Optimal Timing for Spontaneous Breathing Trials","Impact of Spontaneous Breathing Trial Timing on Outcomes in Mechanically Ventilated Adult Patients","Inclusion Criteria:\n\n* Adults aged 21 years or older.\n* Patients who have been on mechanical ventilation for more than 48 hours.\n* Patients who have completed at least one SBT.\n\nExclusion Criteria:\n\n* Patients intubated at other hospitals.\n* Patients intubated for surgical or interventional procedures.\n* Patients receiving venovenous extracorporeal membrane oxygenation (VV-ECMO).\n* Patients with a tracheostomy.","21 Years",{"count":100,"type":21},348,"INTERVENTIONAL",[103],"NA","This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU. SBTs are tests used to determine if a patient is ready to breathe on their own without the help of a ventilator. The study will compare two different timing strategies for these trials: one group of patients will have the test early in the morning, while the other group will have it later in the morning. By observing the outcomes, such as how long patients need to stay on the ventilator, the study hopes to find the best time to perform these trials to help patients recover more quickly and safely.",[25,106],"Weaning",[108,106,109],"Spontaneous breathing trial","Mechanical ventilation duration","2025-09-26",{"date":112,"type":44},"2025-09-30",{"date":114,"type":44},"2024-09-17",{"date":87,"type":21},{"name":117,"class":51},"Rush University Medical Center",1,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":101,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":118},"100525126","non-inferiority-trial-between-sotair-device-attached-to-manual-resuscitator-versus-mechanical-ventilation-100525126","NCT06117683","Non-inferiority Trial Between Sotair® Device Attached to Manual Resuscitator Versus Mechanical Ventilation","Non-inferiority Comparative Trial Between Sotair® Device Attached to Manual Resuscitator Versus Mechanical Ventilation in Patients Undergoing Non-emergent Surgery With General Anesthesia","Inclusion Criteria:\n\n* Adult patients who are scheduled for non-emergency surgery with general anesthesia at Rhode Island Hospital.\n* American Society of Anesthesiologists physical status 1 and 2\n\nExclusion Criteria:\n\n* ASA PS \\>3 (e.g., respiratory disease)\n* Oropharyngeal or facial pathology","80 Years",{"count":128,"type":21},310,[103],"Effective respiratory ventilation is achieved by moving the right amount of air in and out of the lungs while keeping the pressures at a safe level. A disposable safety device, Adult Sotair®, was created to improve manual ventilation delivery. In this non-inferiority study, we will perform a pre-post study design (single group, within-group comparison) to test the non-inferiority of the Adult Sotair® device compared to mechanical ventilation.",[132,25],"Airway Management",[33,38,134,135],"Bag Mask Ventilation","Adult Sotair Device","2025-07-09",{"date":138,"type":44},"2025-07-11",{"date":140,"type":44},"2023-12-20",{"date":142,"type":21},"2025-07",{"name":144,"class":51},"Rhode Island Hospital",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":152,"targetDuration":4,"studyType":101,"phases":154,"briefSummary":149,"conditions":155,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":118},"100597530","high-flow-nasal-cannula-vs-niv-after-extubation-in-children-undergoing-heart-surgery-100597530","NCT07059689","High-Flow Nasal Cannula vs. NIV After Extubation in Children Undergoing Heart Surgery","High Flow Nasal Cannula vs. Non-Invasive Ventilation in Post-Extubation Pediatric Cardiac Surgery Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients under 18 years of age.\n* Post-cardiac surgery patients in the CICU of Cipto Mangunkusumo National General Hospital\n* Patients at high risk of extubation failure (e.g., young age, open sternotomy, mechanical ventilation \\>48 hours).\n* Patients who pass the extubation readiness test and spontaneous breathing trial.\n\nExclusion Criteria:\n\n* Diaphragmatic paralysis.\n* Decreased consciousness.\n* Neuromuscular disease.\n* Pneumothorax without drainage.\n* Airway obstruction.\n* Patients with a tracheostomy.\n* Unplanned extubation.\n* Patient received PEEP (Positive End-Expiratory Pressure) \\>7 prior to extubation",{"count":153,"type":21},114,[103],[156,157,25,158],"Heart Defects, Congenital","Intensive Care Units, Pediatric","Extubation","2025-07-07",{"date":138,"type":44},{"date":162,"type":44},"2025-06-05",{"date":164,"type":21},"2025-12",{"name":166,"class":51},"Indonesia University",{"id":168,"slug":169,"hasResults":11,"nctId":170,"briefTitle":171,"officialTitle":171,"acronym":172,"eligibilityCriteria":173,"healthyVolunteers":11,"sex":17,"minAge":174,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":101,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":191},"100474531","visualization-of-inspiratory-effort-and-respiratory-mechanics-to-promote-lung--and-diaphragm-protective-ventilation-100474531","NCT05459116","Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation","VIREM","Inclusion Criteria:\n\n* age \\> 28 days\n* weight \\> 3kg\n* requiring invasive mechanical ventilation\n* anticipated length of ventilation \\> 48h\n\nExclusion Criteria:\n\n* refusal of consent\n* mechanical ventilation ≤ 2 weeks before inclusion\n* known anatomical malformation of the diaphragm (including congenital diaphragmatic hernia)\n* contra-indication to the placement of a naso-gastric esophageal balloon catheter","29 Days",{"count":176,"type":21},150,[103],"This is a multicentre prospective cohort trial in adult and pediatric ICU patients. The investigators will measure the effect of a patient's inspiratory effort during mechanical ventilation on the lungs and diaphragm. The investigators will daily (for a maximum of 8 days) measure esophageal pressures with a balloon catheter to quantify inspiratory effort and respiratory muscle function, and perform daily ultrasound measurements of the diaphragm and the lungs. The investigators hypothesize that a small inspiratory effort will result in the preservation of diaphragm function and have no adverse effect on lung function.",[180,25,181],"Respiratory Muscles","Respiratory Function Tests","2025-04-03",{"date":184,"type":44},"2025-04-06",{"date":186,"type":44},"2022-09-21",{"date":188,"type":21},"2025-12-01",{"name":190,"class":51},"University Hospital, Antwerp",3,{"id":193,"slug":194,"hasResults":11,"nctId":195,"briefTitle":196,"officialTitle":197,"acronym":4,"eligibilityCriteria":198,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":201,"conditions":202,"keywords":208,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":211,"lastUpdatePostDateStruct":212,"startDateStruct":214,"completionDateStruct":216,"leadSponsor":218,"locationsCount":118},"100459360","analysis-of-the-evolution-of-mortality-in-an-intensive-care-unit-100459360","NCT05261607","Analysis of the Evolution of Mortality in an Intensive Care Unit","Epidemiological Analysis of the Evolution of the Case-mix and Mortality in the Intensive Care Unit of Hospital Universitario De Getafe (1991-2026)","Inclusion Criteria:\n\n• Patients admitted to intensive care unit\n\nExclusion Criteria:\n\n• None",{"count":200,"type":21},25000,"The intensive care units is of the main components of modern healthcare systems. Formally, its aim is to offer the critically ill health care fit to their needs; ensuring that this health care is appropriate, sustainable, ethical and respectful of their autonomy. Intensive medicine is a cross-sectional specialty that encompasses a broad spectrum of pathologies in their most severe condition, and specifically has as its foundation the practice of comprehensive care of the patient with organ dysfunction and susceptible to recovery. Although critically ill patients are a heterogeneous population, they have in common the need for a high level of care, often requiring the use of high technology, specific procedures for the support of organ dysfunction and the collaboration of other medical and surgical specialties for their management and treatment.\n\nSince their origins in the late 1950s, intensive care units have been adapting to the changes arising from the best scientific evidence. In the late 1990s and early 2000s, there were some successful clinical trials published that had tested alternative management strategies in the ICU.\n\nMechanical ventilation is an intervention that defines the critical care specialty. Between 1970 and the 1990s, the management focused on normalizing arterial blood gas with aggressive mechanical ventilation. Over the ensuing decades, it became apparent that performing positive pressure ventilation worsened lung injury. The pivotal moment in the mechanical ventilation story would be the low versus high tidal volume trial. This trial shifted the focus away from normalizing gas exchange to reducing harm with mechanical ventilation. Further, it paved way for further trials testing ventilation interventions (PEEP strategy, prone position ventilation) and nonventilation interventions (neuromuscular blockade, corticosteroids, inhaled nitric oxide, extracorporeal gas exchange) in critically ill patients.\n\nThat evidence-based intensive care medicine has undoubtedly had an influence on the outcome of critically ill patients, in general, and, particularly, of patients requiring mechanical ventilation. Temporal changes in mortality over the time have been scarcely reported for patients admitted to intensive care unit.\n\nObjective of this study is to estimate the changes over the time in several outcomes in the patients admitted to an 18-beds medical-surgical intensive care unit from 1991 (year of start of activity) to 2026",[203,204,205,25,206,67,207],"Intensive Care Unit","Mortality","Epidemiology","Sepsis Syndrome","Neurologic Disorder",[209,210,204],"Intensive care units","Outcome","2025-03-11",{"date":213,"type":44},"2025-03-13",{"date":215,"type":44},"1991-07-01",{"date":217,"type":21},"2026-10-31",{"name":219,"class":51},"Hospital Universitario Getafe",{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":226,"eligibilityCriteria":227,"healthyVolunteers":11,"sex":17,"minAge":228,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":101,"phases":231,"briefSummary":232,"conditions":233,"keywords":234,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":246},"100450123","telehealth-enabled-real-time-audit-and-feedback-for-clinician-adherence-teach-100450123","NCT05141396","Telehealth-Enabled, Real-time Audit and Feedback for Clinician AdHerence (TEACH)","Implementation of Coordinated Spontaneous Awakening and Breathing Trials Using Telehealth-Enabled, Real-Time Audit and Feedback for Clinician Adherence: A Type II Hybrid Effectiveness-Implementation","TEACH","Inclusion criteria:\n\n* Patient age \\>=16 years admitted to study hospital ICU\n* Intubated and mechanically ventilated\n\nExclusion criteria:\n\n* Patient with pre-existing brain death admitted to study hospital for organ donation\n* Died within 24 hours of intubation","16 Years",{"count":230,"type":21},13400,[103],"The purpose of this trial is to evaluate if augmenting a usual audit and feedback implementation approach with telehealth-enabled support improves coordinated spontaneous awakening\u002Fbreathing trials and patient outcomes for mechanically ventilated patients.",[25],[235,236],"Invasive Mechanical Ventilation","Coordinated Spontaneous Awakening and Breathing Trials","2023-06-29",{"date":239,"type":44},"2023-07-03",{"date":241,"type":44},"2022-09-01",{"date":243,"type":21},"2026-10-15",{"name":245,"class":51},"Intermountain Health Care, Inc.",11]