[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiration-disorders\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiration-disorders":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,50,78,102,133,156,180,210],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100639890","elastic-band-resistance-and-breathing-training-for-older-adults-with-pulmonary-function-impairment-100639890",false,"NCT07612072","Elastic-Band Resistance and Breathing Training for Older Adults With Pulmonary Function Impairment","Effects of Elastic-Band Resistance Training With or Without Breathing Exercise on Pulmonary Function and Functional Performance in Community-Dwelling Older Adults With Pulmonary Function Impairment: A Randomized Controlled Trial","EBBT-PFI","Inclusion Criteria:\n\n* Age 60 to 85 years\n* Pulmonary function impairment identified by community-based spirometry screening\n* Community-dwelling older adults\n* Able to communicate and walk independently\n* Willing to participate in the 12-week intervention and all study assessments\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Acute or unstable cardiovascular, respiratory, or severe musculoskeletal disease that made exercise training unsafe\n* Recent acute exacerbation, surgery, severe infection, or other health event that could affect safe participation\n* Significant cognitive impairment, communication disorder, or inability to cooperate with training or assessments\n* Currently receiving systematic pulmonary rehabilitation or regular structured exercise training that could affect the intervention effect\n* Unable to meet spirometry quality-control requirements\n* Unable to complete key baseline outcome assessments","ALL","60 Years","85 Years",{"count":21,"type":22},75,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether elastic-band resistance training, with or without breathing training, can improve lung function and physical function in older adults with pulmonary function impairment living in the community. It will also learn about the safety and feasibility of these exercise programs.\n\nThe main questions it aims to answer are:\n\nDoes elastic-band resistance training improve lung function, lower-limb muscle strength, walking ability, and exercise tolerance?\n\nDoes adding structured breathing training to elastic-band resistance training provide additional benefits for lung function and respiratory-related health status?\n\nAre these exercise programs safe and acceptable for older adults in a community setting?\n\nResearchers will compare three groups: elastic-band resistance training plus breathing training, elastic-band resistance training alone, and usual health education. This will help determine whether elastic-band resistance training is helpful and whether breathing training adds extra benefit.\n\nParticipants will:\n\nTake part in a 12-week study\n\nBe assigned by chance to one of three groups\n\nAttend supervised exercise sessions 3 times per week if assigned to an exercise group\n\nReceive usual health education and daily activity guidance\n\nComplete lung function tests, muscle strength tests, physical function tests, and questionnaires at the start of the study, at 6 weeks, and at 12 weeks",[28],"Respiration Disorders",[30,31,32,33,34,35,36],"Pulmonary Function Impairment","Elastic-Band Resistance Training","Older Adults","Pulmonary Function","Breathing Training","Exercise Intervention","Respiratory Health","NOT_YET_RECRUITING","2026-06-30",{"date":40,"type":41},"2026-07-02","ACTUAL",{"date":43,"type":22},"2026-06-10",{"date":45,"type":22},"2026-09-16",{"name":47,"class":48},"Beijing Sport University","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":49},"100517623","spinal-cord-stimulation-for-respiratory-rehabilitation-in-patients-with-chronic-spinal-cord-injury-100517623","NCT06019949","Spinal Cord Stimulation for Respiratory Rehabilitation in Patients With Chronic Spinal Cord Injury","Neuromodulatory Rehabilitation for Respiratory Motor Function in Individuals With Chronic Spinal Cord Injury","Inclusion Criteria:\n\n* At least 18 years old;\n* stable medical condition;\n* no painful musculoskeletal dysfunction, unhealed fracture, contracture, pressure sore or urinary tract infection that might interfere with respiratory training or stimulation;\n* no clinically significant depression, psychiatric disorders or ongoing drug abuse;\n* non-progressive SCI (no negative change in the neurological level and motor-completeness assessed during screening when compared to the neurological status assessed at 6-mo period after injury or at least 6 months prior to the screening), non-ventilator dependence, motor-complete SCI according to the American Spinal Injury Association Impairment Scale (AIS) grade \"A\" or \"B\" above T5 spinal level;\n* sustained SCI at least 12 months prior to entering the study;\n* compared to the normative values for healthy population, at least 15%-deficit in pulmonary function outcomes (FVC and FEV1) as detected by screening spirometry.\n\nExclusion Criteria:\n\nParticipants will be excluded from the study if there is a presence of\n\n* major pulmonary or cardiovascular disease,\n* ventilator dependence,\n* endocrine disorders,\n* malignancy,\n* marked obesity,\n* deep vein thrombosis,\n* HIV\u002FAIDS-related illness,\n* secondary hypotension (anemia, hypervolemia, endocrine and neurological diseases),\n* major esophageal\u002Fgastrointestinal problem or other major medical illness contraindicated for respiratory training or testing.\n\nDuring screening, the potential participant will be asked whether she is pregnant or planning to become pregnant during the study period. Pregnant women are excluded from this study, as the risk to the fetus is unknown. No pregnancy test or birth control regimen will be required.","18 Years",{"count":59,"type":22},36,[25],"Respiratory complications are among the leading causes of death in patients with chronic spinal cord injury (SCI). Our previous work showed that pulmonary function can be improved by using our original respiratory training method. However, the effectiveness of this intervention is limited due to the disruption of brain-spinal connections and consequently lowered spinal cord activity below the injury level. Our recent studies showed that electrical stimulation of the spinal cord below the level of injury leads to increased ventilation which indicates activation of the spinal cord structures related to respiration. These findings indicate that spinal cord stimulation can be a promising therapeutic additive to the treatment. The goal of this study is to justify the establishment of a new direction in rehabilitation for patients with SCI by using a non-invasive spinal cord stimulation in combination with respiratory training.\n\nOur aims are: 1) to evaluate the effects of such stimulation applied to the injured spinal cord on pulmonary function and respiratory muscle activity, and 2) to evaluate the effectiveness and therapeutic mechanisms of the spinal cord stimulation combined with respiratory training. Thirty-six individuals with chronic SCI will be recruited and assigned to three groups to receive respiratory training or spinal cord stimulation alone or a combination of them. All participants will be tested before and after cycles of experimental procedures with\u002For without stimulation. Our hypotheses will be confirmed if the respiratory training combined with spinal cord stimulation results in the most enhanced positive effects.",[63,28],"Spinal Cord Injuries",[65,66,67],"Spinal Cord Injury","Respiration","Rehabilitation","RECRUITING","2026-03-11",{"date":71,"type":41},"2026-03-13",{"date":73,"type":41},"2023-09-10",{"date":75,"type":22},"2030-04-10",{"name":77,"class":48},"University of Louisville",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":17,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":89,"briefSummary":90,"conditions":91,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100626684","continuous-sedation-vs-daily-sedation-interruption-in-ventilated-children-100626684","NCT07438834","Continuous Sedation vs Daily Sedation Interruption in Ventilated Children","Comparison of Comfort Scores Between Continuous Midazolam Infusion and Daily Sedation Interruption in Mechanically Ventilated Pediatric Patients With Pneumonia: A Randomized Controlled Trial","Inclusion Criteria:\n\nDiagnosed with pneumonia\n\nRequiring mechanical ventilation for at least 48 hours\n\nRequiring sedation with intravenous Midazolam\n\nWritten informed consent obtained from parent or legal guardian\n\nExclusion Criteria:\n\nPre-existing neurological impairment (e.g., traumatic brain injury, stroke, cerebral palsy) that may interfere with comfort assessment\n\nPresence of central nervous system symptoms affecting sedation evaluation\n\nContraindication to Midazolam (e.g., hypersensitivity, severe hypotension, significant hepatic dysfunction)\n\nReceiving multiple sedative agents in addition to Midazolam\n\nRefusal of parental or guardian consent","5 Years","10 Years",{"count":88,"type":22},96,[25],"Sedation is essential for mechanically ventilated pediatric patients to ensure comfort, ventilator synchrony, and prevention of self-extubation. However, excessive sedation may prolong mechanical ventilation and ICU stay, while inadequate sedation may cause agitation and physiological distress. Continuous Sedation Infusion (CSI) and Daily Sedation Interruption (DSI) are two commonly used strategies. Limited data exist comparing their impact on comfort levels in pediatric patients.\n\nThis randomized controlled trial aims to compare comfort scores between continuous Midazolam infusion and daily sedation interruption in mechanically ventilated children aged 5-10 years diagnosed with pneumonia. Comfort will be assessed using the COMFORT-B Scale and Richmond Agitation-Sedation Scale (RASS) every 6 hours for 72 hours.\n\nThe study intends to determine which strategy better maintains optimal sedation and comfort in pediatric intensive care settings.",[92,28],"Pneumonia","2026-02-22",{"date":95,"type":41},"2026-02-27",{"date":97,"type":22},"2026-03-02",{"date":99,"type":22},"2026-12-31",{"name":101,"class":48},"University of Health Sciences Lahore",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":110,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":113,"conditions":114,"keywords":118,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":49},"100591187","investigating-the-impact-of-sepsis-phenotypes-on-antibiotic-treatment-in-patients-with-severe-pneumonia-and-sepsis-100591187","NCT06977165","Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Sepsis","Investigating the Impact of Sepsis Phenotypes on Antibiotic Treatment in Patients With Severe Pneumonia and Sepsis: a Prospective Observational Cohort Study","SIPRES","Inclusion Criteria:\n\n* age ≥ 18 years;\n* admitted to intensive care and receiving at least one-organ supportive care;\n* treated for presumed or confirmed lower respiratory infection;\n* receiving or about to receive piperacillin\u002Ftazobactam as part of standard clinical care;\n* valid informed consent or enrolment through deferred consent pathway appropriate.\n\nExclusion Criteria:\n\n* unlikely to survive 24 hours as judged by the treating physician;\n* study antimicrobial started more than 24 hours prior.",{"count":111,"type":22},119,"OBSERVATIONAL","Aim of the research: To find out why antibiotics work differently in certain patients with severe pneumonia and sepsis.\n\nBackground: Individuals can become very unwell from pneumonia, sometimes requiring admission to hospital or even the intensive care unit (ICU). In some cases, pneumonia can lead to a condition called sepsis, which can be deadly if not treated quickly. In the UK, approximately 30,000 patients die from pneumonia every year. Clinicians use antibiotic injections to treat life-threatening infections such as severe pneumonia. After being injected into the bloodstream, antibiotics quickly spread throughout the body, attacking the infection. Antibiotics are eventually broken down and removed from the body by the kidneys and other organs. However, antibiotics fail to achieve the same consistent result for every patient. This may be to do with the way the antibiotics travel through and are removed from the body, leading to different antibiotic levels in the blood at any one time. Low antibiotic levels can result in worse outcomes and antibiotic resistance. Patients can be grouped based on how their immune system reacts to infections. The SIPRES Study aims to explore if these previously described groups explain the difference in antibiotic levels in patients with severe pneumonia and sepsis.\n\nProcedures: We will study how adult patients with severe pneumonia respond when treated with the most commonly used antibiotic in the ICU called piperacillin\u002Ftazobactam. Alongside information on how quickly patients get better and how long they need to stay in hospital or in ICU, we will collect blood samples to measure antibiotic levels and assess each patient's immune system at two time points during their treatment. This will allow us to measure antibiotic levels in blood at different times and group patients based on their immune system reaction to infection. We will describe the range of antibiotic levels seen in the different immune system reaction groups using mathematical and statistical models.\n\nPatient involvement: We are working closely with people who have experienced severe pneumonia and will work with two patient partners and a patient advisory group to help shape this research. Patient contributors have already shaped the development of the funding application and identified important study outcomes. Patients we have spoken to are concerned over the appropriate dosing of antibiotics and appreciate the need for improved and precise approaches to treating severe infections. Moving forward, patient partners will help finalise the protocol, develop patient and public facing materials, provide their perspective on the study results and shape plans to share the outcomes of the study more broadly.\n\nPotential impact: The SIPRES Study will help identify a group of patients at risk of low antibiotic levels in blood, who are less likely to improve with treatment and more likely to develop antibiotic resistance. Mathematical models that can help clinicians personalise antibiotic dosing for each critically ill patient with severe pneumonia will be developed. Findings have the potential to limit the development of antibiotic resistance and help patients survive and get better faster so that they can return to their normal daily lives. Individualised dosing for patients with low antibiotic levels, as opposed to 'one size fits all' prescribing, also has the potential to more efficiently allocate scarce resources to those who will benefit the most.",[28,115,116,117,92],"Respiratory Failure","Sepsis","Infection in ICU",[119,120,121,122,123],"sepsis","pneumonia","therapeutic drug monitoring","beta-lactam antibiotics","piperacillin-tazobactam","2025-05-08",{"date":126,"type":41},"2025-05-18",{"date":128,"type":22},"2025-09-01",{"date":130,"type":22},"2027-09-30",{"name":132,"class":48},"University of Manchester",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":139,"sex":17,"minAge":140,"maxAge":141,"enrollmentInfo":142,"targetDuration":4,"studyType":23,"phases":144,"briefSummary":145,"conditions":146,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":49},"100579405","the-effect-of-distraction-methods-on-children-aged-3-6-years-receiving-inhaler-therapy-100579405","NCT06823869","The Effect of Distraction Methods on Children Aged 3-6 Years Receiving Inhaler Therapy","Inclusion Criteria:\n\n* people who volunteer\n* Children between 3 and 6 years old\n* children without mental problems Children presenting to the emergency department with respiratory illnesses\n\nExclusion Criteria:\n\n* children with a mental problem\n* non-volunteers",true,"3 Years","6 Years",{"count":143,"type":22},80,[25],"The aim of this study is to observe the effect of distraction methods on children aged 3-6 years who apply to the emergency department due to respiratory complaints and receive inhaler medication.",[28],"2025-02-08",{"date":149,"type":41},"2025-02-12",{"date":151,"type":22},"2025-02-25",{"date":153,"type":22},"2025-07-01",{"name":155,"class":48},"Ondokuz Mayıs University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":163,"minAge":164,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":23,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":4},"100565820","aerobic-training-on-lung-function-in-fibromyalgia-100565820","NCT06647147","Aerobic Training on Lung Function in Fibromyalgia","Impact of Aerobic Training on Lung Function in Women With Fibromyalgia","Inclusion Criteria:\n\n* Well controlled fibromyalgia.\n* Mild restrictive lung affection.\n* Body mass index less than 30kg\u002Fm2.\n* Moderate level of physical activity.\n\nExclusion Criteria:\n\n* Any chest diseases.\n* Musculoskeletal\u002F neurological limitations to exercise.\n* Smokers.\n* Pregnant.","FEMALE","30 Years","40 Years",{"count":143,"type":22},[25],"Exploring the effect of aerobic exercises on lung function, chest movement, and exercise capacity in women suffering from fibromyalgia.",[170,28],"Fibromyalgia (FM)","2024-10-16",{"date":173,"type":41},"2024-10-17",{"date":175,"type":22},"2024-11-25",{"date":177,"type":22},"2025-05-15",{"name":179,"class":48},"Middle East University",{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":4,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":17,"minAge":186,"maxAge":4,"enrollmentInfo":187,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":189,"conditions":190,"keywords":197,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":201,"lastUpdatePostDateStruct":202,"startDateStruct":204,"completionDateStruct":206,"leadSponsor":208,"locationsCount":49},"100526576","the-effect-of-sarcopenic-obesity-on-sleep-in-individuals-with-obesity-hypoventilation-syndrome-100526576","NCT06136533","The Effect of Sarcopenic Obesity on Sleep in Individuals With Obesity Hypoventilation Syndrome","Inclusion Criteria:\n\n* \\>50 years old\n* 30\\\u003C BMI\\\u003C 45 kg\u002Fm2\n* Patients who have undergone polysomnography evaluation within the last 6 months\n\nExclusion Criteria:\n\n* Patient who have immobilized for more than 15 days in the last 6 months\n* Patient who have used corticosteroids in the last 6 months\n* Patient who have been significant weight loss in the last 6 months\n* Patient who have been significant serious comorbidities (cognitive impairments, neuromuscular diseases, unstable heart problems, uncontrolled respiratory problems, unresolved thyroid problems, etc.) that may affect participation in the study","50 Years",{"count":188,"type":22},64,"Obesity Hypoventilation Syndrome(OHS) is characterized by daytime hypercapnia and sleep-disordered breathing without other causes of hypoventilation in individuals with a body mass index above 30 kg\u002Fm2. It is stated that obesity is at the basis of the metabolic changes seen in individuals diagnosed with OHS. Also sedentary lifestyle habits, which are common in obese individuals, cause the risk of sarcopenia due to loss of muscle strength and mass, accumulation of adipose tissue in the body, and decreased exercise capacity. Reduced exercise capacity due to obesity has been shown in the literature to strongly interact with mortality risk. As a result of obesity and all this negative picture, impaired emotional state and decreased quality of life are observed in individuals. Simultaneously, sleep parameters are also negatively affected. In particular, increased adipose tissue leads to loss of muscle mass and strength, increased risk of sarcopenia and sleep-related problems. The association of obesity and sarcopenia is referred to as 'sarcopenic obesity'. Sarcopenic obesity is defined as the coexistence of sarcopenia and obesity. The concept of sarcopenic obesity has recently taken its place in the literature. In particular, there are very few studies on its relationship with sleep parameters. However, while obesity is the basis of OHS, there are no studies on the presence and effects of sarcopenic obesity in this patient group. Based on this point, we aim to investigate the effects of sarcopenic obesity on sleep parameters, exercise capacity and quality of life in individuals with OHS.",[191,192,193,28,194,195,196],"Obesity Hypoventilation Syndrome (OHS)","Obesity","Hypoventilation","Sleep Disorder; Breathing-Related","Sarcopenia","Sarcopenic Obesity",[191,192,195,196,198,199,194,200],"Sleep","Quality of Sleep","Polysomnography","2024-08-11",{"date":203,"type":41},"2024-08-13",{"date":205,"type":22},"2025-07-10",{"date":207,"type":22},"2025-10-01",{"name":209,"class":48},"Istanbul University",{"id":211,"slug":212,"hasResults":11,"nctId":213,"briefTitle":214,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":139,"sex":17,"minAge":216,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":220,"conditions":221,"keywords":227,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":232,"lastUpdatePostDateStruct":233,"startDateStruct":235,"completionDateStruct":237,"leadSponsor":239,"locationsCount":49},"100536929","the-gut-lung-axis-and-respiratory-illness-in-children-100536929","NCT06271213","The Gut-Lung Axis and Respiratory Illness in Children","Inclusion Criteria:\n\n* Any infant\u002Fchild\u002Fyoung person admitted to the RHC, Glasgow for an elective bronchoscopy or GI endoscopy.\n* Any infant\u002Fchild attending for an emergency\u002Felective orthopaedic operation without active respiratory or gastrointestinal conditions or receiving treatment for either condition. (Age range birth to 16 years for all groups recruited).\n* Any child attending respiratory department at RHC who can induce sputum and is having a blood sample taken, with latter part of standard of care.\n* Any infant\u002Fchild\u002Fyoung person admitted to RHC for a clinical care appointment with Asthma\u002Fwheeze before commencement of biologics therapy (treatment group).\n* Any child admitted to RHC with asthma\u002Fwheeze not indicated for biologic therapy (asthma control group).\n\nExclusion Criteria:\n\n* Use of antibiotics by the day of admission or have used antibiotics in the previous month (unless prophylactic antibiotics \\> 1 month use).\n* Any person 17 years old and above.\n* Any child known to be infected with, or at high risk of having had exposure to HIV, hepatitis B or hepatitis C viruses\n* . Any child and\u002For parent\u002Fguardian who cannot understand the English language where consent would be unethical.\n* Any child with Asthma currently receiving Biologics therapy (unless recruited via bronchoscopy route).","0 Years","16 Years",{"count":219,"type":22},150,"The goal of this single-centre observational study conducted at the Royal Hospital for Children in Glasgow, Scotland, is to employ a multi-omics approach to investigate the \"gut-lung axis\" in health and disease.\n\nPart A is a cross-sectional study design investigating the postulated bidirectional link between the gut and lung microbiomes in children suffering from respiratory or gastrointestinal conditions. Children with no GI or respiratory issues attending for orthopaedic care will be used as a benchmark for a healthy gut-lung axis. The main questions we aim to answer are:\n\n* What does a healthy gut-lung axis look like?\n* Do children with respiratory issues show an altered gut microbiome?\n* Do children with GI issues show an altered lung microbiome?\n\nPart B is a longitudinal study design, that aims to assess the effects of biologics on the gut-lung axis by comparing the gut and lung microbiomes in children with asthma at two time-points who are indicated to start biologics therapy (Asthma treatment) or will not receive biologics therapy (asthma control).\n\nParticipants will provide:\n\n* airway samples (to investigate the lung microbiome)\n* blood samples (to assess inflammatory and metabolic factors which may mediate communication between the two sites) whilst under general anaesthetic for a treatment related to their standard of care\n* stool samples (to assess gut microbiome)\n* dietary information (food diary and\u002For food frequency questionnaire) to assess relationships between diet and the gut-lung axis.",[28,222,223,224,225,226],"Respiratory Disease","Asthma in Children","Wheezing","Gastro-Intestinal Disorder","Healthy",[228,229,230,231],"Gut-Lung Axis","Microbiome","Multi-omics","Children","2024-02-14",{"date":234,"type":41},"2024-02-21",{"date":236,"type":41},"2024-02-04",{"date":238,"type":22},"2028-05-01",{"name":240,"class":48},"NHS Greater Glasgow and Clyde"]