[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-complications\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-complications":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,52,82,104,133,157,191,218,246,275],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100645133","effect-of-endotracheal-tube-cuff-pressure-management-on-postoperative-sore-throat-in-pediatric-laparoscopic-appendectomy-100645133",false,"NCT07678086","Effect of Endotracheal Tube Cuff Pressure Management on Postoperative Sore Throat in Pediatric Laparoscopic Appendectomy","The Effect of Intraoperative Endotracheal Tube Cuff Pressure on Postoperative Sore Throat in Pediatric Patients Undergoing Laparoscopic Appendectomy: A Prospective Randomized Controlled Trial.","Inclusion Criteria:\n\n* Pediatric patients aged 6-18 years\n* Patients with ASA physical status classification I-III\n* Patients scheduled for laparoscopic appendectomy\n* Voluntary written informed consent from the patient's legal guardian\u002Fparent after being informed in detail about the purpose and method of the study..\n\nExclusion Criteria:\n\n* Patients under 6 years of age\n* Patients with ASA IV or higher\n* Patients with preoperative sore throat\n* Patients who have not completed the preoperative fasting period\n* Patients who received intraoperative nasogastric tube\n* Patients who received intraoperative N₂O\n* Patients with complicated appendicitis diagnosis\n* Patients who underwent two or more intubation attempts\n* Patients with surgery duration longer than 2 hours\n* Patients with predicted or likely airway difficulties\n* Patients who underwent conversion from intraoperative laparoscopy to laparotomy\n* Presence of tracheal pathology\n* Congenital anomalies affecting the airway\n* Presence of known upper\u002Flower respiratory tract disease\n* Patients requiring planned postoperative mechanical ventilation\n* Patients in shock\n* Patients with decompensated heart failure or respiratory failure\n* Patient or legal representative's refusal to participate in the study\n* Patients with a history of smoking","ALL","6 Years","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Abstract Objective:\n\nThe aim of this study is to compare two different ways of adjusting the air-filled cushion (cuff) of the breathing tube used during general anesthesia in children undergoing laparoscopic appendectomy (closed surgery for appendicitis). The goal is to see if maintaining the pressure in this cushion within a safe, specific range (15-18 mmHg) helps prevent or reduce sore throat, hoarseness, and discomfort, which are common postoperative complications in children.\n\nStudy Design:\n\nThis is a prospective, randomized, controlled study. Sixty children aged 6 to 18 years scheduled for laparoscopic appendectomy will be included. Participants will be randomly assigned to two equal groups: Group A (Control Group): Breathing tube cuff pressure is adjusted using the standard \"feeling\" (finger palpation) method common in routine practice. Group B (Intervention Group): Breathing tube cuff pressure is measured throughout the surgery using a medical pressure sensor (manometer) and maintained within a safe range (15-18 mmHg). Research Questions: Does actively monitoring airway pressure reduce the number of children experiencing postoperative sore throat? Does this method reduce the severity of sore throat, cough, hoarseness, or other respiratory discomfort compared to the standard method? What will happen?\n\nDuring surgery, respiratory and heart rate measurements will be recorded every 15 minutes for all participants. After surgery, researchers will visit participants (and their parents) at 2, 6, and 24 hours postoperatively to assess the presence of sore throat, discomfort, or hoarseness. No additional medications or invasive procedures will be used for this study; only how we manage airway pressure will be compared.",[27,28,29,30],"Appendicitis Acute","Postoperative Sore Throat, Cough, Hoarseness","Airway Complications","Respiratory Complications",[32,33,34,35,36,37,38],"Endotracheal tube cuff pressure","Post-anesthetic complications","Pressure transducer","Laparoscopic appendectomy","Pediatric anesthesia","Airway management","postoperative sore throat","NOT_YET_RECRUITING","2026-06-28",{"date":42,"type":43},"2026-07-01","ACTUAL",{"date":45,"type":21},"2026-06-30",{"date":47,"type":21},"2026-08-25",{"name":49,"class":50},"Ankara Etlik City Hospital","OTHER_GOV",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":51},"100578719","acute-effect-of-the-thoraco-abdominal-rebalance-method-postoperative-cardiac-surgery-100578719","NCT06814951","Acute Effect of the Thoraco-abdominal Rebalance Method Postoperative Cardiac Surgery","Acute Effect of the Thoraco-abdominal Rebalance Method on Diaphragmatic Function, Respiratory Discomfort, Pulmonary Complications and Hemodynamic Variables in Postoperative Cardiac Surgery Patients: Randomized Clinical Trial","Inclusion Criteria:\n\n* Individuals over 35 years of age who undergo coronary artery bypass graft surgery with prescribed physiotherapy treatment will be included in the study.\n\nExclusion Criteria:\n\n* Patients who are intubated and\u002For have remained on mechanical ventilation for more than twelve hours, or who require non-invasive mechanical ventilation (NIV) before or during the collection period will be excluded.","35 Years",{"count":61,"type":21},26,[24],"Introduction: The thoracoabdominal rebalancing (TAR) method aims to promote diaphragmatic juxtaposition, in addition to seeking to increase respiratory muscle strength and adjust muscle tone. However, scientific publications on this method in heart patients undergoing coronary artery bypass grafting (CABG) are still scarce, justifying the need to carry out this study for information, evaluation, diagnosis and treatment purposes in the health area with an emphasis on cardiology.\n\nObjective: To evaluate whether diaphragmatic ultrasound findings differ between the TAR method and conventional physiotherapy in post-CABG patients.\n\nMethods: This is a randomized, single-blind clinical trial. Adults (\\>35 years), hemodynamically stable, who underwent CABG (\\\u003C24 hours) and had a prescription for physiotherapy will be included. Patients will be randomized into two groups: 1) intervention group \\[IG\\] - TAR; 2) control group \\[CG\\] - standard physiotherapy approach. Interventions will be performed at a single time and the following variables will be collected pre- and post-intervention: heart rate (HR), respiratory rate (RR), peripheral oxygen saturation (SpO2), mean arterial pressure (MAP), diaphragmatic ultrasound (US) to identify possible acute findings in both groups, respiratory distress scale and pulmonary complications scale will be applied at the end of the interventions.\n\nKeywords: Physiotherapy; Cardiology; Ultrasonography",[30,65,66],"Diaphragmatic Excursion","Pulmonary Spirometry",[68,69,70],"Physiotherapy","Ultrasonography","Cardiology","RECRUITING","2026-04-22",{"date":74,"type":43},"2026-04-27",{"date":76,"type":43},"2024-09-01",{"date":78,"type":21},"2026-04",{"name":80,"class":81},"Instituto de Cardiologia do Rio Grande do Sul","OTHER",{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":4,"eligibilityCriteria":87,"healthyVolunteers":11,"sex":16,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":51},"100632731","the-course-of-acute-respiratory-failure-in-geriatric-patients-with-hip-fracture-using-different-modes-of-a-vibroacoustic-device-for-the-lungs-100632731","NCT07517497","The Course of Acute Respiratory Failure in Geriatric Patients With Hip Fracture Using Different Modes of a Vibroacoustic Device for the Lungs","* respiratory failure;\n* hip fracture;\n* Injury Severity Score no higher than 8 points.\n\nExclusion Criteria:\n\n* All contraindications for use of the device:\n* terminal condition of the patient;\n* shock;\n* paradoxical pathological breathing;\n* hypertensive crisis;\n* severe hypocoagulation with a risk of hematoma formation or bleeding in the projection of exposure;\n* severe hypercoagulation, risk of thrombus\u002Fembolus migration along the main vessels in the area of exposure;\n* acute cerebrovascular accident in the first 1-3 days;\n* brain edema;\n* presence of multiple purulent or burn wound surfaces in the area of exposure;\n* presence of unstable rib fractures;\n* pneumomediastinum and\u002For subcutaneous emphysema of the chest;\n* osteomyelitis of the ribs and\u002For thoracic spine;\n* spinal fracture without orthopedic fixation;\n* chest or abdominal trauma with bleeding;\n* Injury Severity Score greater than 8 points;\n* concomitant diseases in the stage of decompensation.","60 Years","85 Years",{"count":20,"type":21},[24],"A medical professional trained in the procedure and use of the device will conduct the vibroacoustic therapy session. He will also take blood samples.\n\nIn the control group, patients will undergo vibroacoustic pulmonary therapy in the \"Pneumonia\" mode, and in the control group, in the \"Prevention\" mode. Vibroacoustic pulmonary therapy will be conducted over a period of 5 days. A similar algorithm of actions is planned for both groups. VALT sessions will be conducted 4-6 times a day for 5 minutes in combination with treatment according to the protocol for the use of \"Vibroacoustic Therapy\" of the lungs of the Ministry of Health of the Republic of Kazakhstan. The device's emitters will be applied to the affected areas of the lungs. Since the device has long cords for the emitters and is portable, it is not difficult to change the patient's position and does not require their active participation, which is important for patients on ventilators and with limited mobility.",[94,30],"Vibration","2026-04-02",{"date":97,"type":43},"2026-04-08",{"date":99,"type":43},"2025-03-01",{"date":101,"type":21},"2027-12-01",{"name":103,"class":81},"Astana Medical University",{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":108,"acronym":109,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":16,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":115,"phases":4,"briefSummary":116,"conditions":117,"keywords":122,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":51},"100620358","neonatal-enterovirus-infections-in-italy-virological-characterization-genomic-and-clinical-epidemiological-insights-on-echovirus-11-100620358","NCT07356583","Neonatal Enterovirus Infections in Italy: Virological Characterization, Genomic and Clinical-epidemiological Insights on Echovirus 11","Entero-Neo","Inclusion Criteria:\n\nSamples from consecutive neonates admitted to neonatal intensive care unit.\n\nExclusion Criteria:\n\nInsufficient residual samples (volume less than 1 mL of nasal swab) will be excluded from the study","1 Day","28 Days",{"count":114,"type":21},1600,"OBSERVATIONAL","The Enterovirus genus, belonging to the Picornaviridae family, consists of positively polarized single-stranded RNA viruses classified into the species Enterovirus (EV, comprising Coxsackievirus, Echovirus and Poliovirus) A-J and Rhinovirus (RV) A-C, of which more than 200 different genotypes have been described. Enteroviruses have a global spread and are a common cause of febrile, gastroenteric and exanthematous diseases, usually self-limiting, which are widespread in infants and pediatric populations. However, they can occasionally cause serious diseases, including meningoencephalitis, myelitis, paralysis, myocarditis, sepsis, severe respiratory syndromes, and acute hepatitis. They can be transmitted by respiratory route, with most cases in temperate regions occurring during summer and early autumn. Enteroviruses are characterized by a rapid evolution determined by the high mutation rate (due to the presence of an RNA-dependent RNA-polymerase that lacks proofreading activity) and the high probability of undergoing recombination events. The latter, in particular inter-typical recombination, plays a crucial role in the evolutionary process of Enteroviruses and has been recognized as a major cause of the emergence of strains with higher pathogenicity and\u002For epidemic potential, although the associated genetic determinants are not known to date. Between July 2022 and April 2023, nine cases of neonatal Echovirus 11 (E-11) infection with severe liver failure and neurological and myocardial involvement were reported in France; seven of these cases resulted in fatal outcomes. Following these reports, the World Health Organization (WHO) issued an alert that quickly led to the identification of further cases in Italy, Spain, Croatia and the United Kingdom. As EV infections are not subject to systematic surveillance, there is a lack of data on the actual burden of disease associated with these infections. Thus, EV infections are underestimated and, even more so, data on their typing are scarce - if not absent -, which involve second-level analyses that are generally not carried out routinely in clinical microbiological diagnostic laboratories, are rarely available and are not systematically collected, not even at European level. A condition that therefore makes it impossible to estimate either the impact of EV infections in general, and of E-11 in particular, or the risk factors related to the most serious cases and the most significant transmission routes. Moreover, the characteristics of the immunological and inflammatory response to infection remain to be defined. These elements would allow, if available, the formulation of a specific case definition to ensure rapid laboratory confirmation and recognition of the disease.To strengthen knowledge of the spread and impact of enterovirus infections in newborns, with a focus on E-11, by carrying out the following activities, within the scope of the project's proposed objectives: design and pilot implementation (proof of concept) of epidemiological and genomic surveillance systems with potential national application; molecular characterization and evaluation of viral pathogenic features; search for possible immunological markers and host risk factors associated with severe EV disease, including E-11.\n\nSpecific objectives\n\n1. To implement and validate a protocol for screening activities in neonatal units and neonatal intensive care units aimed at checking for the presence of infections caused by EV and identifying severe forms of infection, with particular attention to E-11.\n2. Characterize EV strains, identified within the activities carried out by specific objectives 1, using next-generation sequencing (NGS) approaches to obtain the whole genome sequence and identify possible recombinant forms. Carry out phylogenetic analysis of the obtained sequences compared with those deposited in the main international databases, to define genomes that can be traced back to variant strains or with specific mutations in the genome.",[118,119,30,120,121],"Enterovirus","Clinical Syndrome","Gastrointestinal","Sepsis",[123],"Enterovirus, E-11, NGS","2026-03-26",{"date":126,"type":43},"2026-03-27",{"date":128,"type":43},"2026-02-01",{"date":130,"type":21},"2027-02-01",{"name":132,"class":81},"Fondazione IRCCS Policlinico San Matteo di Pavia",{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":139,"eligibilityCriteria":140,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":141,"targetDuration":143,"studyType":115,"phases":4,"briefSummary":144,"conditions":145,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":4},"100565251","respiratory-microbioma-and-respiratory-complications-after-hematopoietic-stem-cell-transplantion-100565251","NCT06639750","Respiratory Microbioma and Respiratory Complications After Hematopoietic Stem Cell Transplantion","Dynamic Evaluation of Composition and Evolution of Respiratory Viroma\u002FMicrobioma of Patients Who Have Undergone Hematopoiteic Stem Cell Transplantation (HSCT), as a Possible Biomarker of Occurrence of Post-HSCT Pulmonary Complications.","VIREMIG","Inclusion Criteria:\n\n* Male or female, aged 18 or over\n* French-speaking\n* Followed in the centre's haematology department with a project for a haematopoietic stem cell allograft\n* Whatever the haemopathy, previous treatments, type of transplant (pheno, geno, haplo-identical), type of graft (bone marrow, peripheral stem cells, cord blood), any conditioning (myeloablative or non-myeloablative), any immunosuppressive protocol.\n* Be affiliated to the social security system\n* Person able to understand the information and sign the consent form.\n* Informed consent must be collected and signed\n\nExclusion Criteria:\n\n* Refusal to take part in the research\n* Failure to sign the consent form\n* Contraindication to nasopharyngeal swabbing",{"count":142,"type":21},120,"2 Years","Allogeneic haematopoietic stem cell transplantation (AHSCT) is a therapeutic resource for many haemopathies. The number of HSCTs has risen sharply in recent years due to the use of attenuated conditioning, which has increased the risk of non-haematological complications. Pulmonary pathologies are a frequent cause of complications following HSCA, both infectious and non-infectious(1,3,4).\n\nAmong these, late non-infectious pulmonary complications (LNIPC), all taken together, occur in 25% of post-HSCA cases(1). These NIPCs, the most common of which is bronchiolitis obliterans, significantly alter the prognosis(4,5). The pathophysiology of CPTNI is poorly understood, but it seems that the occurrence of a viral respiratory infection (pre- or post-ACSH) may be a potential trigger for the onset of CPTNI(1). These viral infections can become \"chronic\", given that viral clearance is impaired by the underlying immunodepression, and can thus cause chronic inflammation leading to the fibrosing and irreversible process of obliterative bronchiolitis(6). Given the prognostic importance of this type of CPTNI, it seems essential to gain a better understanding of its pathophysiology, which may involve a number of mechanisms: cellular expression of the graft and its evolution, disruption of the host response (innate immunity) following viral infection, influence of the microbiome and alteration of epithelial repair(1,3,5). Interest in the digestive and respiratory microbiome has been growing in recent years(7-9). The literature is gradually being enriched with data on the links between infection, the microbiome and chronic respiratory pathology and, in the post-HSCA context, a potential link between the enteric microbiome and Chronic Graft Versus Host Disease (cGVHD).\n\nA pilot study comparing respiratory microbiomes using sequencing and metatranscriptomic analysis on 20 respiratory samples (nasopharyngeal swab and bronchoalveolar lavage pairs) taken under the conditions of the proposed study showed that the technique was highly feasible and highly sensitive.\n\nThe aim of this study is therefore to use meta-genomics to investigate the respiratory virome\u002Fmicrobiome in a population of patients who have undergone HSCA: eukaryotic and prokaryotic viruses, bacterial expression and the expression (meta-transcriptomics) of graft-derived cell lines and their possible association with the occurrence of post-HSCA respiratory complications (infectious and non-infectious).\n\nNo study has assessed the link between the composition of the respiratory virome\u002Fmicrobiome and the occurrence of respiratory events (infectious and CPTNI post ACSH), but also more broadly the link with the composition of the microbiome in the broad sense (respiratory virome, respiratory and digestive microbiota).\n\nThe aim of this study is to establish a respiratory viral and bacterial map as a possible biomarker of the occurrence of respiratory events (infectious and CPTNI), thus enabling more personalised monitoring of patients at risk of CPTNI and management of immunosuppressive treatment of patients at risk of an infectious episode, with risk assessment based on the composition of the respiratory virome.\n\nThe interest of this study is that it is multidisciplinary and transdisciplinary, studying the respiratory pathologies and infections of haematology patients and combining clinical and fundamental research, with expected spin-offs for direct patient care (personalised monitoring and management of immunosuppressive treatments).",[146,147,30],"Hematopoietic Stem Cell Transplantation","Microbioata","2026-03-17",{"date":150,"type":43},"2026-03-18",{"date":152,"type":21},"2026-04-01",{"date":154,"type":21},"2030-04-01",{"name":156,"class":81},"University Hospital, Caen",{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":163,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":165,"enrollmentInfo":166,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":176,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":51},"100621011","the-primrose-trial-100621011","NCT07365072","The PRIMROSE Trial","A Randomised Controlled Trial to Evaluate the Impact of Thoracic PRehabilitation With Inspiratory Muscle tRaining cOmpared to Standard prEhabilitation in People With Lung Cancer for Surgical Treatment . The PRIMROSE Trial","PRIMROSE","Inclusion Criteria: Adults with lung cancer with surgically resectable disease who are referred for pre-treatment optimization with Prehab, from the lung cancer Multi-Disciplinary Teams (MDTs).\n\nThe referral criteria for Prehab is below:\n\n* ≥1 Medical Research Council (MRC) dyspnoea score\n* ≥1 World Health Organization (WHO) performance status (PS)\n* Age ≥ 70 years\n* Frailty index \\>3\n* Borderline or poor pulmonary function (forced expiratory volume in one second (FEV1) \\\u003C 50% or diffusion capacity for carbon monoxide (DLCO) \\\u003C50%)\n* Sedentary people despite having adequate FEV1 or DLCO\n* People who are eligible for surgical procedures, including endobronchial excision of tumour, or lobectomy, segmental resection, pneumonectomy or wedge resection, either via a minimally invasive approach or a standard thoracotomy approach\n\nAdditionally:\n\n* Participants will be included in the trial if they are capable of providing verbal and written consent for Prehab, and written consent for undergoing a surgical procedure for lung cancer\n* People over 18 years of age\n* All people will be considered regardless of their baseline respiratory muscle strength\n\nExclusion Criteria: Inclusion criteria not met\n\n* People diagnosed with other cancers namely, metastatic lung cancer, mesothelioma, sarcoma, mediastinal tumours, or benign diseases\n* People who decline Prehab\n* People who do not consent to Prehab, and do not attend Prehab. People who do not consent to surgery\n* People with a high cardiovascular risk for Prehab and awaiting investigations or interventions (including unstable angina and syncope)\n* People with a serious concomitant disorder that would compromise safety during Prehab\n* People with an abdominal hernia or recent abdominal surgery\n* People with a history of spontaneous pneumothorax and\u002For evidence of large bullae on radiological imaging\n* People with an inability to understand written and\u002For spoken English (only if carers are able to translate)\n* People with a perforated ear drum\n* People with worsening heart failure signs and symptoms after IMT\n* People with pulmonary hypertension\n* People who have suffered from or likely to suffer from costochondritis\n* If a participant was involved in a similar study, with potential to cause bias or conflict of interest then they will be excluded","90 Years",{"count":167,"type":21},100,[24],"Smoking is a major cause for developing lung cancer. People diagnosed with lung cancer, may be offered surgery which offers a complete cure. Smoking also damages the lungs and compromises a person's lung function, resulting in shortness of breath. Breathlessness limits the ability to carry out daily physical activities and exercise and makes people vulnerable to developing post procedure complications and even death. Some people with surgically treatable lung cancer have a poor ability to exercise and compromised lung function and are not fit for surgery. They will instead be referred for radiation therapy, chemotherapy or palliative care. Surgery is the preferred treatment option.\n\nThe pulmonary rehabilitation program (Prehab) improves fitness levels. In addition, it improves the level of breathlessness, exercise capacity and vulnerability of people with lung cancer, with the aim of making them fit for safe surgery. By adding a breathing training device to the Prehab program, the investigators aim to further improve participants fitness for surgery, lower their risk of developing complications and the time spent in hospital after the procedure. The breathing training device is called an inspiratory muscle training device. The hand-held device helps to train and strengthen the breathing muscles, which are then able to work more effectively. After the procedure, participants may be able to breathe and exercise more easily reducing their risk of developing complications and improving outcomes.\n\nThe study will compare two groups of people with lung cancer having surgical removal of part of the lung, at a specialist hospital . One group will receive standard Prehab and inspiratory muscle training with the device prior to the procedure; patients in the second group with receive standard Prehab prior to the procedure. Participants will be followed up for twelve months.",[171,172,173,174,30,175],"Cancer","Lung Resection","Inspiratory Muscle Training","Prehabilitation","Length of Hospital Stay",[177,171,178,174,179,180,181],"Inspiratory muscle training","Lung resection","Lung surgery","Randomised control trial","length of hospital stay","2026-01-28",{"date":184,"type":43},"2026-01-30",{"date":186,"type":43},"2025-05-01",{"date":188,"type":21},"2027-05-01",{"name":190,"class":81},"Swansea Bay University Health Board",{"id":192,"slug":193,"hasResults":11,"nctId":194,"briefTitle":195,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":197,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":198,"targetDuration":4,"studyType":22,"phases":200,"briefSummary":201,"conditions":202,"keywords":206,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":4},"100616457","comparison-of-the-effects-of-target-controlled-infusion-method-and-manual-propofol-administration-on-respiratory-function-recovery-and-electroencephalogram-in-endoscopic-submucosal-dissection-cases-100616457","NCT07305857","Comparison of the Effects of Target-Controlled Infusion Method and Manual Propofol Administration on Respiratory Function, Recovery, and Electroencephalogram in Endoscopic Submucosal Dissection Cases","Inclusion Criteria:\n\n* Age: 18-75 years old\n* ASA (American Society of Anaesthesiologists) physical status class I-III\n* Patients with indications for ESD\n* BMI \\\u003C 35 kg\u002Fm²\n* Patients who are cooperative and can be monitored\n\nExclusion Criteria:\n\n* Those with cardiac or pulmonary insufficiency,\n* Those with neurological diseases,\n* Those with severe hepatic or renal dysfunction,\n* Those with psychiatric disorders that could affect their level of consciousness,\n* Those with allergies or hypersensitivity to propofol, midazolam, and fentanyl, Patients who refuse to participate in the study will not be included in this clinical trial.",true,{"count":199,"type":21},50,[24],"Endoscopic submucosal dissection (ESD) has become widely used as a minimally invasive alternative for the resection of early-stage gastrointestinal neoplasms. Due to the lengthy procedure time and intense pain caused by stretching, cutting, and dissecting the gastric wall during ESD, a deeper level of sedation is recommended compared to traditional endoscopic procedures (1). While ensuring adequate patient immobilisation during ESD, preserving respiratory function and rapid recovery are important clinical goals.\n\nTotal intravenous anaesthesia (TIVA) is an alternative method to inhalation anaesthesia, achieved through the combination of agents such as propofol and remifentanil. TIVA applications can be performed using manual or target-controlled infusion (TCI) systems. TCI systems aim to achieve and maintain the targeted plasma or effect site concentration based on pharmacokinetic models. These systems have been shown to provide advantages such as more stable depth of sedation during endoscopy, less haemodynamic fluctuation, and faster recovery (2-4).\n\nPreserving spontaneous breathing is preferred during ESD procedures, which requires careful monitoring of respiration. The Capnostream® device records four variables (SpO₂, RR, non-invasive EtCO₂, heart rate) every 30 seconds via a nasal cannula and integrates them into a single, dimensionless value called the integrated pulmonary index (IPI). The IPI can range from 1 to 10, with 4 and below requiring intervention and 8 to 10 representing the normal range. Furthermore, the use of the bispectral index (BIS) enables objective monitoring of anaesthesia depth by analysing EEG waves and can increase the safety of the recovery process (5).\n\nThis study aims to compare the effects of manual TIVA and TCI applications on recovery time, BIS, and respiratory parameters during ESD procedures in the stomach or colon region performed under sedation in the endoscopy unit. The findings will contribute to the safer and more effective planning of sedation applications.\n\nReferences;\n\n1. Sasaki T, Tanabe S, Azuma M, Sato A, Naruke A, Ishido K, et al. Propofol sedation with bispectral index monitoring is useful for endoscopic submucosal dissection: a randomised prospective phase II clinical trial. Endoscopy. 2012 Jun;44(6):584-9.\n2. Chang YT, Tsai TC, Hsu H, Chen YM, Chi KP, Peng SY. Sedation for gastrointestinal endoscopy with the application of target-controlled infusion. Turk J Gastroenterol Off J Turk Soc Gastroenterol. 2015 Sep;26(5):417-22.\n3. Sarraj R, Theiler L, Vakilzadeh N, Krupka N, Wiest R. Propofol sedation in routine endoscopy: A case series comparing target controlled infusion vs manually controlled bolus concept. World J Gastrointest Endosc. 2024 Jan 16;16(1):11-7.\n4. García Guzzo ME, Fernandez MS, Sanchez Novas D, Salgado SS, Terrasa SA, Domenech G, et al. Deep sedation using propofol target-controlled infusion for gastrointestinal endoscopic procedures: a retrospective cohort study. BMC Anaesthesiol. 10 August 2020;20(1):195.\n5. Sandler NA, Hodges J, Sabino M. Assessment of recovery in patients undergoing intravenous conscious sedation using bispectral analysis. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg. 2001 Jun;59(6):603-11; discussion 611-612.\n6. Ding Y, White PF. Simplified quality of anaesthesia scoring system. Anaesthesia. 1992 Oct;47(10):906-7.",[203,204,205,30],"Endoscopic Submucosal Dissection","Target Controlled Infusion of Propofol","Endoscopy Unit",[207,208],"endoscopic submucosal dissection","target controlled infusion of propofol","2025-12-12",{"date":211,"type":43},"2025-12-26",{"date":213,"type":21},"2026-01-01",{"date":215,"type":21},"2027-03-01",{"name":217,"class":81},"Marmara University Pendik Training and Research Hospital",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":4,"eligibilityCriteria":224,"healthyVolunteers":197,"sex":16,"minAge":18,"maxAge":89,"enrollmentInfo":225,"targetDuration":111,"studyType":115,"phases":4,"briefSummary":227,"conditions":228,"keywords":231,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":51},"100610423","timing-of-opioid-administration-and-postoperative-respiratory-depression-100610423","NCT07227389","Timing of Opioid Administration and Postoperative Respiratory Depression.","The Relationship Between Timing of Opioid Administration and Postoperative Respiratory Depression.","Inclusion Criteria:\n\n* Written informed consent\n* Adults ≥18 years of age and ≤85 years of age\n* Patients planned for general anesthesia with an expected anesthetic time of at least 2 hours\n* Patients expected to receive postoperative opioid analgesia\n\nExclusion Criteria:\n\n* Non-operative procedure (imaging)\n* Patients not admitted to the PACU postoperatively\n* Use of patient-controlled analgesia systems\n* Female patients who are pregnant or breastfeeding\n* Patients with asymmetric lung disease\n* American Society of Anesthesiologists (ASA) classification V\n* Emergency surgery (ASA E Modifier)",{"count":226,"type":21},52,"The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids.\n\nThe primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation.\n\nA secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation.\n\nThe investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.",[30,229,230],"Opioid Induced Respiratory Depression","Postoperative Respiratory Complications",[232,233,234,235,236],"opioids","bio-impedance","hypoxia","hypercapnia","minute ventilation","2025-11-13",{"date":239,"type":43},"2025-11-14",{"date":241,"type":21},"2025-12",{"date":243,"type":21},"2029-01-01",{"name":245,"class":81},"Wayne State University",{"id":247,"slug":248,"hasResults":11,"nctId":249,"briefTitle":250,"officialTitle":251,"acronym":4,"eligibilityCriteria":252,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":253,"targetDuration":4,"studyType":22,"phases":254,"briefSummary":255,"conditions":256,"keywords":260,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":4},"100572116","propofol-vs-sevoflurane-in-cardiac-surgery-100572116","NCT06729086","Propofol vs Sevoflurane in Cardiac Surgery","Propofol vs Sevoflurane in Cardiac Surgery: a Randomized Clinical Trial During the Peroperative and Postoperative Phase","Inclusion Criteria:\n\n* all patients above 18 yeras old that will undergo a cardiac surgery\n\nExclusion Criteria:\n\n* below 18 yeras old",{"count":167,"type":21},[24],"The hypothesis of our study: presence of a relationship between the type of anesthesia and complications after cardiac surgery. The aim is to assess the benefit of using intravenous or inhaled anesthesia on the patients\\' stay and its complications.",[257,258,259,30],"Cardiac Complications","Cardiac Surgery","Neurologic Complications",[261,262,263,264,265],"propofol vs sevoflurane in cardiac surgery","peroperative","postoperative","randomized clinical trial","complications","2024-12-09",{"date":268,"type":43},"2024-12-11",{"date":270,"type":21},"2025-01-04",{"date":272,"type":21},"2025-05-31",{"name":274,"class":81},"Saint-Joseph University",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":280,"acronym":4,"eligibilityCriteria":281,"healthyVolunteers":11,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":282,"targetDuration":284,"studyType":115,"phases":4,"briefSummary":285,"conditions":286,"keywords":291,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":299,"lastUpdatePostDateStruct":300,"startDateStruct":302,"completionDateStruct":304,"leadSponsor":306,"locationsCount":4},"100560951","incidence-and-complications-of-post-extubation-and-post-tracheostomy-dysphagia-in-adult-patients-in-the-critical-care-unit-100560951","NCT06583824","Incidence and Complications of Post-extubation and Post-tracheostomy Dysphagia in Adult Patients in the Critical Care Unit","Incidence and Complications Associated with Acquired Swallowing Disorder in the Intensive Care Unit in Extubated or Tracheotomized Patients: a Cohort Study","Inclusion Criteria:\n\nPatients aged ≥ 18 years, requiring intubation for ≥ 48 hours and\u002For subsequent tracheostomy, with an adequate level of consciousness to perform the dysphagia diagnostic test, and who have signed the consent form.\n\nExclusion Criteria:\n\nPrevious tracheostomy, prior diagnosis of dysphagia, neurodegenerative disease, or a history of stroke (CVA).",{"count":283,"type":21},414,"6 Months","Acquired Swallowing Disorder in ICU (ICU-ASD), also known as postextubation dysphagia, is a multicausal problem experienced by survivors in intensive care units (ICUs) when the efficiency, safety of swallowing, or both are compromised. These alterations can lead to an increased risk of aspiration, respiratory complications, and malnutrition, potentially resulting in prolonged hospitalization, reduced quality of life, poorer clinical outcomes, and even death.\n\nDespite the clinical and social significance of this disorder, there is limited research addressing it. Existing studies primarily focus on incidence and associated factors, with scant attention to the occurrence of complications, and there is a lack of assessment of the quality of life of these patients. In our context, healthcare professionals are increasingly recognizing the importance of this issue, although the real incidence of ICU-ASD, as well as the frequency of respiratory and nutritional complications, remains unknown. Furthermore, the quality of life of patients with this disorder has not been evaluated thus far.\n\nObjectives:Primary: To analyze the occurrence of respiratory and nutritional complications associated with ICU-ASD in patients intubated for ≥48 hours or tracheotomized in the Intensive Care Unit of the University Hospital Complex of Albacete (ICU CHUA) and identify potential factors related to their occurrence.\n\nSpecific: To determine the incidence of ICU-ASD in the polyvalent ICU CHUA, assess the frequency of respiratory complications, evaluate nutritional status, assess quality of life, and determine the mortality of study participants.\n\nMaterial and Method: Prospective observational cohort study. Setting: Polyvalent ICU CHUA. Participants: Intubated patients for ≥48 hours or tracheotomized, with signed consent. Sampling: Consecutive. Sample size: 414 participants. Demographic\u002Fclinical variables. Outcome variables: Occurrence of respiratory complications, nutritional status, quality of life. Instruments: Modified Volume-Viscosity Swallowing Test (mV-VST), Swallowing Quality of Life Questionnaire (SWAL-QoL). Dysphagia detection will occur 24 hours post-extubation and\u002For 4 days after tracheotomy. Follow-up during hospitalization and post-ICU discharge until the outpatient consultation. Statistical analysis: Absolute and relative frequencies, measures of central tendency and dispersion, significance level of p \\< 0.05, 95% CI; Bivariate analysis: Checking group homogeneity and hypothesis testing: Chi-square, Student\\'s t-test, U-Mann-Whitney, ANOVA, or Kruskal-Wallis.",[30,287,288,289,290],"Pneumonia","Quality of Lifte","Death","Swallowing Disorder.Other Specified",[292,293,294,295,296,297,298],"dysphagia","tracheostomy","aspiration","malnutrition","critical care","mechanical ventilation","pneumonia","2024-09-03",{"date":301,"type":43},"2024-09-04",{"date":303,"type":21},"2024-09-10",{"date":305,"type":21},"2026-09-30",{"name":307,"class":81},"Complejo Hospitalario Universitario de Albacete"]