[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-diseases\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-diseases":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,57,91,120,147],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":52,"leadSponsor":54,"locationsCount":4},"100642671","study-on-intervention-effect-of-heat-related-health-risk-early-warning-digital-technology-for-school-age-children-100642671",false,"NCT07643571","Study on Intervention Effect of Heat-related Health Risk Early Warning Digital Technology for School-age Children","School inclusion criteria\n\n1. Willing to participate in the study.\n2. Possess adequate facilities and qualified teaching staff.\n3. The school and teachers maintain good cooperation.\n4. Class size is no less than 35 students.\n5. All participating classrooms are equipped with air conditioners.\n\nParticipant inclusion criteria\n\n1. Fourth-grade primary school students aged 9 to 11, of all genders.\n2. Voluntary participation by students and their parents, good compliance, and signed informed consent.\n3. At least one adult family member has an internet-enabled mobile device.\n4. Good general health with no history of severe physical or mental disorders.\n5. Local permanent residents with a residency of no less than 6 months.\n\nParticipant exclusion criteria\n\n1. Participants who are unable or refuse to complete required examinations.\n2. Students receiving psychological or psychiatric treatment that may confound the study results.\n3. Those currently enrolled in other interventional clinical studies that may affect outcome assessment.\n4. Any other conditions deemed ineligible by the research team. Any participant meeting any of the above exclusion criteria will be excluded from the study.",true,"ALL","9 Years","11 Years",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","This cluster randomized trial is conducted in Beijing primary schools to evaluate the efficacy of a WeChat mini-program-based high-temperature early warning intervention on the physical and cognitive health of school-age children. Six participating schools are randomly assigned to two parallel groups. The intervention group receives tiered heat alerts and guided self-health monitoring via the mini-program. The control group follows standard daily school and family routines, with no dedicated digital high-temperature early-warning intervention. The primary outcome is children's executive function after a 2.5-month follow-up. A range of secondary indicators related to physical status, mental health and health behaviors are assessed concurrently to quantify the intervention's benefits in mitigating adverse health outcomes caused by high temperatures.",[27,28,29,30,31],"Cardiovascular Diseases","Respiratory Diseases","Mental Health Disorders","Heat Illness","Neurocognitive Impairment",[33,34,35,36,37,38,39,40,41,42,43,44],"Heat stress","heat early warning","digital intervention","WeChat mini-program","school-age children","executive function","Wisconsin Card Sorting Test","cognitive function","cluster randomized controlled trial","children's physical health","heat-related disease","climate change","NOT_YET_RECRUITING","2026-06-09",{"date":48,"type":49},"2026-06-11","ACTUAL",{"date":51,"type":21},"2026-06",{"date":53,"type":21},"2026-09",{"name":55,"class":56},"Centers for Disease Control and Prevention, China","OTHER_GOV",{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":65,"enrollmentInfo":66,"targetDuration":4,"studyType":68,"phases":4,"briefSummary":69,"conditions":70,"keywords":73,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":90},"100397953","exhaled-breath-analysis-by-secondary-electrospray-ionization---mass-spectrometry-in-children-and-adolescents-100397953","NCT04461821","Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents","Exhaled Breath Analysis by Secondary Electrospray Ionization - Mass Spectrometry in Children and Adolescents (EBECA)","EBECA","Inclusion Criteria:\n\n* Age 0 ≤ 22 years at study entry and signed informed consent\n\nAdditional inclusion criteria for respiratory disease population:\n\n* Acute disease: - Acute signs for a respiratory disease, indicated by e.g. increased work of breathing (e.g. dyspnea, increased respiratory rate), cough or wheezing.\n* Chronic disease: - Suspected or confirmed chronic airway disease (e.g. asthma).\n\nAdditional inclusion criteria for neurological disease population:\n\n* Acute disease: - Acute presentation or report within 24 hours of any signs of neurological deficit (motor function, sensoneural, or verbal).\n* Chronic disease: - Confirmed chronic neurologic disease (e.g. childhood epilepsy).\n\nAdditional inclusion criteria for T1D disease population:\n\n* Acute disease: - Hyperglycemia and\u002For pH (venous) \\\u003C7.3, bicarbonate \\>10 mmol\u002FL, increased levels of acetone in blood or urine in the context of newly diagnosed or known T1D.\n* Chronic disease: - Confirmed diagnosis of T1D\n\nExclusion Criteria:\n\n* Physical or intellectual impairment precluding protocol adherence.\n\nAdditional exclusion criteria for respiratory disease population:\n\n* Known malignancy, active smoker (passive smoke exposure is not an exclusion criterium), known inflammatory diseases (e.g. autoimmune disease) that require medical and\u002For pharmacological treatment and is associated with an inflammatory response, relevant congenital defects\n\nAdditional exclusion criteria for neurological disease population:\n\n* Known malignancy, active smoker (passive smoke exposure is not an exclusion criterium), known inflammatory diseases (e.g. autoimmune disease) that require medical and\u002For pharmacological treatment and is associated with an inflammatory response, relevant congenital defects.\n\nAdditional exclusion criteria for T1D population:\n\n* Known malignancy, active smoker (passive smoke exposure is not an exclusion criterium), relevant congenital defects.","22 Years",{"count":67,"type":21},3600,"OBSERVATIONAL","This study is to investigate breath analysis (breath metabolomics) combined with established bioinformatic tools as a platform for companion diagnostics.",[28,71,72],"Neurological Disorders","Type 1 Diabetes",[74,75,76,77,78],"Exhaled breath analysis","Therapeutic drug monitoring (TDM)","Secondary Electrospray ionization - mass spectrometry (SESI-MS)","breath analysis platform","breath metabolomics","RECRUITING","2026-05-04",{"date":82,"type":49},"2026-05-08",{"date":84,"type":49},"2020-09-11",{"date":86,"type":21},"2030-07",{"name":88,"class":89},"University Children's Hospital Basel","OTHER",1,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":97,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":16,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":104,"conditions":105,"keywords":106,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":90},"100544225","time-of-exercise-re-training-with-chronic-obstructive-pulmonary-disease-copd-100544225","NCT06366113","Time of Exercise Re-training With Chronic Obstructive Pulmonary Disease (COPD)","Effect of Time of Exercise Re-training on Functional Capacity in Individuals With Chronic Obstructive Pulmonary Disease (COPD)","CHRONOBIO","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patient with chronic obstructive pulmonary disease (COPD)\n* Registered for respiratory re-education and rehabilitation at the Clinique de la Mitterie\n* Number of rehabilitation sessions at least 18 over 4 weeks\n* Written informed consent signed by the patient\n* Membership of a social security\n\nExclusion Criteria:\n\n* \\- cardiovascular contraindications to exercise\n* unstable respiratory status (uncompensated respiratory acidosis)\n* conditions interfering with the pulmonary rehabilitation process (progressive neuromuscular disease, psychiatric illness)","18 Years","85 Years",{"count":102,"type":21},90,[24],"Pulmonary rehabilitation (PR) is an effective intervention for reducing hospital readmissions, secondary events, and mortality in patients with respiratory pathologies.\n\nThe program should not be improved by introducing new subjects such as circadian rhythm.",[28],[107,108,109,110],"respiratory diseases","pulmonary rehabilitation","chronic obstructive pulmonary disease","biological clock","2026-01-09",{"date":113,"type":49},"2026-01-12",{"date":115,"type":49},"2024-01-02",{"date":117,"type":21},"2026-07-01",{"name":119,"class":89},"Michaël RACODON",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":15,"sex":16,"minAge":99,"maxAge":4,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":90},"100599877","rehabilitation-intervention-for-copd-combined-with-cardiovascular-and-cerebrovascular-diseases-100599877","NCT07090200","Rehabilitation Intervention for COPD Combined With Cardiovascular and Cerebrovascular Diseases","RI-COPD & CCD","Inclusion Criteria:\n\n1. Committed to adhering to the study protocol and cooperating with the implementation of the entire research process.\n2. Aged 18 years or older, regardless of gender.\n3. Signed informed consent form.\n\nExclusion Criteria:\n\n1. Individuals with severe mental illness.\n2. Individuals assessed by medical personnel as having a disease that requires immediate hospitalization or a severe, uncontrollable condition that is life-threatening in the short term.\n3. Women who are pregnant, breastfeeding, or using inappropriate contraception methods.\n4. Individuals who refuse to cooperate with follow-up questionnaires or specimen collection.\n5. Patients currently participating in other interventional clinical drug trials.",{"count":128,"type":21},50000,[24],"Firstly, to screen out the high-risk population of COPD combined with cardiovascular and cerebrovascular diseases, COPD with cardiovascular and make a diagnosis. Then, to evaluate the therapeutic effect of Pulmonary rehabilitation exercise and usual care for three months. And finally, to build a trinity model of rehabilitation management of COPD patients. The objective of this project is to establish and promote the application of diagnostic and treatment norms.",[28,27,132],"Cerebrovascular Diseases",[134,135,107,136,137],"prevention","treatment strategies","cardiovascular diseases","cerebrovascular diseases","2025-07-18",{"date":140,"type":49},"2025-07-29",{"date":142,"type":21},"2025-09-01",{"date":144,"type":21},"2028-07-31",{"name":146,"class":89},"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology",{"id":148,"slug":149,"hasResults":11,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":154,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":158,"briefSummary":160,"conditions":161,"keywords":163,"overallStatus":79,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":90},"100536671","early-phase-1-development-of-methods-for-effective-treatment-and-improvement-of-common-somatic-diseases-in-children-100536671","NCT06267859","Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children","Based on Medical Statistical Analysis and Screening (Dispensary) Examination, Identification of the Most Common Somatic and Congenital Diseases in Children, With the Further Development of More Effective Methods of Treatment and Recovery","Inclusion Criteria:\n\n* children from birth to 15 years;\n* children permanently residing in the territory where the clinical examination is carried out;\n* children included in the group of \"frequently ill children\";\n* patients without severe chronic diseases.\n\nExclusion Criteria:\n\n* Teenagers over 15 years old;\n* Patients with severe neurological and mental diseases;\n* Patients with endocrinological diseases;\n* Patients with long-term chronic somatic diseases;\n* Children without genetic pathologies.","3 Days","15 Years",{"count":157,"type":21},110,[159],"EARLY_PHASE1","The goal of the clinical study is to clarify the course of common congenital, infectious, and non-infectious diseases in children living in Uzbekistan, and to develop methods for their treatment and rehabilitation.\n\nThe main questions it aims to answer:\n\n* Analysis of common congenital diseases among children;\n* Analysis of commonly diagnosed bronchopulmonary and cardiovascular diseases among children;\n* Based on the results of the primary research, common diseases among children will be identified;\n* Analysis of existing treatment methods and their effectiveness;\n* Development of modern methods of treatment and rehabilitation of children.",[28,162],"Congenital Heart Defects",[164,165,166,167,168],"children","adolescents","heart diseases","lung diseases","congenital malformations","2025-05-16",{"date":171,"type":49},"2025-05-21",{"date":173,"type":49},"2023-11-08",{"date":175,"type":21},"2034-01-30",{"name":177,"class":89},"Tashkent State Medical University (Tashkent Pediatric Medical Institute), Uzbekistan"]