[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-distress-neonatal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-distress-neonatal":34},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,59,89,117,150],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":35,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100053679","delayed-versus-immediate-cord-clamping-in-preterm-birth-100053679",false,"NCT07699666","Delayed Versus Immediate Cord Clamping in Preterm Birth","Early Neonatal Outcomes After Delayed Versus Immediate Cord Clamping in Preterm Birth: A Comparative Study From A Tunisian Tertiary Maternity Center","PREM-CORD","Inclusion Criteria:\n\n* Preterm neonates born at gestational age between 32 and 37 weeks\n* Live-born infants delivered in the study center\n* Singleton pregnancies\n* Parental consent obtained when applicable according to institutional ethical requirements\n\nExclusion Criteria:\n\n* Major congenital malformations or chromosomal abnormalities\n* Need for immediate advanced resuscitation at birth\n* Severe fetal distress requiring emergency obstetric intervention incompatible with protocol allocation\n* Placental conditions contraindicating delayed cord clamping (e.g., placental abruption with maternal instability, placenta previa bleeding, Placenta accreta spectrum)\n* Intra Uterin Growth Restriction with abnormal umbilical artery Doppler velocimetry","ALL","0 Days",{"count":20,"type":21},200,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this study is to evaluate whether delayed cord clamping improves early neonatal outcomes compared with immediate clamping in preterm birth.\n\nPreterm infants are at higher risk of neonatal complications, and the timing of cord clamping may influence placental transfusion and neonatal adaptation after birth. Delayed cord clamping may increase blood volume, improve iron stores, and reduce some neonatal morbidities, while immediate cord clamping is still commonly practiced in many settings.\n\nIn this study, preterm newborns are assigned to either delayed or immediate cord clamping according to a predefined protocol. Early neonatal outcomes, including respiratory status, need for resuscitation, hemoglobin levels, and early morbidity and mortality, will be assessed.\n\nThe study is conducted in a tertiary maternity center in Tunisia.",[27,28,29,30,31,32,33,34],"Preterm Birth Complication","Neonatal Morbidity and Mortality","Cord Clamping","Delayed Cord Clamping","Anemia","NEC - Necrotizing Enterocolitis","Intraventricular Hemorrhage Neonatal","Respiratory Distress Neonatal",[36,37,38,39,40,41,42,43,44,45],"Delayed cord clamping","Immediate cord clamping","Preterm infants","Preterm birth","Umbilical cord clamping","Neonatal outcomes","Placental transfusion","Neonatal morbidity","Neonatal mortality","Tunisia","RECRUITING","2026-07-08",{"date":49,"type":50},"2026-07-13","ACTUAL",{"date":52,"type":50},"2025-10-02",{"date":54,"type":21},"2026-12-31",{"name":56,"class":57},"Faculty of Medicine of Tunis","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":17,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":4,"studyType":71,"phases":4,"briefSummary":72,"conditions":73,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":87,"locationsCount":58},"100619445","predicting-the-need-for-prolonged-respiratory-support-in-neonates-delivered-in-a-lower-level-nicu-setting-100619445","NCT07344714","Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting","Predicting Respiratory Distress Syndrome in Neonates Delivered in a Lower-Level NICU Setting","Inclusion Criteria:\n\nBoth of the following:\n\n* Neonates born at 32 completed weeks gestational age or older whose deliveries are attended by the neonatal resuscitation team and for whom routine gastric suctioning is indicated\n* Neonates whose parents actively accepted or did not actively decline the Minnesota Research Authorization.\n\nExclusion Criteria:\n\nAny one of the following:\n\n* Neonates with known or suspected congenital anomalies\n* Neonates for whom only comfort measures are planned or possible at time of delivery\n* Neonates whose parents actively declined the Minnesota Research Authorization.\n* Neonates with other identifiable causes of respiratory distress including pneumothorax, meconium aspiration syndrome, or pneumonia.",true,"32 Weeks","41 Weeks",{"count":70,"type":21},500,"OBSERVATIONAL","The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (\\>6 hours of life).",[74,75,76,77,78,79,80,34],"Respiratory Distress Syndrome, Newborn","Respiratory Distress Syndrome in Premature Infant","Transient Tachypnea of the Newborn","Meconium Aspiration Syndrome","Pneumonia Neonatal","Hyaline Membrane Disease","Pneumothorax","2026-03-16",{"date":83,"type":50},"2026-03-18",{"date":85,"type":50},"2026-03-11",{"date":54,"type":21},{"name":88,"class":57},"Mayo Clinic",{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":4,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":22,"phases":100,"briefSummary":101,"conditions":102,"keywords":103,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":58},"100298906","adina-vs-high-flow-nasal-cannula-comparison-study-100298906","NCT03171129","ADINA vs. High Flow Nasal Cannula Comparison Study","Adaptive Dynamic Inspiratory Nasal Apparatus (ADINA): Comparison to High Flow Nasal Cannula (HFNC)","Inclusion Criteria:\n\n* Neonates admitted to NICU\n* Weights of 400-500 grams\n* Requiring oxygen greater than 30%\n* No evidence of focal lobar consolidation in lung fields\n\nExclusion Criteria:\n\n* Intolerance to procedure\n* gelatinous skin\n* known allergy to adhesive material\n* interference with therapy\n* profound sepsis\n* pneumonia\n* unmanaged apnea\u002Fbradycardia\n* known or suspect complex congenital heart disease\n* severe cleft lip or palate\n* suspect or proven lethal congenital anomaly\n* intolerance to the interface used in the devices\n* inability to secure an appropriate fit of the patient nasal interface\n* considered non-viable or of uncertain viability\n* parental refusal.","23 Weeks","40 Weeks",{"count":99,"type":21},40,[24],"This study is to evaluate the feasibility of using a pressure limited nasal cannula system instead of a high flow nasal cannula system in the management of premature babies with respiratory distress.",[34],[104,105,106],"Respiratory Distress","Nasal CPAP","high flow nasal canula","NOT_YET_RECRUITING","2026-01-28",{"date":110,"type":50},"2026-01-30",{"date":112,"type":21},"2026-07",{"date":114,"type":21},"2027-09",{"name":116,"class":57},"Loma Linda University",{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":17,"minAge":125,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":71,"phases":4,"briefSummary":129,"conditions":130,"keywords":134,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":149},"100607084","comparison-of-the-silverman-andersen-score-and-the-downes-score-100607084","NCT07183956","Comparison of the Silverman-Andersen Score and the Downes Score","Comparison of the Silverman-Andersen Score and the Downes Score in Assessing the Severity of Respiratory Distress and Predicting Noninvasive Ventilation Failure in Neonates","CSASDS","Inclusion Criteria:\n\n* Preterm infants born at \\>28 weeks of gestation or term infants born at ≥37 weeks of gestation.\n* Development of respiratory distress within the first 6 hours after birth, defined as the presence of at least two of the following: Respiratory rate ≥60\u002Fmin, Subcostal\u002Fintercostal retractions, Grunting.\n* Persistence of respiratory distress for more than 6 hours.\n* Age within the first 12 hours of life.\n* Silverman-Andersen score ≥3.\n* Receiving NIPPV support.\n\nExclusion Criteria:\n\n* Major congenital malformations.\n* Airway or pulmonary anomalies.\n* Cardiovascular or respiratory instability due to sepsis.\n* Cyanotic congenital heart disease.\n* Severe intraventricular hemorrhage.\n* Contraindications for NIPPV therapy (e.g., congenital nasal anomalies, congenital diaphragmatic hernia, abdominal wall defects).\n* Requirement of intubation or chest compressions in the delivery room.\n* Requirement of intubation within the first hour of life.\n* Death within the first 24 hours of life.\n* Gestational age ≤28 weeks.\n* Diagnosis of air leak syndrome (pneumothorax) prior to initiation of NIPPV therapy.","2 Hours","12 Hours",{"count":128,"type":21},220,"This study aimed to compare the Silverman-Andersen score and the Downes score in predicting noninvasive ventilation (NIPPV) failure in preterm and term infants who received NIPPV support due to postnatal respiratory distress, as well as to evaluate the agreement of these scoring systems with other methods used to assess the severity of respiratory distress.\n\nThe present study was designed as a prospective, multicenter, observational study conducted with neonates undergoing noninvasive ventilation.",[34,131,132,133],"Noninvasive Ventilation","Intubation","Scoring Systems",[135,136,137,138,139],"Silverman-Andersen score","Downes score","Newborn","Respiratory distress","Noninvasive ventilation","2025-09-13",{"date":142,"type":50},"2025-09-19",{"date":144,"type":21},"2025-09-15",{"date":146,"type":21},"2027-02-15",{"name":148,"class":57},"Muğla Sıtkı Koçman University",4,{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":11,"sex":17,"minAge":157,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":71,"phases":4,"briefSummary":160,"conditions":161,"keywords":172,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":191},"100601977","heterogeneity-index-in-neonatologist-performed-lung-ultrasound-in-neonates-receiving-respiratory-support---a-pilot-study-100601977","NCT07117513","Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study","NPLUS HI","Inclusion Criteria:\n\n* Preterm neonates born between 28+0 and 36+6 weeks of gestation and term-born neonates (\\> 37+0 weeks of gestation) admitted to the NICU\n* Presence of respiratory distress requiring respiratory support (invasive and non-invasive) at the timepoint of NPLUS 1.\n* Written informed consent obtained from the parents prior to the measurement.\n\nExclusion Criteria:\n\n* cardiopulmonary malformations\n* pleural effusion\n* pneumothorax","1 Hour","7 Days",{"count":99,"type":21},"Lung ultrasound is an increasingly valuable diagnostic tool in neonatal intensive care due to its safety and accessability.\n\nThis pilot study investigates whether a quantitative approach - the heterogeneity index, previously only used in fetal lung assessment - can enhance the diagnostic accuracy of neonatologist-performed lung ultrasound (NPLUS). The index will be calculated from raw ultrasound images of preterm and term neonates and compared with conventional lung ultrasound scores to evaluate its clinical relevance.",[162,163,164,165,166,167,168,169,170,34,171],"Intensive Care Units, Neonatal","Infant, Newborn","Infant, Premature","Point-of-Care Systems","Ultrasonography","Lung Ultrasound","Lung Ultrasound Score","Image Interpretation, Computer Assisted","Reproducibility of Results","Respiratory Support",[173,167,168,174,175,176,177,178,179,180,181],"Neonatologist-Performed Lung Ultrasound","Quantitative Lung Ultrasound","Neonatal Intensive Care Unit","Observer Variability in Imaging","Ultrasound Artifact Interpretation","Respiratory Distress Syndrome in Neonates","respiratory support","preterm neonate","newborn","2025-08-05",{"date":184,"type":50},"2025-08-12",{"date":186,"type":21},"2025-08-15",{"date":188,"type":21},"2026-08-01",{"name":190,"class":57},"Medical University of Graz",2]