[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-distress-of-newborn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-distress-of-newborn":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644904","how-different-levels-of-cpap-affect-oxygen-delivery-and-lung-expansion-in-preterm-infants-100644904",false,"NCT07674953","How Different Levels of CPAP Affect Oxygen Delivery and Lung Expansion in Preterm Infants","Oxygen Delivery in CPAP and Its Relationship With Regional Lung Ventilation in Preterm Infants","Inclusion Criteria:\n\n* Gestational age at birth must be less than 35 weeks of completed gestation as documented in the subject's initial history and physical\n* The infant must be stable while receiving nasal CPAP at any pressure level at the time of study\n* The infant must be receiving 22-40% at the time of the study\n\nExclusion Criteria:\n\n* Oxygen requirements greater than 40% at time of enrollment\n* currently receiving invasive ventilation or not requiring ventilatory support\n* Major congenital anomalies of the heart and\u002For lungs","ALL",{"count":18,"type":19},10,"ESTIMATED","INTERVENTIONAL",[22],"NA","With this study, it is expected to learn more about preterm babies on breathing support with nasal continuous positive airway pressure (nCPAP). To gain more information on how much oxygen is actually delivered to the baby from the nCPAP machine.",[25,26],"Respiratory Distress Syndrome (Neonatal)","Respiratory Distress of Newborn",[28,29,30,31],"respiratory distress syndrome","CPAP","preterm infant","effective oxygen delivery","RECRUITING","2026-06-23",{"date":35,"type":36},"2026-06-30","ACTUAL",{"date":38,"type":36},"2026-04-15",{"date":40,"type":19},"2027-06",{"name":42,"class":43},"University of Arkansas","OTHER",2,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100609551","predictive-value-of-lung-ultrasound-for-respiratory-decompensation-in-late-preterm-neonates-100609551","NCT07216053","Predictive Value of Lung Ultrasound for Respiratory Decompensation in Late Preterm Neonates","Inclusion Criteria:\n\n* Inborn infants born between 34w0d and 36w6d gestational age\n* In RA or 1 Litre per minute 1LPM NC (room air (RA) or nasal cannula (NC))\n* Admitted to NICU or Well Baby Nursery (WBN)\n\nExclusion Criteria:\n\n* Patients born \\\u003C34 weeks or \\>36w6d\n* Major genetic anomaly or syndromic condition\n* Cardiac or pulmonary structural defects\n* Cord pH \\\u003C7.0 or 5 minute APGAR 5 or less\n* Suspected fetal hemorrhage or other source of significant anemia at birth","34 Weeks","36 Weeks",{"count":54,"type":19},300,"OBSERVATIONAL","Respiratory morbidity presents a significant clinical challenge in the neonatal period, and an individual patient's clinical course is often difficult to predict. This is especially true for late-preterm infants, who share some of the same risks of premature babies in terms or respiratory morbidity, but whose births may not always be attended by a neonatologist, or who may be born at hospitals with lower level Neonatal Intensive Care Units (NICUs) and require transfer if they decompensate.\n\nWith this study, the aim is to 1) determine the efficacy of early point of care lung ultrasound (LUS) to predict respiratory decompensation in the first 48 hours of life in late preterm infants and 2) to compare the performance of three lung ultrasound scoring systems, 3 type-of-lung, high risk pattern and total LUS scoring systems.",[58,26,59],"Pre-Term","Premature",[61,62,63,64],"Lung Ultrasound","Respiratory Decompensation","Late Preterm Neonates","respiratory distress","2026-05-20",{"date":67,"type":36},"2026-05-22",{"date":69,"type":36},"2025-11-06",{"date":71,"type":19},"2027-11",{"name":73,"class":43},"Hackensack Meridian Health",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":20,"phases":87,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":44},"100569723","feasibility-of-using-the-neovent-in-low-resource-settings-100569723","NCT06697951","Feasibility of Using the Neovent in Low-Resource Settings","Feasibility of Using Bubble Nasal Intermittent Pressure Ventilation Using the Neovent in Low-resource Settings","Neovent","Inclusion Criteria:\n\n* Infants ≤ 28 days and \\> 30weeks and\u002For \\> 1000 gram (birthweight or admission weight if birthweight unknown)\n* Mild to moderate respiratory distress (Downes' score 2 - 7)\n* Parental\u002Fguardian permission (informed consent).\n\nExclusion Criteria:\n\n* Congenital abnormality such that noninvasive positive pressure ventilation would be contraindicated (e.g. diaphragmatic hernia, cleft palate, tracheo-esophageal fistula)\n* Need for immediate surgical intervention\n* Suspected neuromuscular abnormality as evidenced by decreased tone\n* Suspected cyanotic congenital cardiac disease or cardiac instability\n* Severe life-threatening condition such that the doctor caring for the patient believes survival of patient will be less than 24 hours and\u002For parents request withdrawal of care","1 Minute","28 Days",{"count":86,"type":19},70,[22],"Breathing problems are a leading cause of newborn death\u002Fsickness worldwide but most of deaths are in low resources areas. Over 99% of newborn death is in countries with limited healthcare resources like Nigeria and Nepal.\n\nBackground For newborns who have trouble breathing, breathing with a machine that does not require an invasive breathing tube but only small nasal tubes is associated with lower rates of lung disease and less pneumonia or lung disease than newborns who have a breathing tube going into their lungs to help their breathing. Nasal Intermittent Positive Pressure Ventilation (NIPPV) is often used in high resource countries, but these machines are expensive. NIPPV gives many newborns the extra support needed to help with trouble breathing by providing extra pressure to help more air\u002Foxygen get into their lungs. Neovent was designed to provide NIPPV at a much lower cost than machines than conventional machines. The Neovent has been shown to be safe and the device feasible in a higher resourced nursery than found in most nurseries in Nigeria and Nepal.\n\nThe primary and critical research gap this study will address is to show that investigators in lower resourced nurseries can use the Neovent thus demonstrating that this device is feasible to provide NIPPV for newborns with breathing problems without any more safety problems that those seen with the continuous positive airway pressure currently used in lower resourced nurseries in Nigeria and Nepal.\n\nAims The investigators believe NIPPV using the Neovent is feasible for use by healthcare providers in lower resourced nurseries in Nepal and Nigeria; that NIPPV provided by Neovent will be as safe as breathing support providing by machine CPAP and newborns on Neovent will not have more nasal irritation or nose bleeds, more stomach problems, or air around their lungs than newborns on machine CPAP.\n\nStudy design Newborns with mild-moderate breathing trouble whose mother\u002Fcaregivers agrees will be placed on Neovent for 6 hours and monitored closely for any problems with the machine or newborn that are related to the machine especially injury to the nose, nosebleeds, swollen belly or abdomen, or air around the lungs.\n\nSample size We plan to enroll 70 newborn infants total from both sites in Nepal and Nigeria.\n\nNext Steps The next step would be to do a study to determine if the Neovent is as good as other more expensive forms of breathing support for newborn infants.",[26],[91,92,64,93,94,95,96],"newborn","neonate","Bilevel ventilation","low resource","Nepal","Nigeria","2025-06-04",{"date":99,"type":36},"2025-06-08",{"date":101,"type":36},"2025-03-10",{"date":103,"type":19},"2025-12-31",{"name":105,"class":43},"Tina Slusher"]