[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-distress-syndrome--hyaline-membrane-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-distress-syndrome--hyaline-membrane-disease":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":4},"100635248","surfactant-administration-methods-in-preterm-infants-with-rds-a-swedish-cohort-study-100635248",false,"NCT07550218","Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study","A Prospective Observational Study of Surfactant AdministrationMethods for Preterm Infants With Respiratory Distress SyndromeWith Long-term Follow-up in the Swedish Neonatal Quality Register","Inclusion Criteria:\n\n* Patient has received surfactant by any administration method\n* Gestational age below 37 weeks'\n* First surfactant treatment given before 48 hours of age\n* Confirmed or suspected diagnosis of respiratory distress syndrome (RDS)\n\nExclusion Criteria:\n\n• Not fulfilling above inclusion criteria","ALL",{"count":18,"type":19},300,"ESTIMATED","6 Years","OBSERVATIONAL","The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS). Preterm infants often have immature lungs and a deficiency of surfactant, a substance that helps keep the lungs open and supports oxygen exchange.Surfactant can be delivered to the lungs using different techniques, including INSURE (brief intubation), LISA (via a thin catheter), SALSA (via a laryngeal mask airway), and traditional administration via endotracheal intubation followed by mechanical ventilation. The main question this study aims to answer is:Which method of surfactant administration is associated with better clinical outcomes in preterm infants with RDS?The study will prospectively collect clinical data on infants receiving surfactant as part of standard care, with long-term follow-up using data from the Swedish Neonatal Quality Register. The results are intended to be used to inform the design of a future randomized multicenter study.",[24,25,26,27,28],"Respiratory Distress Syndrome (& [Hyaline Membrane Disease])","Respiratory Distress Syndrome (Neonatal)","Respiratory Distress Syndrome (RDS)","Respiratory Distress Syndrome of Newborn","Respiratory Distress Syndrome in Premature Infant",[30,31,32,33,34,35,36,37,38,39,40,41,42],"Preterm infants","Premature infants","Surfactant therapy","Supraglottic Airway","Laryngeal Mask Airway","Intubation","LISA","INSURE","Less Invasive Surfactant Therapy","SALSA","Surfactant via Laryngeal or Supraglottic Airway","RDS","Respiratory Distress Syndrome","NOT_YET_RECRUITING","2026-04-17",{"date":46,"type":47},"2026-04-24","ACTUAL",{"date":49,"type":19},"2026-04-27",{"date":51,"type":19},"2029-08-27",{"name":53,"class":54},"Vastra Gotaland Region","OTHER_GOV",{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100622002","combined-oscillation-volume-guarantee-study-100622002","NCT07377955","Combined Oscillation-Volume guarantEe Study","Combined Volume Guarantee High-Frequency Oscillatory Ventilation (HFOV-VG) Versus Conventional High-Frequency Oscillatory Ventilation (HFOV) on Grade 2 to 3 Bronchopulmonary Dysplasia (BPD) or Death in Preterm Infants \u003C32 Weeks With Respiratory Distress Syndrome (RDS)","Inclusion Criteria:\n\n* Gestational age 24+0\u002F7\\\u003C 320\u002F7 weeks\n* Diagnosis of RDS within 72 hours after birth, requiring endotracheal ventilation for both elective and rescue HFOV\n\nExclusion Criteria:\n\n* Severe birth defects: severe congenital heart disease, diaphragmatic hernia, gastrointestinal malformations, congenital brain developmental abnormalities, congenital pulmonary cysts\n* Uncorrected shock\n* Existence of grade 3-4 IVH before ventilated\n* Other conditions deemed unsuitable for enrollment by neonatologists, including endotracheal intubation performed specifically for the purpose of the INSURE or INRECSURE technique.",{"count":63,"type":19},348,"INTERVENTIONAL",[66],"NA","Respiratory Distress Syndrome (RDS) remains the most common respiratory complication in the early postnatal period among preterm infants born before 32 weeks' gestational age. For this population, implementing lung-protective ventilation strategies is essential to shorten the duration of intubation, reduce the incidence and severity of bronchopulmonary dysplasia (BPD), lower mortality, and improve overall outcomes.\n\nHFOV-VG was first reported in 2015 to be safely applied in neonates. The fundamental principle lies in its ability to stabilize the tidal volume of high-frequency ventilation (VThf), thereby reducing sheer stress from amplitude fluctuations, while simultaneously permitting lower VThf settings to minimize volutrauma.\n\nThis study aims to evaluate whether HFOV+VG is superior to HFOV in reducing the composite outcome of grade 2-3 BPD or death at 36 weeks' post-menstrual age (PMA).",[24,69],"Bronchopulmonary Dysplasia (BPD)","2026-01-22",{"date":72,"type":47},"2026-01-30",{"date":74,"type":19},"2026-02-01",{"date":76,"type":19},"2028-02-01",{"name":78,"class":79},"Xingwang Zhu","OTHER"]