[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-distress-syndrome-neonatal\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-distress-syndrome-neonatal":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,45,74,116,146,178,198,237],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644904","how-different-levels-of-cpap-affect-oxygen-delivery-and-lung-expansion-in-preterm-infants-100644904",false,"NCT07674953","How Different Levels of CPAP Affect Oxygen Delivery and Lung Expansion in Preterm Infants","Oxygen Delivery in CPAP and Its Relationship With Regional Lung Ventilation in Preterm Infants","Inclusion Criteria:\n\n* Gestational age at birth must be less than 35 weeks of completed gestation as documented in the subject's initial history and physical\n* The infant must be stable while receiving nasal CPAP at any pressure level at the time of study\n* The infant must be receiving 22-40% at the time of the study\n\nExclusion Criteria:\n\n* Oxygen requirements greater than 40% at time of enrollment\n* currently receiving invasive ventilation or not requiring ventilatory support\n* Major congenital anomalies of the heart and\u002For lungs","ALL",{"count":18,"type":19},10,"ESTIMATED","INTERVENTIONAL",[22],"NA","With this study, it is expected to learn more about preterm babies on breathing support with nasal continuous positive airway pressure (nCPAP). To gain more information on how much oxygen is actually delivered to the baby from the nCPAP machine.",[25,26],"Respiratory Distress Syndrome (Neonatal)","Respiratory Distress of Newborn",[28,29,30,31],"respiratory distress syndrome","CPAP","preterm infant","effective oxygen delivery","RECRUITING","2026-06-23",{"date":35,"type":36},"2026-06-30","ACTUAL",{"date":38,"type":36},"2026-04-15",{"date":40,"type":19},"2027-06",{"name":42,"class":43},"University of Arkansas","OTHER",2,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":20,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100625698","video-vs-direct-laryngoscopy-for-less-invasive-surfactant-administration-100625698","NCT07426016","Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration","Randomized Controlled Trial of Video-Laryngoscopy Intervention or Direct Laryngoscopy for Delivery of Less Invasive Surfactant Administration for Premature Infants","VID LISA","Inclusion Criteria:\n\n* Infants born ≤28 weeks GA successfully resuscitated in the delivery room (DR) and maintained on CPAP • Need for surfactant in the first 36 hours of life based on clinical assessment and\u002For meeting threshold per unit protocol\n\nExclusion Criteria:\n\n* Infants born ≥29 weeks GA or\n* Infants with known congenital anomalies or\n* Infants who are determined by the primary care team to receive comfort care only or\n* Infants who are intubated at any time prior to surfactant administration","0 Hours","3 Days",{"count":56,"type":19},100,[22],"Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?",[25,60],"Surfactant Deficiency Syndrome Neonatal",[62,63,64],"less invasive surfactant","neonatal","video laryngoscopy","2026-06-11",{"date":67,"type":36},"2026-06-15",{"date":65,"type":36},{"date":70,"type":19},"2028-11",{"name":72,"class":43},"University of Texas Southwestern Medical Center",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":81,"targetDuration":83,"studyType":84,"phases":4,"briefSummary":85,"conditions":86,"keywords":91,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":4},"100635248","surfactant-administration-methods-in-preterm-infants-with-rds-a-swedish-cohort-study-100635248","NCT07550218","Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study","A Prospective Observational Study of Surfactant AdministrationMethods for Preterm Infants With Respiratory Distress SyndromeWith Long-term Follow-up in the Swedish Neonatal Quality Register","Inclusion Criteria:\n\n* Patient has received surfactant by any administration method\n* Gestational age below 37 weeks'\n* First surfactant treatment given before 48 hours of age\n* Confirmed or suspected diagnosis of respiratory distress syndrome (RDS)\n\nExclusion Criteria:\n\n• Not fulfilling above inclusion criteria",{"count":82,"type":19},300,"6 Years","OBSERVATIONAL","The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS). Preterm infants often have immature lungs and a deficiency of surfactant, a substance that helps keep the lungs open and supports oxygen exchange.Surfactant can be delivered to the lungs using different techniques, including INSURE (brief intubation), LISA (via a thin catheter), SALSA (via a laryngeal mask airway), and traditional administration via endotracheal intubation followed by mechanical ventilation. The main question this study aims to answer is:Which method of surfactant administration is associated with better clinical outcomes in preterm infants with RDS?The study will prospectively collect clinical data on infants receiving surfactant as part of standard care, with long-term follow-up using data from the Swedish Neonatal Quality Register. The results are intended to be used to inform the design of a future randomized multicenter study.",[87,25,88,89,90],"Respiratory Distress Syndrome (& [Hyaline Membrane Disease])","Respiratory Distress Syndrome (RDS)","Respiratory Distress Syndrome of Newborn","Respiratory Distress Syndrome in Premature Infant",[92,93,94,95,96,97,98,99,100,101,102,103,104],"Preterm infants","Premature infants","Surfactant therapy","Supraglottic Airway","Laryngeal Mask Airway","Intubation","LISA","INSURE","Less Invasive Surfactant Therapy","SALSA","Surfactant via Laryngeal or Supraglottic Airway","RDS","Respiratory Distress Syndrome","NOT_YET_RECRUITING","2026-04-17",{"date":108,"type":36},"2026-04-24",{"date":110,"type":19},"2026-04-27",{"date":112,"type":19},"2029-08-27",{"name":114,"class":115},"Vastra Gotaland Region","OTHER_GOV",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":124,"maxAge":125,"enrollmentInfo":126,"targetDuration":4,"studyType":20,"phases":128,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":105,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":44},"100625120","phase-2-pressure-targeting-during-high-flow-therapy-in-premature-infants-100625120","NCT07418502","Pressure Targeting During High Flow Therapy in Premature Infants","A Phase 2 Crossover Trial of Pressure Targeted High Flow Therapy in Premature Infants","NeoMATCH","Inclusion Criteria:\n\n* Delivery at \\>24+0 weeks and ≤32+6 weeks of gestation\n* Postnatal age \\>7 days but \\\u003C 6 weeks old\n* Weight ≥1,000grams at the time of study\n* Receiving clinically prescribed CPAP at pressures of 5-8cm H2O\n* Requiring an FiO2 of ≤0.60\n\nExclusion Criteria:\n\n* Chromosomal disorder (aneuploidy)\n* Presence of major congenital birth defect including airway anomalies, congenital diaphragmatic hernia or cardiac defects (other than patent foramen ovale and patent ductus arteriosus)\n* Prior pneumothorax\n* Infants in whom chance of survival is uncertain","7 Days","40 Weeks",{"count":127,"type":19},78,[129],"PHASE2","The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants. It will also learn about the effect of these types of breathing support on infant comfort and impact on staffing. The main question it aims to answer is:\n\nDoes Pressure Targeted High Flow provide enough support in premature infants?\n\nParticipants will:\n\nTake spend 24 hours supported by Pressure Targeted High Flow and 24 hours supported by CPAP. During this time their breathing rate, oxygen requirement and other markers of comfort will be monitored.",[132,25,133],"Preterm Infants","BPD - Bronchopulmonary Dysplasia",[135,29,136],"preterm","High Flow","2026-02-10",{"date":139,"type":36},"2026-02-18",{"date":141,"type":19},"2026-05-01",{"date":143,"type":19},"2027-09",{"name":145,"class":43},"University of Texas at Austin",{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":84,"phases":4,"briefSummary":157,"conditions":158,"keywords":164,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":73},"100611173","pulmonary-volume-changes-during-synchonized-noninvasive-positive-pressure-ventilation-100611173","NCT07237139","Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation","Intrapulmonary Volume Changes During Synchronized Noninvasive Positive Pressure Ventilation In Preterm Infants","INSPIRE","Inclusion Criteria:\n\n* Written informed consent by one or both parents or legal guardians\n* Gestational age at birth \\\u003C 30 0\u002F7 weeks\n* Infants on sNIPPV respiratory support\n* Below 4 weeks chronological age\n\nExclusion Criteria:\n\n* Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects)\n* Too ill\u002Funstable in the opinion of the treating physician.","4 Weeks",{"count":156,"type":19},27,"Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.",[159,25,160,161,162,163],"Infant, Preterm","Chronic Lung Disease of Newborn","Respiratory Support","Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)","Lung Volume",[165,166,167,168],"Synchronized noninvasive positive pressure ventilation (SNIPPV)","Lung volume","Electrical Impedance Tomography (EIT)","infant, preterm","2025-12-08",{"date":171,"type":36},"2025-12-09",{"date":173,"type":36},"2025-11-17",{"date":175,"type":19},"2027-01-30",{"name":177,"class":43},"University of Zurich",{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":20,"phases":187,"briefSummary":188,"conditions":189,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":196,"locationsCount":73},"100608495","open-label-randomized-controlled-trial-of-two-protocols-for-weaning-from-high-frequency-oscillatory-ventilation-in-preterm-neonates-with-respiratory-distress-syndrome-admitted-in-the-nicu-of-mansoura-university-children-hospital-100608495","NCT07202299","Open-label Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome Admitted in the NICU of Mansoura University Children Hospital","Randomized Controlled Trial of Two Protocols for Weaning From High Frequency Oscillatory Ventilation in Preterm Neonates With Respiratory Distress Syndrome","Inclusion Criteria:\n\n* Preterm infants with RDS whose gestational age is 34 weeks or less who required HFOV for more than 24 hours duration due to failure of non- invasive respiratory support due to any of the following:\n\n  1. Severe hypercapnea PaCO2 \\> 60 mmHg associated with pH \\\u003C 7.25.\n  2. Hypoxemia PaO2 \\\u003C 50 mmHg, with FiO2 \\> 40%.\n  3. Frequent apneas: 6 or more episodes of apnea requiring mild or moderate stimulation within 6-hour period or one apneic episode requiring bag and mask positive pressure ventilation.\n\nExclusion Criteria:\n\nPreterm infants with any of the following :\n\n1. Major congenital malformations or chromosomal aberrations.\n2. Inborn errors of metabolism.\n3. Severe intraventricular hemorrhage (IVH) grade III or IV",{"count":186,"type":19},110,[22],"Our study is a randomized controlled trial that compares two weaning protocols of preterm infants with respiratory distress syndrome who are ventilated on high frequency oscillatory ventilation in order to establish the best weaning strategy with the least complications possible for this group of patients.",[25],"2025-09-23",{"date":192,"type":36},"2025-10-01",{"date":194,"type":36},"2025-09-22",{"date":143,"type":19},{"name":197,"class":43},"Mansoura University Children Hospital",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":16,"minAge":206,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":20,"phases":210,"briefSummary":212,"conditions":213,"keywords":216,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":18},"100513089","phase-3-infasurfaero-versus-sham-treatment-in-preterm-newborns-with-rds-100513089","NCT05960929","InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS","InfasurfAero™ Versus Sham Treatment in Preterm Newborns With RDS: A Single-dose, Double-blind, Random Allocation, Sham-control, Clinical Trial","Aero-05","Inclusion Criteria:\n\nInclusion criteria include ALL of the following:\n\n1. Written informed consent obtained by parent or legal representative prior to or after birth\n2. Gestational age at birth ≥ 29 0\u002F7 AND ≤ 35 6\u002F7 weeks\n3. Birthweight ≥ 1,000 AND ≤ 3,500 grams\n4. Age ≥ 1 hour AND ≤ 6 hours\n5. Clinical diagnosis of surfactant-deficient RDS, with EITHER i. a Silverman-Anderson Retraction Score ≥ 5 (in Room Air), OR ii. signs of respiratory distress (tachypnea, retractions, grunting) AND radiographic confirmation\n6. Require CPAP\n7. Respiratory Severity Score (RSS) ≥ 1.25 AND ≤ 2.4\n8. If subject is \\>346\u002F7 weeks' gestation a chest radiograph is required\n\nExclusion Criteria:\n\nExclusion criteria are ANY of the following:\n\n1. Surfactant administration prior to randomization\n2. Mechanical ventilation prior to randomization\n3. Major congenital anomaly (suspected or confirmed)\n4. Abnormality of the airway (suspected or confirmed)\n5. Respiratory distress presumed secondary to an etiology other than RDS (e.g., suspected pulmonary hypoplasia, pneumothorax, meconium aspiration syndrome, pneumonia, septic or hypovolemia shock, hypoxic ischemic encephalopathy)\n6. Apgar score \\\u003C 3 at 5 minutes of age\n7. Umbilical cord gas pH \\\u003C7.0 or BD \\> 10\n8. Any condition that, in the opinion of the Investigator, would place the neonate at undue risk","29 Weeks","36 Weeks",{"count":209,"type":19},220,[211],"PHASE3","The purpose of this clinical study is to determine the effectiveness and safety of Infasurf® administered through the InfasurfAero™, a novel oral airway delivery device specifically designed to give Infasurf in a less complicated way and without the need for a breathing tube or interrupting nasal respiratory support.",[25,214,215],"Intubation Complication","Death; Neonatal",[217,218,219,220,221,222,104,223,224,29,97,225,226],"Infasurf","Calfactant","Inhalation","Nebulization","Preterm","InfasurfAero","Neonatal","NICU","Aerosol","CPAP Failure","2025-03-25",{"date":229,"type":36},"2025-03-30",{"date":231,"type":36},"2025-01-01",{"date":233,"type":19},"2026-04-01",{"name":235,"class":236},"ONY","INDUSTRY",{"id":238,"slug":239,"hasResults":11,"nctId":240,"briefTitle":241,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":11,"sex":16,"minAge":244,"maxAge":245,"enrollmentInfo":246,"targetDuration":248,"studyType":84,"phases":4,"briefSummary":249,"conditions":250,"keywords":253,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":256,"lastUpdatePostDateStruct":257,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":265},"100574377","a-prospective-observational-study-of-video-laryngoscopy-versus-direct-laryngoscopy-for-insertion-of-a-thin-endotracheal-catheter-for-surfactant-administration-in-newborn-infants-100574377","NCT06758492","A Prospective Observational Study of Video Laryngoscopy Versus Direct Laryngoscopy for Insertion of a Thin Endotracheal Catheter for Surfactant Administration in Newborn Infants","NEU-VODEtec","Inclusion Criteria:\n\n* newborn infants of any sex who are are having a thin catheter inserted into their trachea for the purpose of surfactant administration\n\nExclusion Criteria:\n\n* no parental consent provided to share their data","0 Minutes","28 Days",{"count":247,"type":19},600,"600 Days","Many premature babies have breathing difficulty after birth and receive help with a breathing machine (nasal continuous positive airway pressure, NCPAP). Some of the babies whose breathing gets worse despite NCPAP are treated with surfactant, a medication that is given directly into their windpipe (trachea). Some of the babies who are given surfactant get it through a ventilation tube (endotracheal tube, ETT), while others get it through a thin catheter that is too small for ventilation. When doctors insert a tube or a thin catheter into the windpipe of a baby, they use an instrument called a laryngoscope, which has a light at its tip, to identify the entrance. Most often doctors look directly into the baby's mouth with a standard laryngoscope to identify the entrance to the windpipe. However, newer video laryngoscopes have a camera along with the light at their tip, which displays a picture of the entrance to the windpipe on a screen. In a study performed at one hospital, doctors inserted an ETT first time more often when they used a video laryngoscope.\n\nThe investigators are doing a study at many hospitals where doctors usually use a standard laryngoscope to insert tubes and thin catheters into a baby's trachea by looking directly into the mouth. Each hospital will switch one-by-one to using a video laryngoscope when inserting a tube. The investigators will compare the information we collect to see if more babies who have a tube inserted first time without falls in their oxygen levels or heart rate with a video laryngoscope. The investigators will also collect information on babies who have a thin catheter inserted to compare whether doctors use fewer attempts when they use a video laryngoscope.",[25,88,251,252],"Video Laryngoscopy","Surfactant",[254,28,255,64],"infant, newborn","surfactant","2025-02-18",{"date":258,"type":36},"2025-02-20",{"date":260,"type":36},"2025-01-13",{"date":262,"type":19},"2025-12-31",{"name":264,"class":43},"University College Dublin",16]