[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-distress-syndrome-newborn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-distress-syndrome-newborn":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,54,78,104,130,152,179,205,235,260,283,315,342],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100642471","phase-4-fentanyl-and-rocuronium-for-tracheal-intubation-in-newborns-100642471",false,"NCT07650552","Fentanyl and Rocuronium for Tracheal Intubation in Newborns","Effect of the Association of Fentanyl and Rocuronium on First-Attempt Success Rate of Tracheal Intubation in Newborns: A Randomized Clinical Trial","NEORIN","Inclusion Criteria:\n\n* Newborns admitted to the NICU, ≤28 postnatal days OR corrected gestational age \\\u003C44 weeks\n* Indication for non-emergent orotracheal intubation (≥5 minutes between decision to intubate and start of laryngoscopy)\n* Informed consent signed by legal guardians\n\nExclusion Criteria:\n\n* Upper airway malformations\n* Use of neuromuscular blocking agent in the 24 hours prior to enrollment\n* Known hypersensitivity to fentanyl or rocuronium\n* Severe hemodynamic instability (ongoing shock)\n* Anticipated difficult airway (micrognathia, cleft palate, or similar)\n* Cyanotic congenital heart disease with critical instability\n* Neonatal abstinence syndrome\n* Concurrent enrollment in another interventional clinical trial","ALL","1 Minute","28 Days",{"count":21,"type":22},102,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","Tracheal intubation is a common and critical procedure in neonatal intensive care units (NICU). Despite its clinical importance, first-attempt success rates remain low (approximately 50%), and adverse events - including oxygen desaturation, bradycardia, and airway trauma - are frequent. Premedication with neuromuscular blocking agents has been associated with improved intubation conditions and fewer adverse events in neonates.\n\nThis randomized, double-blind, parallel-group clinical trial (NEORIN) aims to evaluate whether the addition of rocuronium (0,6 mg\u002Fkg IV) to standard fentanyl premedication (1 mcg\u002Fkg IV) improves first-attempt success rates of tracheal intubation in newborns admitted to the NICU of Maternidade Ana Braga, Manaus, Brazil. The control group will receive fentanyl plus saline placebo. Sugammadex (16 mg\u002Fkg IV) is available as a reversal agent in case of prolonged neuromuscular blockade.\n\nA secondary aim is to assess neonatologists' and residents' knowledge of and barriers to the use of neuromuscular blocking agents in neonatal intubation.",[28,29,30,31],"Infant, Premature","Intubation, Intratracheal","Respiratory Distress Syndrome, Newborn","Apnea of Prematurity",[33,34,35,36,37,38,39,40],"neonatal intubation","rocuronium","premedication","neuromuscular blocking agent","sugammadex","first-attempt success","NICU","newborn","NOT_YET_RECRUITING","2026-06-29",{"date":44,"type":45},"2026-07-01","ACTUAL",{"date":47,"type":22},"2026-09",{"date":49,"type":22},"2029-02",{"name":51,"class":52},"UEA - Universidade Do Estado Do Amazonas","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":4,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":61,"enrollmentInfo":62,"targetDuration":4,"studyType":23,"phases":64,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":71,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":53},"100550390","echography-guided-surfactant-therapy-esther-for-preterm-infants-with-respiratory-failure-100550390","NCT06446453","Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure","Inclusion Criteria:\n\n* The infant's parent\u002Flegal guardian can understand and willingly sign a written informed consent document for this study\n* Birth gestational age between 27w0d-36w6d\n* Diagnosis of respiratory failure secondary to RDS requiring respiratory support with non-invasive positive pressure ventilation\n\nExclusion Criteria:\n\n* Unable to obtain lung ultrasound between 1-2 hours of life\n* Infants already intubated or received surfactant before the point of care lung ultrasound\n* Infants born with congenital cardiac disease, congenital lung disease, or congenital facial\u002Fairway malformations\n* Infants born with chromosomal abnormalities\n* Infants with APGARs ≤ 5 at 10 minutes of life\n* Infants requiring cardiopulmonary resuscitation or therapeutic hypothermia in the first 6 hours of life","0 Hours","2 Hours",{"count":63,"type":22},52,[65],"NA","Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management. POCUS can be used to diagnose the severity of neonatal respiratory distress syndrome (RDS) through a lung ultrasound score. Lung ultrasound scores have also been shown to predict if an infant is treated with an initial dose of surfactant. Therefore, using lung ultrasound scores to guide surfactant therapy for RDS will likely lead to earlier surfactant therapy and may improve short-term respiratory outcomes. This study will test this theory by comparing lung ultrasound score-guided surfactant therapy for premature infants with RDS with our current surfactant administration guidelines.",[30,68,69],"Pulmonary Surfactants","Intensive Care Units, Neonatal","RECRUITING",{"date":44,"type":45},{"date":73,"type":45},"2024-06-25",{"date":75,"type":22},"2027-06",{"name":77,"class":52},"Connecticut Children's Medical Center",{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100600740","speed-of-lung-inflation-during-ventilation-of-extremely-preterm-infants-100600740","NCT07101419","Speed of Lung Inflation During Ventilation of Extremely Preterm Infants","Longer Pressure Rise Time During Mechanical Ventilation of Extremely Preterm Infants: A Randomised Crossover Trial","FLOW-VENT","Inclusion Criteria:\n\n* Admitted to participating neonatal intensive care unit\n* Born between 22+0 to 27+6 weeks' gestation\n* Current weight ≥400 grams\n* Receiving synchronised, patient-triggered, volume-targeted (all breaths) conventional mechanical ventilation (Pressure Control-Assist Control + Volume Guarantee \\[PC-AC+VG\\] mode on Dräger Babylog VN500\u002F800 ventilators) initiated within 72-hours post birth\n* Postnatal age ≥6 hours and ≤7 days\n* Received surfactant therapy\n* Clinically stable (as per treating and research team consensus)\n* Parent(s)\u002Flegal guardian provides prospective informed consent.\n\nExclusion Criteria:\n\n* Major congenital anomaly involving the cardiac, respiratory or gastrointestinal systems, or a known genetic syndrome or diagnosis that might affect respiratory course and outcomes\n* Severe pulmonary hypoplasia due to anhydramnios or oligohydramnios before 22 weeks in which the neonatal consultant anticipates that pulmonary hypoplasia related respiratory failure will be the major respiratory problem in early postnatal life\n* Receiving (or expected to receive within the next 12 hours) any other mode of mechanical ventilation including synchronised intermittent mandatory ventilation (SIMV), pressure support ventilation (PSV) or high-frequency oscillatory ventilation\n* Planned for extubation from mechanical ventilation within the next 12 hours.","6 Hours","7 Days",{"count":89,"type":22},68,[65],"Babies born extremely preterm (\\\u003C28 weeks of pregnancy) require support to breathe. Some babies require help to breathe from a breathing machine (mechanical ventilator). While this keeps babies alive, it may damage their lungs. To reduce this damage, doctors and nurses take particular care to try and provide the gentlest breathing support possible. However, evidence is still required to determine how to best support babies' breathing, whilst preventing lung damage and longer-term lung problems.\n\nThis clinical trial aims to compare two ways of adjusting a common setting on the breathing machine. This setting is called the pressure rise time or PRT. The PRT determines how quickly the breathing machine inflates a premature baby's lungs. A short PRT quickly inflates the lungs. A long PRT inflates the lungs more slowly. Previous research suggests that more slowly inflating the baby's lungs may cause less lung damage and still allow oxygen to be delivered to and carbon dioxide to be cleared from the lungs. However, larger studies are required to determine whether this should become the standard treatment.\n\nThis study investigates whether inflating the baby's lungs more slowly (long PRT) using the breathing machine is as effective as the PRT setting currently used (short PRT, more quickly inflating the lungs).\n\nThe main question it aims to answer is: Does how quickly the breathing machine inflates an extremely preterm baby's lung impact their oxygen levels?",[30,93],"Respiratory Distress Syndrome in Premature Infant","2026-06-21",{"date":96,"type":45},"2026-06-24",{"date":98,"type":22},"2027-02",{"date":100,"type":22},"2028-02",{"name":102,"class":52},"Murdoch Childrens Research Institute",3,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":11,"sex":17,"minAge":111,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":23,"phases":115,"briefSummary":116,"conditions":117,"keywords":118,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":126,"leadSponsor":128,"locationsCount":53},"100626979","utilization-of-lung-ultrasound-score-in-decision-for-minimally-invasive-surfactant-administration-100626979","NCT07442669","Utilization of Lung Ultrasound Score in Decision for Minimally Invasive Surfactant Administration","Utilization of Lung Ultrasound Score in Decision for Minimally Invasive Surfactant Administration: A Pilot Study","Inclusion Criteria:\n\n* Inborn at 27 0\u002F7 to 34 6\u002F7 weeks of gestational age\n* Spontaneously breathing at birth but requiring non-invasive respiratory support\n* RDS diagnosed on chest x-ray (diffuse, bilateral, fine granular opacities in lungs, air bronchograms) or were at risk of developing RDS\n\nExclusion Criteria:\n\n* Outborn\n* Endotracheal intubation in the delivery room or within 2 hours of life\n* Surfactant in the delivery room as part of advanced resuscitation\n* Presence of major congenital malformations or chromosomal anomalies\n* Hydrops fetalis\n* Inherited disorders of metabolism\n* Air leak syndrome (pneumothorax, pneumomediastinum) prior to surfactant administration, congenital diaphragmatic hernia, congenital pneumonia, meconium aspiration syndrome\n* Infants in extremis not expected to survive","27 Weeks","34 Weeks",{"count":114,"type":22},100,[65],"This prospective randomized controlled study aims to determine if using a lung ultrasound score can lead to a faster diagnosis of severe respiratory distress syndrome and quicker administration of surfactant in moderately and late-preterm infants. The research will involve 100 infants, with 67 in the prospective group and 33 serving as controls.\n\nThe primary goal is to shorten the time to treatment for these vulnerable newborns. The study will also assess whether this ultrasound-guided approach improves short-term respiratory outcomes. These secondary objectives include measuring any decrease in the need for and duration of mechanical ventilation, the length of non-invasive respiratory support, and the overall need for oxygen.\n\nThe study population includes infants born between 27 and 34 6\u002F7 weeks of gestation who are admitted to the NICU. Each participant will be monitored from birth until they are discharged or transferred. This research aligns with a growing body of evidence suggesting that lung ultrasound can be a valuable tool in neonatal care, potentially leading to earlier and more precise treatment for respiratory distress syndrome.",[30,93],[119,120,121],"Respiratory Distress","Lung ultrasound","Surfactant Administration","2026-05-20",{"date":124,"type":45},"2026-05-22",{"date":44,"type":22},{"date":127,"type":22},"2028-07-05",{"name":129,"class":52},"Hackensack Meridian Health",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":60,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":23,"phases":140,"briefSummary":141,"conditions":142,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":146,"completionDateStruct":148,"leadSponsor":150,"locationsCount":151},"100612300","optimising-breathing-support-at-extubation-in-very-preterm-infants-a-clinical-study-100612300","NCT07251790","Optimising Breathing Support at Extubation in Very Preterm Infants: A Clinical Study","PrePAP: Pre-Extubation Continuous Positive Airway Pressure in Very Preterm Infants: A Randomised Controlled Trial","PrePAP","Inclusion Criteria:\n\n* The infant is admitted to participating NICU\n* The infant is born between 22+0 to 29+6 weeks gestational age\n* The infant has been on a form of invasive mechanical ventilation for at least 4 hours\n* The infant is being electively extubated for the first time from invasive mechanical ventilation to nCPAP\n* The infant is clinically stable (as per clinical and research team consensus)\n* The parent(s) or legal guardian(s) provides prospective informed consent.\n\nExclusion Criteria:\n\n* The infant is born \\\u003C22 weeks or \\>30 weeks gestational age\n* The infant has a major congenital anomaly involving the cardiac, respiratory or gastrointestinal systems, or a known genetic syndrome or diagnosis that might affect respiratory course and outcomes\n* The infant has severe pulmonary hypoplasia due to anhydramnios or oligohydramnios before 22 weeks in which the neonatal clinician anticipates that pulmonary hypoplasia related respiratory failure will be the major respiratory problem in early postnatal life\n* The infant is receiving invasive mechanical ventilation via nasotracheal intubation\n* The infant is planned for extubation to any other mode of non-invasive respiratory support than nCPAP, or no respiratory support\n* Refusal of informed consent from the parent(s), or the infant does not have a guardian who can provide informed consent.",{"count":139,"type":22},134,[65],"Many babies born very preterm (\\\u003C32 weeks of pregnancy) require support to breathe from a breathing machine (mechanical ventilator) via a breathing tube. Although this keeps babies alive, it can damage their lungs. To reduce this damage, doctors and nurses try to change babies to gentler breathing support that does not require a breathing tube. This is usually done using a method called nasal continuous positive airway pressure (nCPAP) that uses a nosepiece to deliver breaths. This process of removing the breathing tube is called \"extubation\". Many babies will need the breathing tube put back in after extubation (for various reasons) and this is independently associated with poorer outcomes.\n\nThis research study aims to compare two ways of performing extubation - both of which are already used regularly by doctors and nurses. The \"standard extubation\" approach involves taking a baby's breathing tube out first, then applying the nosepiece and starting nCPAP. The more recent approach, called \"prePAP\", involves applying the nosepiece and starting nCPAP before taking the breathing tube out. Previous research suggests that a prePAP approach may provide better support for babies during extubation. However, larger studies are required before this approach is more commonly used.\n\nThis study is investigating whether extubating the baby with prePAP is better than extubating the baby without prePAP.\n\nThe main question it aims to answer is: Does initiating nCPAP before extubation in very preterm babies reduce the fall in their oxygen levels post-extubation?",[30,93],"2026-05-17",{"date":145,"type":45},"2026-05-19",{"date":147,"type":45},"2026-05-04",{"date":149,"type":22},"2028-03-31",{"name":102,"class":52},2,{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":17,"minAge":160,"maxAge":161,"enrollmentInfo":162,"targetDuration":4,"studyType":23,"phases":164,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":53},"100632499","lisa-vs-endotracheal-surfactant-in-preterm-neonates-a-lung-ultrasound-distribution-study-100632499","NCT07514481","LISA vs Endotracheal Surfactant in Preterm Neonates: A Lung Ultrasound Distribution Study","A Prospective Pilot Controlled Trial Comparing the Intrapulmonary Distribution of Exogenous Surfactant Between (LISA) and Conventional Endotracheal Intubation in Preterm Neonates With RDS Using Lung Ultrasound and the NOVEL Surfactant Distribution Homogeneity Index (SDHI)","LISA-Ven-LUS","Inclusion Criteria:\n\nGestational age 24+0 to 42+6 weeks. Clinical and radiographic diagnosis of Respiratory Distress Syndrome (RDS). Requirement for surfactant within the first 3 days of life. Written informed parental consent.\n\nExclusion Criteria:\n\nInfants intubated at birth or who received surfactant prophylactically in the delivery room.\n\nMajor congenital anomalies or lung malformations (e.g., congenital diaphragmatic hernia, pulmonary hypoplasia).\n\nSyndromic or genetic conditions affecting lung or chest wall development. Severe hemodynamic instability or congenital heart disease requiring intensive support.\n\nLack of parental consent for trial participation.","24 Weeks","42 Weeks",{"count":163,"type":22},22,[65],"This prospective, non-randomized, unblinded pilot study evaluates and compares the intrapulmonary distribution of exogenous surfactant in preterm neonates when administered via Less Invasive Surfactant Administration (LISA) versus conventional endotracheal intubation (ETT). Lung ultrasound (LUS) will be utilized to assess the pioneer Surfactant Distribution Homogeneity Index (SDHI) to quantify the evenness and extent of surfactant-induced lung aeration. Secondary objectives include evaluating changes in LUS scores, short-term clinical respiratory outcomes, and feasibility parameters for guiding future larger-scale trials.",[30],[168],"Less Invasive Surfactant Administration, LISA, Lung Ultrasound, Neonatology, Surfactant Distribution Homogeneity Index","2026-04-01",{"date":171,"type":45},"2026-04-07",{"date":173,"type":45},"2026-01-01",{"date":175,"type":22},"2026-07-30",{"name":177,"class":178},"Hamad General Hospital","OTHER_GOV",{"id":180,"slug":181,"hasResults":11,"nctId":182,"briefTitle":183,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":17,"minAge":185,"maxAge":186,"enrollmentInfo":187,"targetDuration":4,"studyType":23,"phases":188,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":53},"100583722","evaluation-of-serial-lung-ultrasound-data-after-surfactant-treatments-applied-with-different-methods-in-preterm-babies-100583722","NCT06880016","Evaluation of Serial Lung Ultrasound Data After Surfactant Treatments Applied With Different Methods in Preterm Babies","Inclusion Criteria:\n\n* Infants of families who agree to participate in the study\n* Preterm infants born before 32 weeks of gestation requiring surfactant therapy due to an RDS diagnosis.\n\nExclusion Criteria:\n\n* Infants whose families did not provide consent\n* Infants with a syndromic appearance or congenital heart disease\n* Preterm infants born after 32 weeks of gestation","1 Day","5 Days",{"count":89,"type":22},[65],"This study aims to investigate the relationship between the method of surfactant administration and improvements in serial lung ultrasound findings in preterm infants requiring surfactant therapy.",[191,30],"Newborn Complication",[193,194,195],"NEWBORN","Respiratory Distress Syndrome","surfactant","2026-03-26",{"date":198,"type":45},"2026-03-31",{"date":200,"type":45},"2024-07-01",{"date":202,"type":22},"2026-10-01",{"name":204,"class":52},"Konya City Hospital",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":212,"sex":17,"minAge":213,"maxAge":214,"enrollmentInfo":215,"targetDuration":4,"studyType":217,"phases":4,"briefSummary":218,"conditions":219,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":53},"100619445","predicting-the-need-for-prolonged-respiratory-support-in-neonates-delivered-in-a-lower-level-nicu-setting-100619445","NCT07344714","Predicting the Need for Prolonged Respiratory Support in Neonates Delivered in a Lower-Level NICU Setting","Predicting Respiratory Distress Syndrome in Neonates Delivered in a Lower-Level NICU Setting","Inclusion Criteria:\n\nBoth of the following:\n\n* Neonates born at 32 completed weeks gestational age or older whose deliveries are attended by the neonatal resuscitation team and for whom routine gastric suctioning is indicated\n* Neonates whose parents actively accepted or did not actively decline the Minnesota Research Authorization.\n\nExclusion Criteria:\n\nAny one of the following:\n\n* Neonates with known or suspected congenital anomalies\n* Neonates for whom only comfort measures are planned or possible at time of delivery\n* Neonates whose parents actively declined the Minnesota Research Authorization.\n* Neonates with other identifiable causes of respiratory distress including pneumothorax, meconium aspiration syndrome, or pneumonia.",true,"32 Weeks","41 Weeks",{"count":216,"type":22},500,"OBSERVATIONAL","The purpose of this study is to analyze the gastric fluid aspirated from the stomachs of neonates receiving routine post-delivery care to predict the need for prolonged respiratory support (\\>6 hours of life).",[30,93,220,221,222,223,224,225],"Transient Tachypnea of the Newborn","Meconium Aspiration Syndrome","Pneumonia Neonatal","Hyaline Membrane Disease","Pneumothorax","Respiratory Distress Neonatal","2026-03-16",{"date":228,"type":45},"2026-03-18",{"date":230,"type":45},"2026-03-11",{"date":232,"type":22},"2026-12-31",{"name":234,"class":52},"Mayo Clinic",{"id":236,"slug":237,"hasResults":11,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":212,"sex":17,"minAge":4,"maxAge":242,"enrollmentInfo":243,"targetDuration":4,"studyType":23,"phases":245,"briefSummary":246,"conditions":247,"keywords":249,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":53},"100516670","phase-4-prophylactic-minimally-invasive-surfactant-evaluation-100516670","NCT06007547","Prophylactic Minimally Invasive Surfactant Evaluation","PreProMISe","Inclusion Criteria:\n\n* Gestational age \\\u003C30 weeks\n* Antenatal consent from Parent\n\nExclusion Criteria:\n\n* Congenital anomalies\n* Alternate cause of respiratory distress","15 Minutes",{"count":244,"type":22},200,[25],"The purpose of this study is to explore the question: Does prophylactic administration of exogenous surfactant in the delivery room, using a minimally-invasive technique, improve outcome in preterm infants 22-29 weeks' gestation compared to rescue treatment using the same technique?",[30,248],"Premature Birth",[194,195,250],"Minimally invasive Surfactant Therapy","2025-08-04",{"date":253,"type":45},"2025-08-07",{"date":255,"type":45},"2024-01-01",{"date":257,"type":22},"2027-07-31",{"name":259,"class":52},"Endeavor Health",{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":268,"targetDuration":4,"studyType":217,"phases":4,"briefSummary":269,"conditions":270,"keywords":272,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":151},"100598336","bedside-ultrasound-to-monitor-lung-function-and-blood-flow-in-newborns-treated-with-surfactant-100598336","NCT07070167","Bedside Ultrasound to Monitor Lung Function and Blood Flow in Newborns Treated With Surfactant","Point-of-Care Ultrasonography for Assessing Lung Aeration and Pulmonary Vascular Resistance Dynamics After Surfactant Administration in Neonates With Respiratory Distress Syndrome","ULISSES","Inclusion Criteria:\n\n* Preterm neonates (gestational age \\\u003C37 weeks) with established Respiratory Distress Syndrome (RDS) or at risk for RDS\n* Decision of the use of surfactant by the attending physician\n\nExclusion Criteria:\n\n* Presence of major congenital abnormalities of the respiratory system\n* Infants requiring primary intubation and mechanical ventilation in the delivery room",{"count":244,"type":22},"The ULISSES study looks at how doctors use bedside ultrasound to help treat premature babies with breathing problems caused by Respiratory Distress Syndrome (RDS). It focuses on whether doctors decide to give a medicine called surfactant based on oxygen levels alone or if they also use lung ultrasound images to guide their decision.\n\nAround 200 babies will take part in the study in hospitals across Poland. Doctors will do ultrasound scans of the babies' lungs before and after surfactant is given. In some hospitals, heart and lung blood flow will also be checked to look for signs of high blood pressure in the lungs.\n\nThe study will see if both lungs improve equally after treatment or if one side stays worse, and whether this affects how much breathing support the baby needs. The results may help doctors improve how and when they give surfactant, leading to better care for newborns with RDS.",[271,30],"Lung Ultrasound",[195],"2025-07-15",{"date":275,"type":45},"2025-07-17",{"date":277,"type":22},"2025-08-30",{"date":279,"type":22},"2026-12-30",{"name":281,"class":282},"Chiesi Poland Sp. z o.o.","INDUSTRY",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":291,"enrollmentInfo":292,"targetDuration":4,"studyType":23,"phases":294,"briefSummary":295,"conditions":296,"keywords":302,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":53},"100585164","an-educational-intervention-to-improve-the-success-of-intubation-in-newborns-using-a-video-laryngoscope-by-reducing-the-time-the-procedure-takes-100585164","NCT06898801","An Educational Intervention to Improve the Success of Intubation in Newborns Using a Video Laryngoscope by Reducing the Time the Procedure Takes.","Neonatal INtubation After \"Just-in-time\" Audiovisual Training: a Randomised Controlled Trial","NINJA","Inclusion Criteria:\n\nNeonates of any age or gestation who require endotracheal intubation in the Neonatal Intensive Care Unit in the National Maternity Hospital during the study period.\n\nExclusion Criteria:\n\n* Neonates with an upper airway malformation.\n* If it is deemed by the treating clinical team that the clinical scenario does not allow time for the intervention e.g. cardiac arrest","1 Year",{"count":293,"type":22},140,[65],"This research focuses on one of the most common problems in newborn medicine: breathing difficulties. Breathing problems are the most common reason for admission to our neonatal unit at the National Maternity Hospital. When a baby has serious breathing difficulty, inserting a breathing tube to place them on a ventilator can be lifesaving. A breathing tube must be placed through the vocal cords into the windpipe (trachea). A device called a laryngoscope is placed in a patients mouth to allow the doctor to see the vocal cords and insert the tube correctly.\n\nThe skill of placing this breathing tube (intubation) is important for doctors and specialists to learn so that they can confidently perform it in an emergency.\n\nIn the past, doctors had more opportunities during their training to learn and practice this with supervision from seniors. In recent years, babies, thankfully, need to be intubated less frequently and doctors working hours are better regulated. As a result, junior doctors have less chances to perform this skill. There is a need to improve how we teach the procedure of intubating babies to doctors in training to meet the needs of trainees today.\n\nThe investigators want to perform a study to help teach doctors in training how to perform intubation of a newborn using a video laryngoscope. The team are looking to assess if showing a short educational video to the doctor and team just before performing an intubation using a video laryngoscope will reduce the time the procedure takes. This is called a \"Just-in-Time\" video. The investigators aim to demonstrate a benefit by performing a randomised control trial. This means that when a baby requires intubation as decided by their treating doctors, the team will be randomly allocated to view a \"Just-in-Time\" video before performing the intubation or not. The investigators will then compare the two groups to see if there is a difference in the total time the procedure takes.",[30,297,298,299,300,301],"Endotracheal Intubation","Neonatal Intubation Performance","Prematurity","Neonate","Education, Medical",[303,304,305],"Just-in-Time","Neonatal intubation","Teaching","2025-03-20",{"date":308,"type":45},"2025-03-27",{"date":310,"type":22},"2025-03",{"date":312,"type":22},"2027-05",{"name":314,"class":52},"University College Dublin",{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":321,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":323,"targetDuration":325,"studyType":217,"phases":4,"briefSummary":326,"conditions":327,"keywords":329,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":4},"100546411","lus-at-birth-in-infants-born-before-26-weeks-100546411","NCT06394583","LUS AT BIRTH IN INFANTS BORN BEFORE 26 WEEKS","DESCRIPTION OF THE LUNG ULTRASOUND PATTERN IN INFANTS UNDER 26 WEEKS OF GESTATION: A NATIONAL MULTICENTER STUDY","MINI-LUS","Inclusion Criteria:\n\n* Infants born before 26 weeks at any of the participant hospitals.\n\nExclusion Criteria:\n\n* received surfactant before LU\n* redirection of care\n* severe malformations of cromosomopathies\n* unable to perform LU",{"count":324,"type":22},150,"5 Years","All infants born before 26 weeks born in a hospital included in the registry will receive a LU at birth, before the first dose of surfactant. We will register as well the length of IMV, NIV or the need of IMV in the whole sample.",[328,30],"Extremely Low Birth Weight Infants",[330,331,332],"lung ultrasound","premature infant","extremely low birth weight infants","2024-04-30",{"date":335,"type":45},"2024-05-01",{"date":337,"type":22},"2024-06-30",{"date":339,"type":22},"2029-12-01",{"name":341,"class":178},"Andaluz Health Service",{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":348,"eligibilityCriteria":349,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":350,"targetDuration":352,"studyType":217,"phases":4,"briefSummary":353,"conditions":354,"keywords":360,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":103},"100274490","european-management-platform-for-childhood-interstitial-lung-diseases---child-eu-register-and-biobank-100274490","NCT02852928","European Management Platform for Childhood Interstitial Lung Diseases - chILD-EU Register and Biobank","Orphans Unite: chILD Better Together - European Management Platform for Childhood Interstitial Lung Diseases \u002F chILD-EU - International Register and Biobank for Children´s Interstital Lung Disease","chILD-EU","Inclusion Criteria:\n\n* all children with suspected or\n* verified diagnosis of ILD or\n* masquerading as ILD and\n* those with rare localized parenchymal lung diseases\n\nExclusion Criteria:\n\n* other indication as inclusion criteria",{"count":351,"type":22},1000,"10 Years","Generation of a common European database and biobank Continous assessment and implementation of guidelines and treatment protocols Establishment of a large observational cohort of chILD patients Determination the value of outcomes used in child Assess treatment variations used, deliver data from defined protocols and linked outcomes",[355,356,357,358,30,359],"Lung Diseases, Interstitial","Pulmonary Alveolar Proteinosis","Pulmonary Eosinophilia","Pulmonary Fibrosis","Child",[361],"ILD; chILD","2022-09-18",{"date":364,"type":45},"2022-09-21",{"date":366,"type":45},"2013-12",{"date":368,"type":22},"2029-12",{"name":370,"class":52},"Matthias Griese"]