[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-failure-with-hypercapnia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-failure-with-hypercapnia":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,51,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100524894","nasal-high-flow-versus-non-invasive-ventilation-for-early-treatment-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-with-hypercapnic-acidosis-100524894",false,"NCT06114667","Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis","Nasal High Flow in Early Management of Patients Admitted to the Emergency Department for Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis : a Randomized Controlled Non Inferiority Study","HiCOPD","Adult Patient admitted to the ED for acute exacerbation of COPD (AE-COPD)and respiratory acidosis (PaCO2 \\> 45 mmHg and pH \\\u003C7.35), for whom ventilatory assistance by NIV is indicated (SPLF 2017, GOLD2023 recommendations)\n\nInclusion Criteria:\n\n* Patients with ability to understand and give an informed consent\n* Patients affiliated with or who benefit from a social security\n* Patients admitted to the emergency department for a clinical suspicion of AE-COPD based on clinical history, physical examination and chest X-ray (SPLF 2017)\n* Patients with acute respiratory failure defined by: Respiratory rate ≥ 25 bpm AND\u002FOR Signs of respiratory failure (use of accessory respiratory muscles, paradoxical abdominal movement)\n* Patients with respiratory acidosis defined by PaCO2 \\> 45 mmHg AND pH \\\u003C 7.35 (measured on arterial blood gas)\n\nExclusion Criteria:\n\n* Patients who have already received NIV treatment before inclusion (including in-hospital or prehospital, with the exception of NIV at home)\n* Contraindication to non-invasive ventilation (SPLF 2017 and GOLD 2023 recommendations)\n* Patient uncooperative, agitated, opponent of the technique","ALL","18 Years","85 Years",{"count":21,"type":22},174,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to determine whether nasal high flow is non inferior to non invasive ventilation (NIV) in the early treatment of patients with acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and hypercapnic acidosis in the emergency department (ED). After obtaining informed consent, participants will be randomly assigned to receive either nasal high flow or non invasive ventilation (NIV, reference treatment) as respiratory support. Researchers will compare both respiratory support groups to see if their blood gas analysis and respiration return to normal ranges.",[28,29,30],"Acute Exacerbation of Chronic Obstructive Pulmonary Disease","Hypercapnic Acidosis","Respiratory Failure With Hypercapnia",[32,33,34,35,36,37,38],"respiratory insufficiency","Hypercapnic Acute Respiratory Failure","chronic obstructive pulmonary disease exacerbation","nasal high flow","non invasive ventilation","emergency department","critical are","RECRUITING","2026-06-17",{"date":42,"type":43},"2026-06-22","ACTUAL",{"date":45,"type":43},"2026-06-16",{"date":47,"type":22},"2028-11-01",{"name":49,"class":50},"University Hospital, Montpellier","OTHER",{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":74},"100592029","management-of-post-operative-respiratory-failure-by-using-niv-and-high-velocity-nasal-insufflation-hvni-100592029","NCT06988111","Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)","A Prospective, Randomized Controlled Trial Comparing Noninvasive Ventilation (NIV) Versus High-Velocity Nasal Cannula (HVNC) in the Management of Acute Post-Operative Respiratory Failure","Inclusion criteria:\n\n* Age above 18 years\n* within 48 hours after major surgery\n* PAO2\u002FFIO2 less than 200\n* Signs of respiratory distress and respiratory rate (RR) more than 25 cycles\u002Fminute\n\nExclusion Criteria:\n\n* Age below 18 years\n* Pregnant ladies\n* Orofacial trauma or burns\n* Active Gastrointestinal bleeding",{"count":59,"type":22},180,[25],"Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations. Traditional escalation often involves invasive mechanical ventilation, which is associated with ventilator-associated pneumonia (VAP), prolonged intensive care unit (ICU) stays, and increased resource burden.",[63,30,64],"Respiratory Failure Without Hypercapnia","Postoperative Respiratory Complication","2026-04-26",{"date":67,"type":43},"2026-04-30",{"date":69,"type":43},"2025-07-01",{"date":71,"type":22},"2026-12-01",{"name":73,"class":50},"Assiut University",1,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":4},"100590640","to-assess-the-types-of-mechanical-ventilation-in-enabling-therapeutic-bronchofiberoscopy-in-patients-with-decompensated-respiratory-acidosis-complete-respiratory-failure-100590640","NCT06970041","To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure).","To Assess the Types of Mechanical Ventilation in Enabling Therapeutic Bronchofiberoscopy in Patients With Decompensated Respiratory Acidosis (Complete Respiratory Failure)","Inclusion Criteria:\n\n1. Patients ≥ 18 years of age with indications for bronchoscopy:\n\n   Therapeutic examination: pneumonia in people with impaired cough reflex, culture and toilet of the bronchial tree, respiratory tract hemorrhages treated with a bronchofiberoscope and aspiration of a foreign body, bronchial unblocking in advanced neoplastic disease.\n2. Patient who signed a written informed consent to participate in the study,\n3. pCO2 \\> 45 mmHg and pH \\\u003C 7.35 in a blood gas analysis performed directly during qualification for FOB.\n\nExclusion Criteria:\n\n1. Lack of written, informed consent of the subject to participate in the research project,\n2. Unstable coronary artery disease chronic coronary syndrome (CCS) III\u002FIV, circulatory failure New York Heart Association (NYHA) III\u002FIV (does not apply to tests for vital indications, e.g. aspiration of a foreign body),\n3. Hemodynamic insufficiency, constant use of pressor amines, myocardial infarction in the last 2 weeks without percutaneous coronary intervention (PCI) treatment, unstable angina pectoris, severe arrhythmias- especially ventricular,\n4. Chronic primary pulmonary hypertension, assessed during right heart catheterization WHO III\u002FIV,\n5. Pneumothorax not secured with drainage,\n6. Platelet count \\\u003C20,000\u002Fµl, if platelets are not transfused immediately before or during the procedure,\n7. International normalized ratio (INR)\\> 2 or activated partial thromboplastin time (APTT) \\> 36 s, in the case of therapeutic FOB \\[16\\],\n\nd. Anemia: hemoglobin (Hb) level \\\u003C6 g\u002Fdl or 6-10 g\u002Fdl if the physician prescribes a blood transfusion, h. Patients who were intubated before randomization.",{"count":83,"type":22},315,[25],"Background:\n\nBronchofiberoscopy (FOB) is a minimally invasive and safe procedure performed for diagnostic and therapeutic purposes. FOB frequently impairs respiratory function, which may lead to possible exacerbation of respiratory failure.\n\nCurrently, the most frequent respiratory support is passive oxygen therapy, but non-invasive ventilation (NIV) and high flow nasal cannula (HFNC) are increasingly attempted, however the optimal setting and indications for NIV and HFNC in patients undergoing FOB with respiratory acidosis, haven't been determined yet.\n\nMethods:\n\nThe study protocol describes a prospective, multicenter, three-armed randomized controlled trial (RCT).\n\nThe investigators aim to study patients undergoing a therapeutic bronchofiberoscopy with decompensated type 2 respiratory failure: (pH \\\u003C7.35 and pCO2 \\>45 mmHg);\n\n1. randomized to: passive oxygen, NIV, HFNC, invasive mechanical ventilation (IMV);\n2. total number of participants: 315. Before FOB, the patient group will undergo arterial blood gas analysis (ABG). During FOB there will be a continuous monitoring of vital signs as in: SpO2, FiO2, TcCO2, ECG, and Heart Rate. After FOB, the investigators are going to perform another ABG, mark endpoints, and complications, if any arise.\n\nResults:\n\nBased on the selected endpoints, or any complication related to FOB the investigators hope to determine which of the respiratory methods: passive oxygen, NIV, HFNC or IMV provides the best support, leading to a lower number of complications and overall a better tolerance of FOB by the patient. Additionally, our aim is to find the optimal settings for NIV and HFNC in the studied group.\n\nConclusions:\n\nThe results of this study are going to assess the need and the role of the optimal respiratory support method among patients with exacerbation of respiratory acidosis, leading to a shorter time from admission to full recovery, better tolerance during the procedure, quicker recovery after procedure.",[30,87],"Therapeutic Bronchofiberoscopy",[89,90,91,92,93,94,95],"Bronchofiberoscopy (FOB)","High Flow Nasal Cannula (HNFC)","Non-Invasive Ventilation (NIV)","Passive Oxygen Therapy","Type 2 respiratory failure","Exacerbation of Chronic Respiratory Acidosis","Invasive Mechanical Ventilation (IMV)","NOT_YET_RECRUITING","2025-05-05",{"date":99,"type":43},"2025-05-14",{"date":101,"type":22},"2025-10-01",{"date":103,"type":22},"2028-10-31",{"name":105,"class":50},"Medical University of Silesia"]