[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-function-impaired\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-function-impaired":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,85],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100497411","neurostimulation-for-respiratory-function-after-spinal-cord-injury-100497411",false,"NCT05756894","Neurostimulation for Respiratory Function After Spinal Cord Injury","Pilot Study: Spike-timing-dependent Plasticity for Respiratory Function After Spinal Cord Injury","Inclusion Criteria:\n\n1. Male and females between ages 18-85 years\n2. SCI at least 6 months post-injury\n3. Spinal Cord injury at C1-C5\n4. Demonstrate respiratory deficit following spinal cord injury as following: (1) Individuals using mechanical ventilation, and (2) individuals with pulmonary function testing (PFT) deficits corresponding to having a vital capacity (VC) \\\u003C 80% (predicted)\n5. Must have a family member or caregiver who is trained and willing to operate the mechanical ventilator during study visits.\n\nExclusion Criteria:\n\n1. Any illness or condition that based on the research team's assessment, will compromise with the participant's ability to comply with the protocol, patient safety, or the validity of the data collected during this study.\n2. Any debilitating disease prior to the SCI that caused exercise intolerance.\n3. Individuals entirely dependent on the support of a diaphragmatic pacer (24 hours per day).\n4. Premorbid, ongoing major depression or psychosis, altered cognitive status.\n5. History of head injury or stroke\n6. Vascular, traumatic, tumoral, infectious, or metabolic lesion of the brain, even without a history of seizure, and without anticonvulsant medication\n7. History of seizures or epilepsy\n8. Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold\n9. Pregnant females\n10. If a woman of childbearing age is unsure of the pregnancy, and does not want to take the pregnancy test\n11. Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, MS, or herniated disk\n12. Metal plate in skull\n13. Individuals with scalp shrapnel, cochlear implants, or aneurysm clips\n14. Individuals taking Bupropion, Dolutegravir, Lacosamide, Trilaciclib, or PR Interval prolonging drugs","ALL","18 Years","85 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this research study is to learn more about the connections between the brain, nerves, and diaphragm after experiencing a cervical spinal cord injury (SCI).The main question it aims to answer is:\n\nChanges in respiratory function and recovery using stimulation and respiratory exercise training in spinal cord-injured individuals.\n\nParticipants will complete a maximum of 55 study visits. They will be asked to complete about 40 treatment sessions which include multiple stimulation sessions over the scalp and neck, followed by about 60 minutes of respiratory training. Assessment sessions will be completed prior at baseline, after 20 sessions and after 40 sessions of study treatment.",[27,28,29],"Spinal Cord Injuries","Cervical Spinal Cord Injury","Respiratory Function Impaired",[31,32,33,34,35,36],"Neural plasticity","Spinal cord injury","Diaphragm","Respiratory training","Spike-timing-dependent plasticity","Neurostimulation","RECRUITING","2025-04-01",{"date":40,"type":41},"2025-04-04","ACTUAL",{"date":43,"type":41},"2023-02-28",{"date":45,"type":21},"2026-12-31",{"name":47,"class":48},"Shirley Ryan AbilityLab","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":4,"briefSummary":63,"conditions":64,"keywords":70,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":49},"100574234","respiratory-functions-thoracoabdominal-movements-and-exercise-capacity-in-neuromuscular-diseases-100574234","NCT06756633","Respiratory Functions, Thoracoabdominal Movements and Exercise Capacity in Neuromuscular Diseases","Evaluation of Respiratory Functions, Thoracoabdominal Movements, and Exercise Capacity in Neuromuscular Diseases","1. Duchenne Muscular Dystrophy (DMD)\n\n   -Inclusion Criteria: Clinically diagnosed with Duchenne Muscular Dystrophy. Age above 5 years. Able to breathe independently. Willing to participate in the study.\n\n   -Exclusion Criteria: Presence of cognitive problems that affect the assessment results. History of pulmonary surgery. Advanced heart failure.\n2. Spinal Muscular Atrophy (SMA)\n\n   -Inclusion Criteria: Clinically diagnosed with Spinal Muscular Atrophy. Age above 5 years. Able to breathe independently. Willing to participate in the study.\n\n   -Exclusion Criteria: Presence of cognitive problems that affect the assessment results. History of pulmonary surgery. Advanced heart failure.\n3. Healthy Controls\n\n   * Inclusion Criteria:\n\nNo diagnosis of neuromuscular diseases. Age above 5 years. Able to breathe independently. Willing to participate in the study.\n\n-Exclusion Criteria: Presence of cognitive problems that affect the assessment results. History of pulmonary surgery. Advanced heart failure.",true,"5 Years","15 Years",{"count":61,"type":21},42,"OBSERVATIONAL","The clinical trial titled \"Investigation of Respiratory Functions, Thoracoabdominal Movements, and Exercise Capacity in Neuromuscular Diseases\" aims to evaluate the respiratory functions, thoracoabdominal movements, and exercise capacity in children with Duchenne Muscular Dystrophy (DMD) and Spinal Muscular Atrophy (SMA) compared to healthy controls. The study will use spirometry, structured light plethysmography (SLP), the six-minute walk test, and the six-minute pegboard ring test to assess these functions. This trial will be conducted at the Lokman Hekim University Muscle and Nerve Diseases Application and Research Center from May 2024 to Dec 2025.",[65,29,66,67,68,69],"Neuromuscular Diseases in Children","Respiratory Insufficiency","Duchenne Muscular Dystrophy","Spinal Muscular Atrophy","Plethysmography",[71,72,73,74],"Duchenne muscular dystrophy","Spinal muscular atrophy","respiratory function tests","plethysmography","2024-12-25",{"date":77,"type":41},"2025-01-03",{"date":79,"type":41},"2024-04-01",{"date":81,"type":21},"2025-12-28",{"name":83,"class":84},"Lokman Hekim University","OTHER_GOV",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":22,"phases":95,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":100,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":105,"leadSponsor":106,"locationsCount":4},"100538296","effects-of-rtms-on-respiratory-function-and-gut-microbiota-in-patients-with-brain-injury-100538296","NCT06288984","Effects of rTMS on Respiratory Function and Gut Microbiota in Patients With Brain Injury","Effects of Repetitive Transcranial Magnetic Stimulation(rTMS) on Respiratory Function and Gut Microbiota in Patients With Brain Injury","Inclusion Criteria:\n\n* In line with the diagnostic criteria of \"Chinese classification of cerebrovascular diseases(2015)\" mRS Score 2-4 points or craniocerebral injury caused by trauma, GCS score \\> 8 points\n* Between 18 and 70 years old\n* The first incidence of cerebrovascular disease or traumatic brain injury, and the course of disease was 10-180 days\n* Vital signs are stable, no progression\n* Voluntary participation with informed consent\n\nExclusion Criteria:\n\n* Patients with a history of respiratory disease, including chronic bronchitis, chronic obstructive pulmonary disease, bronchiectasis, and lung cancer\n* Severe bone malformations in the chest or spine\n* Have other neurological or neuromuscular disorders\n* History of thoracic and abdominal surgery\n* Severe heart, lung, kidney, liver or other organ dysfunction\n* Pregnant and lactating women\n* Epilepsy\n* Metal implant\n* Patients who were judged by the investigator to be unsuitable for participation in this trial","70 Years",{"count":94,"type":21},74,[24],"Impaired respiratory function may occur after brain injury, and will progress to restricted respiratory dysfunction without early intervention. At present, there is a lack of effective treatment options for respiratory dysfunction. Repetitive Transcranial Magnetic Stimulation(rTMS) is a non-invasive, painless and non-invasive neuroregulatory technique. In healthy people, rTMS applied to the respiratory motor cortex induces a contralateral respiratory muscle response. However, whether rTMS can improve respiratory function in patients with brain injury remains unclear. gut microbiota can affect muscle function and mass, and animal experiments have shown that probiotics can increase skeletal muscle mass and grip strength in mice. On the other hand, studies have found that rTMS can improve the nutritional status of patients with vegetative state by regulating the structure of gut microbiota. However, it remains unclear whether rTMS can improve respiratory muscle function in patients with brain injury by regulating gut microbiota. Therefore, the investigators intend to apply rTMS to the respiratory motor cortex to observe whether rTMS can improve respiratory function and reduce the incidence of pneumonia in patients with brain injury, and to observe the role of gut microbiota in this process.",[98,29,99],"Brain Injuries","Gut Microbiota","NOT_YET_RECRUITING","2024-02-25",{"date":103,"type":41},"2024-03-01",{"date":103,"type":21},{"date":45,"type":21},{"name":107,"class":48},"Nanfang Hospital, Southern Medical University"]