[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-function-loss\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-function-loss":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,74,98,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100505038","phase-4-a-study-to-investigate-of-the-effects-of-opioid-exposure-on-the-ability-of-the-diaphragm-muscle-100505038",false,"NCT05856136","A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle","Investigation of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle to Generate Higher Force Behaviors","Inclusion Criteria:\n\n\\- Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system).\n\nExclusion Criteria:\n\n* Patients who refuse research participation.\n* Patients who are pregnant.\n* Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).","ALL","18 Years",{"count":19,"type":20},69,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.",[26,27],"Respiratory Function Loss","Respiratory Complication",[29,30],"elastography","ultrasound","RECRUITING","2026-06-18",{"date":34,"type":35},"2026-06-23","ACTUAL",{"date":37,"type":35},"2023-06-19",{"date":39,"type":20},"2027-01-01",{"name":41,"class":42},"Mayo Clinic","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":43},"100577092","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-application-on-respiratory-functions-in-stroke-patients-100577092","NCT06793800","Effect of Transcutaneous Auricular Vagus Nerve Stimulation Application on Respiratory Functions in Stroke Patients","Effect of TAVNS Application on Respiratory Functions in Stroke Patients","TAVNS","Inclusion Criteria:\n\n* Being a chronic stroke patient with an ischemic or hemorrhagic stroke diagnosis made 1-3 years ago\n* Having been diagnosed with stroke for the first time\n* Ability to understand and follow simple verbal instructions\n* Being between the ages of 40 and 80\n* No conditions affecting perioral muscles, such as facial paralysis or swallowing disorders\n* No visual, auditory, or communication problems\n* No cardiopulmonary disorders\n* No additional neurological, cardiovascular, orthopedic, or similar conditions causing balance problems\n* Mini Mental State Examination (MMSE) score ≥24\n* No surgical operations or Botox applications in the last 6 months\n* Scoring 2 or below on the Modified Ashworth Scale\n\nExclusion Criteria:\n\n* Presence of infection, ulcer, or scar on the auricle\n* Metallic implants in the skull, hypersensitivity, injury, or inflammation inside the ear\n* Chronic pulmonary and\u002For cardiac diseases\n* Resting heart rate below 60 beats per minute\n* Devices such as pacemakers or cochlear implants\n* Uncontrolled hypertension\n* Chronic obstructive pulmonary disease (COPD) or asthma unrelated to stroke\n* History of surgical operation or Botox application within the last 6 months\n* Presence of aphasia, apraxia, or neglect syndrome\n* History of 2 or more strokes (SVO)\n* Comorbid conditions affecting respiratory functions (e.g., Multiple Sclerosis, Parkinson's, spinal cord injury, contractures, deformities after fractures, active upper or lower respiratory infections, etc.)\n* Lack of cooperation","40 Years","80 Years",{"count":55,"type":20},50,[57],"NA","The purpose of this study is to evaluate the effectiveness of Transcutaneous Auricular Vagus Nerve Stimulation (TAVSS) in improving respiratory muscle strength and function in chronic stroke patients. It aims to explore TAVSS as a potential complementary approach in enhancing rehabilitation outcomes for this population.",[60,26],"Hemiplegia",[62,63,64],"hemiplegia","Vagus Nerve Stimulation","Respiration","2026-03-31",{"date":67,"type":35},"2026-04-01",{"date":69,"type":35},"2025-08-05",{"date":71,"type":20},"2027-07-30",{"name":73,"class":42},"Fenerbahce University",{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":21,"phases":84,"briefSummary":85,"conditions":86,"keywords":87,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":43},"100436153","shear-wave-elastography-compared-to-respiratory-function-testing-100436153","NCT04959526","Shear-wave Elastography Compared to Respiratory Function Testing","Comparison of Shear-wave Elastography to State-of-the-art Respiratory Function Testing to Measure the Range of Forces Generated by the Diaphragm Muscle","Inclusion Criteria:\n\n\\- Adult male and female healthy volunteers.\n\nExclusion Criteria:\n\n* Volunteers who are pregnant.\n* Volunteers with known pulmonary pathology (COPD, asthma requiring routine treatment).",true,{"count":83,"type":20},24,[57],"The purpose of this study is to evaluate the relationship between transdiaphragmatic pressure (Pdi) and diaphragm shear-wave elastography (SWE) during state-of-the-art respiratory muscle testing including volitional efforts (e.g., maximal inspiratory pressure, maximal expiratory pressure, Valsalva maneuver), as well as maximal phrenic nerve stimulation.",[26,27],[88,89],"Elastography","Ultrasound","2026-03-12",{"date":92,"type":35},"2026-03-16",{"date":94,"type":35},"2021-07-28",{"date":96,"type":20},"2026-12",{"name":41,"class":42},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":81,"sex":16,"minAge":17,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":108,"phases":4,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":43},"100349858","oesophagectomy-and-chest-wall-and-respiratory-function-100349858","NCT03835273","Oesophagectomy and Chest Wall and Respiratory Function","Changes in Respiratory Function and Chest Wall Movement Following Oesophagectomy","Inclusion Criteria:\n\n* Exposure group:\n\n  1. Patients treated more than a year ago with oesophagectomy for oesophageal cancer, by an open approach.\n  2. Patients able to understand and retain the information provided, thereby being able to give informed consent for inclusion in this study.\n* Control group:\n\n  1. Healthy volunteers with no underlying respiratory disease and no history of upper gastrointestinal surgery.\n  2. Individuals able to understand and retain the information provided, thereby being able to give informed consent for inclusion in this study.\n\nExclusion Criteria:\n\n* Any participant who lacks capacity or is unable to provide informed consent.\n* Any participant younger than 18 or older than 90 years of age.\n* Any patient with evidence of cancer recurrence or on-going postoperative complication at more than one year following surgery for oesophageal cancer.\n* Any pregnant participant.\n* unable to or excluded from performing spirometry or respiratory muscle strength testing (non-invasive testing)","90 Years",{"count":107,"type":20},100,"OBSERVATIONAL","Open surgery for esophageal cancer commonly involves large incisions in the chest, associated with a high rate of pulmonary complications (30-50%). Minimally invasive approach through keyhole surgery has been shown to reduce pulmonary infections by 20%. Enhanced recovery programmes are evidence-based protocols, developed to achieve early recovery after surgery with early mobilisation and chest physiotherapy and have been shown to reduce pulmonary complication rates as well. The investigators intend to objectively measure chest wall movement using 3D motion capture system as well as a wearable measurement system to monitor chest wall movement.",[111,112,26],"Esophageal Cancer","Esophagectomy",[112,114,115,116],"Motion capture","Respiratory","Oesophageal cancer","2025-06-30",{"date":119,"type":35},"2025-07-03",{"date":121,"type":35},"2019-05-29",{"date":123,"type":20},"2025-08-31",{"name":125,"class":42},"Imperial College London",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":133,"enrollmentInfo":134,"targetDuration":136,"studyType":108,"phases":4,"briefSummary":137,"conditions":138,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":43},"100560980","effects-of-erector-spina-plane-block-and-paravertebral-block-on-early-postoperative-pulmonary-function-test-parameters-100560980","NCT06584201","Effects of Erector Spina Plane Block and Paravertebral Block on Early Postoperative Pulmonary Function Test Parameters","Effects of Erector Spina Plane Block and Paravertebral Block on Early Postoperative Pulmonary Function Test Parameters in Patients Undergoing Video-assisted Thoracoscopic Surgery","Inclusion Criteria:\n\n* Both genders\n* Being between the ages of 18 and 65\n* ASA(American Society of Anesthesiologists) I-II-III\n* Body mass index between 19 and 30kg\u002Fm2\n* Providing voluntary participation\n* Must be fully oriented and able to cooperate\n\nExclusion Criteria:\n\n* ASA(American Society of Anesthesiologists) IV-V\n* Patients who refuse to participate in the study\n* Patients under 18 years of age\n* Patients over 65 years of age\n* Presence of active infection in the area to be treated\n* Chronic pain and constant analgesic use\n* Patients with coagulation disorders\n* Patients who cannot cooperate with postoperative pain follow-ups\n* Cases taken urgently\n* Patients with severe renal failure (creatinine\\>2mg\u002Fdl)\n* Severe impairment of heart function (New York Heart Association Functional Classification III-IV)\n* Patients with known allergies to bupivacaine and other amide local anesthetic substances.","65 Years",{"count":135,"type":20},70,"1 Day","The pain experienced by participants after minimally invasive chest surgery (VATS) can make it difficult for them to take deep breaths, which can lead to problems with lung function. This can cause serious problems such as lung collapse, low oxygen levels, and infections, making recovery longer and more difficult. Managing pain well after surgery is important to prevent these problems and speed up recovery. In this study, we aimed to compare two pain relief methods, Erector Spinae Plane Block (ESP) and Paravertebral Block (PVB), in participants who underwent VATS. We will look at which method causes the smallest change in lung function before and after surgery.",[26,139,140],"Pain, Postoperative","Opioid Use","2024-09-01",{"date":143,"type":35},"2024-09-04",{"date":145,"type":35},"2023-11-01",{"date":147,"type":20},"2024-10-01",{"name":149,"class":150},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV"]