[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-function-tests\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-function-tests":33},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,54,84,108,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100630073","transcutaneous-auricular-vagus-nerve-stimulation-and-spirometry-sham-controlled-randomized-trial-100630073",false,"NCT07482930","Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial","Acute Effects Transcutaneous Auricular Vagus Nerve Stimulation on Spirometric Parameters in Healthy Individuals: A Sham-Controlled Randomized Study","taVNS-SPIRO","Inclusion Criteria:\n\n* Aged 18-40 years.\n* Healthy volunteers.\n* Able to perform spirometry and follow study instructions.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Any cardiovascular disease, cardiac arrhythmia, hypertension, or related condition.\n* Any neurological disorder (e.g., diabetes mellitus, peripheral neuropathy, epilepsy).\n* Any diagnosed psychiatric disorder.\n* Any respiratory disease (e.g., asthma, chronic obstructive pulmonary disease).\n* Pregnancy or suspected pregnancy.\n* Ear conditions that prevent stimulation (infection, open wound, pain\u002Ftenderness) or presence of a piercing at\u002Fnear the stimulation site.\n* Vigorous exercise within 24 hours prior to measurement.\n* Caffeine intake, smoking, or alcohol consumption within 4-6 hours prior to measurement.\n* Marked intolerance or hypersensitivity to the device or the procedure.\n* Inability to follow instructions during measurements or refusal to complete the session.",true,"ALL","18 Years","40 Years",{"count":22,"type":23},50,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study will examine the short-term effects of transcutaneous auricular vagus nerve stimulation (a non-invasive electrical stimulation delivered through the outer ear) on lung function measured by spirometry in healthy adults. The vagus nerve is involved in many automatic body functions, and ear-based stimulation has been used in research to explore its possible effects on different physiological systems. However, it is not clear whether a brief stimulation session can acutely influence breathing test results in people without respiratory disease.\n\nHealthy volunteers aged 18-40 will take part in one laboratory visit. Participants will be randomly assigned to one of two groups: (1) active bilateral stimulation applied to specific ear regions that are known to be innervated by the vagus nerve, or (2) sham stimulation using the same device setup but designed to minimize vagal activation. The stimulation session will last approximately 10 minutes. Before and after the stimulation, participants will perform standard spirometry (breathing) tests. Primary spirometric outcomes will include common measures of lung function such as forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF). Heart rate, heart rate variability, and blood pressure may also be recorded to monitor physiological responses and safety during the visit.\n\nParticipation is voluntary and participants may withdraw at any time. The procedure is considered minimal risk. Possible side effects are usually mild and temporary, such as tingling, warmth, or mild discomfort at the ear. Rarely, participants may feel lightheaded; if this occurs, the procedure will be stopped and the participant will be monitored until symptoms resolve. There is no guaranteed direct benefit to participants. The results may help clarify whether short-term ear-based vagus nerve stimulation can influence spirometric parameters and may inform future studies on autonomic and respiratory interactions.",[29,30,31,32,33],"Vagus Nerve Stimulations","Spirometry","Autonomic Nervous System (ANS) Functioning and Mood State","Blood Pressure Monitoring","Respiratory Function Tests",[35,36,37,38,39,40],"transcutaneous auricular vagus nerve stimulation","spirometry","autonomic nervous system","sham stimulation","pulmonary function test","blood pressure","RECRUITING","2026-03-16",{"date":44,"type":45},"2026-03-19","ACTUAL",{"date":47,"type":45},"2026-03-17",{"date":49,"type":23},"2026-04-25",{"name":51,"class":52},"SEFA HAKTAN HATIK","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":4,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":18,"minAge":61,"maxAge":19,"enrollmentInfo":62,"targetDuration":4,"studyType":64,"phases":4,"briefSummary":65,"conditions":66,"keywords":69,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":4},"100623269","respiratory-function-respiratory-muscle-strength-and-hand-function-in-hemiparetic-cerebral-palsy-100623269","NCT07394439","Respiratory Function, Respiratory Muscle Strength, and Hand Function in Hemiparetic Cerebral Palsy","Association of Respiratory Function and Respiratory Muscle Strength With Hand Function in Children With Hemiparetic Cerebral Palsy","Inclusion Criteria:\n\n* Confirmed diagnosis of hemiparetic cerebral palsy by a physician.\n* Sufficient cognitive ability to understand and follow test instructions, as judged by a parent or clinician.\n* Clinically stable condition for at least 3 months, with no changes in medication, acute exacerbations, or modifications in rehabilitation programs.\n* Physical capacity sufficient to tolerate pulmonary function testing (spirometry), maximum inspiratory\u002Fexpiratory pressure (MIP\u002FMEP) measurements, and other study assessments.\n\nExclusion Criteria:\n\n* Current or recent acute respiratory infection, asthma exacerbation, pneumonia, or known cardiopulmonary disease that may affect testing.\n* Receipt of intensive upper extremity interventions other than routine physiotherapy (e.g., botulinum toxin injections, surgical procedures) within the past 6 months.\n* History of major orthopedic surgery (e.g., hip reconstruction, scoliosis surgery) within the past 3 months.\n* Severe musculoskeletal contracture or deformity that prevents the safe performance of pulmonary function testing.\n* Severe epilepsy, uncontrolled seizures, or other neurological conditions that may compromise safety during testing.","6 Years",{"count":63,"type":23},37,"OBSERVATIONAL","The goal of this observational study is to learn how respiratory function and respiratory muscle strength are related to hand use in children and teenagers with hemiparetic cerebral palsy (CP) aged 6 to 18 years.\n\nThe main questions it aims to answer are:\n\nIs respiratory function related to hand function in children with hemiparetic CP? Is respiratory muscle strength related to hand function in children with hemiparetic CP? Is respiratory function related to how strong children can squeeze with their affected hand? Is respiratory muscle strength related to how strong children can squeeze with their affected hand? Is respiratory function related to how well children use their hands in daily activities? Is respiratory muscle strength related to how well children use their hands in daily activities? Is respiratory function related to children's hand skill level? Is respiratory muscle strength related to children's hand skill level?\n\nParticipants will:\n\nVisit the clinic one time for a single assessment session. Do simple lung tests using a small portable device to measure respiratory function.\n\nDo tests that measure how strong their breathing muscles are.\n\nComplete hand and arm tests, including:\n\nA hand grip strength test, A simple block-moving test, A short questionnaire about using the hand in daily life, A standard hand skill rating. Researchers will look at how respiratory measures are related to hand strength, hand skills, and daily hand use. This study may help improve rehabilitation programs by showing whether respiratory muscle strength and hand skills should be trained together in children with hemiparetic CP.",[67,33,68],"Cerebral Palsy","Fine Motor Skills",[70,71,72,73],"Hemiparetic Cerebral Palsy","Respiratory Function","Respiratory Muscle Strength","Hand Function","NOT_YET_RECRUITING","2026-02-03",{"date":77,"type":45},"2026-02-06",{"date":79,"type":23},"2026-01-23",{"date":81,"type":23},"2026-03-09",{"name":83,"class":52},"Halic University",{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":24,"phases":92,"briefSummary":93,"conditions":94,"keywords":4,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100597674","objective-evaluation-of-cough-effort-in-tracheotomized-patients-lost-study-100597674","NCT07061561","Objective Evaluation of Cough Effort in Tracheotomized Patients (LOST Study)","Inclusion Criteria:\n\n* Adult patients (18 years or older)\n* Hospitalized in post-intensive care rehabilitation unit (SRPR) or intensive care unit (ICU)\n* Tracheotomized during the weaning process\n* Medical prescription for physiotherapy assessment\n* Medical prescription for speech therapy assessment\n\nExclusion Criteria:\n\n* Patients who have undergone total laryngectomy\n* Patients with severe swallowing disorders\n* Patients with cognitive impairments incompatible with understanding instructions\n* Patients under medical decision to stop active treatments\n* Patients who refuse to participate or refuse to sign informed consent\n* Patients under guardianship or curatorship\n* Patients not affiliated with a social security scheme",{"count":91,"type":23},34,[26],"This study aims to evaluate how well tracheotomized patients can cough before and after their tracheostomy tube is removed. Cough strength is measured using two different tools-Peak Flow and Lorio. Researchers want to find out if the cough measurement taken before removing the tube can help predict how effective the patient's cough will be afterward. The study will also explore factors that might influence cough strength and compare the usefulness of the two tools. Additionally, it will assess how patients feel about using these devices and the role of diaphragm ultrasound in predicting cough effectiveness.",[95,96,97,33,98],"Tracheostomy","Cough","Weaning","Diaphragm","2025-07-02",{"date":101,"type":45},"2025-07-11",{"date":103,"type":23},"2025-07-15",{"date":105,"type":23},"2026-11-15",{"name":107,"class":52},"Centre Hospitalier de Saint-Denis",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":116,"targetDuration":4,"studyType":24,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":53},"100563081","positive-pressure-therapy-to-optimize-lung-function-after-heart-surgery-100563081","NCT06611527","Positive Pressure Therapy to Optimize LUNG Function After Heart Surgery","Comparison Between Two Methods of Positive Pressure Therapy in the Prevention of Pulmonary Complications in the Immediate Postoperative Period of Cardiac Surgery: a Prospective, Randomized Clinical Trial","PRO-LUNGHS","Inclusion Criteria:\n\n* Immediate postoperative period of myocardial revascularization and\u002For valve replacement or plastic surgery;\n* Patients in the preoperative period at risk of developing pulmonary complications, characterized by the presence of at least 2 of the following risk factors: age ≥ 70 years, productive cough, diabetes, history of smoking, chronic obstructive pulmonary disease (COPD) defined by forced expiratory volume in 1 second (FEV1) lower than 75% of predicted, body mass index (BMI) ≥ 27 kg\u002Fm2, or only FEV1 lower than 80% and FEV1\u002Fforced vital capacity (FVC) ratio lower than 70% of predicted; OR patients in the postoperative period (up to 12 hours after extubation) with mild to moderate complications characterized by a pulmonary complication score lower than 3.\n\nExclusion Criteria:\n\n* Hemodynamic instability characterized by mean arterial pressure (MAP) lower than 60mmHg and\u002For acute arrhythmia of any etiology;\n* Need for intra-aortic balloon;\n* Duration of invasive mechanical ventilation exceeding 24 hours after surgery;\n* Pulmonary complication score ≥ grade 3;\n* Presence of signs of acute respiratory failure, such as respiratory rate (f) ≥ 25 breaths\u002Fmin and use of accessory muscles;\n* Chest tube with air leak;\n* Use of a pacemaker or implantable or external cardioverter-defibrillator.",{"count":117,"type":23},156,[26],"The most common cardiac surgeries are myocardial revascularization and valve replacement or plastic surgery. In the postoperative period of cardiac surgeries, the incidence of pulmonary complications ranges from 30% to 50% and is associated with increased length of hospital stay and morbidity and mortality. To reduce or minimize the occurrence of these complications, respiratory physiotherapy employs positive pressure reexpansion therapies, such as continuous positive airway pressure (CPAP) and positive pressure support with positive end-expiratory pressure (PS+PEEP).\n\nThe goal of this clinical trial is to compare the effects of two positive pressure therapies, CPAP versus PS+PEEP, on the incidence of pulmonary complications in patients in the postoperative period of myocardial revascularization and valve replacement or plastic surgery, with mild to moderate pulmonary dysfunction.\n\nThe main question it aims to answer is: Do patients in the immediate postoperative period of myocardial revascularization or valve replacement\u002Fplastic surgery, exhibiting mild to moderate pulmonary dysfunction, experience a comparable reversal of pulmonary conditions when treated with PS+PEEP versus CPAP?\n\nParticipants will undergo the following assessments: spirometry, respiratory muscle strength testing, handgrip strength testing, and electrical impedance tomography.\n\nIn the immediate postoperative period, participants will be randomized into two treatment groups: • Control Group PS+PEEP - application of 4 sets of 20 repetitions with PS to provide a tidal volume equal to 10ml\u002Fkg of predicted body weight, PEEP equal to 10 cmH2O, and inspired oxygen fraction (FiO2) to achieve peripheral oxygen saturation (SpO2) between 92-94%; • Experimental Group CPAP - application of CPAP at 10 cmH2O with FiO2 to achieve SpO2 between 92-94% for 30 minutes.",[121,122,123,33,124,125],"Postoperative Period","Physical Therapy Modalities","Continuous Positive Airway Pressure","Pulmonary Atelectasis","Heart Surgery","2025-04-08",{"date":128,"type":45},"2025-04-10",{"date":130,"type":45},"2025-01-08",{"date":132,"type":23},"2027-12",{"name":134,"class":52},"Federal University of São Paulo",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":139,"acronym":140,"eligibilityCriteria":141,"healthyVolunteers":11,"sex":18,"minAge":142,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":24,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":159},"100474531","visualization-of-inspiratory-effort-and-respiratory-mechanics-to-promote-lung--and-diaphragm-protective-ventilation-100474531","NCT05459116","Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation","VIREM","Inclusion Criteria:\n\n* age \\> 28 days\n* weight \\> 3kg\n* requiring invasive mechanical ventilation\n* anticipated length of ventilation \\> 48h\n\nExclusion Criteria:\n\n* refusal of consent\n* mechanical ventilation ≤ 2 weeks before inclusion\n* known anatomical malformation of the diaphragm (including congenital diaphragmatic hernia)\n* contra-indication to the placement of a naso-gastric esophageal balloon catheter","29 Days",{"count":144,"type":23},150,[26],"This is a multicentre prospective cohort trial in adult and pediatric ICU patients. The investigators will measure the effect of a patient's inspiratory effort during mechanical ventilation on the lungs and diaphragm. The investigators will daily (for a maximum of 8 days) measure esophageal pressures with a balloon catheter to quantify inspiratory effort and respiratory muscle function, and perform daily ultrasound measurements of the diaphragm and the lungs. The investigators hypothesize that a small inspiratory effort will result in the preservation of diaphragm function and have no adverse effect on lung function.",[148,149,33],"Respiratory Muscles","Respiration, Artificial","2025-04-03",{"date":152,"type":45},"2025-04-06",{"date":154,"type":45},"2022-09-21",{"date":156,"type":23},"2025-12-01",{"name":158,"class":52},"University Hospital, Antwerp",3]