[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-ilness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-ilness":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,53,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":35,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100571925","interprofessional-pharmacogenomics-ipgx-registry-and-repository-100571925",false,"NCT06726590","Interprofessional Pharmacogenomics (IPGx) Registry and Repository","The Texas Interprofessional Pharmacogenomics Registry and Repository","IPGx Registry","Inclusion Criteria:\n\n* The study will invite patients who are eligible for PGX workup\u002FPGX care to participate, provided they meet the following criteria: Use of five or more medications, including over the counter drugs, supplements, natural products, cannabis products, or other recreational drugs, or\n* Individuals taking blood pressure or depression medications, even if less than five medications.\n* Ability to understand and give consent.\n* Able to consent to donate blood and\u002For urine samples and buccal swabs.\n* Able to answer detailed questionnaires, including quarterly questionnaires about ADRs, cognitive testing such as serial mini-mental status exams, and or quality of life questions.\n* Able to understand that their health record and changes in health status will be followed for a five-year period and shared in deidentified form with the research community.\n* All genders.\n* Any age over 18 years.\n\nExclusion Criteria:\n\n* Individuals admitted to hospice.\n* Declines to participate or interact with staff\u002Fshare their medical status.\n* A diagnosis of Alzheimer's disease or related dementias in a medical record as this indicates a progressive, debilitating condition that impairs memory, thought processes, and functioning.,\n* Individuals who are unable or unwilling to provide consent.\n* Unable to verbally communicate and comprehend English language","ALL","18 Years",{"count":20,"type":21},3000,"ESTIMATED","6 Months","OBSERVATIONAL","This program collects genetic and health information to help doctors choose the right medications for patients.",[26,27,28,29,30,31,32,33,34],"Diabetes","Cholesterol","Cancer","Blood Pressure Disorders","Heart Disease","Respiratory Ilness","COPD","Adverse Drug Reaction (ADR)","Poly Pharmacy",[36,37,38,39],"REGISTRY","REPOSITORY","POLYPHARMACY","ADVERSE DRUG REACTION","RECRUITING","2025-09-05",{"date":43,"type":44},"2025-09-12","ACTUAL",{"date":46,"type":21},"2025-11",{"date":48,"type":21},"2029-11",{"name":50,"class":51},"Texas A&M University","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":52},"100576321","study-on-the-correlation-between-tracheotomy-tip-pressure-and-esophageal-pressure-in-patients-weaned-from-tracheotomy-100576321","NCT06783777","Study on the Correlation Between Tracheotomy Tip Pressure and Esophageal Pressure in Patients Weaned from Tracheotomy","Inclusion Criteria:\n\n* Adult patients (≥18 years old), regardless of gender\n* Tracheostomized patients with spontaneous breathing;\n* Weaning criteria: under the condition of mask oxygen inhalation at 5L\u002Fmin, SPO2 \\> 94%, PaO2\u002FFiO2 \\> 150 - 200.\n* The patient has stable hemodynamics and pH ≥ 7.32;\n* Agree to participate in this trial and sign the informed consent form.\n\nExclusion Criteria:\n\n* Patients with contraindications for esophageal catheter insertion and unable to monitor esophageal pressure;\n* Patients with bleeding risks: severe coagulation disorders, esophageal varices；\n* Local injuries: basilar skull fracture, maxillofacial fracture;\n* Pregnant women;\n* Patients considered not suitable by the researcher.","99 Years",{"count":61,"type":21},42,"INTERVENTIONAL",[64],"NA","Whether the correlation between gas incision tip pressure fluctuations (ΔPtt) and esophageal pressure fluctuations (ΔPes) is a potential measure of spontaneous respiratory effort in patients undergoing gas incision offline.",[67,31],"Respiratory Distress Syndrome (RDS)",[69,70],"esophageal-pressure","tracheotomy tip pressure","NOT_YET_RECRUITING","2025-01-15",{"date":74,"type":44},"2025-01-20",{"date":76,"type":21},"2025-02-05",{"date":78,"type":21},"2026-12-26",{"name":80,"class":51},"Shanghai Zhongshan Hospital",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":89,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":52},"100570920","investigating-oestrogen-signalling-and-the-effect-upon-the-extracelluar-matrix-in-patients-with-obstructive-lung-disease-100570920","NCT06713512","InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease","invEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease","ESSENTIAL","Inclusion Criteria:\n\n1. Men and women aged \\> 18 years.\n2. For female participants: pre-menopausal, peri-menopausal and post-menopausal women can all be included.\n3. Participants willing and able to give informed consent for participation in the study.\n4. Healthy controls \\<10 pack year history (participants without Asthma or COPD).\n\nExclusion Criteria:\n\n1. Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus.\n2. Alcohol or recreational drug abuse, is defined as when the use is harmful as per NHS definition.\n3. History of psychiatric, medical, or surgical disorders.\n4. Pregnant\n5. Unable to provide written informed consent\n6. History of advanced medical conditions with an expected prognosis of \\< 3 years.\n7. Patients with a history of active cancer.\n8. Patients on long term oxygen (ambulatory oxygen).",true,{"count":91,"type":21},100,"This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without disease). The study hypothesises that oestrogen loss in patients with asthma and COPD causes accelerated lung function decline and changes to lung structure. It will investigate if this is mediated by inflammation, immune host response or elastin and collagen changes. It is an observational prospective cohort study aiming to recruit healthy controls, and people with asthma or COPD), and\u002For the menopause.",[94,31,95,96],"Chronic Obstructive Lung Disease","Estrogen Deficiency","Asthma",[96,32],"2024-11-27",{"date":100,"type":44},"2024-12-03",{"date":102,"type":21},"2024-12-01",{"date":104,"type":21},"2028-11-01",{"name":106,"class":51},"Guy's and St Thomas' NHS Foundation Trust"]