[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-mechanics\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-mechanics":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,45,83,112,137,168],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100643852","vnotes-vs-laparoscopy-respiratory-mechanics-and-hemodynamics-100643852",false,"NCT07667907","vNOTES vs Laparoscopy: Respiratory Mechanics and Hemodynamics","Comparison of the Effects of vNOTES and Laparoscopic Gynecological Surgery on Intraoperative Respiratory Mechanics and Hemodynamics: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Female patients aged 18 to 75 years\n* Patients scheduled for elective gynecological surgery\n* Patients undergoing mechanical ventilation under general anesthesia\n* ASA physical status I-III\n* Patients providing written informed consent\n\nExclusion Criteria:\n\n* Severe or uncontrolled chronic obstructive pulmonary disease, asthma, or other chronic pulmonary diseases\n* Cardiac arrhythmia\n* ASA physical status IV or above\n* Patients developing intraoperative hemodynamic instability\n* Patients receiving spinal or epidural anesthesia\n* Cases requiring conversion to laparoscopy or laparotomy\n* Patients refusing to participate","FEMALE","18 Years","75 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","Pneumoperitoneum and Trendelenburg position are unavoidable in laparoscopic surgery and are known to have adverse effects on intraoperative respiratory mechanics and hemodynamics. These conditions increase the risk of ventilator-induced lung injury (VILI) and highlight the importance of lung-protective ventilation strategies.\n\nvNOTES (Vaginal Natural Orifice Transluminal Endoscopic Surgery) is a minimally invasive technique that requires less Trendelenburg tilt and lower insufflation pressures compared to conventional laparoscopic surgery, and may therefore offer a more favorable intraoperative profile.\n\nThis prospective, observational, single-center, parallel-group cohort study aims to compare respiratory mechanics parameters (Ppeak, Pplateau, DP, MPtot, MPdyn, Crs) and hemodynamic parameters (MAP, HR, vasopressor requirement) between vNOTES (n=15) and laparoscopic gynecological surgery (n=15) groups at four intraoperative time points.",[25,26],"Respiratory Mechanics","Hemodynamics",[28,29,25,26,30,31],"vNOTES","Laparoscopy","Pneumoperitoneum","Trendelenburg","NOT_YET_RECRUITING","2026-06-19",{"date":35,"type":36},"2026-06-25","ACTUAL",{"date":38,"type":21},"2026-07-01",{"date":40,"type":21},"2027-07-01",{"name":42,"class":43},"Bursa Yuksek Ihtisas Training and Research Hospital","OTHER_GOV",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":44},"100643703","bedside-assessment-of-right-ventricular-output-lying-in-prone-or-supine-position-100643703","NCT07632027","Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position","The BAROLO Study Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position. Hemodynamic Changes Due to Prone Position in Patients After Cardiac Surgery - a Prospective Randomized Controlled Trial Evaluating the Effect of Prone Position on Right Heart Function","BAROLO","Inclusion Criteria:\n\n* Scheduled for cardiac surgery using cardiopulmonary bypass\n\nExclusion Criteria:\n\n* BMI \\>40\n* Emergency surgery\n* In need of secondary surgery\n* Advanced grown up congenital heart disease\n* Pulmonary disease\n* Hemodynamic instability with Norepinephrine \\>0.4mcg\u002Fkg\u002Fmin\n* Any condition which, in the judgement of the investigator, might increase the risk to the patient","ALL",{"count":55,"type":21},80,"INTERVENTIONAL",[58],"NA","Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay. The right ventricle is particularly vulnerable to an increased afterload. By increasing pulmonary vascular resistance (PVR), atelectasis might mitigate a negative effect on the right ventricle.\n\nRecruitment maneuvers have been shown to resolve atelectasis and improve hemodynamics by increasing cardiac output and lowering PVR. However these maneuvers transiently raise airway pressures, which in turn increases right ventricular afterload, a situation often poorly tolerated by patients with RVF.\n\nProne position is used in patients with respiratory failure and has been shown to decrease mortality in patients with ARDS. Prone position decreases atelectasis and moves ventilation dorsally. In ARDS it also seems to mediate beneficial hemodynamic effects such as an increase in cardiac output and a decrease in PVR.\n\nThe investigators hypothesis is that prone position early after cardiac surgery will increase cardiac output by recruitment of atelectasis and thereby decrease PVR.",[61,62,63,64,65,66,67,68,25,69,70,71,72],"Right Ventricular Function","Prone Position","Atelectasis","Atelectases, Postoperative Pulmonary","Cardiac Output","Vasoconstriction","Heart Failure","Recruitment Maneuver","Pulmonary Arterial Pressure","Cardiac Surgery","Cardiac Surgery Recovery","Cardiopulmonary Bypass","2026-06-03",{"date":75,"type":36},"2026-06-08",{"date":77,"type":21},"2026-09",{"date":79,"type":21},"2028-10",{"name":81,"class":82},"Sahlgrenska University Hospital","OTHER",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":4},"100634765","peak-airway-pressure-and-respiratory-mechanics-during-prvc-ventilation-in-laparoscopic-surgery-100634765","NCT07543939","Peak Airway Pressure and Respiratory Mechanics During PRVC Ventilation in Laparoscopic Surgery","Peak Airway Pressure and Respiratory Mechanics During Pressure-Regulated Volume Control Ventilation in Patients Undergoing Laparoscopic Abdominal Surgery: A Prospective Observational Study","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Scheduled for elective laparoscopic abdominal surgery under general anesthesia\n* ASA physical status I-II\n* Patients requiring mechanical ventilation using PRVC mode\n* Provided informed consent\n\nExclusion Criteria:\n\n* Patients with significant cardiopulmonary disease\n* Chronic obstructive pulmonary disease or restrictive lung disease\n* Morbid obesity (BMI \\> 35 kg\u002Fm²)\n* Pregnancy\n* Emergency surgeries\n* Patients with anticipated difficult airway\n* Refusal to participate","65 Years",{"count":92,"type":21},52,"This study aims to evaluate peak airway pressure and respiratory mechanics during pressure-regulated volume control (PRVC) ventilation in patients undergoing elective laparoscopic abdominal surgery. Pneumoperitoneum and patient positioning during laparoscopic procedures can significantly affect respiratory mechanics, including airway pressures and lung compliance.\n\nThe study will assess changes in peak airway pressure, dynamic compliance, and other ventilatory parameters during different intraoperative phases. The findings are expected to provide insights into optimizing ventilatory strategies to improve patient safety and minimize ventilator-associated complications during laparoscopic surgery.",[95,25],"Intraoperative Ventilation",[97,98,99,100,101,102],"PRVC ventilation","Laparoscopic surgery","Peak airway pressure","Dynamic compliance","General anesthesia","Mechanical ventilation","2026-04-18",{"date":105,"type":36},"2026-04-22",{"date":107,"type":21},"2026-05",{"date":109,"type":21},"2026-10",{"name":111,"class":82},"Specialized Medical Center (SMC)",{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":119,"sex":120,"minAge":17,"maxAge":4,"enrollmentInfo":121,"targetDuration":4,"studyType":56,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":4},"100629504","low-flow-versus-minimal-flow-sevoflurane-anesthesia-during-robot-assisted-laparoscopic-radical-prostatectomy-100629504","NCT07475533","Low-flow Versus Minimal-flow Sevoflurane Anesthesia During Robot-assisted Laparoscopic Radical Prostatectomy","A Prospective Randomized Study Comparing Low-Flow (1 L\u002FMin) and Minimal-Flow (0.5 L\u002FMin) Sevoflurane Anesthesia in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy","Inclusion Criteria\n\n* Male patients aged 18 years or older.\n* ASA physical status I-II.\n* Scheduled for elective robot-assisted laparoscopic radical prostatectomy.\n* Provision of written informed consent. Exclusion Criteria\n* ASA physical status III-V.\n* Severe cardiac, respiratory, hepatic, or renal disease.\n* Mental status disorder or significant hearing impairment that prevents consent or communication.\n* Known anxiety, depression, or other psychiatric disorder judged to interfere with study participation.\n* Withdrawal of consent or investigator decision for safety reasons.",true,"MALE",{"count":122,"type":21},70,[58],"Study Synopsis This protocol is formatted for ClinicalTrials.gov-style registration and manuscript-facing documentation. It is based on the uploaded Turkish ethics protocol and keeps the original core design: comparison of low-flow and minimal-flow sevoflurane anesthesia in robot-assisted laparoscopic radical prostatectomy.\n\nBackground and Rationale Robot-assisted laparoscopic radical prostatectomy (RALRP) is increasingly preferred for localized prostate cancer because of lower blood loss, reduced transfusion requirements, shorter hospitalization, and lower complication rates compared with open surgery. However, RALRP requires carbon dioxide pneumoperitoneum and steep Trendelenburg positioning, both of which may adversely affect respiratory mechanics, gas exchange, and hemodynamic stability.\n\nLow-flow and minimal-flow anesthesia may improve humidification and warming of inspired gases, reduce inhalational agent consumption, decrease environmental waste, and potentially lower overall cost. Despite these theoretical and practical advantages, evidence remains limited regarding the physiologic safety and performance of minimal-flow sevoflurane anesthesia during long robotic pelvic surgery performed under pneumoperitoneum and steep Trendelenburg positioning.\n\nAccordingly, this randomized prospective trial will compare low-flow (1 L\u002Fmin) and minimal-flow (0.5 L\u002Fmin) sevoflurane anesthesia during RALRP with respect to respiratory parameters, arterial blood gas values, intraoperative oxygenation variables, anesthetic consumption, and selected postoperative biochemical markers.",[126,127,25],"Prostate Cancer","Anesthesia","2026-04-13",{"date":130,"type":36},"2026-04-15",{"date":132,"type":21},"2026-03-20",{"date":134,"type":21},"2026-08-31",{"name":136,"class":82},"Ankara City Hospital Bilkent",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":145,"enrollmentInfo":146,"targetDuration":148,"studyType":22,"phases":4,"briefSummary":149,"conditions":150,"keywords":153,"overallStatus":158,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":44},"100623088","comparison-of-fcv-and-vcv-in-one-lung-ventilation-100623088","NCT07392086","Comparison of FCV and VCV in One-Lung Ventilation","Comparison of the Effects of Flow-Controlled Ventilation (FCV) and Volume-Controlled Ventilation (VCV) on Respiratory Mechanics and Gas Exchange During One-Lung Ventilation: A Multicenter Prospective Observational Study (FCVOLVent)","FCVOLVent","Inclusion Criteria Adult patients aged 18 years and older Patients undergoing thoracic surgery requiring one-lung ventilation (OLV) Requirement for one-lung ventilation for at least 30 minutes American Society of Anesthesiologists (ASA) physical status I-III Provision of written informed consent Patients ventilated with flow-controlled ventilation (FCV) or volume-controlled ventilation (VCV) as part of routine clinical practice\n\nExclusion Criteria Requirement for emergency surgery History of untreated asthma High pulmonary risk, defined as predicted postoperative FEV₁ \\\u003C 20 mL\u002Fkg in males and \\\u003C 18 mL\u002Fkg in females High cardiac risk, including advanced cardiomyopathy with left ventricular ejection fraction \\\u003C 30% Body mass index (BMI) \\> 35 kg\u002Fm² Contraindication to total intravenous anesthesia (TIVA) Evidence of pulmonary infection prior to surgery Presence of other significant pulmonary pathologies (e.g., tuberculosis, bullous lung disease, bronchiectasis) Severe COPD (GOLD stage III-IV) or significant restrictive lung disease Age \\\u003C 18 years or \\> 80 years, or pregnancy ASA physical status IV or higher Uncontrolled arrhythmia or history of myocardial infarction within the past 3 months Inability to provide informed consent","80 Years",{"count":147,"type":21},60,"1 Year","One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters remain an important clinical concern.\n\nFlow-controlled ventilation (FCV) is a newer ventilation mode that allows precise control of inspiratory and expiratory flow, potentially improving lung mechanics and gas exchange. Volume-controlled ventilation (VCV) is a widely used conventional ventilation strategy during thoracic anesthesia.\n\nThe FCVOLVent study is a multicenter, prospective observational study designed to compare the effects of FCV and VCV during one-lung ventilation in adult patients undergoing thoracic surgery. Patients will be ventilated with either FCV or VCV as part of routine clinical practice.\n\nThe study aims to evaluate respiratory mechanics and oxygenation parameters, including the PaO₂\u002FFiO₂ ratio, airway pressures, lung compliance, and mechanical power during surgery. Data will be collected at predefined time points during one-lung ventilation.\n\nThe results of this study are expected to provide real-world clinical evidence on the potential advantages and limitations of flow-controlled ventilation compared with volume-controlled ventilation during one-lung ventilation.",[151,152,25],"One-lung Ventilation (OLV)","Thoracic Surgery",[154,155,156,157],"Flow-Controlled Ventilation","Thoracic Anesthesia","Volume-Controlled Ventilation","One-Lung Ventilation","RECRUITING","2026-01-29",{"date":161,"type":36},"2026-02-06",{"date":163,"type":36},"2026-01-01",{"date":165,"type":21},"2026-12-01",{"name":167,"class":82},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":56,"phases":178,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":158,"whyStopped":4,"lastUpdateSubmitDate":182,"lastUpdatePostDateStruct":183,"startDateStruct":185,"completionDateStruct":187,"leadSponsor":189,"locationsCount":44},"100616351","effects-of-sevoflurane-versus-desflurane-anesthesia-under-protective-mechanical-ventilation-for-robotic-assisted-surgery-100616351","NCT07304479","Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery","Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery on Airway Plateau Pressure: a Randomized, Prospective, Blinded Pilot Study","Inclusion Criteria:\n\n* Age 18 to 87 years\n* Undergoing elective robotic-assisted abdominal surgery\n* ASA physical status I-III\n\nExclusion Criteria:\n\n* ASA IV or V\n* Emergency surgery\n* Renal insufficiency\n* Clinically significant respiratory disease\n* Cardiomyopathy\n* Uncontrolled hypertension","87 Years",{"count":177,"type":21},50,[58],"Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.",[25,181],"Intraoperative","2025-12-12",{"date":184,"type":36},"2025-12-26",{"date":186,"type":36},"2025-05-01",{"date":188,"type":21},"2026-02-28",{"name":190,"class":82},"National and Kapodistrian University of Athens"]