[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-morbidity\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-morbidity":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,79,107],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100578261","prospective-multicentre-mixed-methods-study-to-explore-extubation-practices-and-respiratory-outcomes-in-extremely-preterm-neonates-100578261",false,"NCT06808997","Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.","Criteria and Reasons for Extubation and Non-extubation in Preterm Infants: A Mixed Methods Study Prospectively Exploring Extubation and Reintubation Practices in Extremely Preterm Infants, and Associated Respiratory Outcomes.","CERAINE","Inclusion Criteria:\n\n* Gestational age \\\u003C 28 weeks of gestation\n* Age at admission to the participating unit \\\u003C24 hours\n\nExclusion Criteria:\n\n* Parental opposition to their infant's clinical data collection\n* Participation in a research protocol with potential impact on extubation and\u002For duration of mechanical ventilation","ALL","1 Minute","5 Months",{"count":21,"type":22},100,"ESTIMATED","OBSERVATIONAL","The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective qualitative and quantitative data. Actual extubation readiness is defined as successful extubation, defined as no reintubation in the 7 days following extubation.\n\nKey research questions are: How do clinicians assess extubation readiness in this population? Does this assessment correlate with actual extubation success? What factors (reasons, clinical status, ventilatory parameters) are associated with extubation readiness? Patients born before 28 weeks gestational age and admitted to the neonatal intensive care unit (NICU) within the first 24 hours are be included. The attending physician will complete a prospectively administered questionnaire with open-ended and multiple-choice questions to daily assess the decision and rationale for extubation or non-extubation of patients mechanically ventilated during the first 15 days of life.\n\nPatient characteristics, respiratory outcomes, and mortality will be recorded until the end of hospitalisation and\u002For definitive weaning from any ventilatory support or supplemental oxygen.",[26,27,28,29,30,31],"PreTerm Neonate","Extubation Readiness","Extubation Failure","Respiratory Morbidity","Bronchopulmonary Dysplasia","Mechanical Ventilation",[33,34,35,36],"extremely preterm infants","extubation","mechanical ventilation","bronchopulmonary dysplasia","RECRUITING","2026-03-11",{"date":40,"type":41},"2026-03-12","ACTUAL",{"date":43,"type":41},"2025-02-17",{"date":45,"type":22},"2026-04-30",{"name":47,"class":48},"Centre Hospitalier Intercommunal Creteil","OTHER",31,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":61,"phases":62,"briefSummary":64,"conditions":65,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100550164","respiratory-trends-during-blood-transfusions-in-newborns-100550164","NCT06443515","Respiratory Trends During Blood Transfusions in Newborns.","Evaluation of Respiratory Trends During Blood Transfusions in Newborns.","ARTE","Inclusion Criteria:\n\n* admitted newborns requiring blood transfusions as per local practice and\u002For international guidelines\n\nExclusion Criteria:\n\n* newborns with major malformations\n* need for palliative care\n* lack of informed consent","1 Month",{"count":60,"type":22},71,"INTERVENTIONAL",[63],"NA","The prevalence of transfusion reactions is between 1 and 11% of transfusions. Most reactions are mild and do not pose a life-threatening risk to the patient. More serious problems may be the only manifestations that lead to suspicion of a transfusion reaction.\n\nMost noninfectious transfusion reactions are immune-mediated. Two main types of reactions can be distinguished: TACO (transfusion associated cardiac overload, which is a cardiogenic pulmonary edema) and TRALI (transfusion related acute lung injury, non-cardiogenic pulmonary edema).\n\nAlthough TRALI are diagnoses of exclusion, the presence of noncardiogenic pulmonary edema and respiratory problems in the vicinity of blood product transfusions should raise suspicion. Other signs of TRALI are hypotension and tachycardia, while in TACO arterial hypertension with positive water balance can be observed.\n\nAccording to previous reports, the prevalence of transfusion reactions in the neonatal population is approximately 8%. Factors associated with these reactions are low birth weight and low gestational age. However, diagnostic criteria of respiratory transfusion reactions are not uniform across studies, and often the generic terms \"acute lung injury\" have been used.\n\nTherefore, the primary objective of this study is to evaluate the respiratory trend during blood transfusions; secondary objectives are the study of risk factors for the development of respiratory worsening and the possible association with complications.",[66,67,68,29],"Blood Transfusion Complication","Blood Transfusion Associated Adverse Reactions","Respiratory Complication","2024-09-23",{"date":71,"type":41},"2024-09-24",{"date":73,"type":41},"2024-07-01",{"date":75,"type":22},"2026-01-15",{"name":77,"class":48},"Fondazione Policlinico Universitario Agostino Gemelli IRCCS",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":61,"phases":92,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":78},"100557380","mouthpiece-with-integrated-cheek-support-vs-manual-cheek-support-during-respiratory-oscillometry-100557380","NCT06537362","Mouthpiece With Integrated Cheek Support vs. Manual Cheek Support During Respiratory Oscillometry","Comparative Evaluation of the Use of a Mouthpiece With Integrated Cheek Support vs. Manual Cheek Support During Respiratory Oscillometry Measurements","COMICUSROM","Inclusion Criteria:\n\n* subjects aged between 5 and 75 years\n\nExclusion Criteria:\n\n* Subjects unable to follow the study procedures or with any physical or mental condition deemed unsuitable by the doctor will be excluded from the study",true,"5 Years","75 Years",{"count":91,"type":22},55,[63],"The study aims to evaluate the measurement accuracy of respiratory impedance during oscillometry (or Forced Oscillation Technique - FOT) under the following conditions: 1)The subject's cheeks are manually supported by an expert (Gold Standard method), 2) The subject's cheeks are supported by an integrated cheek support in the mouthpiece.\n\nIt is a prospective, randomized, cross-over study on Subjects who will present themselves at the offices of the participating doctors, aged between 5 and 75 years. The primary outcome is to Compare the respiratory impedance measurements under the two measurement conditions. Secondary Objectives are to: i)evaluate the patient's comfort during the measurement with the cheek support and compare this comfort to the gold standard condition; ii) assess the maximum and minimum face dimensions of the recruited subjects that allow for effective and comfortable cheek support; iii) evaluate the type and frequency of measurement errors introduced by the use of the integrated cheek support in the mouthpiece.",[29,95],"Lung Function Decreased",[97],"Oscillometry","2024-08-26",{"date":100,"type":41},"2024-08-28",{"date":102,"type":41},"2024-03-26",{"date":104,"type":22},"2024-08",{"name":106,"class":48},"Politecnico di Milano",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":115,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":61,"phases":119,"briefSummary":120,"conditions":121,"keywords":123,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":136},"100492962","low-dose-antenatal-corticosteroids-for-late-preterm-delivery-100492962","NCT05698966","Low Dose Antenatal Corticosteroids for Late Preterm Delivery","Low Dose Antenatal Corticosteroids for Late Preterm Delivery (LoDAC Study)","LoDAC","Inclusion Criteria:- - Singleton pregnancy at 34 weeks 0 days to 36 weeks 5 days of gestation at risk for \u002F high probability of delivery in the late preterm period (34+0-36+5 weeks of gestation).\n\nCriteria for determination of late preterm delivery risk:\n\n1. Preterm uterine contractions with intact membranes, and at least 3 cm dilation or 75% cervical effacement\n2. Spontaneous rupture of the membranes\n3. Expected preterm delivery for any other indication via induction or cesarean between 24 hours to 7 days after the planned randomization, as determined by the obstetric provider.\n\n   \\-\n\n   Exclusion Criteria: They had already received a full course of betamethasone.\n   * Expected delivery in less than 12 hours, irrespective of cause including: 1)ruptured membranes in the presence of more than 6 contractions per hour or cervical dilation of 3 centimeters or more unless oxytocin was withheld for at least 12 hours (although other induction agents were allowed), 2) chorioamnionitis, 3) cervical dilation of 8 cm or more, and 4) evidence of non-reassuring fetal status requiring immediate delivery.\n   * Prior ACS treatment\n   * Current known or suspected infection ( viral, bacterial or other)\n   * Pre-gestational diabetes mellitus.\n   * Any infection that required antibiotics or hospitalization in the month prior to study allocation - Poor understanding of the inform consent language","18 Years","45 Years",{"count":118,"type":22},1510,[63],"This is a study proposal for a clinical trial to evaluate the effectiveness of a reduced dose of antenatal betamethasone (a steroid medication) in preventing respiratory problems in late preterm infants (born between 34 and 36 weeks of gestation). The study will be conducted in medical centers in Israel and will involve women who are at high risk for delivering a late preterm infant. The participants will be randomly assigned to receive either a full dose (12 mg) or a quarter dose (3 mg) of betamethasone, administered 24 hours apart. The main outcome measure of the study will be the incidence of respiratory problems or neonatal death within 72 hours of delivery in the two groups. The study is designed to determine if the reduced dose of betamethasone is non-inferior (i.e., not significantly worse) than the full dose in preventing respiratory problems in late preterm infants.",[29,122],"Preterm Labor",[124,125,126],"corticosteroids","low dose","late prerterm","2024-04-09",{"date":129,"type":41},"2024-04-10",{"date":131,"type":41},"2022-01-01",{"date":133,"type":22},"2028-01-01",{"name":135,"class":48},"Rambam Health Care Campus",16]