[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-muscle-training\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-muscle-training":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100643731","the-effect-of-respiratory-muscle-training-on-cognitive-performance-100643731",false,"NCT07637331","The Effect of Respiratory Muscle Training on Cognitive Performance","Inclusion Criteria:\n\n* 18-40 years old\n* Body mass index \\\u003C30 kg\u002Fm2\n* Naïve to IMT\n* \\>75% of predicted forced expiratory volume in 1 second (FEV1) \u002F forced vital capacity (FVC) (FEV1\u002FFVC)\n* Access to smart phone or tablet with internet\n\nExclusion Criteria:\n\n* Diagnosed:\n\n  * Cardiovascular disease\n  * Respiratory disease (including asthma)\n  * Metabolic disease\n  * Currently pregnant\n  * Unable to adhere to the IMT protocol\n* Answering 'yes' to any of the questions on page one of the PAR-Q+\n* Abnormal cognition assessed via the Montreal Cognitive Assessment (score of 25 or less)\n* Self-reported color blindness\n* Significant acute or chronic medical, neurologic, or illness in the participant that, in the judgment of the Principal Investigator, could compromise subject safety, limit the ability of the participant to complete the study, and\u002For compromise the objectives of the study",true,"ALL","18 Years","40 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"NA","Determine if exercise training for the respiratory muscles improves cognitive performance during periods when breathing against a resistance.",[27],"Respiratory Muscle Training","RECRUITING","2026-06-24",{"date":31,"type":32},"2026-06-26","ACTUAL",{"date":34,"type":32},"2026-03-27",{"date":36,"type":21},"2027-04",{"name":38,"class":39},"Indiana University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":49,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":40},"100493843","muscle-recruitment-during-neck-flexion-and-inspiratory-muscle-training-100493843","NCT05710432","Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training","Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training in Difficult and Prolonged Weaning Patients: a Physiological Study - The FLEX Study","FLEX","Inclusion Criteria:\n\n* Patients receiving invasive MV via endotracheal tube who had failed a planned extubation or failed at least three spontaneous breathing trials (SBTs) or receiving MV via tracheostomy (who required tracheostomy because of difficult or prolonged weaning, failed extubation and\u002For prolonged ventilation) and able to spontaneously trigger the ventilator.\n* Over or equal to 16 years of age\n* Tolerating levels of pressure support of 10 cmH2O or lower (or equivalent support in NAVA or PAV+) for at least 15 minutes\n* In stable clinical and hemodynamic conditions and adequate level of oxygenation (cardiac frequency ≤ 140 beats\u002Fminute, systolic blood pressure 90-160 mmHg, no or minimal vasopressors, PaO2\u002FFiO2 over or equal to 150 mmHg)\n* Able to understand and follow simple verbal instructions\n\nExclusion Criteria:\n\n* Patients with a previously diagnosed severe neuromuscular disorder (such as amyotrophic lateral sclerosis, muscular dystrophy, multiple sclerosis, myasthenia gravis or spinal cord injury)\n* Patients with chronic respiratory failure already ventilated before ICU admission\n* Patients unable to collaborate or understand instructions","16 Years",{"count":51,"type":21},10,[24],"Respiratory muscle dysfunction is highly prevalent in patients with prolonged weaning from mechanical ventilation and is strongly associated with weaning failure. Efforts to strengthen the respiratory muscles, aimed at reversing or minimizing the impact of respiratory muscle weakness on clinical outcomes, have generally focused on the diaphragm with specific inspiratory muscle training (IMT) exercises. However, the effectiveness of these exercises and impact on clinical outcomes are not current practice in the majority of ICUs, as they are hardly feasible in ICU patients who often cannot be disconnected from the ventilator and cannot fully cooperate.\n\nPromising results have been published concerning non-respiratory training techniques, which can also target the accessory muscles, particularly important in the presence of increased load to the respiratory system, as in the case of the weaning phase. These non-respiratory training techniques would have the advantage of not entailing disconnection of the patient from the ventilator. In particular, in healthy subjects, a quasi-isometric neck contraction, called neck flexion, appeared to generate greater or comparable recruitment of some principal and accessory muscles of respiration, when compared to conventional IMT. However, this has not been studied in patients requiring prolonged mechanical ventilation, for whom IMT with threshold loading devices remains the primary recommended rehabilitation strategy.\n\nTherefore, the primary aim of the investigators is to assess the feasibility, tolerability, and safety of neck flexion and to compare them with IMT technique in patients with difficult and prolonged weaning from mechanical ventilation. Secondary aims are: i) to characterize which respiratory muscles are recruited and their level of activation at different levels of ventilatory assistance and ii) to assess which respiratory muscles are recruited and their level of activation during the two techniques and to compare these findings.\n\nThe hypothesis of the investigators is that neck flexion will be feasible (more than conventional IMT), well tolerated, and safe in patients with difficult and prolonged weaning. The investigators also hypothesize that, reducing the level of assistance and during unassisted breathing, a progressively increasing activation of the diaphragm, neck and trunk respiratory muscles, reflecting increased ventilatory load, will be fund. Finally, the hypothesis of the investigators is that the level of muscle activation\u002Frecruitment during neck flexion will be comparable or even greater to that occurring during IMT, as found in healthy subjects.\n\nFinding a new and highly feasible rehabilitative technique, able to recruit and train the respiratory muscles (including accessory muscles), will have the potential to promote patients' weaning and improve all related clinical outcomes, and therefore to dramatically shift the paradigm about the role of rehabilitation in ICU.",[55,27],"Mechanical Ventilator Weaning",[57,58,59,55],"Mechanical Ventilation","Inspiratory Muscle Training","Neck Flexion","2025-05-15",{"date":62,"type":32},"2025-05-20",{"date":64,"type":32},"2023-02-09",{"date":66,"type":21},"2025-11-15",{"name":68,"class":39},"Unity Health Toronto",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":40},"100567881","effect-of-respiratory-trainer-on-cardiopulmonary-functions-in-patients-with-upper-cross-syndrome-post-cardiac-surgery-100567881","NCT06673953","Effect of Respiratory Trainer on Cardiopulmonary Functions in Patients with Upper Cross Syndrome Post-Cardiac Surgery","Inclusion Criteria:\n\n* Sixty post-CABG-male-patients for at least three months and their age ranges from 45 to 55 years old.\n* Craniovertebral angle \\\u003C 51°, but not less than 30°.\n* Non-specific chronic neck pain: defined as neck pain without an identifiable pathological cause and attributed to poor posture without radiation to upper limbs.\n* VAS score between 3-7.\n* Their body mass index ranges from (25 -29.9) kg\u002Fm2.\n* Values of FEV1 and FVC lower than 80%\n\nExclusion Criteria:\n\n* Rheumatoid arthritis, cervical disc pathology, and traumatic neck pain.\n* History of respiratory disease and clinical signs of severe cardiac events.\n* Neurological disorders which affect the diaphragm.\n* Patients whose BMI is less than 25, or greater than 30 kg\u002Fm2.\n* Smokers.\n* Values of FEV1 and FVC higher than 80%\n* Patients with chronic obstructive pulmonary disease or asthma.","MALE","45 Years","55 Years",{"count":79,"type":21},60,[24],"The purpose of this study is to investigate if there is any effect of the respiratory training on cardiopulmonary functions in patients with upper cross syndrome post-cardiac surgery.\n\nHypothesis:\n\nNull hypothesis: There is no effect of the respiratory training on pulmonary functions in patients with upper cross syndrome post-cardiac surgery.",[83,84,85,86,27],"Post Coronary Artery Bypass Grafting","Post-Cardiac Surgery Patients","Upper Cross Syndrome","Respiratory Muscle Weakness",[88],"Post-CABG \u002F Upper Cross Syndrome \u002F Respiratory Muscle Training","2024-11-02",{"date":91,"type":32},"2024-11-05",{"date":93,"type":32},"2024-08-28",{"date":95,"type":21},"2025-02-25",{"name":97,"class":39},"Cairo University"]