[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-muscle-weakness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-muscle-weakness":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,69,101],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100635727","longitudinal-assessment-of-lung-function-and-respiratory-muscle-strength-following-training-of-the-inspiratory-muscles-in-frail-older-adults-imt-3-100635727",false,"NCT07556445","Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)","Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults: A Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Adults aged 80 years or older.\n* Clinical diagnosis of frailty, defined by a Short Physical Performance\n* Battery (SPPB) score \\\u003C 9.\n* Ability to stand and walk with or without assistive devices.\n* Ability to understand and follow instructions for inspiratory muscle training.\n* Stable medical condition for at least 3 months prior to enrollment.\n* Capacity to provide informed consent or availability of a legal\n\nExclusion Criteria:\n\n* Severe cognitive impairment that prevents understanding the procedures.\n* Diagnosis of neuromuscular diseases affecting respiratory muscles (e.g., ALS, myopathies).\n* Severe or uncontrolled hypertension (≥180\u002F110 mmHg).\n* Recent thoracic or abdominal surgery (\\\u003C3 months).\n* Severe musculoskeletal disorders limiting participation in training.\n* History of recurrent syncope, severe dizziness, or intolerance to respiratory maneuvers.\n* Any condition judged by the research team to compromise safety or participation.",true,"ALL","80 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above. Frailty is associated with reduced physical capacity, declines in functional performance, impaired respiratory performance, and a higher risk of disability. Inspiratory muscle training is a simple, low-cost intervention that may improve breathing function, inspiratory muscle strength, and overall health in very old adults, but evidence in this age group remains limited. Participants will be randomly assigned to one of two groups: a high-load inspiratory muscle training group or a low-load sham training group. Both groups will use a threshold device and perform 30 breaths once per day, five days per week, for eight weeks. The experimental group will train with progressively increasing resistance (50% to 80% of maximal inspiratory pressure), while the sham group will use a minimal and non-progressive load (15% of maximal inspiratory pressure). All sessions will be supervised and monitored for safety. The main goal of the study is to determine whether inspiratory muscle training improves maximal inspiratory pressure (MIP), maximal expiratory pressure (MEP) and lung function. These outcomes will allow the evaluation of the clinical relevance of improvements in respiratory muscle strength in this population.\n\nAssessments will be performed before the intervention, immediately after the 8-week program, and again at one and three months after the end of the intervention to examine both immediate and short-term effects. This study may contribute valuable evidence regarding the safety, feasibility, and clinical benefits of inspiratory muscle training in frail very old adults, particularly its impact on respiratory muscle strength and lung function, supporting its potential implementation in rehabilitation and geriatric care.",[27,28,29,30],"Frailty Syndrome","Geriatric Health","Respiratory Muscle Weakness","Age-Related Frailty",[32,33,34,35],"Inspiratory Muscle Training","Older Adults","Lung Function","Respiratory Muscle Strength","NOT_YET_RECRUITING","2026-04-29",{"date":39,"type":40},"2026-04-30","ACTUAL",{"date":42,"type":21},"2026-05-20",{"date":44,"type":21},"2026-12-01",{"name":46,"class":47},"Universidad Francisco de Vitoria","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100618185","longitudinal-assessment-of-maximal-inspiratory-pressure-and-functional-capacity-following-inspiratory-muscle-training-in-frail-older-adults-imt-2-100618185","NCT07328334","Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle Training in Frail Older Adults (IMT-2)","Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle Training in Frail Older Adults: A Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Adults aged 80 years or older.\n* Clinical diagnosis of frailty, defined by a Short Physical Performance Battery (SPPB) score \\\u003C 9.\n* Ability to stand and walk with or without assistive devices.\n* Ability to understand and follow instructions for inspiratory muscle training.\n* Stable medical condition for at least 3 months prior to enrollment.\n* Capacity to provide informed consent or availability of a legal\n\nExclusion Criteria:\n\n* Acute or unstable cardiovascular, respiratory, or metabolic conditions.\n* Severe cognitive impairment that prevents understanding the procedures.\n* Diagnosis of neuromuscular diseases affecting respiratory muscles (e.g., ALS, myopathies).\n* Severe or uncontrolled hypertension (≥180\u002F110 mmHg).\n* Recent thoracic or abdominal surgery (\\\u003C3 months).\n* Severe musculoskeletal disorders limiting participation in training.\n* History of recurrent syncope, severe dizziness, or intolerance to respiratory maneuvers.\n* Any condition judged by the research team to compromise safety or participation.",{"count":20,"type":21},[24],"This study aims to evaluate the effects of an 8-week inspiratory muscle training program on maximal inspiratory pressure and functional capacity in frail older adults aged 80 years and above. Frailty is associated with reduced physical capacity, declines in functional performance, impaired respiratory performance, and a higher risk of disability. Inspiratory muscle training is a simple, low-cost intervention that may improve breathing function, inspiratory muscle strength, and overall health in very old adults, but evidence in this age group remains limited.\n\nParticipants will be randomly assigned to one of two groups: a high-load inspiratory muscle training group or a low-load sham training group. Both groups will use a threshold device and perform 30 breaths once per day, five days per week, for eight weeks. The experimental group will train with progressively increasing resistance (50% to 80% of maximal inspiratory pressure), while the sham group will use a minimal and non-progressive load (15% of maximal inspiratory pressure). All sessions will be supervised and monitored for safety.\n\nThe main goal of the study is to determine whether inspiratory muscle training improves maximal inspiratory pressure (MIP), an established measure of global inspiratory muscle strength. Secondary outcomes include measures of functional capacity, reflecting the ability to perform physical tasks relevant to daily living in very old adults. These outcomes will allow the evaluation of the clinical relevance of improvements in inspiratory muscle strength in this population.\n\nAssessments will be performed before the intervention, immediately after the 8-week program, and again at one and three months after the end of the intervention to examine both immediate and short-term effects. This study may contribute valuable evidence regarding the safety, feasibility, and clinical benefits of inspiratory muscle training in frail very old adults, particularly its impact on inspiratory muscle strength and functional capacity, supporting its potential implementation in rehabilitation and geriatric care.",[27,28,29,30],[32,60,33],"Diaphragm Ultrasound","2026-01-03",{"date":63,"type":40},"2026-01-09",{"date":65,"type":21},"2026-02-01",{"date":67,"type":21},"2026-09-10",{"name":46,"class":47},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":17,"minAge":75,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":85,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100575487","effects-of-a-pulmonary-and-cardiovascular-rehabilitation-program-100575487","NCT06772922","Effects of a Pulmonary and Cardiovascular Rehabilitation Program","Inclusion Criteria:\n\n* Candidates for the pulmonary rehabilitation program: users diagnosed with chronic obstructive pulmonary disease (COPD), pulmonary emphysema, pulmonary fibrosis, asthma or other lung disease.\n* Candidates for the cardiovascular rehabilitation program: users diagnosed with acute myocardial infarction, myocardial revascularization surgery, coronary angioplasty, stable angina, valve replacement, chronic heart failure and who meet the criteria for phase III of cardiovascular rehabilitation.\n* Referral with medical clearance for rehabilitation\n\nExclusion Criteria:\n\n* Patients with any contraindication to aerobic or muscle-strengthening physical exercise, such as significant arrhythmias, untreated heart disease, myocarditis, recent or untreated pulmonary embolism, and uncontrolled systemic arterial hypertension, among other conditions.","18 Years",{"count":77,"type":21},26,[24],"Non-communicable chronic diseases (NCDs) affect approximately 30% of the adult global population, significantly impacting respiratory function and quality of life. Pulmonary and cardiovascular rehabilitation has proven to be an effective therapeutic intervention for managing respiratory symptoms and cardiovascular and improving functional capacity in patients with chronic respiratory conditions. The objective of this study is to evaluate the effects of the pulmonary and cardiovascular rehabilitation program on users of the physical therapy service of CECOM of UNICAMP related to functional capacity, quality of life and respiratory variables after 3 months of the program. Candidates for the pulmonary rehabilitation program are users diagnosed with chronic obstructive pulmonary disease (COPD), pulmonary emphysema, pulmonary fibrosis, asthma or other lung disease. Candidates for the cardiovascular rehabilitation program are users diagnosed with: infarction (AMI), myocardial revascularization surgery, coronary angioplasty, stable angina, valve replacement, chronic heart failure and who meet the criteria for phase III of cardiovascular rehabilitation. They should be referred to physical therapy by the cardiologist with complementary exams and exercise test. The program's assessment will consist of: anamnesis, analysis and recording of complementary exams, physical assessment (weight, height, BMI, cardiac and pulmonary auscultation, blood pressure, heart rate, peripheral oxygen saturation, respiratory muscle strength), functional capacity (six-minute walk test) and quality of life (questionnaire). The program will include aerobic exercises on a treadmill or stationary bike with an intensity between 50-70% of the reserve HR, below the ischemic thresholds. It will also include peripheral muscle strength exercises for the upper and lower limbs, in addition to respiratory muscle training for lung disease patients.",[29,81,82,83,84],"Quality of Lifte","Dyspnea; Asthmatic","Dyspnea; Cardiac","Dyspnea",[86,87,88,89],"pulmonary rehabilitation","Non-communicable chronic diseases","cardiovascular disease","cardiac rehabilitation","RECRUITING","2025-01-11",{"date":93,"type":40},"2025-01-14",{"date":95,"type":40},"2019-03-03",{"date":97,"type":21},"2025-12-20",{"name":99,"class":47},"University of Campinas, Brazil",1,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":107,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":119,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":100},"100567881","effect-of-respiratory-trainer-on-cardiopulmonary-functions-in-patients-with-upper-cross-syndrome-post-cardiac-surgery-100567881","NCT06673953","Effect of Respiratory Trainer on Cardiopulmonary Functions in Patients with Upper Cross Syndrome Post-Cardiac Surgery","Inclusion Criteria:\n\n* Sixty post-CABG-male-patients for at least three months and their age ranges from 45 to 55 years old.\n* Craniovertebral angle \\\u003C 51°, but not less than 30°.\n* Non-specific chronic neck pain: defined as neck pain without an identifiable pathological cause and attributed to poor posture without radiation to upper limbs.\n* VAS score between 3-7.\n* Their body mass index ranges from (25 -29.9) kg\u002Fm2.\n* Values of FEV1 and FVC lower than 80%\n\nExclusion Criteria:\n\n* Rheumatoid arthritis, cervical disc pathology, and traumatic neck pain.\n* History of respiratory disease and clinical signs of severe cardiac events.\n* Neurological disorders which affect the diaphragm.\n* Patients whose BMI is less than 25, or greater than 30 kg\u002Fm2.\n* Smokers.\n* Values of FEV1 and FVC higher than 80%\n* Patients with chronic obstructive pulmonary disease or asthma.","MALE","45 Years","55 Years",{"count":111,"type":21},60,[24],"The purpose of this study is to investigate if there is any effect of the respiratory training on cardiopulmonary functions in patients with upper cross syndrome post-cardiac surgery.\n\nHypothesis:\n\nNull hypothesis: There is no effect of the respiratory training on pulmonary functions in patients with upper cross syndrome post-cardiac surgery.",[115,116,117,29,118],"Post Coronary Artery Bypass Grafting","Post-Cardiac Surgery Patients","Upper Cross Syndrome","Respiratory Muscle Training",[120],"Post-CABG \u002F Upper Cross Syndrome \u002F Respiratory Muscle Training","2024-11-02",{"date":123,"type":40},"2024-11-05",{"date":125,"type":40},"2024-08-28",{"date":127,"type":21},"2025-02-25",{"name":129,"class":47},"Cairo University"]