[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory-support\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory-support":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,49,93,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100611173","pulmonary-volume-changes-during-synchonized-noninvasive-positive-pressure-ventilation-100611173",false,"NCT07237139","Pulmonary Volume Changes During Synchonized Noninvasive Positive Pressure Ventilation","Intrapulmonary Volume Changes During Synchronized Noninvasive Positive Pressure Ventilation In Preterm Infants","INSPIRE","Inclusion Criteria:\n\n* Written informed consent by one or both parents or legal guardians\n* Gestational age at birth \\\u003C 30 0\u002F7 weeks\n* Infants on sNIPPV respiratory support\n* Below 4 weeks chronological age\n\nExclusion Criteria:\n\n* Severe congenital malformation adversely affecting lung aeration or perfusion (e.g., congenital heart defects)\n* Too ill\u002Funstable in the opinion of the treating physician.","ALL","4 Weeks",{"count":20,"type":21},27,"ESTIMATED","OBSERVATIONAL","Current evidence suggests that noninvasive positive pressure ventilation (NIPPV) is more effective than continuous positive airway pressure (CPAP) in preventing respiratory failure in preterm infants with respiratory distress syndrome (RDS), both as initial and post-extubation support. NIPPV may be delivered in synchronized (sNIPPV) or non-synchronized (nsNIPPV) modes, with sNIPPV offering clear benefits by coordinating support with the infant's own breathing. Recent studies indicate sNIPPV is superior to nsNIPPV in preventing respiratory failure, though the intrapulmonary mechanisms behind this advantage remain unclear. To address this, the present study uses Electrical Impedance Tomography (EIT) to evaluate how lung volume changes during different types of breaths and ventilator inflations - spontaneous breaths, synchronized inflations, non-synchronized inflations, and backup inflations - in preterm infants receiving sNIPPV.",[25,26,27,28,29,30],"Infant, Preterm","Respiratory Distress Syndrome (Neonatal)","Chronic Lung Disease of Newborn","Respiratory Support","Synchronized Noninvasive Positive Pressure Ventilation (SNIPPV)","Lung Volume",[32,33,34,35],"Synchronized noninvasive positive pressure ventilation (SNIPPV)","Lung volume","Electrical Impedance Tomography (EIT)","infant, preterm","RECRUITING","2025-12-08",{"date":39,"type":40},"2025-12-09","ACTUAL",{"date":42,"type":40},"2025-11-17",{"date":44,"type":21},"2027-01-30",{"name":46,"class":47},"University of Zurich","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":60,"conditions":61,"keywords":72,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":92},"100601977","heterogeneity-index-in-neonatologist-performed-lung-ultrasound-in-neonates-receiving-respiratory-support---a-pilot-study-100601977","NCT07117513","Heterogeneity Index in Neonatologist-performed Lung Ultrasound in Neonates Receiving Respiratory Support - a Pilot Study","NPLUS HI","Inclusion Criteria:\n\n* Preterm neonates born between 28+0 and 36+6 weeks of gestation and term-born neonates (\\> 37+0 weeks of gestation) admitted to the NICU\n* Presence of respiratory distress requiring respiratory support (invasive and non-invasive) at the timepoint of NPLUS 1.\n* Written informed consent obtained from the parents prior to the measurement.\n\nExclusion Criteria:\n\n* cardiopulmonary malformations\n* pleural effusion\n* pneumothorax","1 Hour","7 Days",{"count":59,"type":21},40,"Lung ultrasound is an increasingly valuable diagnostic tool in neonatal intensive care due to its safety and accessability.\n\nThis pilot study investigates whether a quantitative approach - the heterogeneity index, previously only used in fetal lung assessment - can enhance the diagnostic accuracy of neonatologist-performed lung ultrasound (NPLUS). The index will be calculated from raw ultrasound images of preterm and term neonates and compared with conventional lung ultrasound scores to evaluate its clinical relevance.",[62,63,64,65,66,67,68,69,70,71,28],"Intensive Care Units, Neonatal","Infant, Newborn","Infant, Premature","Point-of-Care Systems","Ultrasonography","Lung Ultrasound","Lung Ultrasound Score","Image Interpretation, Computer Assisted","Reproducibility of Results","Respiratory Distress Neonatal",[73,67,68,74,75,76,77,78,79,80,81],"Neonatologist-Performed Lung Ultrasound","Quantitative Lung Ultrasound","Neonatal Intensive Care Unit","Observer Variability in Imaging","Ultrasound Artifact Interpretation","Respiratory Distress Syndrome in Neonates","respiratory support","preterm neonate","newborn","NOT_YET_RECRUITING","2025-08-05",{"date":85,"type":40},"2025-08-12",{"date":87,"type":21},"2025-08-15",{"date":89,"type":21},"2026-08-01",{"name":91,"class":47},"Medical University of Graz",2,{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":17,"minAge":101,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":104,"conditions":105,"keywords":106,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":48},"100455169","the-accessit-study-100455169","NCT05207046","The ACCESSIT Study","Role of ACCESsory Muscles in Mechanically Ventilated Patients After Spinal Cord Injury and Trauma: a Physiological Study - The ACCESSIT Study","ACCESSIT","Inclusion Criteria:\n\n* Presence of traumatic spine lesion (with and without spinal cord injury)\n* Requiring invasive mechanical ventilation, via oro-tracheal or tracheostomy tube,\n* 16 years of age or older\n* Patient or substitute decision maker able to provide consent\n\nExclusion Criteria:\n\n* Expected withdrawal of treatments within 24 hours of screening\n* Chronic respiratory failure already treated with mechanical ventilation before the injury\n* Documented pre-existing neuromuscular diseases","16 Years",{"count":103,"type":21},30,"The study is designed to characterize and monitor the structure, degree of activation and function of the different respiratory muscles during mechanical ventilation after spine trauma and spinal cord injury.",[28],[107,108,109,110,111,112],"Spinal cord injury","Trauma","Respiratory muscles","Mechanical ventilation","Acute respiratory failure","Diaphragm dysfunction","2025-05-15",{"date":115,"type":40},"2025-05-20",{"date":117,"type":40},"2021-12-17",{"date":119,"type":21},"2026-06",{"name":121,"class":47},"Unity Health Toronto",{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":129,"sex":17,"minAge":130,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":133,"conditions":134,"keywords":141,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":48},"100589962","effectiveness-of-ventilation-modes-in-intensive-care-a-comparison-of-mandatory-minute-ventilation-and-synchronized-intermittant-mandatory-ventilation-using-bioelectrical-impedance-tomography-100589962","NCT06961227","Effectiveness of Ventilation Modes in Intensive Care: A Comparison of Mandatory Minute Ventilation and Synchronized Intermittant Mandatory Ventilation Using Bioelectrical Impedance Tomography","Comparative Analysis of Ventilation Distribution in Intensive Care: Mandatory Minute Ventilation Versus Synchronized Intermittent Mandatory Ventilation Using Electrical Impedance Tomography\"","Inclusion Criteria:\n\n* Age ≥ 18 years\n\nIntubated and receiving invasive mechanical ventilation\n\nHemodynamically stable (no vasopressor support)\n\nFiO₂ ≤ 60%\n\nPEEP ≤ 8 cmH₂O\n\nNot receiving neuromuscular blocking agents\n\nAble to tolerate switching between SIMV and MMV modes\n\nExclusion Criteria:\n\nPregnant or breastfeeding patients\n\nPatients with neuromuscular diseases affecting respiratory drive\n\nUnstable hemodynamics or ongoing need for vasopressors\n\nPatients requiring high PEEP (\\>8 cmH₂O)\n\nPatients with DNR (do not resuscitate) status\n\nParticipation in another interventional study\n\n\\-",true,"18 Years",{"count":132,"type":21},25,"Synchronized Intermittent Mandatory Ventilation (SIMV) is a commonly used ventilatory mode available in many modern ventilators, frequently applied in intensive care units for patients requiring invasive mechanical ventilation. SIMV delivers a preset tidal volume or pressure at a predetermined respiratory rate and synchronizes with the patient's spontaneous breathing efforts, thereby enhancing patient-ventilator interaction and contributing to rehabilitation.\n\nMandatory Minute Ventilation (MMV) is a hybrid mode combining features of SIMV and Pressure Support Ventilation (PSV), guaranteeing a preset minute ventilation (tidal volume × respiratory rate). It synchronizes support based on the patient's spontaneous efforts and compensates in cases of insufficient minute ventilation.\n\nElectrical Impedance Tomography (EIT) is a non-invasive, radiation-free imaging technique that enables real-time monitoring of pulmonary ventilation and perfusion by applying alternating electrical currents through surface electrodes. EIT has demonstrated strong correlation with findings from computed tomography, nitrogen washout, PET, and SPECT imaging modalities.\n\nThis study aims to evaluate the effectiveness of MMV compared to SIMV in mechanically ventilated, hemodynamically stable adult patients (\\>18 years old) in the intensive care unit. Patients must not require vasopressors, have a FiO₂ ≤ 60%, PEEP ≤ 8 cmH₂O, or receive neuromuscular blocking agents.\n\nPatients will be monitored under both SIMV and MMV modes, separated by a 12-hour interval. To minimize carry-over effects, a one-hour washout period will be implemented before data collection with EIT. Key parameters including PO₂\u002FFiO₂ ratio, PaCO₂, and EtCO₂ will be assessed. The sequence of ventilatory mode application will follow a crossover study design.",[135,136,137,28,138,139,140],"Ventilation Modes","Mechanical Ventilation","Critical Illness","Intensive Care Unit (ICU) Patients","Mechanical Ventilation Dependence","Evaluation of Mechanical Ventilation Modes (SIMV and MMV) in Adult Intensive Care Unit Patients Using Electrical Impedance Tomography",[136,142,143,144,145,146],"SIMV","MMV","Electrical Impedance Tomography","EIT","Intensive Care Unit","2025-04-29",{"date":149,"type":40},"2025-05-07",{"date":151,"type":40},"2025-03-10",{"date":153,"type":21},"2025-10-31",{"name":155,"class":47},"Harran University"]