[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"respiratory\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:respiratory":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,55,85,112,139,168],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100626083","childrens-health-respiratory-inflammation-and-short-term-air-pollution-100626083",false,"NCT07431021","Children's Health, Respiratory Inflammation and Short-term Air Pollution","CHERISH","Inclusion Criteria:\n\n* Attending schools in Central and East London that have been recruited to the study\n\nExclusion Criteria:\n\n* Not able to engage with PE lessons on safety grounds, reported by their parents.\n* Children with learning or physical disabilities sufficient for them to be unable to give informed assent to the study, or to carry out study procedures",true,"ALL","7 Years","11 Years",{"count":21,"type":22},330,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution.",[28,29],"Asthma Acute","Respiratory",[31,32,33,34,35,36,37,38,39,40,41],"air pollution","physical activity","children","exercise","no2","Public health","air quality","pollution","paediatric","exposure","environment","RECRUITING","2026-06-12",{"date":45,"type":46},"2026-06-15","ACTUAL",{"date":48,"type":46},"2025-10-20",{"date":50,"type":22},"2027-07-01",{"name":52,"class":53},"Queen Mary University of London","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":70,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":54},"100623026","strategy-for-early-recognition-of-cancer-copd--heart-failure-in-the-emergency-department-100623026","NCT07391280","Strategy for EArly Recognition of Cancer, COPD & Heart Failure in the Emergency Department","SEARCH-ED","Inclusion Criteria:\n\nUnconsented Use of Harrison CXR Algorithm in Emergency Department (ED):\n\n* Frontal Chest X-Ray (CXR) (AP or PA) acquired in the Queen Elizabeth University Hospital (QEUH) ED\n* Patients aged 18 or over\n* Appropriate meta data (DICOM) to allow for Harrison CXR processing and secondary capture report provision.\n\nPatient Focus Groups:\n\n* Aged 18 or over\n* Able to provide written, informed consent in English.\n\nClinician Focus Groups:\n\n* Aged 18 or over\n* Able to provide written, informed consent in English.\n* Working as a doctor, advanced nurse practitioner or advanced clinical practitioner in ED, radiology or downstream medical specialties\n* For post-implementation focus groups only, must have at least 4 months experience of working with Harrison CXR algorithm.\n\nDiagnostic Clinic:\n\n* Patients without terminal illness or advanced frailty\n* Usual healthcare provider based in NHS GGC\n\nExclusion Criteria:\n\nApplies to use of unconsented CXRs:\n\n\\- Patient has requested that they are removed from the study, or has objected to the use of AI in their routine clinical care and this has been subsequently upheld by the health board.\n\nApplies to invitation to combined diagnostic clinic:\n\n* Patients not available to follow up, including patients i.e. whose the patient's usual care (or onward care following index admission) is out-with NHS GGC.\n* Patients who have been referred to palliative care for end-stage disease, or patients with severe frailty (i.e. bedbound) will not be invited to the combined diagnostic clinic\n\nFor Patient and Clinician Focus Groups:\n\n* Unable to provide informed written consent in English\n* Aged \\\u003C18","18 Years",{"count":64,"type":22},17000,[25],"SEARCH-ED is a research study which is running in Emergency Department (ED) of the Queen Elizabeth University Hospital. The aim of the study is to find out if using a computer programme can help doctors diagnose heart and lung problems from chest x-rays.\n\nWe want to compare how many people are diagnosed with heart or lung problems for the first time when doctors have access to the computer programme results, in comparison to when they don't.",[68,69,29],"Cancer","Cardiovascular",[71,72,73,74,75],"Artificial Intelligence","Chest X-Ray","Lung Cancer","Heart Failure","COPD","2026-05-28",{"date":78,"type":46},"2026-06-01",{"date":80,"type":46},"2026-05-25",{"date":82,"type":22},"2027-06",{"name":84,"class":53},"NHS Greater Glasgow and Clyde",{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":16,"sex":17,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":98,"overallStatus":101,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":111},"100622071","integrated-study-on-gut-microbiota-immune-indicators-and-trace-elements-in-children-with-respiratory-tract-infections-100622071","NCT07378852","Integrated Study on Gut Microbiota, Immune Indicators, and Trace Elements in Children With Respiratory Tract Infections","Inclusion Criteria\n\n1. Aged 3-14 years;\n2. Good compliance and complete clinical data;\n3. Guardians are informed and sign written consent;\n4. MPP group: meets diagnostic criteria of Guidelines for Diagnosis and Treatment of Mycoplasma Pneumoniae Pneumonia in Children (2023 Edition);\n5. NMP group: acute respiratory tract infection with negative MP-DNA\u002FRNA;\n6. RRTIs group: meets diagnostic criteria of Clinical Diagnosis and Treatment Pathway for Recurrent Respiratory Tract Infections in Children (2022 Edition);\n7. Healthy controls: no respiratory infection history within the past month.\n\nExclusion Criteria\n\n1. Other infectious diseases (e.g., measles, pertussis, tuberculosis);\n2. Congenital heart disease, immunodeficiency, or major organ dysfunction;\n3. Use of antibiotics, probiotics, immunomodulators, hormones, or microecological preparations within the past 15-30 days;\n4. Unqualified biological samples or incomplete laboratory data.","3 Years","14 Years",{"count":94,"type":22},120,"OBSERVATIONAL","This observational study aims to investigate the characteristics of gut microbiota and their associations with immune and nutritional indicators in children with different respiratory health statuses. A total of 120 children will be enrolled and categorized into four groups: children with Mycoplasma pneumoniae pneumonia (MPP), children with acute respiratory tract infections without Mycoplasma pneumoniae (NMP), children with recurrent respiratory tract infections (RRTIs), and healthy controls. By comparing gut microbiota composition and diversity, as well as immune- and nutrition-related indicators across groups, this study seeks to clarify the potential role of intestinal dysbiosis and host immune-nutritional interactions in the pathogenesis and clinical manifestations of pediatric respiratory tract infections.",[29],[33,99,100],"respiratory","gut microbiota","NOT_YET_RECRUITING","2026-02-01",{"date":104,"type":46},"2026-02-04",{"date":106,"type":22},"2026-01-30",{"date":108,"type":22},"2026-06-30",{"name":110,"class":53},"Min-Tze LIONG",2,{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":121,"conditions":122,"keywords":125,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":54},"100615491","the-pneumorator-study-100615491","NCT07293299","The PneumoRator Study","Clinical Validation of the PneumoRator Respiratory Rate Sensor in a Perioperative Cohort","Inclusion Criteria:\n\n1. Have undergone or are referred for CPET\n2. are scheduled for elective surgery and expected to have \\>24 hours postoperative hospital stay\n3. Will be admitted to the Surgical High Dependancy Unit (SHDU) as part of their planned care\n4. will receive invasive arterial pressure monitoring as part of routine care\n5. are aged 18 or over\n6. have the capacity to give consent to participate\n\nExclusion Criteria:\n\n1. do not proceed to surgery following CPET referral\n2. are aged less than 18 years\n3. do not have capacity to consent\n4. decline to consent\n5. have sensitivity or allergy to medical adhesives\n6. patients with fragile, erythematous, or broken skin at the site of PnemoRator attachment or any other condition which, in the view of the clinical research team, may mean that the use of the PnemoRator device and adhesive is likely to cause patient harm.\n7. patients with implantable electronic medical devices (e.g. pacemakers, nerve stimulators)",{"count":120,"type":22},50,"Healthcare workers measure heart rate, blood pressure, temperature, oxygen levels and breathing rate to monitor how unwell a patient is. All these apart from breathing rate are now normally measured by machines. But there still isn't a machine that does this well enough for breathing rate to be used in most places. The machines that do exist are either uncomfortable or don't work well on patients who are moving. Instead, a healthcare worker will count the number of breaths a patient takes. This needs staff time and isn't very accurate.\n\nIt is known that changes in breathing rate can happen any time. But healthcare systems normally only measure it every few hours because it takes time. Breathing rate could be monitored all the time, we might pick up people getting sick earlier and be able to treat them more quickly, which could save lives.\n\nA team at the University of Southampton has made a small device, called a PneumoRator, that gets stuck to onto a person's chest. Once stuck there it can measure their breathing rate and store or send that information wirelessly. The device has been tested on healthy volunteers but has never been tested on patients in hospital.\n\nIn this study the team will put the device on patients having major operations. The investigators will record information already collected about patients during normal care. This includes their breathing rate using the best measurement we have, where a patient's breathing is measured by a gas they breathe out. The gas is carbon dioxide, and the measurement is called capnography. This way of measuring is only used in operating theatres and intensive care units but is a good way to check if the PneumoRator is accurate.\n\nThe investigators want to attach the PneumoRator to patient's chests before they go to sleep for their operation and leave it there for the first few days after their operation. This will let them see how the PneumoRator compares to capnography and manual breath counting. It will also let them see how the device works at different times in the patient's journey. The investigators will look at the time when patients are asleep, when breathing is controlled by a machine. Then when patients wake up investigators can measure with both capnography and the PneumoRator. Finally, when patients go to the high dependency ward, investigators will compare it against manual counting. The study team will also ask patients how they found wearing the device and any problems they found.\n\nWith this information the investigators hope to show the PenumoRator is accurate at measuring breathing rate and comfortable for patients. This will help them get the device approved for use in hospitals and other places where breathing rate needs to be measured accurately.",[29,123,124],"Monitored Anaesthesia Care","Perioperative",[126,127,128,129],"monitoring","respiratory rate","sensor","wearable","2025-12-16",{"date":132,"type":46},"2025-12-19",{"date":134,"type":46},"2025-04-25",{"date":136,"type":22},"2026-04-24",{"name":138,"class":53},"University Hospital Southampton NHS Foundation Trust",{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":146,"minAge":62,"maxAge":147,"enrollmentInfo":148,"targetDuration":4,"studyType":23,"phases":150,"briefSummary":152,"conditions":153,"keywords":157,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":54},"100478064","early-phase-1-modification-of-the-early-life-respiratory-microbiome-through-vaginal-seeding-100478064","NCT05505110","MOdification Of THe Early-Life Respiratory Microbiome Through Vaginal SEEDing","MOTHER SEED","Inclusion Criteria:\n\nFor the mother:\n\n* Female 18-40 years of age who is in good general health, is fully able to provide consent to participate in the study, anticipates being available for the duration of the study, and is willing to comply with all study procedures\n* Singleton pregnancy\n* Completed ≧3 prenatal care visits at Vanderbilt University Medical Center (any facility)\n* Having rectovaginal swabs collected at ≧36 weeks of gestation to screen for Group B Streptococcus (GBS) as part of prenatal screening tests\n* Having a scheduled (planned or non-emergency) C-section at Vanderbilt University Medical Center (main campus only)\n* No intent to relocate outside the middle Tennessee region within 12 months of recruitment\n\nFor the child:\n\n* Estimated gestational age ≧37 weeks\n* Birth weight ≧2,500 grams\n\nExclusion Criteria:\n\nFor the mother:\n\n* Past medical history of any of the following:\n\n  * Previous child with GBS infection or prior positive GBS testing\n  * Hepatitis B, hepatitis C, or human immunodeficiency virus (HIV) infection\n  * Genital herpes simplex virus (HSV) infection, genital herpetic lesions, or prior positive genital HSV testing\n  * Genital human papilloma virus (HPV) infection, genital HPV lesions, or prior positive genital HPV testing\n  * Diabetes type I or type II\n* Laboratory evidence during the current pregnancy of any of the following:\n\n  * GBS bacteriuria in urine samples collected at any time (performed as standard of care)\n  * GBS colonization in rectovaginal swabs collected at ≧36 weeks of gestation (performed as standard of care)\n  * Chlamydia, trichomoniasis, or gonorrhea in urine samples collected at ≧36 weeks of gestation (performed as part of the screening procedures for this study)\n  * Hepatitis B, hepatitis C, HIV, or syphilis in blood samples collected at ≧36 weeks of gestation (performed as part of the screening procedures for this study)\n* Uncontrolled gestational diabetes\n* Any serious obstetric disease (e.g., preeclampsia with severe features, placental abruption or severe bleeding, or thromboembolic disease) as deemed by the PI or co-investigators\n* Prior abnormal Pap smear\n* C-section scheduled for a genitourinary infection that would have interfered with vaginal delivery (e.g., genital herpetic lesions)\n* Lack of available prenatal screening tests\n* Use of systemic (i.e., oral, intramuscular, or intravenous) antibiotics in the 4 weeks prior to delivery (except for those being administered as part of the C-section)\n* Use of systemic (i.e., oral, intramuscular, or intravenous) immunosuppressive, biologic, or chemotherapeutic agents in the 3 months prior to delivery (except for systemic immunosuppressive agents not being used for their immunosuppressive effects \\[e.g., prenatal intramuscular beclomethasone for fetal lung maturation\\])\n* Fever (≧100.4°F \\[38°C\\]) in the 72 hours prior to delivery\n* Symptoms (e.g., dysuria, pruritus, or discharge) suggestive of a genitourinary infection (e.g., bacterial vaginosis, vaginal yeast infection, chorioamnionitis, or urinary tract infection) on the day of delivery\n* Symptoms (e.g., pain, tenderness, tingling, burning, itching, or swollen lymph nodes) suggestive of genital HSV infection on the day of delivery\n* Other symptoms (e.g., new-onset rhinorrhea, sore throat, cough, body aches, chills, nausea, vomiting, or diarrhea) suggestive of an acute infectious disease on the day of delivery\n* Physical exam findings (e.g., fever \\[≧100.4°F (38°C)\\] or vesicles, warts, or ulcers in the genital, perineal, or anal region) suggestive of a genitourinary infection on the day of delivery (performed as part of the screening procedures for this study if not performed as standard of care)\n* Maternal vaginal pH\\>4.5 on the day of delivery (performed as part of the screening procedures for this study)\n* Need for a switch from a scheduled C-section to an emergency C-section\n* Prelabor prolonged rupture of membranes (i.e., ≧18 hours prior to delivery)\n* Pregnancy as the result of an assisted reproductive technology or surrogacy\n* Participation in another clinical trial that involves an intervention that could impact the quality or interpretation of the study data as deemed by the PI or co-investigators\n* Other past or current medical problems that could compromise the safety of participants, interfere with their ability to comply with study requirements, or impact the quality or interpretation of the study data as deemed by the PI or co-investigators\n\nFor the child:\n\n* Need for neonatal measures outside routine clinical care (i.e., drying, tactile stimulation, bulb syringe or catheter suction of nose and mouth, or temperature maintenance) in the delivery room\n* Transfer to the neonatal intensive care unit immediately after delivery\n* Thick particulate meconium noted during delivery\n* Physical exam findings (e.g., tachypnea, nasal flaring, retractions, cyanosis, or grunting) suggestive of neonatal acute respiratory distress immediately after delivery (performed as part of the screening procedures for this study)\n* Prenatal diagnosis of a serious genetic, respiratory, cardiovascular, or neurological disease\n* Prenatal diagnosis of intrauterine growth restriction\n* Prenatal diagnosis of a major congenital anomaly (e.g., cleft lip or palate, cystic hygroma, or giant omphalocele)\n* Participation in another clinical trial that involves an intervention that could impact the quality or interpretation of the study data as deemed by the PI or co-investigators\n* Other past or current medical problems that could compromise the safety of participants, interfere with their ability to comply with study requirements, or impact the quality or interpretation of the study data as deemed by the PI or co-investigators","FEMALE","40 Years",{"count":149,"type":22},20,[151],"EARLY_PHASE1","This is a single-center, parallel-arm, blind, sham-controlled, feasibility randomized controlled trial (RCT) to be conducted in healthy cesarean-born children. Eligible children will be randomized 1:1 to have their nose swabbed with either maternal vaginal secretions or a sterile swab (intervention vs. control group, respectively). The main hypothesis is that conducting an RCT assessing the utility of vaginal seeding in modifying the early-life upper respiratory tract (URT) microbiome of children born by cesarean section (C-section) is feasible and that the intervention is safe.",[154,155,29,156],"C-section","Vaginal Seeding","Microbiome",[154,158,29,156],"Vaginal seeding","2025-11-06",{"date":161,"type":46},"2025-11-10",{"date":163,"type":46},"2022-11-09",{"date":165,"type":22},"2028-08-10",{"name":167,"class":53},"Vanderbilt University Medical Center",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":176,"targetDuration":178,"studyType":95,"phases":4,"briefSummary":179,"conditions":180,"keywords":184,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":54},"100571147","predicting-failure-of-non-invasive-ventilatory-support-using-non-invasive-monitoring-in-non-intubated-patients-with-acute-hypoxemic-respiratory-failure-or-post-extubation-failure-the-prevision-study-100571147","NCT06716463","PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure. The PREVISION Study","PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure: the PREVISION Study","PREVISION","Inclusion Criteria:\n\n* Age of ≥ 18 years\n* Using NIV or HFNC anywhere in the hospital\n\nExclusion Criteria:\n\n* Chronic CO2 retention\n* Neuromuscular disorder\n* Requiring home NIV (CPAP or BIPAP)\n* Tracheostomy\n* Contraindication to EIT placement: pacemaker\u002Fdefibrillator implantation, burns at the area of EIT placement",{"count":177,"type":22},80,"3 Months","The goal of this observational study is to assess the potential non-invasive tools (e.g. regional ventilation, respiratory muscle response, lung mechanic's parameters) to identify the risk of failure when using high flow nasal cannula (HFNC) or non-invasive ventilation (NIV).\n\nThe main question, it aims to answer is:\n\nDoes abnormal regional ventilation could predict HFNC or NIV failure?",[181,182,183,29],"Ventilatory Failure","Hypoxemic Respiratory Failure","Weaning Failure",[185,186,187,188,189,190,191],"Electrical impedance tomography","High flow nasal cannula","Non-invasive ventilation","Diaphragm","Weaning failure","Post-extubation","Hypoxemic respiratory failure","2025-05-15",{"date":194,"type":46},"2025-05-20",{"date":196,"type":46},"2025-01-27",{"date":198,"type":22},"2025-06",{"name":200,"class":53},"Unity Health Toronto"]