[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"restrictive-lung-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:restrictive-lung-disease":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100434757","the-effect-of-spinal-mobilization-on-respiratory-parameters-in-parkinsons-disease-patients-100434757",false,"NCT04941326","The Effect of Spinal Mobilization on Respiratory Parameters in Parkinson's Disease Patients","Investigation of the Effect of Spinal Mobilization and Respiration Techniques on Posture and Respiratory Function in Parkinson's Patients","Inclusion Criteria:\n\n* Have been diagnosed with Parkinson's disease\n* Volunteering to participate in the study\n* Modified Medical Research Council (MMRC) score \\>2\n\nExclusion Criteria:\n\n* Those with COVID-19\n* Diseases that increase intra-abdominal pressure\n* Diseases affecting diaphragmatic motility\n* Those who had a recent thoracic or abdominal operation\n* Those who have a parenchymal, pleural or chest wall mass that will cause restriction on a recent chest X-ray or CT will not be included in the study","ALL","50 Years","85 Years",{"count":20,"type":21},63,"ESTIMATED","INTERVENTIONAL",[24],"NA","Parkinson's patients suffer from respiratory distress for different reasons. It is thought that physiotherapy methods that have an indirect effect on the diaphragm can improve respiratory functions. The aim of this study is to investigate the effects of spinal mobilization and diaphragmatic breathing techniques on respiratory function.",[27,28,29],"Parkinson Disease","Camptocormia","Restrictive Lung Disease",[31,32],"Rehabilitation","Posture","RECRUITING","2025-06-19",{"date":36,"type":37},"2025-06-22","ACTUAL",{"date":39,"type":37},"2021-08-15",{"date":41,"type":21},"2025-12-01",{"name":43,"class":44},"Abant Izzet Baysal University","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":59,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":75},"100593922","thoracic-mobilization-for-restrictive-lung-disease-100593922","NCT07012733","Thoracic Mobilization for Restrictive Lung Disease","A Randomized Controlled Trial Comparing the Effects of Thoracic Mobilization and Conventional Respiratory Therapy on Cough Capacity, Dyspnea, and Pulmonary Function in Patients With Restrictive Lung Disease","Inclusion Criteria:\n\n* Age 19 years or older\n* Currently receiving respiratory therapy at C Hospital in Sejong City\n* Pulmonary function test indicating restrictive pattern: FVC \\\u003C 80% and FEV1\u002FFVC ≥ 70%\n* FVC above the lower limit of normal (LLN) for age and sex\n* Diagnosed with restrictive lung disease, such as idiopathic pulmonary fibrosis, scoliosis, or neuromuscular disorders (e.g., myopathy, amyotrophic lateral sclerosis)\n\nExclusion Criteria:\n\n* FEV1\u002FFVC ratio \\\u003C 70%\n* Evidence of airway obstruction on pulmonary function testing","19 Years",{"count":55,"type":21},24,[24],"This study aims to investigate the immediate effects of thoracic mobilization techniques on cough capacity, dyspnea, and pulmonary function in patients with restrictive lung disease. The intervention will be applied in a single session, and outcomes will be measured before and after the intervention to evaluate short-term physiological changes.",[29],[60,61,62,63,64],"thoracic mobilization","pulmonary function","cough capacity","dyspnea","restrictive pulmonary disorder","NOT_YET_RECRUITING","2025-06-01",{"date":68,"type":37},"2025-06-10",{"date":70,"type":21},"2025-06-09",{"date":72,"type":21},"2025-12-26",{"name":74,"class":44},"Chungnam National University Sejong Hospital",1,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":16,"minAge":85,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":88,"phases":4,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100586138","from-inflammation-to-remodelling-towards-personalized-diagnosis-in-post-acute-sequelae-of-covid-19-100586138","NCT06911476","From Inflammation to Remodelling Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19","From Inflammation Biomarkers to Remoddeling (FAPI PET\u002FCT) Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19","LIBERATE","Inclusion Criteria:\n\n\\- Self-reported complaints of dyspnea or fatigue \\> 3 months after SARS-CoV-2 infection confirmed with PCR, serology test or COVID-19 Reporting and Data System (CO-RADS) score 4\u002F5.\n\nExclusion Criteria:\n\n* Inability or unwilling to give informed consent.\n* History of claustrophobia or feeling of inability to tolerate supine position for the PET\u002FCT scans.\n* Individuals who are pregnant or currently breastfeeding are not eligible to participate",true,"20 Years",{"count":87,"type":21},60,"OBSERVATIONAL","Rationale: The diagnosis and pathogenesis of long COVID remains unknown. We have previously shown that \\[68Ga\\]FAPI Positron Emission Tomography-Computed Tomography (PET\u002FCT) imaging shows potential for diagnosis and molecular understanding of this syndrome. We have previously shown that fibroblast activation protein (FAP) can be imaged in the lung, muscle and nasopharynx of long COVID patients (with dyspnea and fatigue). However, these preliminary data are derived from a selective group of patients with long COVID after critical COVID-19. We aim to explore the generalizability of these findings in patients with long COVID with dyspnea and fatigue, irrespective of the severity of their acute SARS-CoV-2 infection.\n\nPrimary objective: To assess if pulmonary fibroblast activity, measured by \\[68Ga\\]FAPI-46 PET\u002FCT, is higher in patients with current long COVID dyspnea and fatigue compared to patients with resolved complaints.\n\nStudy design: This is a ZonMw funded single centre prospective observational cohort study of long COVID-19 patients with dyspnea and fatigue.\n\nStudy population: We will recruit 60 adult long COVID patients (aged \\>20 years) of which 30 have complaints of dyspnea and fatigue and compare them to 30 patients with resolved complaints and healthy controls.\n\nMain study parameters\u002Fendpoints: The primary endpoint is FAP expression in the lung measured by \\[68Ga\\]FAPI-46 PET\u002FCT. Secondary endpoints are the expression of FAP in other tissues (muscle) and the relation between FAP and inflammation and remodelling biomarkers in various biological samples (e.g. serum\u002Fnasal epithelium).\n\nStudy procedures: In a single visit day the following data and samples will be collected: questionnaires, a lung function test, 6-minute walking test, blood samples, nose swabs, \\[68Ga\\]FAPI PET\u002FCT scan and HRCT scan. When increased \\[68Ga\\]FAPI uptake is measured in the muscles a muscle biopsy will be performed as well.",[91,92,93,94,95,96,97,98,29],"PASC Post Acute Sequelae of COVID 19","Long COVID","Long Covid-19","PASC","FAPI","FAP","Fibroblast Activation Protein Inhibitor","Fibroblast","2025-04-03",{"date":101,"type":37},"2025-04-04",{"date":103,"type":21},"2025-05",{"date":105,"type":21},"2025-12",{"name":107,"class":44},"University Medical Center Groningen"]