[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"resuscitation-trauma-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:resuscitation-trauma-patients":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":5},"100629898","phase-4-pv-aco-gap-guided-resuscitation-in-adult-polytrauma-patients-a-prospective-randomized-controlled-trial-100629898",false,"NCT07480655","Pv-aCO₂ Gap-Guided Resuscitation in Adult Polytrauma Patients: A Prospective Randomized Controlled Trial","Evaluation of Effect of Pv-aCO2-Gap on Clinical Outcomes With Standard Resuscitation End-points in Adult Poly-trauma Patients Admitted to the ICU --- Prospective Randomized Control Trial","Inclusion Criteria:\n\n* Either Gender\n* Poly-trauma patients\n\n  ○ Both penetrating and blunt trauma\n* Both surgical and non-surgical\n* Shock States\n\nExclusion Criteria:\n\n* Any Chest trauma\n* Patients with Obstructive and restrictive lung disease\n* Obstructive sleep apnea\n* Septic shock\n* Pregnant patients\n* Patients who will require readmission within 48 h after step-down from the ICU.\n* Patients who will need extra-corporeal membrane oxygenation support","ALL","18 Years","70 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","dult patients with multiple traumatic injuries admitted to the ICU from the operating room, emergency department, or hospital wards who meet the study criteria will be included after obtaining informed consent from the patient or their legal guardian. Participants will be randomly divided into two groups: one group will receive treatment guided by the difference between carbon dioxide levels in venous and arterial blood, while the other group will receive treatment based on standard resuscitation parameters commonly used in critical care. As part of routine monitoring, all patients will have a central venous catheter and an arterial line inserted to measure blood parameters. Blood samples from both lines will be taken shortly after ICU admission and at regular intervals during the first three days. These samples will be analyzed using a bedside blood gas machine, and the results will be compared between the two groups to determine whether monitoring the difference in carbon dioxide levels between venous and arterial blood improves patient outcomes compared with standard care.",[27,28],"Polytrauma","Resuscitation, Trauma Patients",[30,31],"Veno-arterial carbondioxide gap","Polytrauma resuscitation","RECRUITING","2026-03-15",{"date":35,"type":36},"2026-03-18","ACTUAL",{"date":38,"type":21},"2026-03-16",{"date":40,"type":21},"2026-06-16",{"name":42,"class":43},"Pakistan Institute of Medical Sciences","OTHER_GOV"]