[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"resuscitation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:resuscitation":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,44,69,105,130,159],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100640435","perception---super-early-neuroprognostication-in-ecpr-patients-100640435",false,"NCT07584187","PERCEPTION - Super-Early Neuroprognostication in eCPR Patients","Super-Early Neuroprognostication in eCPR Patients: Feasibility of Automated Pupillometry and Cerebral Near-Infrared Spectroscopy - A Prospective Feasibility Study","PERCEPTION","Inclusion Criteria:\n\n* All patients ≥ 18 years evaluated for eCPR treatment at the Department of Emergency Medicine\n\nExclusion Criteria:\n\n* Return of spontaneous circulation before ECMO initiation.\n* Anatomical infeasibility for measurement, including but not limited to:\n* Severe facial trauma or deformity preventing the placement of the automated pupillometry device.\n* Scalp injuries, dressings, or conditions that interfere with the correct positioning of near-infrared spectroscopy (NIRS) sensors.\n* Pre-existing ocular conditions that preclude reliable pupillometry (e.g., enucleation, opaque cornea, or severe anisocoria unrelated to neurological status).","ALL","18 Years",{"count":20,"type":21},45,"ESTIMATED","OBSERVATIONAL","Background Extracorporeal cardiopulmonary resuscitation (eCPR) is a rescue therapy for a selected group of patients. Extracorporeal membrane oxygenation (ECMO) is initiated to bypass the cardiac system and bridge time to definitive treatment of the cardiac arrest (CA) origin. eCPR treatment is very time-critical and, if indicated, should be initiated as early as possible. Patient selection for this highly specific treatment is challenging and relies on numerous factors. In the following phase of intensive care treatment, neuroprognostication is performed. However, following current guidelines, this is only recommended 72hours after CA. Once ECMO is initiated, a complex intensive care treatment is expected, without a guarantee for full neurological recovery. There is a recognized clinical need for more precise selection criteria, alongside predictive values, to enable earlier, reliable neuroprognostication.\n\nAim This study aims to investigate whether super-early neuroprognostication before ECMO initiation is feasible. Super-early neuroprognostication will be performed using automated pupillometry and cerebral near-infrared spectroscopy (cNIRS) before ECMO initiation.\n\nMethods Patients evaluated for eCPR treatment at the Department of Emergency Medicine will be included in this study. By a study member not involved in clinical treatment, cNIRS and automated pupillometry will be performed before ECMO initiation and at predefined intervals: 10-20 minutes after ECMO Initiation, 1 hour (±15 minutes), 2 hours (±15 minutes), and 3 hours (±15 minutes). Follow-up measurements will be taken 24 hours (± 6 hours), 48 hours (± 6 hours), and 72 hours ± 6 hours after ECMO initiation. The secondary objective is to interpret the collected data regarding outcome parameters.",[25,26,27,28],"Resuscitation","Extra Corporeal Life Support","ECMO","Extracorporeal Cardiopulmonary Resuscitation",[30,27,31],"eCPR","CPR","RECRUITING","2026-05-12",{"date":35,"type":36},"2026-05-14","ACTUAL",{"date":33,"type":36},{"date":39,"type":21},"2028-10",{"name":41,"class":42},"Medical University of Vienna","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":43},"100528769","the-association-between-post-resuscitation-time-series-management-in-the-emergency-department-and-short-term-outcomes-for-out-of-hospital-cardiac-arrest-patients-100528769","NCT06165081","The Association Between Post-resuscitation Time Series Management in the Emergency Department and Short-term Outcomes for Out-of-hospital Cardiac Arrest Patients","Inclusion Criteria:\n\n* Adults over the age of 20 who have experienced cardiac arrest prior to arrival and have been resuscitated to regain spontaneous heartbeat in the emergency department\n\nExclusion Criteria:\n\n* Traumatic mechanism, Loss of medical record","20 Years",{"count":52,"type":21},6000,"This study examines the impact of emergency department (ED) management on short-term outcomes of nontraumatic adult out-of-hospital cardiac arrest (OHCA) patients. Conducted by a research team at National Taiwan University Hospital and its affiliated hospitals, including branches in Hsinchu and Yunlin, the study spans from January 2016 to August 2023. It focuses on a sequential population of patients, analyzing data like age, gender, medical history, prehospital care details (e.g., witnessed collapse, bystander CPR), and specifics of ED management.\n\nOHCA, with an incidence rate of 50-100 per 100,000 people, presents high mortality and severe complications, leading to significant healthcare expenditures. After resuscitation in the ED, only about one-fifth of patients achieve return of spontaneous circulation (ROSC). The prognosis for these patients remains grim, with a mere 5% experiencing favorable neurological outcomes. Understanding the mechanisms of OHCA, identifying risk factors, effective interventions, and the timing of ED treatments like vasopressors and electrocardiography are crucial.\n\nPatients post-OHCA often undergo a postcardiac arrest syndrome (PCAS), marked by cellular hypoxia and a consequential inflammatory response. Stability of vital signs and rapid ED interventions, including identifying OHCA causes and coordinating with specialists, are vital for short-term recovery. This study aims to determine if ED management and time-related factors from ROSC to various interventions (e.g., ECG, CT scans) affect short-term survival rates, including survival to hospital admission and survival after 1, 3, and 7 days.\n\nBy retrospectively analyzing patient data, including Utstein Style prehospital cardiac arrest registry variables and emergency department management details, the study seeks to shed light on the crucial phase of post-resuscitation care. The ultimate goal is to improve survival rates and neurological outcomes in OHCA patients, emphasizing the need for more comprehensive research in this area",[25,55,56],"Emergency Department","Outcome",[58,59],"Out-of-hostpital cardiac arrest","Short-term outcome","2025-11-17",{"date":62,"type":36},"2025-11-18",{"date":64,"type":36},"2024-01-01",{"date":66,"type":21},"2026-12-31",{"name":68,"class":42},"National Taiwan University Hospital",{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":88,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":43},"100398167","impact-of-a-mhealth-supportive-tool-on-cardiopulmonary-resuscitation-situational-awareness-100398167","NCT04464603","Impact of a mHealth Supportive Tool on Cardiopulmonary Resuscitation' Situational Awareness","Impact of a Shared Decision-making mHealth Tool on Caregivers' Team Situational Awareness, Communication Effectiveness, and Performance During Pediatric Cardiopulmonary Resuscitation: a Randomized Controlled Trial","InterFACE","Inclusion Criteria:\n\n* Any physician performing a fellowship in the pediatric emergency department.\n* Any postgraduate residents pursuing a \\\u003C5 years residency in pediatrics.\n* To be registered nurses from the PED.\n* To have previously completed a standardized 15-min introductory course on the use of the InterFACE tool dispensed by the study investigators.\n* Participation agreement\n\nExclusion Criteria:\n\n* To have not undergone the standardized 15-min introductory course on the use of the InterFACE tool dispensed by the study investigators.\n* Participation to a simulation in the past month is an exclusion criterion to avoid a recent training effect.",true,"65 Years",{"count":80,"type":21},36,"INTERVENTIONAL",[83],"NA","This study will be a prospective, single-center, randomized controlled trial in a tertiary pediatric emergency department with two parallel groups of voluntary pediatric physicians and nurses. The impact of a mHealth supportive tool will be compared with conventional communication methods on situational awareness, leadership, team communication effectiveness and performance during standardized, simulation-based, pediatric in-hospital cardiac arrest scenario using a high-fidelity manikin. Thirty-six participants will be randomized (1:1). The primary endpoint is the situational awareness score measured with the situation awareness global assessment technique (SAGAT) instrument.",[86,87,25],"Cardiopulmonary Arrest","Pediatric ALL",[89,90,91,92,93,94],"Information technologies","Situation Awareness","Teamwork","Leadership","Mobile applications","Biomedical Technology","NOT_YET_RECRUITING","2025-08-17",{"date":98,"type":36},"2025-08-19",{"date":100,"type":21},"2025-11-01",{"date":102,"type":21},"2026-01-31",{"name":104,"class":42},"Pediatric Clinical Research Platform",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":43},"100457932","interactive-resuscitation-application-for-mothers-about-to-experience-premature-infant-resuscitation-100457932","NCT05243043","Interactive Resuscitation Application for Mothers About to Experience Premature Infant Resuscitation","Impact of an Interactive Maternal Resuscitation Navigation Application (MARINA) on Mothers' Experience During and After Premature Infant Resuscitation in the Delivery Room","Inclusion Criteria:\n\n* Control group: English-speaking mothers, age 18 or older, delivered a premature infant at UIHC between 24- and 32-weeks and their infant born during this most recent gestation.\n\nExclusion Criteria:\n\n* control group: Infant death, mothers who required general anesthesia at the time of delivery, active investigation by Department of Human Services, prisoners, twin gestation","60 Years",{"count":114,"type":21},80,"The purpose of this study is to design, develop, validate and pilot test an interactive Maternal Resuscitation Navigation Application (MARINA) for the purpose of providing information and guidance about the expected events that a premature infant will experience during initial resuscitation upon delivery. This information will be shared via computer app prior to the time that the mother would be in distress due to active labor. The application will be pilot tested for functionality, usability and feasibility of future use and research in clinical settings. Focused aspects of the application will include simulated video of the active delivery environment, explanation of each team member's role in resuscitation and specific activities involved in premature infant resuscitation. To assure the application addresses key information mothers would desire, the application will include content developed with input from a consulting group of mothers who have experienced premature infant resuscitation in the delivery room. Additionally, prior research by the research team will inform the build of this application. The application will have the ability for mothers to choose whether to view close up procedures (bag\u002Fmask positive pressure oxygen delivery, intubation, line placement, etc.). She may alternatively select to only view the broader view of the room while listening to the description of activities occurring at that time. The mother will be able to choose her level of interactivity depending on her comfort level. The application will go through multiple levels of testing throughout the development process. After an iterative process, when the research team finds the application acceptable, a small group of consulting parents and experienced clinicians will review the application for functionality (ease of use) and content validity.\n\nAim 2: To pilot test the functionality, usability and feasibility of the interactive Maternal Resuscitation Navigation Application (MARINA) for future use and research in clinical settings to reduce maternal distress associated with premature infant resuscitation.",[25],[118,119,120],"Mothers' experience","Premature infant resuscitation","Post traumatic stress","2025-08-10",{"date":123,"type":36},"2025-08-12",{"date":125,"type":36},"2022-08-31",{"date":127,"type":21},"2027-12",{"name":129,"class":42},"Stephanie Stewart",{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":11,"sex":17,"minAge":138,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":142,"conditions":143,"keywords":145,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":43},"100577838","delivery-room-intervention-and-evaluation-network-100577838","NCT06803498","Delivery Room Intervention and Evaluation Network","Delivery Room Intervention and Evaluation (DRIVE) Network","DRIVE Network","Inclusion Criteria:\n\nInborn infant in receipt of a significant resuscitation intervention (CPAP, PPV, intubation, or CPR) at birth\n\nExclusion Criteria:\n\nNot live born","0 Days","1 Day",{"count":141,"type":21},3000000,"The American Academy of Pediatrics (AAP) convened the multi-center Delivery Room Intervention and Evaluation (DRIVE) Network to establish essential infrastructure to collect, coordinate, and analyze core demographic, resuscitative, and outcome data for an inclusive and diverse population of infants who receive delivery room resuscitation at participating centers. The DRIVE Network consists of delivery hospitals across the United States, covering a range of geographic, urban\u002Frural, racial\u002Fethnic diversity across the country. Together, DRIVE seeks to compare practice-level delivery system characteristics, identify best practices, evaluate outcomes from various interventions, and promote professional development through dissemination via the wide reach of the Neonatal Resuscitation Program.",[25,144],"Infant, Newborn",[146,147,148,149],"Continuous Positive Airway Pressure","Intermittent Positive Pressure Ventilation","Intubation, Intratracheal","Cardiopulmonary Resuscitation","2025-01-27",{"date":152,"type":36},"2025-01-31",{"date":154,"type":36},"2022-01-01",{"date":156,"type":21},"2042-01-01",{"name":158,"class":42},"American Academy of Pediatrics",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":165,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":81,"phases":168,"briefSummary":170,"conditions":171,"keywords":176,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":43},"100569603","phase-3-venous-excess-ultrasound-for-personalized-resuscitation-in-septic-shock-100569603","NCT06696391","Venous Excess Ultrasound for Personalized Resuscitation in Septic Shock","Venous Excess Ultrasound (VEXUS)-Guided Management Versus Usual Care in Patients with Septic Shock: a Pilot Randomized Controlled Trial","VESPER","Inclusion Criteria:\n\n1. Adult patients (≥18 years)\n2. Within 12 hours of meeting septic shock diagnosis based on following Sepsis-3 criteria: requirement for vasopressors to maintain organ perfusion, lactate \\> 2 mmol\u002FL, and suspected or confirmed infection)\n3. Within 48 hours of intensive care unit admission.\n\nExclusion Criteria:\n\n1. Already receiving renal replacement therapy\n2. Patients for whom a decision to initiate renal replacement therapy has been made prior to study enrolment\n3. Patients who have limitations on medical therapy or restrictions on goals of care\n4. Active bleeding causing hemodynamic instability\n5. Veno-venous or veno-arterial extracorporeal membrane oxygenation\n6. Previously enrolment in study\n7. 10% or more of body surface area acute burn injury\n8. Suspected or confirmed liver cirrhosis\n9. Established allergy to sulfa drugs;\n10. Patients receiving treatments that require continuous IV fluid infusions (e.g., diabetic ketoacidosis, diabetes insipidus)\n11. Unable to measure fluid balance accurately\n12. Contra-indication to study recommended interventions (e.g., diuretics, inotropes)\n13. Unable to perform VEXUS due to anatomical barriers (e.g., surgical dressings);\n14. Unable to complete VEXUS scan during the 6-hour resuscitation window\n15. Moderate to Severe Tricuspid Regurgitation\n16. Untreated Metabolic\u002Fbiochemical findings (Hypokalemia \\[K+\\]\\\u003C 3.0 mmol\u002FL; metabolic alkalosis \\[Bicarbonate \\> 40 mmol\u002FL and\u002For pH \\> 7.55\\], Hypomagnesemia \\[Mg2+\\] \\\u003C 0.6, and Hypernatremia \\[Na+\\] \\> 155 mmol\u002FL)",{"count":114,"type":21},[169],"PHASE3","The goal of this pilot clinical trial is to determine if conducting a larger study using venous excess ultrasound (VEXUS) to guide fluid management in patients with septic shock is feasible. Septic shock is a life-threatening condition where infection causes dangerously low blood pressure. While fluids are essential for treatment, too much fluid can harm the kidneys and result in the need for dialysis. The main questions it aims to answer are:\n\n1. Is it feasible to recruit patients, obtain consent, and follow the VEXUS-guided management protocol?\n2. Does VEXUS-guided management, compared with usual care, improve the health and well-being of patients with septic shock?\n\nResearchers will compare two groups: one receiving VEXUS-guided fluid management versus another receiving standard care, to assess the feasibility of a larger trial and explore whether VEXUS prevents fluid overload and kidney problems.\n\nParticipants in the VEXUS group will:\n\n1. Undergo VEXUS scans every 24 hours for 3 days\n2. Receive fluid management guided by VEXUS findings (including fluid restriction or removal if we identify venous congestion) and undergo cardiac ultrasound if we identify moderate to severe congestion\n3. Be monitored for 28 days to track kidney function, need for dialysis, and survival.",[172,173,174,175,25],"Septic Shock","Sepsis","Shock","Critical Care, Intensive Care",[177,178,179,172,180,25],"Randomized Controlled Trial","Ultrasound","Venous Congestion","Pilot Study","2024-11-18",{"date":183,"type":36},"2024-11-20",{"date":185,"type":21},"2024-12-01",{"date":187,"type":21},"2027-12-28",{"name":189,"class":42},"Western University, Canada"]