[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"retention-in-care\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:retention-in-care":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,79,107,137],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100518217","structured-peer-delivered-art-and-reentry-community-strategy-100518217",false,"NCT06027671","Structured Peer-delivered ART and Reentry Community Strategy","Structured Peer-delivered Antiretroviral Therapy (ART) and Reentry Community Strategy to Overcome Barriers to HIV Care Continuity During Community Re-entry From Incarceration in South Africa","SPARCS","Inclusion Criteria:\n\n* Incarcerated at one of the participating study enrolment sites, awaiting trial (un-sentenced) and sentenced individuals.\n* Diagnosed with HIV and ART at the time of enrolment.\n* Anticipated release or trial date within three months of study enrolment.\n* Self-report expected to reside in an unrestricted environment within Ekurhuleni, Tshwane, or Johannesburg districts of Gauteng Province and within proximity to one of the SPARCS intervention sites (i.e., within 20km, 45-minute travel time, or two local taxi minibus rides)\n* Willing to participate in study post-release follow-up activities and provide contact information for post-release follow-up.\n\nExclusion Criteria:\n\n* \\\u003C18 years of age.\n* Condition (severe cognitive dysfunction or mental illness) rendering the individual unable to provide informed consent.\n* Unable to provide informed consent to participate in the study.\n* Assessment by DCS health staff indicating that the individual requires a high intensity of care exceeding that which can be provided in a differentiated model of care setting.\n* Not released from the correctional facility during the period of intervention delivery.\n* Release to a region outside of Gauteng.",true,"ALL","18 Years",{"count":21,"type":22},400,"ESTIMATED","INTERVENTIONAL",[25],"NA","The overarching goal of this study is to implement a transition community adherence club strategy (Full-SPARCS) for HIV-positive individuals transitioning from correctional to community settings in South Africa. The investigators seek to provide actionable findings to inform policy decisions to contribute to HIV care continuity with this population. The investigators note that effectiveness and scalability often conflict with intervention design; thus, the investigators have proposed testing whether a group approach is effective and the investigators will assess the costs of each component\n\n* To compare the effectiveness of Full-SPARCS to care as usual to achieve HIV RNA suppression 6 months following correctional facility release\n* To assess determinants of implementation of Full-SPARCS\n* To assess the scalability through costing and cost effectiveness analysis of Full-SPARCS",[28],"Retention in Care",[30,31,32,33,34],"Viral Load Suppression","Prison","Transition","Care continuity","HIV","RECRUITING","2026-06-01",{"date":38,"type":39},"2026-06-02","ACTUAL",{"date":41,"type":39},"2024-11-18",{"date":43,"type":22},"2028-07-01",{"name":45,"class":46},"Johns Hopkins University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":59,"conditions":60,"keywords":65,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100514081","peer-recovery-to-improve-polysubstance-use-and-mobile-telemedicine-retention-100514081","NCT05973838","Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention","Peer-Delivered, Behavioral Activation Intervention to Improve Polysubstance Use and Retention in Mobile Telemedicine OUD Treatment in an Underserved, Rural Area","PRISM","Inclusion Criteria:\n\nPatient participants in the RCT must be 18 or older; receive OUD treatment as part of the telemedicine program; and exhibit polysubstance use within the past three-months (i.e., use of one or more non-prescribed substances (excluding opioids and\u002For tobacco) by urine toxicology or self-report.\n\nExclusion Criteria:\n\n* Demonstrating active, unstable or untreated psychiatric symptoms, including mania and\u002For psychosis that would interfere with study participation\n* Inability to understand the study and provide informed consent in English",{"count":57,"type":22},160,[25],"The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among patients with OUD and polysubstance use in underserved areas. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this hybrid, Type-1 effectiveness-implementation randomized controlled trial (RCT), the investigators will evaluate the effectiveness and implementation of Peer Activate vs. treatment as usual (TAU) over twelve months.",[61,62,63,28,64],"Polysubstance Addiction","Opioid Medication Assisted Treatment","Treatment Adherence","Substance-Related Disorders",[64,66,67,68],"Opioid-Related Disorders","Polysubstance Use","Mental disorders","2026-04-21",{"date":71,"type":39},"2026-04-27",{"date":73,"type":39},"2023-06-15",{"date":75,"type":22},"2027-09-01",{"name":77,"class":46},"University of Maryland, College Park",4,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":86,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":47},"100588482","partnering-with-antenatal-navigators-to-transform-health-in-pregnancy-100588482","NCT06941974","Partnering With Antenatal Navigators to Transform Health in Pregnancy","PATH","Inclusion Criteria:\n\n* Singleton gestation \\\u003C20 weeks of gestation\n* Nulliparous: no prior pregnancies ≥20 weeks excluding terminations\n* Low income (public insurance or residence in a neighborhood in which \\>10% of household incomes are \\\u003C125% of federal poverty line\n* Ability to speak and read English or Spanish\n* Established patient at one of practices associated with Northwestern Medical Group\n* Age 16 years or older\n\nExclusion:\n\n* Intent to transfer care to an outside institution\n* Prior enrollment in PATH\n* Concurrent enrollment in a study with competing aims\u002Fintervention","FEMALE","16 Years","50 Years",{"count":90,"type":22},600,[25],"The Partnering with Antenatal Navigators to Transform Health in Pregnancy (PATH) study aims to evaluate whether an antenatal patient navigation program improves maternal health, neonatal health, pregnant women's experiences, and health care utilization outcomes among low-income pregnant women and their neonates. Patient navigation is an individualized, barrier-focused, longitudinal, patient-centered intervention that offers support for a defined set of health services. In this randomized controlled trial, pregnant women who are randomized to receive antenatal patient navigation will be compared to pregnant women who are randomized to receive usual care. Navigators will support pregnant women from before 20 weeks of gestation through 2 weeks postpartum. The PATH intervention will be grounded in understanding and addressing factors that influence health and access to care in order to promote self-efficacy, enhance access, and sustain long-term engagement.\n\nThe main objectives of the study are to:\n\n1. Evaluate whether PATH, compared to usual care, improves maternal health outcomes. We hypothesize the PATH model of antenatal patient navigation for low-income women will reduce the incidence of a composite of adverse maternal outcomes, all of which are known to be increased among women with barriers to care.\n2. Evaluate whether PATH, compared to usual care, improves perinatal health outcomes. We hypothesize PATH will reduce the incidence of a composite of adverse perinatal outcomes. We will also investigate neonatal\u002Fpediatric health care utilization.\n3. Evaluate patient, clinician, navigator, and healthcare system experiences with PATH in preparation for widespread implementation and dissemination of the PATH obstetric navigation model. This aim will be accomplished through investigating patient-reported outcomes, completing qualitative and process mapping interviews with navigated participants, and completing qualitative and process mapping interviews with clinicians, navigators, and health administrators.",[94,95,96,28,97],"Maternal Morbidity","Antenatal Health","Neonatal Morbidity","Prenatal Care","2026-04-02",{"date":100,"type":39},"2026-04-06",{"date":102,"type":39},"2025-10-06",{"date":104,"type":22},"2030-06-01",{"name":106,"class":46},"Northwestern University",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":18,"minAge":114,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":5},"100625691","digital-peer-support-based-anti-hiv-stigma-intervention-among-adolescents-living-with-hiv-in-ethiopia-100625691","NCT07425925","Digital Peer-support-based Anti-HIV Stigma Intervention Among Adolescents Living With HIV in Ethiopia","Feasibility and Effectiveness of Digital Peer-support-based Anti-HIV Stigma Intervention in Improving Clinical Outcomes Among Adolescents Living With HIV in Ethiopia","Inclusion Criteria:\n\n* Adolescents who have been disclosed of their HIV status\n* adolescents and young people between the age of 15 and 22 years old\n* receiving antiretroviral medications; and\n* completed at least first cycle primary school education (i.e. grade 4).\n\nExclusion Criteria:\n\n* Participants with known diagnosed mental health condition\n* Participants with hearing loss or loss of vision","14 Years","22 Years",{"count":117,"type":22},282,[25],"Advances in HIV care and treatment turned a once deadly disease into a chronic condition where people living with HIV, including perinatally HIV acquired children, can now lead a healthy life and live longer with their highly effective antiretroviral therapy. Despite the advancements and successes in HIV care and treatment, HIV-related stigma remained a challenge to people living with HIV and for the provision of the available successful treatment and support. Stigma and discrimination related to HIV infection inhibit health-seeking behaviour, clinical outcomes, physical and psychosocial wellbeing and is a major obstacle for timely diagnosis.\n\nPeer support programs to people living with HIV appeared to have improved self-confidence of members and consequently reduced self-stigma and improved their coping ability against external stigma. However, these services are limited in terms of geography owing to lack of adequate financing to cover operational costs for adolescents coming from rural areas and space and facility limitation to accommodate large groups.\n\nThe eHealth services have potential to provide some of the services offered in the in-person sessions of the peer support group. Despite this important potential of eHealth services, they are underutilized and are not often used to target HIV-related stigma in adolescents living with HIV. The present study will investigate whether the digital peer-support anti-HIV stigma reduces internalized and anticipated stigma among adolescents living with HIV (ALHIV) in South Ethiopia. Further, we will explore the health-related outcomes including adolescent's psychological wellbeing, retention in care and sustained viral load suppression.",[121,122,28],"HIV-related Stigma","Psychological Wellbeing",[124,125,126,127],"digital peer-support","HIV-related stigma","adolescents living with HIV","south Ethiopia","2026-02-19",{"date":130,"type":39},"2026-02-23",{"date":132,"type":39},"2025-11-13",{"date":134,"type":22},"2026-05-01",{"name":136,"class":46},"Lund University",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":86,"minAge":145,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":148,"briefSummary":149,"conditions":150,"keywords":156,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":174},"100562583","optimizing-prevention-and-care-for-pregnant-and-postpartum-adolescent-girls-and-young-women-with-hiv-in-tanzania-100562583","NCT06605053","Optimizing Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania","ENding HIV Transmission to Infants by Generating Evidence to Optimize Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania (ENGAGE)","ENGAGE","Sub-study 1 (registry-based cohort analysis):\n\nInclusion Criteria:\n\n* Pregnant\u002Fpostpartum adolescent girls and young women (AGYW) with HIV aged 15-24 years, who started PMTCT services between January 1, 2018, and December 31, 2020.\n* Infants born to the included AGYW during this period.\n\nExclusion Criteria:\n\n* AGYW whose ART (Antiretroviral Therapy) status was not recorded.\n* Women who had not started ART.\n\nSub-study 2 (qualitative):\n\nInclusion Criteria:\n\n* AGYW living with HIV who are currently pregnant, previously pregnant\u002Fpostpartum, and never pregnant).\n* HCPs (Health Care Providers) at clinics providing PMTCT services.\n* Spouses\u002Fpartners\u002Fparents of AGYW and community stakeholders within the study setting.\n\nExclusion criteria\n\n\\- Mentally or severely ill individuals unable to participate in the study activities.\n\nSub-study 3 (co-production)\n\nInclusion criteria:\n\n* AGYW, HCPs, spouses\u002Fpartners, parents, and community stakeholders who participated in the qualitative study II.\n* Research team members.\n\nExclusion criteria:\n\n\\- Mentally or severely ill individuals unable to participate in the study activities.\n\nSub-study 4 (cluster-randomized implementation trial)\n\nInclusion criteria:\n\n\\- Pregnant AGYW living with HIV (new, previously diagnosed, and transfers) receiving vertical HIV prevention services in routine healthcare between January 1, 2026, and June 30, 2026, and followed up for at least one year until June 30, 2027.\n\nExclusion criteria:\n\n* AGYW whose ART (Antiretroviral Therapy) status was not recorded.","15 Years",{"count":147,"type":22},222,[25],"The goal of this clinical trial is to find better ways to care for pregnant and postpartum adolescent girls and young women (AGYW) aged 15-24 years with HIV in Tanzania, and to prevent them from passing HIV to their babies. The main questions it aims to answer are:\n\n* How often do young pregnant women with HIV go to their health appointments and stay on their treatment up to two years after giving birth?\n* How many babies born to young women with HIV stay HIV-free for two years?\n* How soon do young women with HIV get pregnant again after giving birth, and what factors affect this?\n* What are the best ways to help young women with HIV stay in care and stay healthy during and after pregnancy?\n* What social and structural factors affect whether young pregnant women with HIV go to their health appointments and stay on their treatment?\n* How can we work with young women with HIV to create and test a package of interventions to improve their healthcare during and after pregnancy?\n* Can this package of interventions help young women with HIV stay in care and remain healthy during and after pregnancy?\n\nParticipants will:\n\n* Have their health data analyzed via health service records of all women who received HIV prevention services between 2018 and 2020, and were followed until 2023, across 559 health facilities in Tanzania.\n* Participate in qualitative interviews to share their experiences and challenges with staying in care.\n* Help to co-create a package of interventions to improve care.\n* Take part in a cluster-randomized trial to test these interventions. Researchers will compare the outcomes of the intervention package to see if they improve care engagement, retention, and health outcomes for AGYW with HIV during and after pregnancy.",[151,152,153,28,154,155],"HIV Antiretroviral Therapy (ART) Adherence","PMTCT","Pregnancy","HIV Viremia","Early Infant HIV Diagnosis",[157,34,158,152,159,160,161,162,163,164],"Adolescent girls and young women","Vertical transmission","Co-production","Co-design","Intervention","Tanzania","Sub-Saharan Africa","Retention in care","2025-06-27",{"date":167,"type":39},"2025-06-29",{"date":169,"type":39},"2024-10-07",{"date":171,"type":22},"2027-12",{"name":173,"class":46},"Karolinska Institutet",2]