[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"retinal-vessels\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:retinal-vessels":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100599456","identifying-biomarkers-for-endothelial-dysfunction-in-women-with-preeclampsia-100599456",false,"NCT07084727","Identifying Biomarkers for Endothelial Dysfunction in Women With Preeclampsia","Retinal Biomarkers as a Tool for Early Detection of Endothelial Dysfunction in Women With Preeclampsia","DAISY","Inclusion Criteria:\n\n* at least 18 years old\n* willing to undergo vascular assessments\n* informed consent signed\n\nExclusion Criteria:\n\n* Unwilling to provide informed consent\n* Open-angle glaucoma\n* Epilepsia\n* (gestational) Diabetes\n* Multiple pregnancies\n* Fetal malformations\n* Hypercholesterolemia\n* Kidney disease\n* Auto-immune disorders\n* Connective tissue diseases",true,"FEMALE","18 Years","40 Years",{"count":22,"type":23},60,"ESTIMATED","INTERVENTIONAL",[26],"NA","Every pregnancy has a major impact on a woman's heart and blood vessels due to changes required by the body to maintain proper blood flow between mother and foetus. When the placenta does not work properly, preeclampsia can occur. An important first symptom is high blood pressure. Women who have experienced preeclampsia are at higher risk of developing blood pressure and heart problems later on. Therefore, it is very important to detect changes in the blood vessel system so that they can be treated promptly and correctly. We aim to do this by using a new, non-invasive eye test that examines the blood vessels of the retina.",[29,30,31],"Endothelial Function (FMD)","Preeclampsia","Retinal Vessels","RECRUITING","2025-07-17",{"date":35,"type":36},"2025-07-24","ACTUAL",{"date":38,"type":36},"2025-07-01",{"date":40,"type":23},"2025-12-15",{"name":42,"class":43},"University Hospital, Antwerp","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":54,"maxAge":55,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":70,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":44},"100587090","controlled-evaluation-of-an-exercise-program-for-overweight-adolescents-100587090","NCT06923865","Controlled Evaluation of an Exercise Program for Overweight Adolescents","Now! Project - a Controlled Evaluation of a Physical Activity Program for Adolescents With Overweight","Now!","Inclusion Criteria:\n\n* BMI above the 90th percentile for their age and gender (WHO reference table)\n* Deficits in movement motivation and motor skills\n* No health complaints or movement-restricting conditions\n* No health risks for maximal exertion\n* Ability to verbally communicate pain or discomfort\n* Unremarkable PAR-Q questionnaire\n* Signed parental consent form\n\nExclusion Criteria:\n\n* Acute or chronic illness\n* Inability to follow the study procedures (e.g., language barriers, psychological disorders)","ALL","12 Years","14 Years",{"count":57,"type":23},150,[26],"Physical activity decreases as young people get older, especially during the shift from early to late adolescence. Unfortunately, around 81% of school-aged children worldwide between the ages of 11 and 17 do not meet the recommendation of at least one hour of physical activity per day - and this is also true in Switzerland. Not being active enough, whether normal weight or overweight, can lead to long-term health problems and is a major factor in becoming overweight over time. This results in healthcare costs and negatively affects quality of life. Supporting physical activity in overweight youth requires well-rounded, thoughtful programs.\n\nThe investigators studying the impact of the movement programs now! and now!+ on the physical activity and health of young people. The goal is to look at both physical and mental changes equally.\n\nTaking part in this study involves minimal physical or mental risk for the participants. These small risks from the testing methods and activities are taken into account in how the program is explained and carried out.\n\nThe benefits for the participants - feeling healthier and fitter physically, and more confident and capable mentally - clearly outweigh any potential risks, thanks to the additional, guided, and personalized exercise program.\n\nThe participants take part in the now! and now!+ exercise programs run by the Basel-Stadt Sports Office and the DSBG. now! is a 90-minute group session with up to 14 young people, while now!+ is a 90-minute small-group session with 2 to 4 participants. Both programs take place once a week over a 12-month period and pause during school holidays (38 training weeks in total).\n\nEach session includes a warm-up, a strength or endurance training block, and a coordination phase. The program is modular and adapted to the physical and personal needs of each participant. This ensures that overweight adolescents are not overstrained and don't develop symptoms like pain, frustration, or lack of motivation (Behringer et al., 2011), while still allowing for a training stimulus that supports physical improvement.\n\nThe results of the evaluations are directly used to improve and further develop the exercise program. The overall project includes three rounds, each consisting of one year of training and three test sessions, each lasting about two hours. The now! and now!+ programs are held weekly for a total of 38 weeks per year, with breaks during school holidays.\n\nEach of the three test sessions includes the same set of assessments (see \"Study Intervention\") and follows a set order: The process begins with measuring body size and blood pressure, followed by a static retinal vessel analysis. After these medical checks, participants do a 5-minute warm-up on a stationary bike at a set resistance level. Then, strength tests are performed: knee extension on the IsoMed 2000, handgrip strength, and jump power on the Leonardo force plate. The endurance test using spiroergometry marks the end of the physical assessments.\n\nFinally, impulse control is tested, and participants complete a set of questionnaires. At the end of the session, each participant is given an actigraph (a small motion sensor worn on the body) to track their physical activity over the following seven days.",[61,62,63,64,65,66,67,31,68,69],"Adolescent","Pediatric Obesity","Exercise Therapy","Health Promotion","Program Evaluation","Impulse Control Disorders","Quality of Life","Strength Training Effects","Aerobic Capacity",[71,72,73,74,75],"Overweight adolescents","Youth physical activity","Motor performance in children","Impulse control and fitness","training in peer groups","NOT_YET_RECRUITING","2025-04-04",{"date":79,"type":36},"2025-04-11",{"date":81,"type":23},"2025-06-01",{"date":83,"type":23},"2029-12",{"name":85,"class":43},"University Hospital, Basel, Switzerland"]