[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"retinoblastoma-recurrent\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:retinoblastoma-recurrent":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100571816","detailed-phenotypic-and-genotype-study-to-correlate-rb1-mutations-relating-to-primary-ocular-tumors-and-secondary-extra-ocular-metastasis-100571816",false,"NCT06725173","Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.","Genetic Associations of Ocular Cancers","Inclusion Criteria:\n\n* Patients with molecularly proven retinoblastoma due to RB1 or a typical clinical retinoblastoma phenotype with genetic screening pending.\n* Able to give consent\u002Fparent or guardian able to give consent.\n\nExclusion Criteria:\n\n* Patients unable or unwilling to undertake consent or clinical testing.\n* Patients unwilling to donate a saliva or blood sample in order to establish the genetic cause of their condition.",true,"ALL",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is undertake a detailed phenotypic and genotypic study of patients with ocular and secondary cancers due to mutations in the RB1 gene. Our research sequencing approach will allow advanced insight to for further detailed genotypic understanding of parent-of-origin for valuable insight into the genotype-phenotype relationship of this cancer syndrome.",[24,25,26,27,28],"Retinoblastoma Bilateral","Retinoblastoma Unilateral","Retinoblastoma, Extraocular","Retinoblastoma, Recurrent","Retinoblastoma",[30,31],"retinoblastoma","parent-of-origin","RECRUITING","2026-03-17",{"date":35,"type":36},"2026-03-18","ACTUAL",{"date":38,"type":20},"2026-03-16",{"date":40,"type":20},"2031-01-01",{"name":42,"class":43},"University of Washington","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":44},"100590836","early-phase-1-high-dose-topotecan-for-retinoblastoma-with-recurrent-or-refractory-vitreous-seed-100590836","NCT06972602","High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed","High-dose Topotecan for Retinoblastoma With Recurrent or Refractory Vitreous Seed(A Prospective Non-controlled Single Arm Trial)","Inclusion Criteria:\n\n1. Patients with retinoblastoma with a somatic mutation of the gene RB1 and active tumor in a single eye, or germinal mutation of RB1 with active tumor\u002Fs in an eye and the contralateral eye unaffected, enucleated or without tumor activity. In both cases, relapsed or refractory vitreous seeding with the use of systemic, intraarterial or intravitreal chemotherapy or radiotherapy, in accordance with the availability at his\u002Fher referral site, in whom enucleation is the only recommended treatment under opinion of the medical team treating the case at the originating referral site. But the patient has a strong desire to preserve the eye.\n2. Normal renal function: serum creatinine: \\\u003C 45 μmol\u002FL (0-2 years); \\\u003C 57 μmol\u002FL (3-6 years); \\\u003C 60 μmol\u002FL (7-10 years); \\\u003C 80 μmol\u002FL (11-13 years).\n3. Normal Hepatic function: serum ALT: \\\u003C 0,52 μkat\u002FL (de 9 months -12 years); serum AST: 61-80 g\u002FL (8 months-5 years); 63-83 g\u002FL (5-9 years); 63-82 g\u002FL (9-12 years).\n4. Adequate marrow reserve manifested in an absolute neutrophil count \\> 1000 \u002F mm3, platelets \\> 100,000 \u002F mm3 and hemoglobin\\> 8 g \u002F dl, without transfusional or cytokine support at least one month prior to study entry.\n5. Age greater than 1 year and less than 12 years at the time of inclusion in the study.\n6. Sign the informed consent form and be willing to follow up at the specified time.\n\nExclusion Criteria:\n\n1. Presence of factors that require immediate enucleation of the affected eye such as glaucoma, rubeosis iridis, anterior chamber involvement.\n2. Comorbidities: Uncontrolled epilepsy with anticonvulsant treatment, cardiac disease not compensated by treatment.\n3. Active Infections.\n4. Other chronic or active acute diseases that under the criterion of the researcher were an exclusion criterion.\n5. History of having received attenuated or live vaccines in the 30 days prior to inclusion in the study.\n6. Any cause of Immunosuppression.\n7. Trilateral Retinoblastoma.\n8. Extraocular spread.\n9. History of having received treatment for retinoblastoma with chemotherapy or radiation therapy by any means within 30 days prior to inclusion in the study.\n10. Patients who can not complete the study procedures for reasons psychologically or socially","1 Year","12 Years",{"count":55,"type":20},10,"INTERVENTIONAL",[58],"EARLY_PHASE1","Retinoblastoma is the most common intraocular malignancy in infancy and childhood,with an estimated 8000 new cases globally each year.The major cause of failure in the management of retinoblastoma remains the persistence or recurrence of resistant vitreous seeding.Currently,with the emergence of new administration routes, intravitreal chemotherapy has been used for vitreous seeds and the rate of eye preservation has been effectively improved. However, the use of high doses of chemotherapeutic agents may lead to visual impairments due to long term retinal toxicity and some tumors recur or become resistant to chemotherapeutic agents after treatment. In such cases, ocular resection is the only option to prevent extraocular metastasis and death.\n\nTherefore, studies on retinoblastoma are currently focused on finding new targeted therapies at appropriate doses to increase anti-tumor activity and reduce side effects. In this study, Topotecan at a dosage of 100μg will be used to treat patients with refractory or recurrent retinoblastoma.\n\nOn one hand, topotecan, as a topoisomerase I inhibitor, prevents the reconnection of broken single stranded DNA, causing irreversible DNA damage. On the other hand, topotecan upregulates PTEN protein to restore its inhibitory effect on the PI3K\u002FAKT signaling pathway, thereby jointly promoting tumor cell apoptosis and weakening cell proliferation activity.Topotecan at a dosage of 100μg has been proven safe in animal experiments, and there have been a few retrospective case reports on its application in retinoblastoma, but relevant prospective clinical studies are still lacking.\n\nBased on the above background, this study will explore the feasibility and effectiveness of intravitreal injection of Topotecan at a dosage of 100μg in patients with refractory or recurrent retinoblastoma through a prospective study,while evaluating immune response and visual preservation.",[28,27],"2025-05-07",{"date":63,"type":36},"2025-05-15",{"date":65,"type":36},"2025-04-01",{"date":67,"type":20},"2027-12-31",{"name":69,"class":43},"Eye & ENT Hospital of Fudan University"]