[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"retinoblastoma-unilateral\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:retinoblastoma-unilateral":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100436120","retinoblastoma-patient-clinical-database-and-tissue-repository-100436120",false,"NCT04959097","Retinoblastoma Patient Clinical Database and Tissue Repository","Inclusion Criteria:\n\n* All patients, age 0 days to 18 years, with a diagnosis unilateral or bilateral retinoblastoma (RB) seen at CHLA (Children's Hospital Los Angeles).\n\nExclusion Criteria:\n\n* Patients referred for second opinions only and not treated at CHLA for any reason.","ALL","0 Years","18 Years",{"count":19,"type":20},800,"ESTIMATED","3 Years","OBSERVATIONAL","Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed.\n\nGiven this limitation, we use aqueous humor (AH), the clear fluid in the front of the eye to detect specific markers, or information, that comes from the tumor itself.",[25,26,27],"Retinoblastoma","Retinoblastoma Bilateral","Retinoblastoma Unilateral",[25,29,30,31],"RB","Ocular oncology","Aqueous humor","RECRUITING","2026-04-17",{"date":35,"type":36},"2026-04-22","ACTUAL",{"date":38,"type":36},"2017-01-01",{"date":40,"type":20},"2030-12-31",{"name":42,"class":43},"Children's Hospital Los Angeles","OTHER",9,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100571816","detailed-phenotypic-and-genotype-study-to-correlate-rb1-mutations-relating-to-primary-ocular-tumors-and-secondary-extra-ocular-metastasis-100571816","NCT06725173","Detailed Phenotypic and Genotype Study to Correlate RB1 Mutations Relating to Primary Ocular Tumors and Secondary Extra-ocular Metastasis.","Genetic Associations of Ocular Cancers","Inclusion Criteria:\n\n* Patients with molecularly proven retinoblastoma due to RB1 or a typical clinical retinoblastoma phenotype with genetic screening pending.\n* Able to give consent\u002Fparent or guardian able to give consent.\n\nExclusion Criteria:\n\n* Patients unable or unwilling to undertake consent or clinical testing.\n* Patients unwilling to donate a saliva or blood sample in order to establish the genetic cause of their condition.",true,{"count":54,"type":20},100,"The goal of this observational study is undertake a detailed phenotypic and genotypic study of patients with ocular and secondary cancers due to mutations in the RB1 gene. Our research sequencing approach will allow advanced insight to for further detailed genotypic understanding of parent-of-origin for valuable insight into the genotype-phenotype relationship of this cancer syndrome.",[26,27,57,58,25],"Retinoblastoma, Extraocular","Retinoblastoma, Recurrent",[60,61],"retinoblastoma","parent-of-origin","2026-03-17",{"date":64,"type":36},"2026-03-18",{"date":66,"type":20},"2026-03-16",{"date":68,"type":20},"2031-01-01",{"name":70,"class":43},"University of Washington",1]