[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"revision-total-knee-arthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:revision-total-knee-arthroplasty":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,68,99],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100502942","clinical-evaluation-of-antiseptic-skin-preparation-in-revision-total-joint-arthroplasty-of-the-hip-and-knee-100502942",false,"NCT05828810","CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee","CLinical Evaluation of ANtiseptic Skin Preparation in Revision Total Joint Arthroplasty of the Hip and Knee - A Vanguard Randomized Controlled Registry Trial (CLEAN Joint Trial)","CLEANJoint","Inclusion Criteria:\n\n1. Aged 18 years or older\n2. Scheduled to undergo aseptic revision total hip arthroplasty or total knee arthroplasty with exchange of at least one prosthetic component\n\nExclusion Criteria:\n\n1. Revision for prosthetic joint infection or wound complication\n2. Known history of previous prosthetic joint infection in the operative joint\n3. Any degree of clinical concern for prosthetic joint infection\n4. History of allergy to iodine, chlorhexidine, or alcohol","ALL","18 Years",{"count":20,"type":21},400,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare two types of skin preparation solutions (chlorhexidine gluconate-alcohol solution and povidone-iodine solution) that help eliminate harmful bacteria on the skin at the time of surgery for patients having revision arthroplasty surgery of the hip or knee.\n\nThe main outcome of interest for the definitive study is the need for re-operation for a wound complication or an infection of the prosthetic joint within one year after surgery.\n\nFor the pilot trial, our main interest is to determine feasibility of a definitive trial. Feasibility outcomes will include: ability to recruit patients, ability to randomize patients, ability to collect complete data, estimate the event rate of our primary outcome, ability to carry out data linkages and determine the accuracy of collected data.\n\nParticipants will be contacted at two time points after surgery to complete a 5-minute survey: after 30 days, and after 1 year.",[27,28],"Revision Total Hip Arthroplasty (RTHA)","Revision Total Knee Arthroplasty",[30,31,32],"prosthetic joint infection","registry-based RCT","PJI","RECRUITING","2026-04-22",{"date":36,"type":37},"2026-04-24","ACTUAL",{"date":39,"type":37},"2023-07-25",{"date":41,"type":21},"2026-11",{"name":43,"class":44},"Sunnybrook Health Sciences Centre","OTHER",3,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100614705","io-vancomycin-into-the-medial-malleolus-vs-iv-administration-in-revision-tka-100614705","NCT07283068","IO Vancomycin Into the Medial Malleolus vs IV Administration in Revision TKA","Intraosseous (IO) Vancomycin Into the Medial Malleolus vs Intravenous (IV) Administration in Revision Total Knee Arthroplasty (TKA)","Inclusion Criteria:\n\n* Patient is undergoing a revision total knee arthroplasty where in the opinion of the investigator, the patient's existing tibial component excludes the tibial tubercle as a valid intraosseous injection site.\n* Patient is able to understand the study design and intervention and gives informed consent to participate in the study.\n* Age \\> 18 years.\n\nExclusion Criteria:\n\n* Contraindication to receiving vancomycin, cefepime, ancef, or other standard of care pre-operative antibiotic (allergy, medical issue, etc).\n* Patient received or is scheduled to receive intravenous Vancomycin within 7 days prior to their planned revision procedure.\n* Any hardware, condition, or anatomic status that prevents the medial malleolus from being a viable intraosseous injection site.\n* Refusal to participate\n* Any condition, in the opinion of the primary investigator, that deems the participant unsuitable for participation in the research study.",{"count":54,"type":21},40,[24],"Purpose of this study is to compare the efficacy of intravenous and intraosseous antibiotic administration techniques during revision total knee arthroplasty",[28],"NOT_YET_RECRUITING","2026-04-17",{"date":61,"type":37},"2026-04-20",{"date":63,"type":21},"2026-06-15",{"date":65,"type":21},"2030-06-15",{"name":67,"class":44},"The Methodist Hospital Research Institute",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100589212","gut-microbiome-in-orthopaedics-revision-total-knee-arthroplasty-100589212","NCT06951477","Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty","Gut Microbiome in Orthopaedics: Investigating the Role of Gut Microbiome Composition in Total Knee Arthroplasty Failure","GUMBO","Inclusion Criteria:\n\n* Scheduled to undergo a revision TKA\n* Willing and able to comply with follow-up requirements\n* Ability to provide informed consent\n* Ability to read, write, and speak English\n\nExclusion Criteria:\n\n* Pregnancy\n* Less than 3 months post-operation from primary surgery\n* Diagnosis of periprosthetic fracture\n* Scheduled for DAIR (debridement, antibiotics, and implant retention) revision surgery\n* Scheduled for stage 2 PJI revision",{"count":77,"type":21},30,"OBSERVATIONAL","Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening. The role of the gut microbiome-the collection of bacteria and other microbes within the human gastrointestinal tract-is just beginning to be recognized in orthopaedics. The gut microbiome has been found to affect the immune response and bone regulation, potentially contributing to infection or loosening after total joint replacement. Antibiotics are regularly used in orthopaedic surgery to reduce the risk of infection, yet they might also harm gut microbiota and reduce their potentially beneficial effects. As a result, understanding the relationship between gut microbiota and surgical outcomes has become increasingly important. Therefore, this study aims to determine if there are differences in gut microbiota composition between patients with well-functioning knee replacements and those requiring revision knee replacements. Additional study aims include assessing inflammation, implant loosening, metal ion levels, and circulating bacteria in blood or tissue between well-functioning or failed knee replacements.",[28,81],"Osteoarthritis, Knee",[83,84,85,86,87,88],"Revision TKA","Gut Microbiome","Implant Loosening","Inflammation","Weight-Bearing Computed Tomography","PET\u002FCT","2025-09-15",{"date":91,"type":37},"2025-09-19",{"date":93,"type":21},"2025-10",{"date":95,"type":21},"2027-12",{"name":97,"class":44},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's",1,{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":45},"100463422","multigen-plus-cck-and-amf-tt-cones-follow-up-study-100463422","NCT05314491","Multigen Plus CCK and AMF TT Cones Follow Up Study","A Prospective, Post-marketing Study Evaluating Clinical and Radiographic Early Outcomes of Total Knee Arthroplasty With Multigen Plus CCK Alone or Involving the AMF TT Cones.","Inclusion Criteria:\n\n* Male or female.\n* Age ≥ 18 years old.\n* Given written informed consent approved by the reference Ethics Committee (EC).\n* Subjects in whom a decision has already been made to perform a Total Knee Arthroplasty with Multigen Plus system as per Indication For Use. The decision to implant a Multigen Plus CCK system, alone or involving the AMF TT cones, must be taken prior to, and independently from, the decision to enrol the subject. This decision should be made in accordance with routine clinical practice at the study site concerned.\n* Subjects able to comply with the Study Protocol.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years old.\n* Subjects with any Multigen Plus system contraindication for use, or any AMF TT cones contraindication for use when used in combination with the Multigen Plus CCK, as reported in the current Instruction For Use.\n* Any clinically significant pathology based on the medical history that the Investigator feels may affect the study evaluation.\n* Female subjects who are pregnant, nursing, or planning a pregnancy.\n* Previous knee replacement on the contralateral side within the last year and whose outcome is achieving an KSS \\\u003C 70 points.",{"count":107,"type":21},68,"This study is aimed to provide a clinical and radiographic evaluation of 68 condylar-constrained Total Knee Arthroplasty (TKA) using a single type of prosthesis (Multigen Plus CCK configuration), alone or involving the AMF TT cones, in patients with joint instability or inadequate ligament function, both in complex primary and revision procedures.",[110,28],"Total Knee Arthroplasty","2025-03-05",{"date":113,"type":37},"2025-03-10",{"date":115,"type":37},"2022-06-21",{"date":117,"type":21},"2026-07",{"name":119,"class":120},"Limacorporate S.p.a","INDUSTRY"]