[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rhinoplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rhinoplasty":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,40,72,96,125,154,183,206,234,254],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100053659","effect-of-controlled-hypotension-on-gfap-and-cognition-in-rhinoplasty-100053659",false,"NCT07699133","Effect of Controlled Hypotension on GFAP and Cognition in Rhinoplasty","Evaluation of the Effect of Controlled Hypotension During Elective Rhinoplasty on Serum Glial Fibrillary Acidic Protein (GFAP) and Cognitive Functions","Inclusion Criteria:\n\nScheduled for elective rhinoplasty or septorhinoplasty under general anesthesia.\n\nASA physical status I or II. Literate and willing to provide written informed consent.\n\nExclusion Criteria:\n\nHistory of neurological (e.g., cerebrovascular event, epilepsy) or psychiatric diseases.\n\nTotal septal reconstruction requiring costal (rib) cartilage grafts. Expected surgical duration exceeding 3 hours. Preoperative severe cognitive impairment. Pregnancy or lactation.","ALL","18 Years","50 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the neurological safety of controlled hypotension (Mean Arterial Pressure 50-65 mmHg) during elective rhinoplasty. The investigators will assess whether this standard intraoperative hypotensive strategy causes cellular stress by measuring serum Glial Fibrillary Acidic Protein (GFAP) levels and early postoperative cognitive changes using the Montreal Cognitive Assessment (MoCA) test.",[25,26,27],"Nasal Septum Deviation","Rhinoplasty","Induced Hypotension","NOT_YET_RECRUITING","2026-07-07",{"date":31,"type":32},"2026-07-13","ACTUAL",{"date":34,"type":21},"2026-07-10",{"date":36,"type":21},"2027-03-30",{"name":38,"class":39},"Kahramanmaras Sutcu Imam University","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":48,"targetDuration":50,"studyType":22,"phases":4,"briefSummary":51,"conditions":52,"keywords":55,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":71},"100633832","patient-reported-outcomes-and-complications-after-structural-rhinoplasty-using-septal-extension-grafts-100633832","NCT07531810","Patient-Reported Outcomes and Complications After Structural Rhinoplasty Using Septal Extension Grafts","Patient-Reported Outcomes and Complications Following Structural Rhinoplasty Using Septal Extension Grafts: A Prospective Cohort Study","SEG-PROM","Inclusion Criteria:\n\n* Age 18 years or older\n* Undergoing primary structural rhinoplasty with septal extension graft\n* Able to understand and complete patient-reported outcome questionnaires (PROMs)\n* Willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* History of previous nasal surgery (revision rhinoplasty)\n* Undergoing concomitant major craniofacial procedures\n* Missing preoperative PROM data\n* Unable to complete postoperative follow-up assessments",{"count":49,"type":21},50,"6 Months","Structural rhinoplasty with septal extension graft (SEG) is commonly used to achieve stable nasal tip support and predictable long-term outcomes. However, surgical success is not limited to structural stability alone and should also be evaluated from the patient's perspective.\n\nPatient-reported outcome measures (PROMs) have gained increasing importance in rhinoplasty, as they reflect patient satisfaction and perceived nasal function. Despite the widespread use of SEG, prospective studies evaluating PROMs together with postoperative clinical findings over time remain limited.\n\nThis prospective observational cohort study aims to evaluate longitudinal changes in patient-reported outcomes and postoperative findings in adult patients undergoing primary structural rhinoplasty with SEG-based nasal tip support. Validated PROM instruments will be applied preoperatively and during routine postoperative follow-up visits at approximately 1, 3, and 6 months.\n\nIn addition, postoperative complications and revision procedures will be recorded. The study aims to provide a more comprehensive understanding of patient-centered outcomes and their relationship with clinical findings in SEG-based rhinoplasty.",[53,26,54],"Nasal Deformity","Nasal Obstruction",[56,57,58,59,60],"Structural rhinoplasty","Septal extension graft","Patient reported outcomes","SCHNOS","Rhinoplasty outcomes","RECRUITING","2026-06-17",{"date":64,"type":32},"2026-06-22",{"date":66,"type":32},"2026-04-01",{"date":68,"type":21},"2027-06",{"name":70,"class":39},"Cumhuriyet University Hospital",1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":4},"100639921","ai-in-assessing-aesthetic-outcomes-in-rhinoplasty-100639921","NCT07580573","AI in Assessing Aesthetic Outcomes in Rhinoplasty","Use of Artificial Intelligence in Assessment of Aesthetic Outcomes in Rhinoplasty","Inclusion Criteria:\n\n* Patients age\\> 18 years old.\n* patients schedule for rhinoplasty surgery\n\nExclusion Criteria:\n\n* Pervious nasal trauma that affect anatomical land mark\n* pervious nasal surgery (rhinoplasty or others)\n* patients with psychological disorders.\n* patients with any coagulopathy disorders",{"count":80,"type":21},20,"INTERVENTIONAL",[83],"NA","This study aims to thoroughly assess the predictive accuracy of artificial intelligence-based nasal outcome simulations by comparing AI-generated preoperative predictions with objective postoperative nasal morphology using digital image analysis.\n\nTo assess accuracy of AI-image measurement compared with imageJ software",[26,86],"AI (Artificial Intelligence)","2026-05-05",{"date":89,"type":32},"2026-05-12",{"date":91,"type":21},"2026-06-01",{"date":93,"type":21},"2027-07-01",{"name":95,"class":39},"Assiut University",{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":103,"sex":16,"minAge":17,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":81,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":71},"100595483","effects-of-red-and-infrared-photobiomodulation-in-rhinoplasty-at-a-single-centre-100595483","NCT07033039","Effects of Red and Infrared Photobiomodulation in Rhinoplasty at a Single Centre","Effects of Photobiomodulation With Red and Infrared Low-level Laser Diodes in Individuals Undergoing Rhinoplasty at a Single Centre: Protocol for a Randomized, Double-blind, Controlled Clinical Trial","Inclusion criteria:\n\n* individuals 18-60 years of age;\n* ASA I or II; no comorbidities (no pre-existing diseases);\n* indication for rhinoplasty;\n* regardless of gender identity.\n\nExclusion criteria:\n\n* use of anticoagulant,\n* anti-inflammatory, or corticosteroid medications;\n* indication for closed rhinoplasty;\n* procedures not performed using the Piezo device (Schuster SW Surgery II);\n* intraoperative complications (e.g., haemorrhage or technical difficulties);\n* prior nasal filler with hyaluronic acid;\n* use of vitamin A derivatives (oral isotretinoin or topical retinoic acid) within 30 days before surgery;\n* or known allergy to any mandatory intra- or postoperative medication.",true,"60 Years",{"count":106,"type":21},60,[83],"This single-centre, randomized, double-blind, sham-controlled clinical trial evaluates whether preoperative photobiomodulation (PBM) with red and infrared light can reduce early postoperative periorbital edema in patients undergoing primary open rhinoplasty with osteotomies. Sixty participants will be randomly assigned to receive active PBM or sham PBM one hour before surgery. The primary outcome is periorbital edema on postoperative day 3 measured using a validated ordinal clinical scale with standardized photographic documentation. Secondary outcomes include ecchymosis, postoperative pain, analgesic consumption, nasal tip skin thickness, and patient-reported functional and aesthetic outcomes. Participants will be followed for up to 12 months after surgery.",[26,110],"Edema",[112,113,114,115],"Photobiomodulation","Low-Level Laser Therapy","Postoperative","Inflammation","2026-03-19",{"date":118,"type":32},"2026-03-24",{"date":120,"type":32},"2026-01-30",{"date":122,"type":21},"2030-11-30",{"name":124,"class":39},"University of Nove de Julho",{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":131,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":104,"enrollmentInfo":133,"targetDuration":4,"studyType":81,"phases":135,"briefSummary":136,"conditions":137,"keywords":140,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":71},"100617386","lateral-crural-steal-with-columellar-strut-graft-in-primary-open-rhinoplasty-100617386","NCT07317947","Lateral Crural Steal With Columellar Strut Graft in Primary Open Rhinoplasty","The Effect of Lateral Crural Steal With Columellar Strut Graft on Nasal Tip Projection and Rotation in Primary Open Rhinoplasty","LCS\u002FCS","Inclusion Criteria:\n\n* Patients seeking primary rhinoplasty for aesthetic and\u002For functional indications.\n* Presence of inadequate nasal tip projection and\u002For rotation suitable for correction using lateral crural steal with columellar strut graft.\n* Ability to provide written informed consent and comply with follow-up visits.\n\nExclusion Criteria:\n\n* History of prior nasal surgery.\n* History of severe nasal trauma, altering cartilage architecture.\n* Significant functional nasal obstruction requiring complex external nasal valve reconstruction.\n* Patients with excessively wide alar base requiring alar base reduction involving vestibular sill excision (to prevent confounding on projection\u002Frotation).\n* Patients with facial skeletal or developmental abnormalities e.g. maxillary hypoplasia, maxillary prognathism, dentofacial deformities.\n* Patients with psychiatric illness or Body Dysmorphic Disorder.\n* Significant medical comorbidities contraindicating elective surgery or general anesthesia.\n* Inability to provide informed consent or comply with follow-up.",{"count":134,"type":21},22,[83],"The goal of this clinical trial is to assess the effect of Lateral crural steal with Columellar strut graft done in Primary Open Rhinoplasty and its long-term sustainability on nasal tip projection and nasal tip rotation.",[26,138,139],"Nasal Surgery","Aesthetic Outcomes",[26,141,142,143,144],"Lateral crural steal","Columellar strut","Rhinobase","Rhinoplasty Outcome Evaluation","2026-01-08",{"date":147,"type":32},"2026-01-09",{"date":149,"type":32},"2026-01-05",{"date":151,"type":21},"2027-02",{"name":153,"class":39},"Kafrelsheikh University",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":81,"phases":165,"briefSummary":166,"conditions":167,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":71},"100610896","preoperative-maxillary-nerve-block-and-remifentanil-use-in-septorhinoplasty-100610896","NCT07233538","Preoperative Maxillary Nerve Block and Remifentanil Use in Septorhinoplasty","Effect of Preoperative Ultrasound-guided Bilateral Maxillary Nerve Block Via the Pterygopalatine Fossa on Intraoperative Remifentanil Use in Septorhinoplasty","PRISM","Inclusion Criteria:\n\n* Those with an ASA (American Society of Anesthesiologists) score of I-II\n* Those with a body mass index (BMI) between 18 and 30\n* Those scheduled for elective surgery\n* Those who are fully cooperative Patients who meet the criteria for septorhinoplasty surgery\n\nExclusion Criteria:\n\n* Conditions that constitute a relative contraindication to regional anesthesia (e.g., coagulation disorders, thrombocytopenia, severe valvular heart disease, local infection at the injection site, allergy to local anesthetic agents)\n* International Normalized Ratio (INR) \\> 1.5\n* Facial paralysis or a history of facial paralysis\n* History of central nervous system vascular disease\n* Presence of neuropathy\n* History of surgery in the region where the block will be performed\n* American Society of Anesthesiologists (ASA) physical status classification of III or higher\n* Patients who do not want to participate in the study\n* Patients with chronic pain or chronic opioid use\n* Patients with alcohol, substance or drug addiction\n* Patients with limited cooperation such as dementia, psychiatric disorders\n* Pregnant and breastfeeding patients will be excluded from the study.\n* Patients who cannot communicate in their native language will be excluded from the study","65 Years",{"count":164,"type":21},90,[83],"Septorhinoplasty is generally a prolonged surgical procedure that frequently involves osteotomy, which may lead to increased intraoperative remifentanil requirements. Moreover, it is often associated with significant bleeding due to the dense capillary network of the nasal region, making the maintenance of low-to-normal blood pressure preferable during surgery. Consequently, achieving stable hemodynamics and providing sufficient analgesia throughout the procedure is essential.\n\nThis study aims to evaluate the effects of bilateral maxillary nerve block on intraoperative remifentanil consumption and postoperative analgesic efficacy in patients undergoing Septorhinoplasty. A total of 90 patients will be included in the study. Forty-five patients (Group M) will undergo Septorhinoplasty under general anesthesia combined with bilateral maxillary nerve block, while the remaining 45 patients (Group N) will receive general anesthesia alone.\n\nIn the preoperative phase, a bilateral maxillary nerve block will be performed under ultrasound guidance via the pterygopalatine fossa. During the intraoperative period, total remifentanil consumption will be recorded, alongside assessments of hemodynamic stability, sevoflurane consumption, extubation time, intraoperative bleeding volume, and the satisfaction levels of both the anesthesiologist and the surgeon.\n\nIn the postoperative period, patient satisfaction, pain scores at 0, 1, 2, 4, 6, 12, 18, and 24 hours as well as at 1 month (measured using the Visual Analog Scale - VAS), additional analgesic requirements, and Quality of Recovery-15 (QoR-15) scores (assessed on preoperative day 1, postoperative day 1, and at 1 month) will be evaluated.",[168,169,26,170,171,172],"Head and Neck Surgery","Plastic Surgery","Pain","Regional Anaesthesia","Nerve Blocks","2025-11-17",{"date":175,"type":32},"2025-11-18",{"date":177,"type":32},"2025-08-20",{"date":179,"type":21},"2026-12-08",{"name":181,"class":182},"Ankara Etlik City Hospital","OTHER_GOV",{"id":184,"slug":185,"hasResults":11,"nctId":186,"briefTitle":187,"officialTitle":188,"acronym":4,"eligibilityCriteria":189,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":162,"enrollmentInfo":190,"targetDuration":4,"studyType":81,"phases":191,"briefSummary":192,"conditions":193,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":202,"leadSponsor":204,"locationsCount":71},"100590369","intraoperative-combination-of-ketamine-and-magnesium-sulfate-infusions-on-postoperative-analgesia-in-open-rhinoplasty-100590369","NCT06966518","Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Open Rhinoplasty","Effectiveness of Intraoperative Combination of Ketamine and Magnesium Sulfate Infusions on Postoperative Analgesia in Patients Undergoing Open Rhinoplasty: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I - II.\n* Scheduled for rhinoplasty under general anesthesia.\n\nExclusion Criteria:\n\n* Receiving analgesic or any medications since 48 hours before the surgery.\n* Drug addiction.\n* Cardiovascular disease.\n* Respiratory disease, renal, liver, metabolic and neurological disease.\n* Pregnancy or breast feeding.\n* Asthma.",{"count":49,"type":21},[83],"The study aims to evaluate the effectiveness of intraoperative combination of ketamine and magnesium sulfate infusions on postoperative analgesia in patients undergoing open rhinoplasty.",[194,195,196,197,26],"Intraoperative","Ketamine","Magnesium Sulfate","Postoperative Analgesia","2025-05-12",{"date":200,"type":32},"2025-05-13",{"date":198,"type":32},{"date":203,"type":21},"2025-10-01",{"name":205,"class":39},"Ain Shams University",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":4,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":215,"conditions":216,"keywords":218,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":225,"lastUpdatePostDateStruct":226,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":232,"locationsCount":71},"100356775","outcome-analysis-in-septorhinoplasty-100356775","NCT03925389","Outcome Analysis in Septorhinoplasty","Functional and Aesthetic Outcome Analysis in External Septorhinoplasty","Inclusion Criteria:\n\n* at least 18 years old\n* Patients eligible for external septorhinoplasty: patients seen in consultation because of nasal obstruction were evaluated. Patients who had symptoms of nasal obstruction for at least 1 year that were the result of an identifiable anatomical cause such as septal deviation, turbinate hypertrophy, internal valve collapse, or external valve collapse were included in the study.\n\nExclusion Criteria:\n\n* \\\u003C 18 years\n* mental or physical incapacity to answer the questionnaires\n* nasal fracture or surgery in the past year\n* nasal cocaine use in the past year",{"count":214,"type":21},750,"A prospective observational cohort study that measures pre- and postoperative outcome of septorhinoplasty by means of patient-related outcome measures (PROMS: NOSE, FACE-Q, Utrecht Questionnaire, SCHNOS and BDDQ-AS) as well as with functional tests (NAR, AR, PNIF).",[26,54,217],"Esthetics",[219,220,221,222,223,224,217],"Nasal function","Septorhinoplasty","Patient-reported outcome","Rhinomanometry","Acoustic Rhinometry","Peak Nasal Inspiratory Flow","2025-03-24",{"date":227,"type":32},"2025-03-27",{"date":229,"type":32},"2019-05-07",{"date":231,"type":21},"2025-12-10",{"name":233,"class":39},"FRANK DECLAU",{"id":235,"slug":236,"hasResults":11,"nctId":237,"briefTitle":238,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":103,"sex":16,"minAge":240,"maxAge":17,"enrollmentInfo":241,"targetDuration":4,"studyType":81,"phases":242,"briefSummary":243,"conditions":244,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":71},"100555345","single-stage-versus-multiple-staged-repair-of-nasal--alveolar-deformities-in-patients-with-cleft-lip-and-palate-100555345","NCT06510881","Single Stage Versus Multiple Staged Repair of Nasal & Alveolar Deformities in Patients With Cleft Lip and Palate","Inclusion Criteria:\n\n\\- Patients with unilateral cleft lip and palate deformities with evident nasal and cleft lip and palate aged between 5 - 18 years.\n\nExclusion Criteria:\n\n* \\* Patients with bilateral complete cleft palate .\n\n  * Patients with only cleft lip.\n  * Patients with cleft secondary palate.\n  * Patients non fit for surgery.\n  * Patients refuse the consent.","5 Years",{"count":20,"type":21},[83],"Cleft lip and palate patients are commonly seen among maxillofacial patients. Patients with cleft lip and palate have evident cosmetic nasal deformities. The interrupted insertion of orbicularis oris muscle into the columella on the noncleft side forces the premaxilla, columella and caudal nasal septum towards that side. At the same time, as the orbicularis oris inserts into the alar base on the cleft side, the base is pulled laterally, inferiorly and posteriorly. The malformed lower lateral cartilage on the side of the cleft contributes majorly to the deformity of the nasal tip, causing it to be more blunt. A shorter medial crus and longer lateral crus on the cleft side results in a horizontally wider and displaced nostril on the cleft side. In addition, those patients have alveolar bone defect which results in both cosmetic and dental problems. Repair of the deformed nose along with the reconstruction of the alveolar defect may have an advantage over the staged repair in:- decrease the surgical burden on the patient , correction of the facial asymmetry by redeeming the maxillary bony support , peri-alar augmentation and accordingly obtaining faster and better socio-cosmetic benefit .",[245,26],"Cleft Lip and Palate","2024-07-18",{"date":248,"type":32},"2024-07-19",{"date":250,"type":21},"2024-07-20",{"date":252,"type":21},"2027-02-20",{"name":95,"class":39},{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":103,"sex":16,"minAge":17,"maxAge":260,"enrollmentInfo":261,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":263,"conditions":264,"keywords":268,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":4},"100545635","the-impact-of-rhinoplasty-approach-and-used-autologous-cartilage-grafts-on-the-nasal-skin-soft-tissue-envelope-metabolism-100545635","NCT06384469","The Impact of Rhinoplasty Approach and Used Autologous Cartilage Grafts on the Nasal Skin-soft Tissue Envelope Metabolism","Inclusion Criteria:\n\n* Adult patients undergoing primary functional rhinoplasty who comply with the study\n* Adult patients undergoing primary functional rhinoplasty who have singed the informed consent, previously approved by the ethics commitee.\n\nExclusion Criteria: -\n\n* patients with previous surgical procedures to the nose\n* patients with greater previous injury or burns to the nasal skin\n* patients with autoimmune skin conditions\n* patients with significant cardiovascular diseases\n* patients unwilling to comply with the study\n* patients who do not want to sign the informed consent, previously approved by the ethics commitee.","80 Years",{"count":262,"type":21},100,"This is a prospective observation cohort investigation. Patients, that is participants, undergoing primary functional rhinoplasty will be evaluated in terms of measuring capillary blood lactic acid concentration in the nasal skin-soft tissue envelope immediately after the procedure and 7 days after the procedure.\n\nThe aim of our study is to test whether or not different rhinoplasty approaches and volume of the used autologous cartilage grafts impact the nasal skin-soft tissue metabolism.",[26,265,266,267],"Nasal Skin-soft Tissue Envelope Metabolism","Lactic Acid","Autologous Cartilage Grafting",[269,270,271,272,273,274],"Open rhinoplasty approach","Closed rhinoplasty approach","Lactic acid","Skin-soft tissue envelope","Metabolism","Autologous cartilage grafting","2024-04-25",{"date":277,"type":32},"2024-04-29",{"date":279,"type":21},"2025-01-02",{"date":281,"type":21},"2026-09-01",{"name":283,"class":39},"University Hospital Sestre Milosrdnice"]