[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rib-fracture-multiple\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rib-fracture-multiple":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,45,71,97,131,163,190],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100471170","randomized-control-trial-cryoablation-as-an-adjunct-to-surgical-stabilization-of-rib-fractures-100471170",false,"NCT05415384","Randomized Control Trial, Cryoablation as an Adjunct to Surgical Stabilization of Rib Fractures","Single Center, Randomized Control Trial of Cryoablation During Surgical Stabilization of Rib Fractures","Inclusion Criteria:\n\n* The patient is admitted to the trauma service.\n* The patient has multiple displaced rib fractures (≥2 ribs), offered fixation, and consents to SSRF\n* The patient is not being treated for chronic pain\n* The patient is \\>18 years of age.\n* Surgery anticipated \\\u003C120 hours from injury\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years or ≥ 80 years\n* Flail chest: either radiographic or clinical. Radiographic flail chest is defined on CT chest as ≥ 2 ribs each fractured in ≥ 2 places. Clinical flail is defined as visualization of a segment of chest wall with paradoxical motion on physical exam.\n* Moderate or severe traumatic brain injury (Intra-cranial hemorrhage visualized on CT head with GCS at the time of consideration for enrollment \\\u003C 12)\n* Prior or expected emergency exploratory laparotomy during this admission\n* Prior or expected emergency thoracotomy during this admission\n* Prior or expected emergency craniotomy during this admission\n* Spinal cord injury\n* Pelvic fracture that has required, or is expected to require, operative intervention during this admission\n* The patient was unable to accomplish activities of daily living independently prior to injury (e.g., dressing, bathing, preparing meals)\n* The patient is incarcerated\n* The patient is known to be pregnant\n* Unable to perform Video Assisted Thoracoscopy (VATS) at time of SSRF due to lung isolation or previous pathology","ALL","18 Years","80 Years",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","To determine if patients with intraoperative cryoablation have better analgesia results compared to the control group of Surgical Stabilization of Rib Fractures (SSRF) without cryoablation",[27,28],"Pain, Postoperative","Rib Fracture Multiple",[30,31],"Locoregional pain","thoracotomy","RECRUITING","2026-06-26",{"date":35,"type":36},"2026-06-29","ACTUAL",{"date":38,"type":36},"2022-08-01",{"date":40,"type":21},"2026-11",{"name":42,"class":43},"Wake Forest University Health Sciences","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":44},"100618979","surgery-for-unstable-chest-wall-injuries---how-many-fractures-should-be-fixed-100618979","NCT07338656","Surgery for Unstable Chest Wall Injuries - How Many Fractures Should be Fixed?","Inclusion Criteria:\n\n* Patients scheduled for surgery of acute (≤7 days after trauma) unstable injuries in the chest wall at the Department of Surgery, Sahlgrenska University Hospital\n* Both parts of the unstable segment must be accessible for surgery.\n\nExclusion Criteria:\n\n* Patients with injuries resulting from CPR\n* Patients with severe head injury (Head AIS\\>3)\n* Patients with spinal injury\n* Patients with neurological or musculoskeletal disease affecting chest wall mobility.",{"count":52,"type":21},100,[24],"The goal of this prospective, randomized study is to learn about the effects of two different surgical techniques for treating unstable chest wall injuries in adults. The main questions it aims to answer are:\n\nDoes fixing two fractures per rib lead to better healing than fixing one fracture per rib in patients with unstable chest injuries? Does the choice of surgical method affect lung function, pain, other symptoms, risk of pneumonia, or the risk of complications?\n\nParticipants will:\n\n* Undergo surgery using either the standard method (fixing one fracture per rib) or an alternative method (fixing two fractures per rib), both using a muscle-sparing technique.\n* Be followed up at 1, 3, and 12 months after surgery.\n* Have CT scans at 3 months (and at 12 months if healing is incomplete) to assess bone healing.\n* Be evaluated for lung function, pain, symptoms, and complications.\n\nThis study aims to provide new knowledge about which surgical method is best for unstable chest wall injuries, helping to improve treatment and recovery for these patients.",[28,56],"Flail Chest",[58,56,59,60],"Rib Fractures","Traumatology","Comparative Study","NOT_YET_RECRUITING","2026-04-27",{"date":64,"type":36},"2026-04-28",{"date":66,"type":21},"2026-05-05",{"date":68,"type":21},"2028-12",{"name":70,"class":43},"Sahlgrenska University Hospital",{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":78,"targetDuration":80,"studyType":81,"phases":4,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":44},"100630296","zimmer-biomet-ribfix-titan-100630296","NCT07485829","Zimmer Biomet-RibFix Titan","Zimmer Biomet Patient Outcomes and Experience After Chest Wall Repair With RibFix Titan™","Inclusion Criteria:\n\n1. At least 18 years of age\n2. Willing and able to sign an Institutional Review Board (IRB) approved Informed Consent Form and able to comply with study requirements, in the Investigator's opinion\n3. Independent of study participation, patient qualifies for fixation, stabilization, and\u002For fusion of rib fractures or osteotomies of normal and osteoporotic bone with the study device\n\nExclusion Criteria:\n\n1. Midline Sternotomy: sternotomy incisions crossing the midline\n2. Active Infection: patients should not have any ongoing infections\n3. Material Sensitivity: where sensitivity to materials is suspected, comprehensive testing should be conducted before implantation\n4. Inability to Adhere to Post-operative Care: Patients must have the ability and willingness to comply with post-operative care instructions, which may not be possible for individuals with certain mental or neurological conditions\n5. Patients not expected to survive the duration of follow-up due to the involvement of trauma situations\n6. Patients with a history of alcohol or substance abuse, as well as vulnerable populations such as prisoners and pregnant women",{"count":79,"type":21},54,"1 Year","OBSERVATIONAL","Prospective, single-center, non-randomized, single-cohort, post-market clinical follow-up study to confirm the safety, performance, and clinical benefits for the use of the RibFix Titan™ system implants and instrumentation) in the fusion, stabilization, and fixation of fractures in the chest wall including rib reconstructive surgical procedures, trauma, or planned osteotomies.",[84,28],"Rib Fracture",[86],"RibFix Titan","2026-04-15",{"date":89,"type":36},"2026-04-21",{"date":91,"type":36},"2026-03-31",{"date":93,"type":21},"2028-03",{"name":95,"class":96},"Zimmer Biomet","INDUSTRY",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":103,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":106,"briefSummary":107,"conditions":108,"keywords":116,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":123,"startDateStruct":125,"completionDateStruct":127,"leadSponsor":129,"locationsCount":44},"100557114","percutaneous-cryoablation-of-intercostal-nerves-for-the-treatment-of-rib-fractures-100557114","NCT06533904","Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures","Inclusion Criteria:\n\n* \\> 18 years old\n* \\> 2 rib fractures\n* Verbal Pain score \\> 5\n* Incentive Spirometry \\\u003C 60% of predicted\n\nExclusion Criteria:\n\n* Isolated Fractures of Ribs 1-3 and\u002For 10-12\n* Posterior Rib Fracture \\\u003C 4 cm from costovertebral joint\n* Sternal, Clavicle, Scapula Fracture\n* Thoracic Spinal Fracture of any type\n* Open Abdominothoracic Surgery\n* Unstable Spine\n* Extensive Subcutaneous Emphysema\n* BMI \\> 35\n* Plan for Rib Plating\n* Chronic Opioid Use\n* Prior to study enrollment: Intubated, Traumatic Brain Injury, Dementia, Cognitive Impairment, Encephalopathy\n* Coagulopathy, Shock at time of ablation\n* Inability to participate in activities of daily living prior to injury\n* Home O2 use prior to trauma\n* Inhalation Injury\n* Rib Fractures due to cardiopulmonary resuscitation\n* Life Expectancy \\\u003C 6 months\n* \\> 48 hours from injury\n* Pregnant, Incarcerated",true,{"count":105,"type":21},30,[24],"The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes. The main questions it aims to answer are:\n\nDoes percutaneous cryoablation improve short and long term pain scores? Does percutaneous cryoablation improve short and long term respiratory mechanics? Does percutaneous cryoablation improve long term quality of life? Does percutaneous cryoablation decrease delirium?\n\nResearchers will compare cryoablation to standard multimodal pain therapy to see if this impacts respiratory recovery.\n\nParticipants will undergo randomization, percutaneous cryoablative procedure, and participate in tests at pre-determined intervals to evaluate their pulmonary recovery.",[109,58,110,111,112,113,28,114,115],"Trauma","Chest Wall Disorder","Respiratory Insufficiency","Pain, Chest","Rib Trauma","Respiratory Failure","Respiratory Distress Syndrome",[109,114,117,111,58,118,119,120,121],"Respiratory Distress","Chest Wall Trauma","Percutaneous Cryoablation","Multimodal Pain Therapy","Multimodal Pain Regimen","2026-02-05",{"date":124,"type":36},"2026-02-09",{"date":126,"type":21},"2026-09",{"date":128,"type":21},"2028-07",{"name":130,"class":43},"Loma Linda University",{"id":132,"slug":133,"hasResults":11,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":150,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":154,"lastUpdatePostDateStruct":155,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":44},"100505741","ultrasound-guided-percutaneous-intercostal-nerve-cryoneurolysis-for-analgesia-following-traumatic-rib-fracture-100505741","NCT05865327","UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture","UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture, a Pilot Randomized Control Trial (UNPIN Trial)","UNPIN","Inclusion Criteria:\n\n* Aged ≥18\n* Unilateral traumatic rib fractures (3 to 8)\n* Candidate for ESP block catheter\n* Within 48hrs of admission to hospital\n\nExclusion Criteria:\n\n* Lack of patient consent; unlikely to comply with follow up\n* Unable to use Patient Controlled Regional Analgesia (Ventilated\u002Fsedated patients or Moderate to severe traumatic brain injury)\n* Chronic pain (opioid use \\> 30mg oral morphine equivalent per day)\n* Substance use disorder\n* CrCl \\\u003C 50\n* BMI \\> 45\n* Significant distracting injuries (unreduced long bone fractures, unstable pelvic or spine fractures and patients requiring trauma laparotomy- also preclude positioning for block placement (lateral decubitus or sitting up))\n* Contraindications for ESP catheter placement (pre-existing medical\u002Fneurological\u002Fhematologic diseases, localized infection\u002Ftrauma at site of intervention, allergy to amide local anesthetics)\n* Contraindications to CN (cryoglobulinemia, paroxysmal cold hemoglobinuria, multiple myeloma and cold urticarial).\n* Unable to return to Trauma Recovery Clinic (in-person or virtual) at 3 months","100 Years",{"count":141,"type":21},24,[24],"Traumatic rib fractures (i.e., broken ribs caused by a physical injury) are common and very painful. They also often lead to serious complications, more time spent in hospital, and can even lead to death. Even after rib fractures have healed, they can lead to long-term pain and a lower quality of life.\n\nA technology called cryoneurolysis, which acts to freeze nerves causing pain using a small tool which can turn very cold, is a promising new way to manage rib fracture pain. This study is a test with a small number of people to see if it is feasible to use this technology for patients with rib fractures. If this is successful, we will recruit more people for a larger study to see if cryoneurolysis, along with standard pain control techniques, is better at stopping pain, compared to just the normal techniques alone. Participants in our study will be asked to rate their pain, and record pain medications that they take for 3 months after their pain procedure.",[58,28,145,146,147,148,109,149],"Rib; Fracture, With Flail Chest","Pain","Pain, Acute","Pain, Chronic","Trauma Injury",[151,152,153],"Cryoneurolysis","Rib Fracture Pain","Intercostal Nerve Block","2025-09-05",{"date":156,"type":36},"2025-09-12",{"date":158,"type":36},"2023-10-23",{"date":160,"type":21},"2025-12",{"name":162,"class":43},"Sunnybrook Health Sciences Centre",{"id":164,"slug":165,"hasResults":11,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":168,"eligibilityCriteria":169,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":170,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":172,"conditions":173,"keywords":176,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":44},"100595462","assessment-of-morbidity-and-mortality-following-serratus-anterior-plane-block-sapb-for-unilateral-rib-fractures-100595462","NCT07032766","Assessment of Morbidity and Mortality Following Serratus Anterior Plane Block (SAPB) for Unilateral Rib Fractures","SAPB","Inclusion Criteria:\n\n* Patients over 18 years of age being treated in the Emergency Department at Jacobi Medical Center\n* Presenting within 24 hours of injury\n* Patient with 2 or more unilateral, anterior or lateral rib fractures\n* Able to provide consent (patient or health care proxy)\n* Clinical team believes the patient will require inpatient admission at the time of enrollment\n\nExclusion Criteria:\n\n* Patients in traumatic arrest or hemodynamic instability\n* Patient expected to be discharged from the hospital within 24 hours\n* Prisoner\n* Pregnancy\n* Children less than 18 years of age\n* The patient is known or is suspected to be allergic to anesthetic\n* Significant pain from another traumatic and distracting injury\n* Patients without the ability to consent (or no health care proxy to consent)\n* Patients with bilateral or posterior rib fractures",{"count":171,"type":21},220,"The goal of this observational study is to learn about the long-term effects of the serratus anterior plane block (SAPB) in adult patients who suffered multiple unilateral anterolateral rib fractures within 24 hours of patient presentation to the emergency department. The main question it aims to answer is:\n\nDoes the SAPB for multiple anterolateral rib fractures demonstrate reduction in patient morbidity and mortality, including incidence of pneumonia, length of hospital stay, discharge disposition, and death, as compared to standard analgesic regimens.\n\nThe SAPB will be performed if a physician trained in the SAPB is available within 24 hours of injury. If a trained physician is not available and the patient meets inclusion criteria, they will receive parental analgesia with opioid therapy. They will be followed until date of hospital discharge, up until 60 days.",[174,28,175],"Pain Management","Serratus Anterior Plane Block",[177,178,179,180],"serratus anterior plane block","rib fractures","mortality","morbidity","2025-08-11",{"date":183,"type":36},"2025-08-13",{"date":185,"type":36},"2025-08-10",{"date":187,"type":21},"2026-08",{"name":189,"class":43},"Albert Einstein College of Medicine",{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":4,"eligibilityCriteria":196,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":197,"targetDuration":4,"studyType":22,"phases":199,"briefSummary":200,"conditions":201,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":44},"100496755","ultrasound-guided-serratus-anterior-plane-block-for-rib-fractures-100496755","NCT05748366","Ultrasound Guided Serratus Anterior Plane Block for Rib Fractures","Ultrasound Guided Serratus Anterior Plane Block Versus Standard Therapy for Analgesic Relief of Rib Fractures in the Emergency Department","Inclusion Criteria:\n\n* Age \\>18 years\n* \\>1 Unilateral, acute rib fractures diagnosed on x-ray or CT imaging\n* Patient presenting to the WellSpan York Hospital ED\n* Patient requiring IV analgesia or oral opioid to control pain related to rib fractures\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Inability to provide informed consent\n* Allergy to local anesthesia\n* Subsequent visit for rib fractures\n* Patients taken emergently to the OR or discharged from the ED\n* Significant distracting injuries\u002Fpolytrauma that would not be expected to be responsive to analgesia from SAPB and confound pain scores, i.e. long bone fractures, intraabdominal injuries, etc.",{"count":198,"type":21},60,[24],"This study is a single center, randomized controlled trial examining the effect of serratus anterior plane block (SAPB) on pain, PIC scores and other clinical outcomes in emergency department patients with multiple rib fractures in comparison to the use of analgesic medication alone.\n\nObjectives\n\n1. Compare SAPB performed in the ED setting to analgesic medication alone with regard to pain, respiratory status and PIC score of patients with multiple rib fractures.\n2. Assess the safety and feasibility of performing ultrasound-guided SAPB in the ED.\n3. Evaluate outcomes of patients receiving the SAPB in the ED including amount of analgesic medications used, level of care required, need for upgrading level of care, and length of stay.",[28],"2025-07-15",{"date":204,"type":36},"2025-07-18",{"date":206,"type":36},"2023-03-31",{"date":208,"type":21},"2027-06-30",{"name":210,"class":43},"WellSpan Health"]