[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rib-fractures\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rib-fractures":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,40,68,98,120,155,178,202,236,267,298,318,343,366],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100447358","evaluation-of-serratus-plane-block-on-the-respiratory-pattern-in-patients-with-multiple-rib-fractures-100447358",false,"NCT05105399","Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures","Evaluation of Serratus Plane Block on the Respiratory Pattern in Patients With Multiple Rib Fractures: a Perspective Randomized Controlled Study","Inclusion Criteria:\n\n1. Chest trauma with at least 2 monolateral rib fractures (monofocal or multifocal) with no flail chest\n2. Age\\>18 years\n3. Hospital admission\n4. Ability to provide written informed consensus\n5. Awake patient, spontaneous ventilation","ALL",{"count":18,"type":19},72,"ESTIMATED","INTERVENTIONAL",[22],"NA","In patients admitted following a trauma, the incidence of multiple rib fractures is reported to be 9,7%, and this can be even higher in high energy trauma like motor vehicle accidents (1). Pain deriving from rib fractures cause the patient to breath shallow in order to limit discomfort and this bring about negative consequences: shallow breathing and inability to clear secretions may cause pulmonary atelectasis eventually evolving to pneumonia. Given the aforementioned concerns, it is easy to understand why, in a context like this, control of chest pain become crucial. The best way to achieve adequate pain control have not yet been established: the aim of this study is to investigate on this clinical dilemma. In this study, 72 people with at least two monolateral rib fractures are going to be randomized into three groups: 1) standard treatment alone (intravenous analgesia: acetaminophen + morphine PCA); 2) continuous serratus plane block + standard treatment; 3) single-shot serratus plane block + standard treatment. The variables that are going to be recorded are the following: pain through the NRS scale, FEV1 and FVC through spirometry and finally an arterious gas analysis. Recording are going to be repeated at 72h after admission. The primary endpoint is to evaluate if the continuous serratus plane block is able to improve the FEV1\u002FFVC compared to single shot or standard treatment alone. Secondary endpoints will be: the effect of continuous block on 1) resting and incident pain; 2) opioid consumption; 3) blood gas analysis parameters; 4) pulmonary complications at 1 month; 5) length of stay",[25,26],"Rib Fractures","Spirometry","NOT_YET_RECRUITING","2026-04-13",{"date":30,"type":31},"2026-04-16","ACTUAL",{"date":33,"type":19},"2026-06-01",{"date":35,"type":19},"2027-05-01",{"name":37,"class":38},"Niguarda Hospital","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":20,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":39},"100581645","deep-breathing-exercises-and-incentive-spirometry-after-rib-fracture-100581645","NCT06853002","Deep Breathing Exercises and Incentive Spirometry After Rib Fracture","Comparison Between Deep Breathing Exercises and Incentive Spirometry After Rib Fracture","Inclusion Criteria:\n\n* Patients who developed rib fractures due to thoracic trauma\n\nExclusion Criteria:\n\n* Patients who are unconscious\n* Patients with a history of chronic obstructive pulmonary disease or asthma\n* Patients with an Injury Severity Score (ISS) ≥ 16\n* Patients who require mechanical ventilation","18 Years","80 Years",{"count":50,"type":19},104,[22],"Chest trauma patients constitute approximately 10-15% of all traffic accidents. Many complications may occur after chest trauma, including rib fracture, pneumothorax, hemothorax, lung contusion, flail chest, atelectasis, respiratory failure and even death. Atelectasis is the most common of these complications. This study planned to investigate the effects of spirometry and deep breathing exercises on oxygenation after rib fracture.",[25,54],"Oxygenation",[25,56,57],"Breathing exercises","Postoperative complications","RECRUITING","2026-03-13",{"date":61,"type":31},"2026-03-16",{"date":63,"type":31},"2025-02-15",{"date":65,"type":19},"2026-11-01",{"name":67,"class":38},"Samsun University",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":20,"phases":78,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":39},"100564219","blue-light-as-an-anti-inflammatory-and-analgesic-strategy-in-thoracic-trauma-100564219","NCT06626334","Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma","Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma: A Randomized Controlled Trial in Adults With Rib Fractures","BLAASTT","Inclusion Criteria:\n\n* Age greater than or equal to 18 years\n* Admitted to a single large academic level I trauma center (Presbyterian\u002FMontefiore hospital) within the first 48 hours of traumatic injury\n* Greater than or equal to 1 acute rib fracture\n* Pain related to rib fracture(s), by one or more of the following criteria: 1. Pain \\>\u002F= 4\u002F10 at rest, 2. Pain \\>\u002F= 4\u002F10 with incentive spirometer (IS) use, and\u002For 3. Inspiratory volume \\\u003C 1000 cc\n* Anticipated length of stay greater than or equal to 48 hours\n* Alert, with capacity to provide informed consent\n\nExclusion Criteria:\n\n* Mechanical ventilation\\* or non-invasive positive pressure ventilation administered for respiratory insufficiency prior to the time of informed consent\n* Delirium (positive CAM screening) at the time of informed consent\n* Ocular trauma, which may interfere with the mechanism of action\n* Traumatic brain injury (TBI) or history of TBI or stroke, which may interfere with the mechanism of action\n* Splenectomy upon admission or history of splenectomy, which may interfere with the mechanism of action\n* History of significant ocular dysfunction\\*\\* (i.e., macular degeneration, glaucoma, cataracts), which may interfere with the mechanism of action\n* History of cataract surgery, due to the possibility of blue light filtering intraocular lens placement\n* History of bipolar disorder or schizophrenia, which could increase the risk of an adverse reaction to light exposure (i.e., acute mania)\n* History of dementia, which would compromise the reliability of pain intensity and delirium measures\n\n  * Or other condition in which a patient cannot open eyes to receive light intervention or report a pain score \\*\\*Myopia, hyperopia, and\u002For astigmatism corrected for with contact lenses or spectacle corrective eyeglasses will NOT be a criterion for exclusion",{"count":77,"type":19},75,[22],"The main goal of this clinical trial is to learn if light therapy improves pain and inflammation in adults with painful rib fractures. The main question it aims to answer is:\n\n\\- Does bright blue light therapy in addition to standard pain treatments improve pain with breathing in adults with painful rib fractures?\n\nResearchers will compare participants who receive bright blue light therapy to participants who receive white light therapy and participants who receive only usual lighting conditions to look for differences in their pain control. In addition to their assigned light treatment, all participants will receive standard pain control treatments.\n\nParticipants will be assigned randomly to one of three groups: one-third will be assigned to bright blue light therapy, one-third will be assigned to bright white light therapy, and one-third will be assigned to usual light only. They will receive their assigned light treatment for 4 hours during the morning\u002Fearly afternoon for up to 3 days while they are in the hospital. On each day they receive the light treatment and on the day after their final light treatment:\n\n* They will be asked twice to rate their pain at rest and with taking a deep breath.\n* They will be tested to confirm that they are not experiencing delirium, or confusion related to being in the hospital.\n* Blood samples will be collected to look for changes in inflammation and the circadian clock, the body's natural 24-hour cycle.",[25,81],"Pain, Acute",[83,84,85,86,87,88],"Light Therapy","Blue Light Therapy","Pain Control","Analgesia","Immunomodulation","Bright Light Therapy","2026-03-02",{"date":91,"type":31},"2026-03-04",{"date":93,"type":31},"2024-10-23",{"date":95,"type":19},"2026-08",{"name":97,"class":38},"Rebecca E Kotcher, MD",{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":20,"phases":107,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":39},"100542823","phase-4-cryo-rib-fracture-study-100542823","NCT06347874","Cryo Rib Fracture Study","Comparison of Cryoablation of Intercostal Nerves to Erector Spinae Plane Catheters in Patients With Rib Fractures","Inclusion Criteria:\n\n* Patients who are over 18 who have more than one ribs fractured.\n\nExclusion Criteria:\n\n* Patients who have an exclusion to regional anesthesia.\n* Patients who are pregnant via self-report or pregnancy test if they take one.\n* Non-English speakers\n* Patients who have cold urticaria\n* Patients with bilateral fractures\n* Patients currently intubated",{"count":106,"type":19},48,[108],"PHASE4","The purpose of this study is to determine if patients with rib fractures who undergo cryoablation of the intercostal nerves have improved pain control 7 days from procedure when compared to those who have a ESP catheter.",[25],"2026-02-13",{"date":113,"type":31},"2026-02-17",{"date":115,"type":31},"2025-01-10",{"date":117,"type":19},"2027-03-13",{"name":119,"class":38},"University of Minnesota",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":126,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":127,"targetDuration":4,"studyType":20,"phases":129,"briefSummary":130,"conditions":131,"keywords":140,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":146,"lastUpdatePostDateStruct":147,"startDateStruct":149,"completionDateStruct":151,"leadSponsor":153,"locationsCount":39},"100557114","percutaneous-cryoablation-of-intercostal-nerves-for-the-treatment-of-rib-fractures-100557114","NCT06533904","Percutaneous Cryoablation of Intercostal Nerves for the Treatment of Rib Fractures","Inclusion Criteria:\n\n* \\> 18 years old\n* \\> 2 rib fractures\n* Verbal Pain score \\> 5\n* Incentive Spirometry \\\u003C 60% of predicted\n\nExclusion Criteria:\n\n* Isolated Fractures of Ribs 1-3 and\u002For 10-12\n* Posterior Rib Fracture \\\u003C 4 cm from costovertebral joint\n* Sternal, Clavicle, Scapula Fracture\n* Thoracic Spinal Fracture of any type\n* Open Abdominothoracic Surgery\n* Unstable Spine\n* Extensive Subcutaneous Emphysema\n* BMI \\> 35\n* Plan for Rib Plating\n* Chronic Opioid Use\n* Prior to study enrollment: Intubated, Traumatic Brain Injury, Dementia, Cognitive Impairment, Encephalopathy\n* Coagulopathy, Shock at time of ablation\n* Inability to participate in activities of daily living prior to injury\n* Home O2 use prior to trauma\n* Inhalation Injury\n* Rib Fractures due to cardiopulmonary resuscitation\n* Life Expectancy \\\u003C 6 months\n* \\> 48 hours from injury\n* Pregnant, Incarcerated",true,{"count":128,"type":19},30,[22],"The goal of this double blinded randomized control trial is to learn if percutaneous cryoablation of traumatic rib fractures improves outcomes. The main questions it aims to answer are:\n\nDoes percutaneous cryoablation improve short and long term pain scores? Does percutaneous cryoablation improve short and long term respiratory mechanics? Does percutaneous cryoablation improve long term quality of life? Does percutaneous cryoablation decrease delirium?\n\nResearchers will compare cryoablation to standard multimodal pain therapy to see if this impacts respiratory recovery.\n\nParticipants will undergo randomization, percutaneous cryoablative procedure, and participate in tests at pre-determined intervals to evaluate their pulmonary recovery.",[132,25,133,134,135,136,137,138,139],"Trauma","Chest Wall Disorder","Respiratory Insufficiency","Pain, Chest","Rib Trauma","Rib Fracture Multiple","Respiratory Failure","Respiratory Distress Syndrome",[132,138,141,134,25,142,143,144,145],"Respiratory Distress","Chest Wall Trauma","Percutaneous Cryoablation","Multimodal Pain Therapy","Multimodal Pain Regimen","2026-02-05",{"date":148,"type":31},"2026-02-09",{"date":150,"type":19},"2026-09",{"date":152,"type":19},"2028-07",{"name":154,"class":38},"Loma Linda University",{"id":156,"slug":157,"hasResults":11,"nctId":158,"briefTitle":159,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":20,"phases":165,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":169,"lastUpdatePostDateStruct":170,"startDateStruct":172,"completionDateStruct":174,"leadSponsor":176,"locationsCount":39},"100433759","phase-3-low-dose-dexmedetomidine-versus-normal-saline-in-multiple-fracture-ribs-100433759","NCT04928300","Low Dose Dexmedetomidine Versus Normal Saline in Multiple Fracture Ribs","Diaphragmatic Function, Pain Quality & Anti-inflammatory Properties: A Low Dose Dexmedetomidine Versus Ketamine in Patients With Multiple Fracture Ribs Needing Conservative Treatment","Inclusion Criteria:\n\n* Adults (age 18-65 years) of American Society of Anaesthesiologists (ASA) physical status I-II\n* Traumatic multiple fracture ribs 3 ribs or more, who will be subjected to thorough assessments including chest 3D-CT\n* Undergoing conservative treatment (chest strappings)\n* Intractable pain with visual analogue scale (VAS) over 6 after traditional therapies\n* Glasgow Coma Scale (GCS) ≥ 13.\n\nExclusion Criteria:\n\n* Multiple traumas to body parts other than chest with an abbreviated injury scale over 3\n* Serious head trauma with a Glasgow coma scale lower than 13\n* Mechanically ventilated patients\n* Massive hemothorax\n* Injury to the trachea or bronchus with requirement for immediate surgery\n* Dementia\n* Use of corticosteroids during ICU stay\n* Sepsis\n* Continued use of neuromuscular blocking agents and aminoglycosides antibiotic use as they are known risk factors for ICU-acquired weakness and any known hypersensitivity\n* Contraindication to the study drugs.","65 Years",{"count":164,"type":19},60,[166],"PHASE3","In our study, we assess the diaphragmatic function, pain quality and anti-inflammatory properties between low dose infusion of dexmedetomidine normal saline in patients with multiple fracture ribs on conservative treatment.",[25],"2025-12-27",{"date":171,"type":31},"2026-01-02",{"date":173,"type":31},"2021-06-12",{"date":175,"type":19},"2027-07-25",{"name":177,"class":38},"Assiut University",{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":185,"targetDuration":4,"studyType":20,"phases":187,"briefSummary":188,"conditions":189,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":196,"completionDateStruct":198,"leadSponsor":200,"locationsCount":39},"100611284","effectiveness-of-an-innovative-chest-stabilizer-in-rib-fracture-treatment-impact-on-respiratory-function-complications-and-clinical-outcomes-100611284","NCT07238582","Effectiveness of an Innovative Chest Stabilizer in Rib Fracture Treatment: Impact on Respiratory Function, Complications, and Clinical Outcomes","Effectiveness of an Innovative Chest Stabilizer in the Treatment of Rib Fractures: Impact on Respiratory Function, Complications, and Clinical Outcomes","Inclusion Criteria:\n\nAdults aged 18 to 80 years. Blunt chest trauma with at least three rib fractures confirmed by imaging. Numeric Rating Scale (NRS) pain score ≥ 5 at rest, during deep inspiration, or with movement.\n\nAble to perform spirometry reliably (FVC, FEV1, PEF). Hemodynamically stable and medically suitable for participation. Able and willing to provide informed consent.\n\nExclusion Criteria:\n\nAge younger than 18 or older than 80 years. Penetrating chest trauma. Patients who have undergone surgical rib fixation. Active pneumonia, clinically significant atelectasis, or severe pulmonary infection at admission.\n\nUncontrolled cardiovascular, renal, or hepatic disease. Severe cognitive impairment, psychiatric disorders, or inability to comply with study procedures.\n\nSevere respiratory failure requiring invasive mechanical ventilation. Skin infection, open wounds, or dermatologic conditions preventing stabilizer application.\n\nCoagulopathy or contraindications to external chest compression. Pregnancy. Refusal or inability to give informed consent.",{"count":186,"type":19},74,[22],"This study aims to evaluate the effectiveness of an innovative, non-invasive chest stabilizer in patients with multiple rib fractures caused by blunt chest trauma. Rib fractures often lead to severe pain, breathing difficulties, and complications such as pneumonia or atelectasis. Participants will be randomly assigned to one of two groups: standard pain management or the new chest stabilizer, which will be used for 10 days.\n\nThe study will assess improvements in pain levels, breathing function (including FVC, FEV1, and PEF), and the occurrence of lung-related complications. Additional outcomes such as hospital stay, patient comfort, and skin reactions related to the device will also be evaluated. The goal of this research is to determine whether the innovative stabilizer can provide safer, more comfortable, and more effective treatment compared with current standard care for rib fracture patients.",[25,190,191,192],"Blunt Chest Trauma","Thoracic Injuries","Pulmonary Complications","2025-11-16",{"date":195,"type":31},"2025-11-20",{"date":197,"type":19},"2025-12-01",{"date":199,"type":19},"2027-12-01",{"name":201,"class":38},"Caner İşevi, MD",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":207,"acronym":4,"eligibilityCriteria":208,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":20,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":227,"lastUpdatePostDateStruct":228,"startDateStruct":230,"completionDateStruct":232,"leadSponsor":234,"locationsCount":39},"100557458","clinical-utility-of-portable-dynamic-chest-x-ray-ddr-in-the-icu-100557458","NCT06538376","Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU","Clinical Utility of Portable Dynamic Chest X-Ray (DDR) in the ICU: Clinical Trial to Demonstrate the Feasibility of Deploying DDR Technology in the ICU - A Study to Prove Its Increased Diagnostic Value","Inclusion Criteria: Participants must meet all the following inclusion criteria to participate in this study:\n\n* Adults (at least 18 years of age) including both intubated\u002Fventilated and non-intubated patients\n* Likely to have pathology related to either, abnormal diaphragmatic excursion and lung aeration, pulmonary perfusion, increased lung water content or all the above, as well as for cricopharyngeal dysfunction\u002Fswallowing difficulties at risk for aspiration.\n* The subject or a legally authorized representative has provided written informed consent.\n\nExclusion Criteria: Candidates meeting any of the exclusion criteria at baseline will be excluded from study participation. These criteria are:\n\n* Special populations, including women with known pregnancy, prisoners, or institutionalized individuals\n* Patients where additional radiation is clinically contraindicated\n* Care team does not provide assent for approaching patient\u002Fsurrogate\n* For women of child-bearing potential, defined as premenopausal women, a pregnancy test will be administered to determine pregnancy status and confirm eligibility for the study. A pregnancy test will NOT be administered to women who are post-menopausal or have documentation of surgical sterilization.",{"count":210,"type":19},230,[22],"Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second. It is coupled with an analytical software that allows it to provide more advanced measures of lung motion, ventilation, and perfusion compared to traditional chest radiography. While implementation of DDR fixed machines are beginning elsewhere in the US, this trial involves the first applications of an FDA-approved portable DDR machine, for use at the bedside in the ICU.\n\nThe goal of this clinical trial is to determine the feasibility and safety of portable DDR technology in the ICU, as well as to evaluate the improved clinical diagnostic value of the portable DDR system over current standards of care.\n\nParticipants will receive one to three sets of DDR images, which will then be compared to their clinical gold standard exams (such as chest x-rays, CTs, or VQ scans) to assess and improve the precision and accuracy of measurements such as diaphragmatic motion, lung movement, and perfusion.",[214,215,216,217,218,219,25,220,221,222,223,224,225,226],"Pulmonary Edema","Pneumonia","Atelectasis","Pleural Effusion","Acute Rejection of Lung Transplant (Disorder)","Airway Obstruction","Acute Copd Exacerbation","Asthma COPD","Pulmonary Embolism","Hemothorax","Pneumothorax","Mesothelioma","Diaphragmatic Paralysis","2025-10-28",{"date":229,"type":31},"2025-10-29",{"date":231,"type":31},"2023-12-12",{"date":233,"type":19},"2027-11",{"name":235,"class":38},"Brigham and Women's Hospital",{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":20,"phases":245,"briefSummary":246,"conditions":247,"keywords":248,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":39},"100488585","phase-4-intercostal-nerve-block-efficacy-of-cinb-for-patients-with-multiple-rib-fractures-100488585","NCT05642026","INTERCOSTAL NERVE BLOCK: Efficacy of CINB for Patients With Multiple Rib Fractures","The Efficacy of Continuous Intercostal Nerve Blocks in the Treatment of Patients With Multiple Rib Fractures","Inclusion Criteria:\n\n* Subjects will be at least 18 years old\n* Subjects will have 2 or more identified rib fractures\n* Subjects will be willing to provide informed consent for procedure\n* Subjects will be identified as appropriate for initiation of continuous nerve block therapy for treatment of rib fracture associated pain.\n\nExclusion Criteria:\n\n* Documented allergy to study medication\n* Epidural catheter use\n* Prisoners\n* Refusal of CINB therapy",{"count":244,"type":19},180,[108],"This is a prospective, randomized, non-blinded study comparing CINB plus medical therapy versus standard medical care (non-steroidals and opioids intravenous\u002Foral inpatient and oral outpatient) alone for patients with multiple rib fractures. The objective of this study is to analyze the effect of continuous intercostal nerve block (CINB) in the treatment of patients admitted to the adult trauma service with rib fractures. The effectiveness of CINB as adjunctive treatment will be compared to standard medical therapy involving nonsteroidal and intravenous\u002Foral opioid medications.",[25],[249,250,251,252,253,254,255,256,257],"intercostal","nerve block","opioid","non steroidal","inpatient","outpatient","catheter","anesthetic","epidural","2025-10-01",{"date":260,"type":31},"2025-10-07",{"date":262,"type":31},"2025-09-23",{"date":264,"type":19},"2027-02-01",{"name":266,"class":38},"Zachary Warriner",{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":20,"phases":278,"briefSummary":279,"conditions":280,"keywords":285,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":39},"100505741","ultrasound-guided-percutaneous-intercostal-nerve-cryoneurolysis-for-analgesia-following-traumatic-rib-fracture-100505741","NCT05865327","UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture","UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture, a Pilot Randomized Control Trial (UNPIN Trial)","UNPIN","Inclusion Criteria:\n\n* Aged ≥18\n* Unilateral traumatic rib fractures (3 to 8)\n* Candidate for ESP block catheter\n* Within 48hrs of admission to hospital\n\nExclusion Criteria:\n\n* Lack of patient consent; unlikely to comply with follow up\n* Unable to use Patient Controlled Regional Analgesia (Ventilated\u002Fsedated patients or Moderate to severe traumatic brain injury)\n* Chronic pain (opioid use \\> 30mg oral morphine equivalent per day)\n* Substance use disorder\n* CrCl \\\u003C 50\n* BMI \\> 45\n* Significant distracting injuries (unreduced long bone fractures, unstable pelvic or spine fractures and patients requiring trauma laparotomy- also preclude positioning for block placement (lateral decubitus or sitting up))\n* Contraindications for ESP catheter placement (pre-existing medical\u002Fneurological\u002Fhematologic diseases, localized infection\u002Ftrauma at site of intervention, allergy to amide local anesthetics)\n* Contraindications to CN (cryoglobulinemia, paroxysmal cold hemoglobinuria, multiple myeloma and cold urticarial).\n* Unable to return to Trauma Recovery Clinic (in-person or virtual) at 3 months","100 Years",{"count":277,"type":19},24,[22],"Traumatic rib fractures (i.e., broken ribs caused by a physical injury) are common and very painful. They also often lead to serious complications, more time spent in hospital, and can even lead to death. Even after rib fractures have healed, they can lead to long-term pain and a lower quality of life.\n\nA technology called cryoneurolysis, which acts to freeze nerves causing pain using a small tool which can turn very cold, is a promising new way to manage rib fracture pain. This study is a test with a small number of people to see if it is feasible to use this technology for patients with rib fractures. If this is successful, we will recruit more people for a larger study to see if cryoneurolysis, along with standard pain control techniques, is better at stopping pain, compared to just the normal techniques alone. Participants in our study will be asked to rate their pain, and record pain medications that they take for 3 months after their pain procedure.",[25,137,281,282,81,283,132,284],"Rib; Fracture, With Flail Chest","Pain","Pain, Chronic","Trauma Injury",[286,287,288],"Cryoneurolysis","Rib Fracture Pain","Intercostal Nerve Block","2025-09-05",{"date":291,"type":31},"2025-09-12",{"date":293,"type":31},"2023-10-23",{"date":295,"type":19},"2025-12",{"name":297,"class":38},"Sunnybrook Health Sciences Centre",{"id":299,"slug":300,"hasResults":11,"nctId":301,"briefTitle":302,"officialTitle":302,"acronym":4,"eligibilityCriteria":303,"healthyVolunteers":126,"sex":16,"minAge":47,"maxAge":304,"enrollmentInfo":305,"targetDuration":4,"studyType":20,"phases":307,"briefSummary":308,"conditions":309,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":310,"lastUpdatePostDateStruct":311,"startDateStruct":313,"completionDateStruct":315,"leadSponsor":317,"locationsCount":4},"100591538","ultrasound-guided-mid-point-transverse-process-to-pleura-block-versus-thoracic-paravertebral-block-for-pain-management-in-patients-with-multiple-rib-fractures-a-prospective-randomized-double--blinded-non-inferiority-trial--100591538","NCT06981728","Ultrasound-Guided Mid-Point Transverse Process to Pleura Block Versus Thoracic Paravertebral Block for Pain Management in Patients With Multiple Rib Fractures (A Prospective Randomized Double- Blinded, Non-inferiority Trial )","Inclusion Criteria:\n\n* Adult patients aged between 18 and 70 years, from both genders, who had uni lateral traumatic multiple rib fractures (three or more confirmed by a CT chest scan).\n\nExclusion Criteria:\n\n* Significant head injury\u002Funconsciousness (GCS less than 15).\n* Patients with Pain score \\>6.\n* those having significant trauma outside the chest wall, e.g., acute spine or pelvic fracture, severe traumatic brain or spinal cord injury, or abdominal visceral injuries.\n* Obese patients with body mass index ≥ 35.\n* coagulopathy.\n* History of drug allergy to local anesthetics.\n* Patient refusal.\n* Local infection at the injection site.\n* Opioid addiction.","70 Years",{"count":306,"type":19},70,[22],"The aim of our study is to investigate whether the analgesic effect of MTPB is non inferior to that of TPVB in trauma patients with multiple rib fractures.",[25],"2025-05-13",{"date":312,"type":31},"2025-05-21",{"date":314,"type":19},"2025-06",{"date":316,"type":19},"2027-09",{"name":177,"class":38},{"id":319,"slug":320,"hasResults":11,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":4,"eligibilityCriteria":324,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":48,"enrollmentInfo":325,"targetDuration":4,"studyType":20,"phases":327,"briefSummary":328,"conditions":329,"keywords":330,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":340,"leadSponsor":342,"locationsCount":39},"100575010","ultrasound-for-diagnosing-costochondral-joint-separation-100575010","NCT06766721","Ultrasound for Diagnosing Costochondral Joint Separation","Diagnostic Effectiveness of Ultrasound in Costochondral Joint Separation: A Prospective Study","Inclusion Criteria:\n\n* Patients aged 18 to 80 years\n* Patients with blunt thoracic trauma\n* Patients suspected of having costochondral joint separation\n* Patients who provide consent for ultrasound and CT imaging\n\nExclusion Criteria:\n\n* Patients under 18 or over 80 years of age\n* Patients with penetrating thoracic trauma\n* Patients with subcutaneous emphysema that prevents ultrasound evaluation\n* Patients allergic to ultrasound gel\n* Pregnant patients (as CT imaging is contraindicated)\n* Patients unable to undergo CT imaging\n* Patients who refuse to participate in the study\n* Obese patients (body mass index \\>30), as ultrasound evaluation may be challenging",{"count":326,"type":19},51,[22],"This study aims to evaluate the diagnostic effectiveness of ultrasound in detecting costochondral joint separation in patients with blunt thoracic trauma. By comparing ultrasound findings to computed tomography (CT) results, the study seeks to determine the sensitivity, specificity, and overall accuracy of ultrasound as a diagnostic tool. The results will help improve the diagnosis and management of costochondral injuries while minimizing radiation exposure. The study is a prospective, interventional trial conducted at Ondokuz Mayıs University Faculty of Medicine.",[25,191],[331,332,333,334,335],"Costochondral Joint Separation","Ultrasound","Blunt Thoracic Trauma","Thoracic Surgery","Computed Tomography","2025-03-29",{"date":338,"type":31},"2025-04-01",{"date":197,"type":19},{"date":341,"type":19},"2027-03-01",{"name":201,"class":38},{"id":344,"slug":345,"hasResults":11,"nctId":346,"briefTitle":347,"officialTitle":348,"acronym":349,"eligibilityCriteria":350,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":4,"enrollmentInfo":351,"targetDuration":4,"studyType":353,"phases":4,"briefSummary":354,"conditions":355,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":356,"lastUpdatePostDateStruct":357,"startDateStruct":359,"completionDateStruct":361,"leadSponsor":363,"locationsCount":365},"100547274","costal-fracture-assessment-for-relief-and-enhancement-of-quality-of-life-100547274","NCT06405841","Costal Fracture Assessment for Relief and Enhancement of Quality of Life","Costal Fracture Assessment for Relief and Enhancement of Quality of Life - CARE Study","CARE","Inclusion Criteria:\n\n* Patients with rib fractures\n\nExclusion Criteria:\n\n* cognitive impairment\n* chronic pain due to pathologic fractures\n* active cancer",{"count":352,"type":19},950,"OBSERVATIONAL","This study explores the impact of rib fractures on patient well-being and quality of life, aiming to identify effective interventions for pain relief and functional improvement. It investigates the long-term outcomes of conservative treatment for rib fractures, analyzing factors such as analgesic therapy, hospitalization duration, and respiratory infection rates. Anticipated results include a comprehensive assessment of patient quality of life and the potential translational implications for healthcare practice. Furthermore, the study aims to inform healthcare resource optimization, potentially guiding treatment decisions and improving patient outcomes within the National Health Service.",[25,136],"2024-11-18",{"date":358,"type":31},"2024-11-21",{"date":360,"type":19},"2025-01",{"date":362,"type":19},"2027-01",{"name":364,"class":38},"Ospedali Riuniti Trieste",4,{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":11,"sex":16,"minAge":47,"maxAge":275,"enrollmentInfo":373,"targetDuration":4,"studyType":20,"phases":375,"briefSummary":376,"conditions":377,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":382,"leadSponsor":384,"locationsCount":39},"100533170","breathing-exercise-for-rib-fracture-100533170","NCT06222333","Breathing Exercise for Rib Fracture","Can Breathing Exercise Reduce Pulmonary Complications in Rib Fractures: Randomized Prospective Study","Inclusion Criteria:\n\n* Isolated thoracic injury within 24 hours\n* Age between 18-100\n\nExclusion Criteria:\n\n* Pneumothorax and hemothorax requiring intervention at admission\n* Injury severity index \\>16\n* COPD, Atshma\n* Extrathoracic trauma",{"count":374,"type":19},62,[22],"Respiratory physiotherapy is routinely performed after thoracic surgery operations to increase lung expansion and prevent pulmonary complications such as atelectasis and pneumonia. It is a controversial issue whether respiratory physiotherapy reduces pulmonary complications in rib fractures. In our study, patients with rib fractures will be divided into two groups. In the control group, standard treatment consisting of routine analgesic treatments will be applied. In the other group, respiratory physiotherapy will be applied with triflu for 8 hours a day. At the end of the study, pulmonary complications in both groups will be compared.",[25,26],"2024-11-13",{"date":380,"type":31},"2024-11-14",{"date":378,"type":31},{"date":383,"type":19},"2026-04-01",{"name":385,"class":38},"Kastamonu University"]