[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"ridge-augmentation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:ridge-augmentation":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,73,90,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100538726","evaluation-of-free-gingival-graft-timing-100538726",false,"NCT06294587","Evaluation of Free Gingival Graft Timing","Evaluation of Free Gingival Graft Timing in Staged Guided Bone Regeneration: A Randomized Controlled Trial","Inclusion Criteria:\n\n* • At least 18 years old\n\n  * No uncontrolled medical conditions or medications that will affect their bone healing.\n  * Good oral hygiene is defined as a full-mouth plaque score ≤25%11.\n  * Must be able to read and understand the informed consent document.\n  * Has a need for implants to replace missing tooth\u002Fteeth in at least 1 quadrant of the mouth.\n  * Insufficient alveolar ridge width for endosseous implant placement, defined as 5 mm or less, as determined by bone sounding and CBCT scan.\n  * The patient and\u002For guardian is willing and able to comply with pre-operative and post-operative diagnostic and clinical evaluations required.\n  * The patient is not pregnant or breastfeeding.\n\nExclusion Criteria:\n\n* Active infectious diseases.\n\n  * Liver or kidney dysfunction\u002Ffailure.\n  * Uncontrolled diabetes (HbA1c ≥ 8.5).\n  * Active cancer treatment - such as active chemotherapy radiation therapy, or radiotherapy performed within ≤12 months from the procedure.\n  * Taking medications that will affect their bone healing (for example, bisphosphonates and long-term anti-inflammatory medications).\n  * Metabolic bone diseases that affect bone healing such as osteoporosis.\n  * Pregnant or lactating women (self-reported).\n  * Current tobacco and Marijuana smokers have 10 or more cigarettes per day, and former smokers (\\> 10 cigarettes) who quit \\< 10 ago (self-reported).\n  * Poor oral hygiene.\n  * Vertical loss of bone at the edentulous ridge.\n  * History of periodontal disease.\n  * The patient is pregnant or breastfeeding",true,"ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical trial aims to compare and evaluate the clinical outcomes between two distinct treatment sequences: free gingival graft surgery preceding guided bone regeneration and guided bone regeneration followed by free gingival graft.",[27,28],"Ridge Augmentation","Alveolar Mucosa",[27,30,31],"Attached mucosa","Dental implants","RECRUITING","2025-08-04",{"date":35,"type":36},"2025-08-06","ACTUAL",{"date":38,"type":36},"2024-08-12",{"date":40,"type":21},"2027-08-30",{"name":42,"class":43},"University of Alabama at Birmingham","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":44},"100584585","one-stage-ridge-splitting-using-2-different-techniques-in-maxilla-100584585","NCT06891261","One Stage Ridge Splitting Using 2 Different Techniques in Maxilla","Evaluation of Endosseous Implants in One Stage Ridge Splitting Using the Conventional Technique Versus the Use of Piezo Surgery in the Maxilla","Inclusion Criteria:\n\n* Patients with maxilla residual alveolar bone height not less than 8 mm.\n* Alveolar bone width from 5mm to 3mm.\n* Both genders.\n* At least single missing tooth.\n* Previous failed implants.\n* Tapered or cylinder cross sectioned alveolar bone defect pattern.\n\nExclusion Criteria:\n\n* Heavy smokers more than 20 cigarettes per day.\n* Patients with bone disease that may affect normal healing, example; hyperparathyroidism.\n* Patients had radiotherapy and chemotherapy in head and neck.\n* Patients had neoplasms in sites to be grafted.\n* Patients with Metabolic diseases uncontrolled diabetic patients, Glycated hemoglobin (Hb A1c) more than 7 mg\\\\dl.\n* Pregnant females.\n* Patients with Para functional habits, apprehensive and non-cooperative.\n* Bone pathology related to the site to be grafted.\n* Psychological problems, stress situation (socially or professionally), emotional instability, and unrealistic patients' expectations.\n* Intraoral soft and hard tissue pathology.\n* Systemic condition that contraindicates implant placement.\n* Under the age of 18 years.\n* Hourglass defects or defects with bone concavities and or undercuts.","20 Years","48 Years",{"count":55,"type":21},20,[24],"* The selected patients will be informed of the nature of the research work and informed consent will be obtained.\n* Patients of both groups will be subjected to CBCT.\n* Intra operative procedures (for both groups) followed by CBCT will be taken for every patient after 4 months.\n* Infiltration local anesthesia will be given to the patient (Articaine 4% 1:100 000 epinephrine)\n\nBoth the study and control group will receive:\n\n* In Recipient site, full thickness mucoperiosteal flap pyramidal flap, reflection using mucoperiosteal elevator.\n* The defective site is reevaluated.\n* Flap advancement inorder to allow tension free flap closure.\n* In the Study group: Piezo surgery bone inserts is used to cut crestal osteotomies.\n* In the Control group: Bone discs diameter is used.\n* Followed by, the use of bone chisels.\n* The point and pilot implant drills are used followed by bone expanders. Based on the preexisting bone, the defect morphology and bone quality. The implant is submerged below the alveolar crest to compensate for crestal bone resorption.\n* Following partial immobilization of the buccal bone segment either book or island pattern. The fixture is inserted submerged below the alveolar bone crest.\n\nFollowed by bone smoothening and roundation under external saline irrigation at recommended speed of 38000rpm and gear ratio 1:1 calibrated on fesiodespenser.\n\n* Xenogenic bone particle size of 0.5 mm to 1mm is going to be condensed into the dead space.\n* Recheck adequate flap advancement to allow tension free closure.\n* Double line closure using horizontal mattress followed by interrupted sutures to allow contact area and wound edge eversion.",[27,59],"Bone Augmentation",[61,62,63],"ridge augmentation","One stage ridge splitting in maxilla.","Piezo Surgery","2025-07-12",{"date":66,"type":36},"2025-07-16",{"date":68,"type":36},"2025-02-26",{"date":70,"type":21},"2025-10-31",{"name":72,"class":43},"Cairo University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":86,"startDateStruct":87,"completionDateStruct":88,"leadSponsor":89,"locationsCount":44},"100584589","one-stage-ridge-splitting-using-2-different-techniques-in-the-posterior-mandible-100584589","NCT06891313","One Stage Ridge Splitting Using 2 Different Techniques in the Posterior Mandible","Evaluation of Endosseous Implants in One Stage Ridge Splitting Using the Conventional Technique Versus the Use of Piezo Surgery in the Posterior Mandible Region (Randomized Clinical Trial)","Inclusion Criteria:\n\n* Patients with mandibular residual alveolar bone height not less than 8 mm.\n* Alveolar bone width from 5mm to 3mm.\n* Both genders.\n* At least single missing tooth.\n* Previous failed implants.\n* Tapered or cylinder cross sectioned alveolar bone defect pattern.\n\nExclusion Criteria:\n\n* Heavy smokers more than 20 cigarettes per day.\n* Patients with bone disease that may affect normal healing, example; hyperparathyroidism.\n* Patients had radiotherapy and chemotherapy in head and neck.\n* Patients had neoplasms in sites to be grafted.\n* Patients with Metabolic diseases uncontrolled diabetic patients, Glycated hemoglobin (Hb A1c) more than 7 mg\\\\dl.\n* Pregnant females.\n* Patients with Para functional habits, apprehensive and non-cooperative.\n* Bone pathology related to the site to be grafted.\n* Psychological problems, stress situation (socially or professionally), emotional instability, and unrealistic patients' expectations.\n* Intraoral soft and hard tissue pathology.\n* Systemic condition that contraindicates implant placement.\n* Under the age of 18 years.\n* Hourglass defects or defects with bone concavities and or undercuts.",{"count":55,"type":21},[24],"The selected patients will be informed of the nature of the research work and informed consent will be obtained.\n\nThe control group ridge splitting with simultaneous implants using the conventional technique and study group ridge splitting with simultaneous implants using the piezo surgery.\n\n* Pre operative procedures Patients of both groups will be subjected to CBCT.\n* Intra operative procedures (for both groups) followed by CBCT will be taken for every patient after 4 months.\n* Infiltration local anesthesia will be given to the patient (Articaine 4% 1:100 000 epinephrine).\n\nBoth the study and control group will receive:\n\n* In Recipient site, incision of full thickness mucoperiosteal flap inorder to obtain, three-line pyramidal flap, followed by flap reflection.\n* The defective site is reevaluated.\n* Flap advancement using periosteal releasing incision.\n* In the Study group: Piezo surgery bone inserts are used.\n* In the Control group: Bone discs diameter are used.\n* Followed by bone chisels.\n* The point and pilot implant drills are used followed by the sequential use of bone expanders. Based on the preexisting bone, the defect morphology and bone quality. The implant is submerged below the alveolar crest.\n* The fixture is inserted submerged below the alveolar bone crest followed by bone smoothening and roundation under external saline irrigation at recommended speed of 38000rpm and gear ratio 1:1 calibrated on fesiodespenser.\n* Xenogenic bone particle size of 0.5 mm to 1mm is going to be condensed into the dead space.\n* Recheck adequate flap advancement.\n* Double line closure using horizontal mattress sutures followed by interrupted sutures on top to allow contact area and wound edge eversion.",[27,59],[61,85,63],"One stage ridge splitting in posterior mandible.",{"date":66,"type":36},{"date":68,"type":36},{"date":70,"type":21},{"name":72,"class":43},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":99,"conditions":100,"keywords":101,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":44},"100573488","reconstruction-of-deficient-atrophic-ridges-using-guide-bone-regeneration-technique-100573488","NCT06746935","Reconstruction of Deficient Atrophic Ridges Using Guide Bone Regeneration Technique","Reconstruction of Deficient Atrophic Ridges Using Guided Bone Regeneration Technique With Native Collagen Membrane and Polytetrafluoroethylene Membrane (Randomized Clinical Trial)","Inclusion Criteria:\n\n* Patients with maxillary residual alveolar bone height not less than 8 mm.\n* Alveolar bone width from less than or equal 5 mm.\n* Both sexes.\n* At least missing single tooth.\n* Previous Failed Implants.\n* Previous Failed Grafting.\n\nExclusion Criteria:\n\n* Heavy smokers more than 20 cigarettes per day.\n* Patients with bone disease that may affect normal healing, example; hyperparathyroidism.\n* Patients had radiotherapy and chemotherapy in head and neck.\n* Patients had neoplasms in sites to be grafted.\n* Patients with Metabolic diseases uncontrolled diabetic patients, Glycated hemoglobin (Hb A1c) more than 7 mg\\\\dl.",{"count":55,"type":21},[24],"patients will be informed of the nature of the research work and informed consent will be obtained then randomized in 2 groups. Mixture 1:1 autogenous and xenogenic bone covered with Polytetrafluoroethylene membrane control group and study group p covered with native collagen membrane.\n\n* Patients of both groups will be subjected to CBCT (diagnostic for upper arch), diagnostic wax-up and stent fabrication.\n* Intra operative procedures (for both groups) followed by CBCT will be taken for every patient after 4 months.\n\nBoth the study and control group will receive:\n\n* In Recipient site, using 15C blade on Bard Parker handle incision of full thickness mucoperiosteal flap inorder to obtain, three-line pyramidal flap, reflection using mucoperiosteal elevator molt 9.\n* The defective site is reevaluated after its primary evaluation on CBCT using UNC (University of North Carolina) periodontal probe and a template is cut using sterile suture pack, prior to donor site preparation.\n* Flap advancement using periosteal releasing incision inorder to allow later tension free flap closure.\n* In Donor site, mucoperiosteal flap is done, auto chip maker (ACM) is used for autogenous bone harvesting.\n* Autogenous particulate bone graft is obtained using auto chip maker bur (ACM), in implant contra 20:1 using surgical motor recommended drilling speed 100 rpm and maximum torque 50 Ncm. as well as, using bone scrapper in push direction.\n* Xenogenic bone graft particles (De-proteinized bovine bone mineral small granules (0.25-1 mm). is added to the autogenous bone particles to obtain homogenous mixture ratio 1:1.\n* The gold standard is a mixture of autogenous bone containing viable cells and xenogenic bone which has slower rate of resorption is to be placed in recipient decorticated site and covered by PTFE membrane.\n* The assemble is to be fixed by titanium bone tacks of diameter 2.5 mm and length 3.5 mm, to avoid micro movements of particulate bone assembly.\n* In the Study group: The assemble is going to be covered by resorbable collagen membrane and fixed by tacks.\n* Recheck adequate flap advancement by visualizing passive flap approximation, to allow tension free closure.\n* Double line closure using horizontal mattress placed 5mm away from flap margins followed by interrupted sutures on top to allow contact area which is preferred to point contact and wound edge eversion.",[27,59],[61,102,103],"Polytetrafluoroethylene","native collagen membrane","2025-02-16",{"date":106,"type":36},"2025-02-19",{"date":108,"type":36},"2025-01-01",{"date":110,"type":21},"2025-10-29",{"name":72,"class":43},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":4,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":134},"100484171","ridge-augmentation-treatment-using-ossix-breeze-vs-jason-100484171","NCT05584566","Ridge Augmentation Treatment Using OSSIX® BREEZE vs Jason®","Ridge Augmentation Treatment Using OSSIX® BREEZE vs Jason® Membrane in Simultaneous Implantations. A Prospective, Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Males and females, age 18 and above.\n2. General good health (ASA 1 and ASA 2).\n3. Adults with buccal bone defect, who are in need of implant placement, and going through a guided bone regeneration treatment.\n4. Patient needs 1-3 implants.\n5. Good oral hygiene (full mouth plaque index \\\u003C25%).\n6. Adequate control of inflammation (full mouth bleeding on probing \\\u003C25%).\n7. Patient is willing to sign an informed consent and participate in the clinical study.\n\n10 8. Patient is able to understand and comply with the study related procedures, such as exercising good oral hygiene and attending all follow-up examinations.\n\nExclusion Criteria:\n\n1. Physical status ASA III or ASA IV.\n2. General contraindications for dental and\u002For surgical treatments.\n3. Inflammatory and autoimmune disease of the oral cavity.\n4. Patients with known collagen hypersensitivity.\n5. Patients with sensitivity to porcine-derived materials.\n6. Patients suffering from autoimmune diseases and connective tissue diseases, such as: systemic lupus erythematosus, dermatomyositis, etc.\n7. Acute infection in the oral cavity or acute inflammation at the implantation site.\n8. General diseases, where measures of stomatology, maxillo-facial surgery, implantology, periodontology, endodontology or other measures of oral surgery are contraindicated.\n9. Disease of oral mucosa.\n10. Uncontrolled periodontal disease\n11. Concurrent or previous radiotherapy of head area.\n12. Concurrent or previous immunosuppressant, bisphosphonate, or high-dose corticosteroid therapy.\n13. Smoking (over 10 cigarettes a day).\n14. Pregnant or lactating women.\n15. Women of childbearing potential, who are not using a highly effective method of birth control.\n16. Participation in another investigational device, drug, or biologics study within the last 24 weeks prior to study entry.",{"count":120,"type":21},65,[24],"This is a prospective randomized controlled parallel trial. The aim of this study is to evaluate bone formation and soft tissue healing after 4 and 8 months in patients with ridge deficiencies in simultaneous implantation approach. The trial will compare a (sugar cross linked) - SCL pericardium membrane OSSIX® Breeze vs native pericardium membrane (Jason®).",[27],"2024-10-14",{"date":126,"type":36},"2024-10-16",{"date":128,"type":36},"2022-12-01",{"date":130,"type":21},"2026-07-01",{"name":132,"class":133},"Datum Dental LTD","INDUSTRY",3]