[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"right-bundle-branch-block\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:right-bundle-branch-block":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100459661","his-bundle-corrective-pacing-in-heart-failure-100459661",false,"NCT05265520","His-Bundle Corrective Pacing in Heart Failure","HIS-CRT","Inclusion Criteria:\n\n* Age 18 years or older (no upper age limit)\n* Optimal medical therapy for heart failure by current guidelines\n* Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:\n\n  * New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR\n  * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR\n  * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb)\n\nExclusion Criteria:\n\n* Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization\n* Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology\n* Unable or unwilling to follow study protocol\n* Less than 12 months life expectancy at consent\n* Pregnancy or planned pregnancy during duration of the study\n* On heart transplant list or likely to undergo heart transplant","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).",[26,27,28,29],"Right Bundle-Branch Block","Heart Failure","His-bundle Pacing","Cardiac Resynchronization Therapy","RECRUITING","2026-02-04",{"date":33,"type":34},"2026-02-09","ACTUAL",{"date":36,"type":34},"2022-12-02",{"date":38,"type":20},"2028-07-01",{"name":40,"class":41},"University of Rochester","OTHER",14,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":50,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100507578","prophylactic-permanent-pacemaker-in-patients-with-right-bundle-branch-block-undergoing-transcatheter-aortic-valve-implantation-100507578","NCT05889208","Prophylactic Permanent Pacemaker in Patients With Right Bundle Branch Block Undergoing Transcatheter Aortic Valve Implantation","TAVI-PACE","Inclusion Criteria:\n\n* Patients undergoing TAVI indicated by severe valvular aortic stenosis\n* Written informed consent\n* Left ventricular ejection fraction ≥ 40 %\n* Persistent RBBB in 12-lead electrocardiogram (RSR' pattern in V1-3, QRS duration \\> 120 milliseconds, and wide S wave in leads I, aVL, V5-6)\n\nExclusion Criteria:\n\n* Other indications for pacemaker implantation or previously implanted pacemaker\n* Life expectancy \\\u003C 1 year\n* No written informed consent","70 Years",{"count":52,"type":20},320,[23],"The goal of this clinical trial is to learn about the safety and outcome of prophylactic pacemaker implantation in patients with right bundle-branch block undergoing trans-catheter aortic valve (TAVI) implantation in patients with severe aortic stenosis and left ventricular ejection fraction.Participants will be randomized to:\n\n* Prophylactic pacemaker implantation prior TAVI\n* Conservative strategy",[56,26],"Aortic Stenosis",[58,59],"Trans-catheter aortic valve implantation","Pacemaker","NOT_YET_RECRUITING","2023-05-26",{"date":63,"type":34},"2023-06-05",{"date":65,"type":20},"2023-12-01",{"date":67,"type":20},"2027-12-01",{"name":69,"class":41},"Aalborg University Hospital"]