[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"right-ventricular-function\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:right-ventricular-function":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,40,68,105,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100620801","right-ventricle-response-to-major-lung-resection-in-vats-and-robotic-surgery-100620801",false,"NCT07362342","RIght VEntricle Response to Major Lung Resection in VATS and Robotic Surgery","RIght VEntricle Response to Major Lung Resection in VATS and Robotic Surgery (the RIVER-2 Study)","RIVER-2","Inclusion Criteria:\n\n* Adult patients aged ≥18 years\n* Scheduled for elective lobectomy (or bilobectomy) via minimally invasive or open thoracic surgery\n* Ability to provide written informed consent at the time of hospital admission\n* Moderate to high cardiopulmonary risk, defined by at least one of the following criteria:\n\n  * ASA physical status classification 3\n  * Predicted postoperative FEV1 \\\u003C60% and 6-minute walk test \\\u003C400 m or cardiopulmonary exercise test \\\u003C20 ml\u002Fkg\u002Fmin\n  * DASI index \\\u003C34\n  * RCRI \\>2\n  * Coronary artery disease\n  * Heart failure\n  * Right ventricular systolic dysfunction (TAPSE \\\u003C17 mm and\u002For S' wave on TDI \\\u003C10 cm\u002Fs)\n  * Left ventricular systolic dysfunction (EF \\\u003C55%)\n\nExclusion Criteria\n\n* Urgent\u002Femergency surgery\n* History of pulmonary embolism\n* Previous right or left pneumonectomy\n* Previous lobectomy\n* Completion pneumonectomy\n* Pregnancy (confirmed or suspected)\n* History of severe pulmonary hypertension (PAPs \\>40 mmHg)","ALL","18 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","Major pulmonary resection is associated with high postoperative morbidity and mortality, mainly due to cardiorespiratory complications. Right ventricular (RV) function is closely related to pulmonary artery pressure and tone, and it is particularly sensitive to changes in afterload. An increase in RV flow resistance can lead to acute RV dilation and reduced left ventricular compliance, potentially progressing to cardiogenic shock. In a previous study (RIVER), it was observed that increased afterload following open thoracic surgery reduces RV function, although this impairment remains subclinical. The aim of this study is to investigate the same parameters in patients with severe cardiovascular comorbidities undergoing pulmonary resection via minimally invasive approaches (VATS and robotic surgery) compared to open thoracotomy.",[25,26],"Lung Surgery","Right Ventricular Function","RECRUITING","2026-06-22",{"date":30,"type":31},"2026-06-25","ACTUAL",{"date":33,"type":31},"2026-01-20",{"date":35,"type":21},"2027-12-01",{"name":37,"class":38},"Istituto Clinico Humanitas","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":39},"100643944","multimodality-rv-phenotyping-for-risk-stratification-and-short-term-outcomes-in-group-1-pah-100643944","NCT07667673","Multimodality RV Phenotyping for Risk Stratification and Short-Term Outcomes in Group 1 PAH","Multimodality Imaging-Based Right Ventricular Phenotyping for Risk Stratification and Short-Term Outcomes in Group 1 Pulmonary Arterial Hypertension: The MIRROR-PAH Study","MIRROR-PAH","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Diagnosis of Group 1 pulmonary arterial hypertension (PAH) according to ESC\u002FERS guidelines\n* Followed at the study center with a diagnosis of PAH\n* Availability of right heart catheterization (RHC) and cardiac magnetic resonance (CMR) imaging data obtained within a clinically relevant time interval\n* Availability of analyzable clinical, imaging, and hemodynamic data\n* Willingness to participate in the study and provision of written informed consent\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Pulmonary hypertension groups other than Group 1 PAH (Groups 2-5 PH)\n* Absence of either right heart catheterization or cardiac magnetic resonance imaging data within a clinically relevant time interval\n* Incomplete clinical or imaging data preventing analysis\n* Unavailable follow-up data",{"count":49,"type":21},50,"The MIRROR-PAH is a single-center, prospective, observational cohort study evaluating the incremental value of multimodality imaging-derived right ventricular characteristics for risk stratification in patients with Group 1 pulmonary arterial hypertension (PAH). The study aims to determine whether incorporation of echocardiographic and cardiac magnetic resonance (CMR)-derived right ventricular parameters into established non-invasive risk assessment models results in risk reclassification and improves identification of patients at risk for short-term clinical worsening.\n\nAdult patients with established Group 1 PAH undergoing routine follow-up and with available right heart catheterization (RHC) and CMR data will be consecutively enrolled. Clinical, laboratory, echocardiographic, and follow-up data will be prospectively collected over a 6-month period. Associations between multimodality imaging findings, invasive hemodynamic measurements, risk classification, and short-term clinical outcomes will be evaluated.",[52,53,26],"Pulmonary Hypertension","Pulmonary Arterial Hypertension",[55,56,57,58,59],"pulmonary arterial hypertension","transthoracic echocardiography","cardiac magnetic resonance imaging","right heart catheterization","risk stratification","2026-06-19",{"date":30,"type":31},{"date":63,"type":31},"2026-05-11",{"date":65,"type":21},"2027-05",{"name":67,"class":38},"Istanbul University - Cerrahpasa",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":79,"briefSummary":81,"conditions":82,"keywords":4,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":39},"100643703","bedside-assessment-of-right-ventricular-output-lying-in-prone-or-supine-position-100643703","NCT07632027","Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position","The BAROLO Study Bedside Assessment of Right Ventricular Output Lying in Prone Or Supine Position. Hemodynamic Changes Due to Prone Position in Patients After Cardiac Surgery - a Prospective Randomized Controlled Trial Evaluating the Effect of Prone Position on Right Heart Function","BAROLO","Inclusion Criteria:\n\n* Scheduled for cardiac surgery using cardiopulmonary bypass\n\nExclusion Criteria:\n\n* BMI \\>40\n* Emergency surgery\n* In need of secondary surgery\n* Advanced grown up congenital heart disease\n* Pulmonary disease\n* Hemodynamic instability with Norepinephrine \\>0.4mcg\u002Fkg\u002Fmin\n* Any condition which, in the judgement of the investigator, might increase the risk to the patient",{"count":77,"type":21},80,"INTERVENTIONAL",[80],"NA","Right ventricular failure (RVF) is a common complication to cardiac surgery, which is associated to mortality, kidney failure, stroke, prolonged mechanical ventilation and ICU stay. The right ventricle is particularly vulnerable to an increased afterload. By increasing pulmonary vascular resistance (PVR), atelectasis might mitigate a negative effect on the right ventricle.\n\nRecruitment maneuvers have been shown to resolve atelectasis and improve hemodynamics by increasing cardiac output and lowering PVR. However these maneuvers transiently raise airway pressures, which in turn increases right ventricular afterload, a situation often poorly tolerated by patients with RVF.\n\nProne position is used in patients with respiratory failure and has been shown to decrease mortality in patients with ARDS. Prone position decreases atelectasis and moves ventilation dorsally. In ARDS it also seems to mediate beneficial hemodynamic effects such as an increase in cardiac output and a decrease in PVR.\n\nThe investigators hypothesis is that prone position early after cardiac surgery will increase cardiac output by recruitment of atelectasis and thereby decrease PVR.",[26,83,84,85,86,87,88,89,90,91,92,93,94],"Prone Position","Atelectasis","Atelectases, Postoperative Pulmonary","Cardiac Output","Vasoconstriction","Heart Failure","Recruitment Maneuver","Respiratory Mechanics","Pulmonary Arterial Pressure","Cardiac Surgery","Cardiac Surgery Recovery","Cardiopulmonary Bypass","NOT_YET_RECRUITING","2026-06-03",{"date":98,"type":31},"2026-06-08",{"date":100,"type":21},"2026-09",{"date":102,"type":21},"2028-10",{"name":104,"class":38},"Sahlgrenska University Hospital",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":111,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":4,"studyType":78,"phases":116,"briefSummary":117,"conditions":118,"keywords":122,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":134,"leadSponsor":136,"locationsCount":39},"100626126","effect-of-acute-hypoxia-on-right-ventricular-function-in-asthma-100626126","NCT07431580","Effect of Acute Hypoxia on RIght VEntRicular Function in Asthma.","Effect of Acute Hypoxia on RIght VEntRicular Function. A Single-Center, Double-Blind, Randomized Controlled Cross-Over Trial.","RIVER-Asthma","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed and well controlled asthma bronchiale\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition including past HAPE\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment","80 Years",{"count":115,"type":21},18,[80],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with asthma responds to this stress is still not well understood.\n\nTherefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with asthma. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability.\n\nIn addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random.\n\nThe aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[119,120,121,26],"Hypoxia, Altitude","Hypoxia","Normobaric Hypoxia",[123,124,125,126,127,128,129],"right ventricular free wall strain","RVFWS","right ventricular function","tissue oxygenation","breathing difficulty","blood gas","heart rate","2026-05-26",{"date":132,"type":31},"2026-05-29",{"date":130,"type":31},{"date":135,"type":21},"2030-01",{"name":137,"class":38},"Mona Lichtblau",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":110,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":113,"enrollmentInfo":145,"targetDuration":4,"studyType":78,"phases":146,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":157,"locationsCount":39},"100626124","effect-of-acute-hypoxia-on-right-ventricular-function-in-hape-100626124","NCT07431554","Effect of Acute Hypoxia on RIght VEntRicular Function in HAPE.","RIVER-HAPE","Inclusion Criteria:\n\n* Signed informed consent\n* Diagnosed or suspicion of past HAPE\n* 18-80 years (age group young: 18-39.99 years \u002F age group older: 40-80 years)\n* All sex and genders\n* Living \\\u003C800m and without altitude exposure \\> 2500 m and \\> 24h within the last three weeks\n\nExclusion Criteria:\n\n* \\\u003C18, \\>80 years old\n* Any other diagnosed cardiopulmonary condition\n* Other clinically significant severe concomitant disease states (e.g. renal, hepatic dysfunction, etc.)\n* Inability to follow the procedures of the study due to language problems, psychological neurological disorders or orthopaedic disorders\n* Participants permanently living \\>800m and altitude exposure \\> 2500 m and \\>24h within the last three weeks\n* Pregnancy: Participants will be asked if pregnant or not, no screening for undetected pregnancy\n* Lactating women\n* Participation in other study with active treatment",{"count":115,"type":21},[80],"More and more people are engaging in sports in the mountains, including individuals with heart or lung diseases. At the same time, such diseases are becoming more common in Switzerland. At high altitude, less oxygen is available, which places stress on the body-particularly on the heart, which has to pump blood through the lungs. How the heart, especially the right ventricle, in people with past HAPE responds to this stress is still not well understood. Therefore, this study investigates how the heart responds to simulated altitudes of 2,500 m and 4,000 m, both at rest and during light physical activity in patients with past HAPE. The primary objective is to assess how right ventricular function changes under conditions of reduced oxygen availability. In addition, vital signs, changes in blood gases, oxygen levels in blood and tissue and shortness of breath are assessed. The \"altitude\" is simulated using a special gas mixture that participants inhale. Participants undergo three altitude conditions (490, 2,500, and 4,000 m above sea level). The order of the altitude conditions is assigned at random. The aim is to better understand how the right ventricle and other parameters respond to low-oxygen conditions and how affected patients can be better supported in the future.",[149,120,121,26],"Altitude Hypoxia",[123,124,125,126,127,128,129],"2026-04-28",{"date":153,"type":31},"2026-05-01",{"date":155,"type":31},"2026-03-17",{"date":135,"type":21},{"name":137,"class":38}]