[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"right-ventricular-pacing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:right-ventricular-pacing":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,81,107,135,159],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100534655","csp-versus-bivp-for-heart-failure-patients-with-rvp-upgraded-to-cardiac-resynchronization-therapy-100534655",false,"NCT06241651","CSP Versus BiVP for Heart Failure Patients With RVP Upgraded to Cardiac Resynchronization Therapy","Conduction System Pacing Versus Biventricular Pacing for Heart Failure Patients With Right Ventricular Pacing Upgraded to Cardiac Resynchronization Therapy: a Prospective Multicenter Non-inferiority Randomized Controlled Study","CSP-UPGRADE","Inclusion Criteria:\n\n1. Patients with symptomatic heart failure (LVEF \\\u003C50%) after right ventricular pacing for at least 3 months;\n2. NYHA class II-IV;\n3. NT-proBNP \\>125pg\u002FmL in patients with sinus rhythm, NT-proBNP \\>250pg\u002FmL in patients with atrial fibrillation;\n4. Right ventricular pacing percentage \\>40%;\n5. Adult patients aged 18-80;\n6. With informed consent signed.\n\nExclusion Criteria:\n\n1. History of acute myocardial infarction within 3 months before enrollment;\n2. Frequent premature ventricular contraction (\\>15%) or malignant ventricular arrhythmia which is difficult to control;\n3. History of valvular heart disease intervention within 3 months before enrollment;\n4. After mechanical tricuspid valve replacement;\n5. Ventricular septal hypertrophy (≥15mm during diastole);\n6. Complex congenital heart disease;\n7. History of heart transplantation;\n8. Enrollment in any other study;\n9. Pregnant or with child-bearing plan;\n10. A life expectancy of less than 12 months.","ALL","18 Years","80 Years",{"count":21,"type":22},66,"ESTIMATED","INTERVENTIONAL",[25],"NA","The present study is a prospective, multicenter, non-inferiority, randomized controlled trail. It aims to investigate whether the efficacy of conduction system pacing (CSP) is non-inferior to biventricular pacing (BiVP) in patients with heart failure and right ventricular pacing (RVP) requiring upgrading to cardiac resynchronization therapy (CRT).",[28,29,30,31,32],"Conduction System Pacing","Biventricular Pacing","Cardiac Resynchronization Therapy","Right Ventricular Pacing","Heart Failure","RECRUITING","2026-05-11",{"date":36,"type":37},"2026-05-14","ACTUAL",{"date":39,"type":37},"2024-01-01",{"date":41,"type":22},"2027-03",{"name":43,"class":44},"The First Affiliated Hospital with Nanjing Medical University","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100609654","left-bundle-branch-area-pacing-lbbap-pmcf-study-100609654","NCT07217392","Left Bundle Branch Area Pacing (LBBAP) PMCF Study","LBBAP PMCF","Inclusion Criteria:\n\n1. Meets current clinical practice guidelines for implantation of Tendril STS 2088TC or UltiPace LPA1231 lead in the Left Bundle Branch Area\n2. Are ≥ 18 years of age or age of legal consent, whichever age is greater.\n3. Subject is willing to comply with clinical investigation procedures and agrees to return to clinic for all required follow-up visits, tests, and exams.\n4. Subject has been informed of the nature of the clinical investigation, agrees to its provisions and has provided a signed written informed consent, approved by the IRB\u002FEC.\n\nExclusion Criteria:\n\n1. Patient meets a standard contraindication for lead implant including:\n\n   1. the presence of tricuspid atresia\n   2. patients with mechanical tricuspid valves\n   3. patients who are expected to be hypersensitive to a single dose of one milligram of dexamethasone sodium phosphate\n2. Patient is currently implanted with a pacemaker, ICD, or CRT-D\u002FP device\n3. Patient has had a previous unsuccessful attempt to place a lead in the LBB area\n4. Patient has planned cardiac surgical procedures or interventional measures within 3 months after implant\n5. Patient is expected to receive a heart transplant within 6 months\n6. Patient life expectancy less than 6 months\n7. Patient has the presence of another life-threatening, underlying illness separate from their cardiac disorder\n8. Patient is enrolled or planning to enroll in another clinical trial that might confound the results of the present study\n9. Pregnant or nursing subjects and those who plan pregnancy during the clinical investigation follow-up period.\n10. Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the subject's ability to participate in the clinical investigation or to comply with follow-up requirements of the clinical investigation.",{"count":54,"type":22},200,[25],"The objective of this study is to evaluate the safety and effectiveness of LBBA pacing\u002Fsensing in patients implanted with the Tendril STS 2088TC or UltiPace LPA1231 lead through 6 months post-implant.",[58,31,32,59,60,61,28],"Bradycardia","Atrial Fibrillation (AF)","Cardiac Disease","Left Bundle Branch Area Pacing",[63,64,65,66,67,68,69],"Right ventricular pacing","cardiac disease","heart failure","atrial fibrillation","bradycardia","left bundle branch area pacing","conduction system pacing","2026-04-22",{"date":72,"type":37},"2026-04-24",{"date":74,"type":37},"2025-07-24",{"date":76,"type":22},"2027-04-30",{"name":78,"class":79},"Abbott Medical Devices","INDUSTRY",13,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":91,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":45},"100531262","randomized-study-of-physiological-vs-right-ventricular-pacing-in-patients-with-normal-ventricular-function-post-tavi-100531262","NCT06197503","Randomized Study of Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post TAVI","Ranodmized Study of Physiological vs Right Ventricular Pacing in Patients With Normal Ventricular Function Post TAVI (PHYSTAVI II)","PHYSTAVIII","Inclusion Criteria:\n\n* Successful implantation of TAVI according to VARC-3 criteria.\n* Indication of cardiac pacing due to AV block according to ESC Guidelines.\n* LVEF\\> 50%.\n* The patient must indicate their acceptance to participate in the study by signing an informed consent document.\n\nExclusion Criteria:\n\n* Ventricular dysfunction: LVEF \\\u003C50%.\n* Transapical TAVI.\n* Participating currently in a clinical investigation that includes an active treatment.\n* Patients with left bundle branch block but without indication of pacing (AV block).\n* Life expectancy \\\u003C12 months.",{"count":90,"type":22},48,[25],"Single-center randomized trial in patients with pacing indication (AV block) after TAVI (transfemoral aortic valve implantation) and LVEF\\> 50%, that aims to study the percentage of patients who improve at 12 months in a combined clinical endpoint.",[94,95,31,96,97],"Transcatheter Aortic Valve Implantation","Physiological Pacing","AV Block","Preserved Left Ventricular Systolic Function","2026-03-30",{"date":100,"type":37},"2026-03-31",{"date":102,"type":37},"2023-11-30",{"date":104,"type":22},"2026-12-15",{"name":106,"class":44},"Hospital Clinic of Barcelona",{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":113,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":134},"100614199","central-haemodynamics-and-pacing-for-av-block-100614199","NCT07276490","Central Haemodynamics and Pacing for AV Block","The Pacing in Atrioventricular Block: a Comparative Evaluation of Central Haemodynamics, Cardiac Function, and Quality of Life","PACE-CCQ","Inclusion Criteria:\n\n* Age 18-80 years\n* Diagnosis of atrioventricular block\n* Expected survival \\>1 year\n\nExclusion Criteria:\n\n* Reduced left ventricular ejection fraction (EF \\\u003C45%)\n* Expected ventricular pacing burden \\\u003C20%\n* Inter-arm systolic blood pressure difference \\>15 mmHg\n* Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days\n* Secondary hypertension\n* Orthostatic hypotension\n* Clinically significant valvular heart disease\n* Congenital heart disease\n* Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed\n* Pregnancy or breastfeeding\n* Withdrawal of consent by the subject\n* Loss of contact during the study",{"count":116,"type":22},124,[25],"A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.",[120,121,31,28],"Atrioventricular Block","Pacing Therapy",[69,123,124],"atrioventricular block","right ventricular pacing","2026-03-06",{"date":127,"type":37},"2026-03-09",{"date":129,"type":37},"2025-11-28",{"date":131,"type":22},"2027-12-31",{"name":133,"class":44},"University of Tartu",2,{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":158},"100501937","physiological-vs-right-ventricular-pacing-outcome-trial-evaluated-for-bradycardia-treatment-protect-hf-100501937","NCT05815745","\"Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment\" (PROTECT-HF)","Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment","PROTECT-HF","We will recruit patients who are referred for clinically indicated pacemaker implantation\n\nInclusion Criteria:\n\n1\\. Adults aged over 18 with left ventricular ejection fraction \\>35% and one or more of the following guideline based ventricular pacing indications:\n\n1. Permanent or intermittent 3rd degree AV block\n2. Permanent or intermittent Mobitz type II AV block\n3. First Degree AV block with a pacing indication\n4. Slow chronic Atrial Fibrillation or Proposed AV node ablation\n5. Bifascicular block with a pacing indication\n6. Trifascicular block with a pacing indication\n7. Wenckebach with a pacing indication\n\nExclusion Criteria:\n\n1. Patients who are likely to only need occasional ventricular pacing, i.e. those with isolated sick sinus syndrome.\n2. Pregnant women.\n3. Unable to provide informed consent.\n4. Those with comorbidity leading to a life expectancy \\\u003C1year.",{"count":144,"type":22},2600,[25],"The PROTECT-HF multi-centre randomised controlled trial will compare two different pacing approaches for treating patients with slow heart rates. In it the investigators will compare a long-standing standard approach for pacing; right ventricular pacing, with a new form of pacing, physiological pacing (His and Left bundle area pacing) in 2600 patients.\n\nPatients will be allocated at random to receive either right ventricular pacing or physiological pacing. Endpoint measurements will be undertaken at baseline, and at six-monthly intervals post-randomisation. Treatment allocation will be blinded to the endpoint assessor and the patient.\n\nRecruitment and pacemaker implantation will be carried out at each participating centre. The primary analysis will be intention to treat. The investigators will also perform an on-treatment analysis.\n\n2048 patients are needed to detect the expected effect size with 85% power. A total of 2600 patients will be recruited to allow for patient drop-out and crossover.\n\n500-patient sub-study will assess within patient, and between groups, echocardiographic changes over a 24-month period to try and improve mechanistic understanding of PICM (Pacing Induced Cardiomyopathy).",[58,148,31,149,61],"Pacing","His Bundle Pacing","2025-11-21",{"date":129,"type":37},{"date":153,"type":37},"2023-06-05",{"date":155,"type":22},"2029-12-04",{"name":157,"class":44},"Imperial College London",45,{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":23,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":173,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":45},"100517918","the-impact-of-lbbap-vs-rvp-on-the-incidence-of-new-onset-atrial-fibrillation-in-patients-with-atrioventricular-block-100517918","NCT06023784","The Impact of LBBAP vs RVP on the Incidence of New-onset Atrial Fibrillation in Patients With Atrioventricular Block","The Impact of Left Bundle Branch Area Pacing Versus Right Ventricular Pacing on the Incidence of New-onset Atrial Fibrillation in Patients With Atrioventricular Block: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18-85;\n* AV block patients with ventricular pacing indications and the expected rate of ventricular pacing(VP)\\> 40%, including (a) third-degree AV block; (b) second degree AV block (type II); (c) intermittent advanced AV block with expected VP\\>40%; (d) symptomatic first degree AV block and PR interval on ECG \\> 300ms;\n* Signed informed consent;\n\nExclusion Criteria:\n\n* Baseline echocardiographic assessment of patients with impaired LV function (LVEF\\\u003C50%);\n* Patients with the history of atrial fibrillation;\n* Having difficulties in follow-up: Those who cannot accept 2-year follow-up on time due to physical condition or other reasons;\n* Pacemaker replacement without new implanted ventricular electrodes;\n* Surgery is required within 1 year due to severe structural heart disease;\n* Patients with tricuspid mechanical valve replacement, or congenital heart disease (including transposition of the great arteries, or permanent left superior vena cava, etc);\n* AV block resulting from: (a) Hypertrophic cardiomyopathy(HCM), (b) ventricular septal defect repair, and those who are unlikely to achieve successful LBBAP procedure.","85 Years",{"count":168,"type":22},530,[25],"This is a single-center, randomized controlled study. The aim of this study is to compare the impact of left bundle branch area pacing versus traditional right ventricular pacing on the incidence of atrial fibrillation in patients with atrioventricular block.",[61,31,120,172],"Atrial Fibrillation","NOT_YET_RECRUITING","2023-09-03",{"date":176,"type":37},"2023-09-05",{"date":178,"type":22},"2023-09-30",{"date":180,"type":22},"2030-12-31",{"name":182,"class":44},"Peking Union Medical College Hospital"]