[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"risk-factors-cardiovascular-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:risk-factors-cardiovascular-disease":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":33,"overallStatus":47,"whyStopped":4,"lastUpdateSubmitDate":48,"lastUpdatePostDateStruct":49,"startDateStruct":52,"completionDateStruct":54,"leadSponsor":56,"locationsCount":5},"100612570","follow-up-study-of-varapodio-trial-effect-of-longevity-and-fasting-mimicking-diet-on-risk-factors-age-correlated-and-biomarkers-of-aging-100612570",false,"NCT07255300","Follow up Study of Varapodio Trial: Effect of Longevity and Fasting Mimicking Diet on Risk Factors Age Correlated and Biomarkers of Aging","Follow up Study of the Effects of the Longevity and the Fasting Mimicking Diet on Body Composition, Age-related Risk Factors and Biomarkers of Aging in a Randomized Study 1 and 2","Inclusion Criteria:\n\nSubjects of 30-65 years of age;\n\nExclusion Criteria:\n\nindividuals with a family member already included in the study; individuals who are allergic to tree nuts (macadamia, cashew, almond, pecan), soy, oats, sesame, or celery\u002Fceleriac; pregnant females; Individuals with any documented cancer diagnosis within the past 5 years; documented myocardial infarction within past 5 years; documented cerebrovascular accident within past 5 years; chronic steroid use (longer than 45 consecutive days); insulin-dependent diabetes mellitus; individuals taking insulin or insulin-like drugs and individuals taking hypoglycemic agents other than metformin. In this last case, close attention will therefore be paid to the self-monitoring of blood glucose during the FMD cycles; Individuals with severe hypertension (systolic greater than 200 mmHg and or diastolic greater than 105 mmHg.\n\nChange in prescription medications, over-the-counter (OTC) medications, medical foods, and nutritional supplements within 30 days prior to the start and for the duration of the study.\n\nUse of medications classified as narcotics 15 days prior start and for the duration of the study.\n\nUse of prescription medications and\u002For over-the-counter medications for acute and semi- acute medical conditions 15 days prior to start and for the duration of the study.\n\nUse of acetaminophen is permitted on an as-needed basis. Use of an investigational drug or participation in an investigational study within 30 days prior to the start and for the duration of the study.\n\nUse of oral or injectable corticosteroids within 30 days prior to the start and for the duration of the study.\n\nUse of anticoagulant medications (heparin compounds or warfarin) within 30 days prior to the start and for the duration of the study. Use of aspirin 81 mg or 325 mg once daily is permitted.\n\nUse of neuroactive prescription medications including major and atypical antipsychotic medications, anti-depressants, anti-anxiolytics, and epilepsy medications within 30 days prior to the start and for the duration of the study.\n\n(subjects will not be allowed to discontinue prohibited prescription medications to meet enrolment criteria).\n\nA history of allergy or intolerance to study products. Detailed descriptions of study product are included in Section 4.1 and 4.2, appended to the Study Informed Consent.\n\nClinically significant vital sign abnormalities (systolic blood pressure \\\u003C90 mmHg or \\>200 mmHg, diastolic blood pressure \\\u003C50 mmHg or \\>105 mmHg or resting heart rate of \\\u003C50 or \\>100 bpm) at screening visit.\n\nA serious, unstable illness including cardiac, hepatic, renal, gastrointestinal, respiratory, endocrinologic, neurologic, immunologic, or hematologic disease.\n\nKnown infection with HIV, TB or Hepatitis B or C.\n\nA current diagnosis or personal history of:\n\nAny cardiovascular disease including myocardial infarction, angina, cardiovascular surgery (within 5 years), congestive heart failure, cardiac arrhythmias or conduction abnormalities, cerebrovascular accident, transient ischemic attack (TIA), or peripheral vascular disease, deep vein thrombosis or pulmonary embolus. Diabetes mellitus requiring inhaled or injected insulin.\n\nAny autoimmune disease such as inflammatory bowel disease (including Crohn's disease and\u002For ulcerative colitis), multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, polymyositis, scleroderma and\u002For thyroiditis.\n\nAny significant liver or kidney disease such as cirrhosis or non-alcoholic fatty liver disease, glomerulonephritis, and\u002For ongoing dialysis treatment.\n\nAny malignancy (with the exception of adequately treated malignancies with no known recurrence for \\>2 years).\n\nAny serious mental illness including a history of attempted suicide. Any medical condition that in the opinion of the primary care doctor or a specialist would preclude safe participation in this study or interfere with compliance.\n\nUse of drugs of abuse (such as marijuana, cocaine, phencyclidine \\[PCP\\] and methamphetamine) 15 days prior to Day 1 and for the duration of the study.\n\nHistory of regular intake of \\>14 alcoholic drinks per week for females, and \\>21 drinks per week for males (1 drink = 35 cl. beer, 12 cl. wine, or 30 ml. hard liquor).\n\nTechnical reasons\n\nAny condition in which bioelectrical impedance testing would be impossible or uninterpretable (e.g. prostheses in extremities on both sides, limb amputation, implanted pacemaker, inability to lay still or supine, or skin defects on preferred electrode placement sites.\n\nOther Exclusion Criteria: Inability to comply with study and\u002For follow-up visits.\n\nAny concurrent condition (including clinically significant abnormalities in medical history, physical examination or laboratory evaluations) which, in the opinion of the PI, would preclude safe participation in this study or interfere with compliance.\n\nAny sound medical, psychiatric and\u002For social reason which, in the opinion of the PI, would preclude safe participation in this study or interfere with compliance.\n\nAbnormal laboratory findings including: abnormal blood counts (hematocrit \\\u003C 33% or \\> 47%; WBC \\\u003C 3.0 or \\> 12.0 x10\\^3\u002Fmm3; platelets \\\u003C 140 or \\> 500 x 10\\^9\u002FL); abnormal kidney function test (creatinine \\> 2.5 mg\u002FdL) or liver function test(s) (AST, ALT, alkaline phosphatase) \\> 1.5X the upper limit of normal; serum calcium \\> 11 mg\u002FdL); serum K \\\u003C 3.5 mEq\u002FL; Na \\\u003C 134 or \\> 148 mmolL-1 Women of Childbearing Potential Contraception: the effects of the study products on the developing human fetus have not been studied extensively. For this reason, women of childbearing potential must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation. Females of childbearing potential will have a pregnancy test prior to receiving study products. Should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform study staff and her primary care physician immediately.\n\nPregnancy: because there is an unknown but potential risk for adverse events in pregnant women during treatment with the study products, pregnant women are not eligible for study participation.\n\nBreast-feeding: Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with the study products, breastfeeding mothers are not eligible for study participation.",true,"ALL",{"count":19,"type":20},135,"ESTIMATED","INTERVENTIONAL",[23],"NA","A large ongoing randomized, open-label trial aimed at evaluating the effects of two different dietary interventions, FMD and LD, on body composition and cardiovascular (CV) biomarkers in a real word population (NCT05698654) is actually ongoing. This trial started in January 2024 will enrol 501 adult subjects between the ages of 30 and 65: 167 subjects randomized to the FMD arm with a 5-day meal program once every three months for a 6-month period (arm 1); 167 subjects randomized to follow the FMD plus a Longevity Diet program (FMD+LD) for a 6-month period (arm 2); 167 randomized to the control group (arm 3) that will continue their usual diet. On 2024,410, participants were enrolled and randomly assigned to FMD, FMD + LD, or control arm. Although preliminary data demonstrated the beneficial effects of such nutritional plans on body weight, BMI, body composition, and cardiovascular (CV) biomarkers, limited data is available on the long-term effects of these powerful nutritional interventions.",[26,27,28,29,30,31,32],"Fat Mass","Risk Factors Cardiovascular Disease","Epigenetic Aging","Metabolism Changes","Overweight (BMI > 25)","Risk Behavior","Obesity (Disorder)",[34,35,36,37,38,39,40,41,42,43,44,45,46,26],"fasting","fasting mimicking diet","Longevity Diet","Longevity","Diet","Aging","FMD","Nutrition","Diseases","LD","Clinical Trial","Randomized","Health","RECRUITING","2025-11-20",{"date":50,"type":51},"2025-12-01","ACTUAL",{"date":53,"type":51},"2025-05-02",{"date":55,"type":20},"2027-06-02",{"name":57,"class":58},"Fondazione Valter Longo","OTHER"]