[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"risk-factors\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:risk-factors":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,49,84,115,144,174,198,221,247,272,300,322,346,377,407],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100563444","training-community-members-to-be-coaches-to-deliver-the-healthylifetime-program-100563444",false,"NCT06616246","Training Community Members to be Coaches to Deliver the HealthyLifetime Program","Evaluating the Use of Community Members Trained as Health Coaches to Deliver the HealthyLifetimeTM Program","Inclusion Criteria:\n\n* Be at least 30 years of age, with no more than three, uncomplicated chronic conditions and want to learn to take better care of their health.\n* Independent Living Index (ILI) greater than 35. ILI is derived by averaging the outcome measures scores.\n* A score of less than 4 on items related to anxiety and depressive symptoms\n* Have Medicare and\u002For Medicaid insurance.\n* Be able to read, speak, and hear English - but may use glasses or hearing aids, if needed;\n* Tell us their age, date of birth, address, and phone number, and explain their health problems;\n* Have a computer, iPad (Tablet), or Smartphone with an Internet connection, email address, a working camera, and microphone;\n* Be able to use their computer\u002Ftablet to connect to video chat sessions like Zoom in a private space in their home or a private room\n* Are not currently participating in any other studies involving diet, weight management, exercise and\u002For coaching at the current time; and\n* Reside in Michigan.\n\nExclusion Criteria:\n\n* ● Are less than 30 years of age.\n\n  * Have more than three, uncomplicated chronic conditions.\n  * A score of more than 4 on items related to anxiety and depressive symptoms\n  * Do not have Medicare and\u002For Medicaid insurance.\n  * Do not reside in Michigan.\n  * Have a new acute health problem that requires seeing a doctor more than once a month for acute medical treatment.\n  * Have been told their illness is not curable.\n  * Need help remembering their name, date of birth, or health problems.\n  * Cannot use glasses or a hearing aid to see or hear well enough to read materials on the computer or talk to the nurse easily.\n  * Are currently participating in any other studies involving diet, weight management, exercise and\u002For coaching at the current time; and\n  * Do not have, or cannot use, a computer, iPad, or another device with the Internet at home to use Zoom (e.g., internet streaming).","ALL","30 Years",{"count":19,"type":20},300,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this randomized controlled study is to learn if, in addition to nurses, community members can be trained as health coaches to deliver the HealthyLifetime (HL) program to people without complex chronic health conditions, an intervention that provides a short-term and effective health coaching intervention delivered through a virtual platform to improve health, resiliency, and independent self-care to participants who are without complex chronic conditions. The main question it aims to answer is:\n\n• Can Community Health Coaches achieve the same level of competency and outcome as Nurse Health Coaches in participants without complex chronic conditions?",[26,27,28,29],"Health Behaviors","Functional Decline","Chronic Disease","Risk Factors",[31,32,33,34,35],"health coach","health resiliency","independent self-care","community health workers","independent aging","RECRUITING","2026-06-18",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":40},"2025-05-15",{"date":44,"type":20},"2028-12",{"name":46,"class":47},"University of Michigan","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":67,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100454296","acute-acute-surgical-care--risk-factors-and-outcomes-for-patients-in-need-of-acute-surgical-care-100454296","NCT05195697","ACUTE-Acute Surgical Care- Risk Factors and Outcomes for Patients in Need of Acute Surgical Care","ACUTE","Inclusion Criteria: Patients admitted to Skåne University hospital in need of acute surgical care -\n\nExclusion Criteria: Below 18 years old\n\n\\-","18 Years",{"count":58,"type":20},3000,"OBSERVATIONAL","Observational retrospective study of patients in need of acute surgical care admitted to Skåne University Hospital between 2009 and 2019.",[29,62,63,64,65,66],"Complication of Surgical Procedure","Complication of Treatment","Complication of Anesthesia","Long Term Effects After Emergency Surgery","Long Term Effects After GI Bleeding",[68,69,70,71,72,73],"Emergency surgery","Acute surgery","Complications","Risk factors","Frailty","Ageing","2026-06-15",{"date":76,"type":40},"2026-06-17",{"date":78,"type":40},"2020-01-01",{"date":80,"type":20},"2030-12",{"name":82,"class":47},"Region Skane",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":16,"minAge":56,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":21,"phases":96,"briefSummary":97,"conditions":98,"keywords":102,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":83},"100542231","ct-guided-lung-biopsy-risk-optimization-method-100542231","NCT06340178","CT-guided Lung Biopsy Risk Optimization Method","CT-guided Lung Biopsy Risk Optimization Method - Effect of Fluid Application in the Pleural Cavity and the Gravitational Effect of Pleural Pressure","BROM-I","Inclusion Criteria:\n\n* Ability to provide informed consent (knowledge of project languages), \\>18 years.\n* Indeterminate or suspicious lung lesion unsuitable for transbronchial biopsy or Status after unsuccessful transbronchial biopsy\n* Indication for biopsy given by referring specialist (in patients).\n\nExclusion Criteria:\n\n* Preintervention bleeding into the pleural cavity\n* More than 1 lesion should be biopsied at the same time\n* Infiltration of the thoracic wall\n* Pregnancy",true,"100 Years",{"count":95,"type":20},198,[23],"The purpose of this randomized controlled study is to evaluate the extent to which injection of a small amount of fluid in the pleural cavity at the biopsy site may reduce the risk of pneumothoraces, in addition to patient positioning to allow biopsy in gravity-dependent areas of the lung.",[99,100,29,101],"Pneumothorax","Biopsy, Needle","Radiology, Interventional",[103,29,104,105,99],"Image-Guided Biopsy","Tomography","Biopsy","2026-01-29",{"date":108,"type":40},"2026-02-02",{"date":110,"type":40},"2025-09-29",{"date":112,"type":20},"2027-04-01",{"name":114,"class":47},"Insel Gruppe AG, University Hospital Bern",{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":92,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":124,"conditions":125,"keywords":130,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":83},"100528356","telecommunication-technology-based-online-survey-100528356","NCT06159699","Telecommunication Technology-based Online Survey","New Challenges for the Population on the Path to Achieving Active Longevity: an Online Survey of Respondents Using Telecommunication Technologies","Inclusion Criteria:\n\n* age of 18 years and older\n* signing the informed concent form online\n* completion of the entire questionnaire\n\nExclusion Criteria:\n\n* age under 18 years\n* refuse to sign the informed concent form",{"count":123,"type":20},2000,"The aim of this study is to identify and assess new health-associated risk factors, including clinical-pharmacological risk factors. The cohort is built using telecommunication approaches. The associations between clinical-pharmacological, social, demographic, behavioral, and environmental characteristics will be assessed. The continuous depersonalized online survey is performed using the original informational resources in the form of specially designed web-site aimed at identification and assessment of population-based pharmacotherapy patterns including characteristics of self-medication, biologically active food supplement intake, polypharmacy, and adverse drug-drug interactions in the people residing in the ecological conditions of various regions of the country. The invitations to participate in the online survey are sent via the SMS messages using the SMS-Target tool provided by OOO T2 Mobile Company. The survey is performed online at www.zdorov.tpu.ru and www.zdorov.expert both specifically designed for questionnaire publication and data accumulation.",[29,126,127,128,129],"Polypharmacy","Drug Interactions","Self Medication","COVID-19",[126,131,128,129,132,133,134],"Potential Drug-Drug Interactions","Medical Imaging","Environmental Risk Factors","Protracted Low-Dose-Rate Radiation Exposure","2026-01-23",{"date":137,"type":40},"2026-01-27",{"date":139,"type":40},"2022-12-02",{"date":141,"type":20},"2028-12-31",{"name":143,"class":47},"Tomsk National Research Medical Center of the Russian Academy of Sciences",{"id":145,"slug":146,"hasResults":11,"nctId":147,"briefTitle":148,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":21,"phases":153,"briefSummary":154,"conditions":155,"keywords":161,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":83},"100558744","acute-preoperative-pain-and-chronic-post-surgical-pain-in-emergency-surgery-100558744","NCT06555107","Acute Preoperative Pain and Chronic Post-surgical Pain in Emergency Surgery","POCSE","Inclusion Criteria:\n\n* Age ≥18 years old.\n* Emergency orthopaedic and\u002For abdominal surgery.\n* Informed consent.\n* Affiliation to a social security scheme\n\nExclusion Criteria:\n\n* Intraoperative complications that are life-threatening or require the surgical procedure to be discontinued.\n* Post-operative intensive care unit admission.\n* Ambulatory surgery.\n* Endoscopic surgery.\n* Repeat surgery at the same site in less that 3months.\n* Pregnant or breast-feeding patients.\n* Patients under guardianship or deprived of liberty.\n* Patients suffering from psychiatric pathologies.\n* Patients suffering from neurodegenerative pathologies.\n* Patients for whom self-assessment of pain using a numerical scale (0-10) cannot be carried out (non-communicative patients, non-French-speaking patients, and so on).",{"count":152,"type":20},693,[23],"Studies evaluating postoperative pain as a risk factor for CPSP are almost exclusively carried out in the context of scheduled surgery. As a result, the preoperative pain studied as a risk factor for chronicity is essentially a state of pain that has persisted for several weeks or even several months.\n\nIn emergency surgeries, patients are subject to acute preoperative pain of varying intensity and the duration of which may vary by a few days. A few studies have highlighted the intensity of acute preoperative pain as a factor favouring moderate to severe postoperative pain. At this point, no study has addressed the long-term consequences of this intense preoperative pain the emergency context.\n\nAn evaluation in the field of emergency surgery, where the preoperative pain is often intense and limited in time, would enable us to identify more precisely the impact of acute pain on the incidence of CPSP.\n\nThe investigators are hypothesising that the occurrence of CPSP at 3 months in patients undergoing emergency orthopaedic or abdominal surgery is associated with acute preoperative pain.",[156,157,158,159,160,29],"Chronic Postsurgical Pain","Acute Pain","Emergency Surgery","Opioid","Postoperative Pain",[162,156,157,163,164,160],"risk factors","emergency surgery","opioid","2026-01-15",{"date":167,"type":40},"2026-01-16",{"date":169,"type":40},"2024-08-29",{"date":171,"type":20},"2027-04",{"name":173,"class":47},"Centre Hospitalier Universitaire, Amiens",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":180,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":183,"conditions":184,"keywords":187,"overallStatus":188,"whyStopped":4,"lastUpdateSubmitDate":189,"lastUpdatePostDateStruct":190,"startDateStruct":192,"completionDateStruct":194,"leadSponsor":196,"locationsCount":83},"100615904","cardiovascular-risk-factors-in-middle-eastern-patients-with-stroke-100615904","NCT07298668","Cardiovascular Risk Factors in Middle Eastern Patients With Stroke","Standard Modifiable Risk Factors in Middle Eastern Patients With Stroke (Jo-SMMART Study)","JoSMMART","Inclusion Criteria:\n\n* Diagnosis of stroke upon admission to the hospital\n* Adult aged 18 years or older\n* Available lipid profile on hospital admission\n\nExclusion Criteria:\n\n* Stroke diagnosis unconfirmed\n* age younger than 18 years\n* No available lipid profile on admission",{"count":123,"type":20},"Stroke is a well-known a leading cause of death and disability in the Middle East. There remain many knowledge gaps in evaluating the prevalence of risk factors among patients with stroke in the Middle East. Unravelling the impact of these risk factors and controlling them can positively lower the incidence of stroke. Disparities in stroke risk factors, may well be related to ethnicity of the Middle Eastern populations , will be compared with those among stroke patients in the western literature.",[185,186,29],"Stroke","Low-Density-Lipoprotein-cholesterol Level",[185,71],"NOT_YET_RECRUITING","2025-12-22",{"date":191,"type":40},"2025-12-23",{"date":193,"type":20},"2025-12-31",{"date":195,"type":20},"2027-01-31",{"name":197,"class":47},"Jordan Collaborating Cardiology Group",{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":205,"enrollmentInfo":206,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":208,"conditions":209,"keywords":4,"overallStatus":188,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":83},"100616811","perinatal-risk-factors-in-motor-development-100616811","NCT07310459","Perinatal Risk Factors in Motor Development","Evaluation of Perinatal Risk Factors in Future Gross Motor Development of Preterm Infants: a Cross-sectional Study","Inclusion Criteria:\n\n* preterm infants showing biological risk factors\n* parents or tutors signe an informed consent.\n\nExclusion Criteria:\n\n* Diagnosis of encephalopathy\n* genetic syndromes\n* congenital malformations\n* neuromuscular disorders\n* myopathies\n* metabolic and oncologic diseases","18 Months",{"count":207,"type":20},160,"The aim of this study is to analyze the effect of preterm gestational age, birth weight and perinatal risks factors on gross motor development of preterm infants.\n\nWe will compare the data of infants evaluated by the Alberta Infant Motor Scale (AIMS) and the Perinatal Risk Inventory (PERI) in an Infant Development and Early Intervention Center (IDEIC).",[210,29,211],"Premature Infant","Motor Development of Premature Infants","2025-12-15",{"date":214,"type":40},"2025-12-30",{"date":216,"type":20},"2026-02-01",{"date":218,"type":20},"2026-04-30",{"name":220,"class":47},"Universidad de Murcia",{"id":222,"slug":223,"hasResults":11,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":231,"conditions":232,"keywords":235,"overallStatus":188,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":241,"completionDateStruct":243,"leadSponsor":245,"locationsCount":83},"100614677","falls-in-spanish-people-with-intellectual-disabilities-risk-factors-and-predictive-equation-fallsdi-study-100614677","NCT07282704","Falls In Spanish People With Intellectual Disabilities: Risk Factors And Predictive Equation. Falls.Di Study","Falls In Spanish People With Intellectual Disabilities: Analysis Of Risk Factors And Predictive Equation. Multicenter Study (Falls.Di)","Falls_Di","Inclusion Criteria:\n\n* Diagnosis of intellectual disability (all degrees of severity: mild, moderate, severe, and profound).\n* 18 years of age or older.\n* The participant must be able to stand and walk independently or with technical\u002Fpersonal aids.\n* Sign the informed consent form to participate.\n\nExclusion Criteria:\n\n* If the participant has poorly controlled epilepsy with seizures or absences that cause falls.\n* Wheelchair use.\n* Other musculoskeletal, neurological, or trauma conditions that contraindicate participation in the study.",{"count":230,"type":20},900,"This multicenter study aims to understand the specific risk factors for falls in Spanish people with intellectual disabilities in order to design an instrument to assess the risk of future falls in this population.\n\nTo this end, a prospective cohort study will be conducted in a sample of people with intellectual disabilities who meet predefined inclusion criteria from the Fundación Hospitalarias España centers that care for people with intellectual disabilities.\n\nParticipants' medical records will be reviewed for sociodemographic variables and associated comorbidities, and gait and balance will be assessed to identify potential risk factors. The number of falls experienced by participants will be monitored for 12 months.\n\nAfter the observation period, a statistical analysis will be performed to identify the main risk factors in the sample. These factors will be used to model a mathematical equation predicting the number of future falls.",[233,234,29],"Falls","Intellectual Disabilities (F70-F79)",[233,236,237,238],"Risk Factor","Intellectual Disability","Predictive Equation","2025-12-01",{"date":212,"type":40},{"date":242,"type":20},"2026-01-01",{"date":244,"type":20},"2027-04-30",{"name":246,"class":47},"Fundación Hospitalarias Betanzos",{"id":248,"slug":249,"hasResults":11,"nctId":250,"briefTitle":251,"officialTitle":251,"acronym":252,"eligibilityCriteria":253,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":4,"enrollmentInfo":254,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":256,"conditions":257,"keywords":259,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":48},"100610889","prevalence-of-h-pylori-in-stomach-cancers-in-the-west-indies-100610889","NCT07233447","Prevalence of H. Pylori in Stomach Cancers in the West Indies","PyloCaGe","Inclusion Criteria:\n\n* Patient over 18 years of age residing in Guadeloupe for more than 6 months and with a primary diagnosis of gastric cancer\n* Patient having read the information note and having signed the consent to participate in the study\n* Patient with social security coverage.\n\nExclusion Criteria:\n\n* Refusal to participate.\n* Patient who could not answer the questionnaires\n* Patient not affiliated to a social security scheme\n* Patient under legal protection (judicial safeguard, guardianship, curatorship, etc.)\n* Pregnant or breastfeeding woman\n* Subject participating in another research study that includes an exclusion period still ongoing at the time of pre-inclusion",{"count":255,"type":20},100,"The incidence and mortality of stomach cancer are higher in the French West Indies than in mainland France. The prevalence of H. pylori infection associated with this cancer remains unknown in these populations. The main objective of the study is to estimate the prevalence of H. Pylori detected by immunohistochemistry in patients newly diagnosed with cancer.",[258,29],"Oncology Epidemiology",[260,261,262],"H. Pylori","Guadeloupe","stomach cancer","2025-11-14",{"date":265,"type":40},"2025-11-18",{"date":267,"type":40},"2025-02-24",{"date":269,"type":20},"2027-02-24",{"name":271,"class":47},"Centre Hospitalier Universitaire de la Guadeloupe",{"id":273,"slug":274,"hasResults":11,"nctId":275,"briefTitle":276,"officialTitle":276,"acronym":4,"eligibilityCriteria":277,"healthyVolunteers":11,"sex":278,"minAge":56,"maxAge":279,"enrollmentInfo":280,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":282,"conditions":283,"keywords":287,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":290,"lastUpdatePostDateStruct":291,"startDateStruct":293,"completionDateStruct":295,"leadSponsor":297,"locationsCount":83},"100590463","epidemiological-factors-and-optimization-of-conservative-approaches-to-precancerous-lesions-of-female-reproductive-organs-100590463","NCT06967740","Epidemiological Factors and Optimization of Conservative Approaches to Precancerous Lesions of Female Reproductive Organs","Inclusion Criteria:\n\n* Informed Consent\n* cervical biopsy - HG lesion\n* Age: 18-46 years\n* colposcopicaly visible transformation zone\n* HPV: Unvaccinated\n* cytology all except AIS, adenocarcinoma, squamous cell carcinoma, AGC NEO\n\nExclusion Criteria:\n\n* cytology AIS, AGC NEO, adenocarcinoma, squamous cell carcinoma\n* immunosuppression\n* active autoimmune disease\n* history of cervical cryodestruction\n* HPV vaccinated prior to start of the study","FEMALE","46 Years",{"count":281,"type":20},200,"The primary aim of this study is to develop a recommended clinical practice guideline for managing women with HPV HR (high-risk human papillomavirus) positivity and cervical lesions. Additionally, in collaboration with the Bioptic Laboratory, the study will analyze the integration of HPV HR testing into screening programs for women aged 35, 45, and 55, with a focus on optimizing management strategies for HPV HR-positive women.\n\nResearch Objectives:\n\n* Evaluate spontaneous regression\u002Fprogression over two years based on HPV HR genotyping (three groups - according to Alinity: high, intermediate, and low risk).\n* Assess spontaneous regression\u002Fprogression over two years based on HPV HR genotyping and viral load in HPV-vaccinated vs. non-vaccinated patients.\n* Evaluate spontaneous regression\u002Fprogression over two years based on methylation results.\n* Assess spontaneous regression\u002Fprogression over two years based on CinTec plus results.",[284,285,29,286],"Cervical Cancer","Cervical Intraepithelial Neoplasia (CIN)","Conservative Management",[285,288,289],"Conservative management","Precancerous cervical lesions","2025-07-29",{"date":292,"type":40},"2025-07-31",{"date":294,"type":40},"2024-11-01",{"date":296,"type":20},"2029-12",{"name":298,"class":299},"Nikola Janovska","OTHER_GOV",{"id":301,"slug":302,"hasResults":11,"nctId":303,"briefTitle":304,"officialTitle":305,"acronym":4,"eligibilityCriteria":306,"healthyVolunteers":92,"sex":16,"minAge":56,"maxAge":307,"enrollmentInfo":308,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":310,"conditions":311,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":83},"100525184","establishment-and-validation-of-a-clinical-predictive-model-for-gastrointestinal-cancer-screening-based-on-patient-related-risk-factors-100525184","NCT06118437","Establishment and Validation of a Clinical Predictive Model for Gastrointestinal Cancer Screening Based on Patient-related Risk Factors","Establishment and Validation of a Clinical Predictive Model for Gastrointestinal Cancer Screening Based on Patient-related Risk Factors: a Prospective, Multicenter Cross-sectional Study","Inclusion Criteria:\n\n* Individuals aged 18-80;\n* Undergoing both gastroscopy and colonoscopy simultaneously.\n\nExclusion Criteria:\n\n* History of esophageal, gastric, or colorectal cancer;\n* Suspicions of gastrointestinal obstruction or perforation;\n* History of gastrointestinal tract surgery;\n* Not suitable for endoscopic examination due to serious diseases or unstable hemodynamics;\n* Unavailable relevant information;\n* Pregnancy or lactation period;\n* Unavailable informed consent form.","80 Years",{"count":309,"type":20},1550,"Gastrointestinal tumors (esophageal cancer, gastric cancer, colorectal cancer) seriously threaten human health, with a high incidence rate and cancer related hope mortality. Digestive endoscopy is the main method for screening gastrointestinal tumors. Early screening of gastrointestinal tumors can improve the detection of early cancer and improve prognosis. The five-year survival rate of early stage tumors after comprehensive treatment can reach 90%, while the five-year survival rate of late stage tumors is less than 30%. Therefore, the screening of gastrointestinal tumors is very important.\n\nStudies have shown that there are similarities in risk factors for gastrointestinal tumors, such as age, gender, family history, smoking, alcohol consumption, etc. Currently, established digestive malignancies are targeted at a single malignant tumor. At present, there is a lack of understanding of the overall risk factors associated with gastrointestinal tumors and the establishment of relevant risk prediction models.\n\nTherefore, we conducted a prospective, multicenter cross-sectional study to explore the independent risk factors of combined gastrointestinal tumors and establish a risk prediction model for combined screening of gastrointestinal tumors.",[312,29],"Malignant Tumor of Digestive Tract","2025-07-23",{"date":315,"type":40},"2025-07-24",{"date":317,"type":40},"2023-07-15",{"date":319,"type":20},"2025-07",{"name":321,"class":47},"Air Force Military Medical University, China",{"id":323,"slug":324,"hasResults":11,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":4,"eligibilityCriteria":328,"healthyVolunteers":11,"sex":16,"minAge":329,"maxAge":330,"enrollmentInfo":331,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":333,"conditions":334,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":83},"100432563","targeted-health-dialogues-in-primary-care-100432563","NCT04912739","Targeted Health Dialogues in Primary Care","Targeted Health Dialogues in Primary Care: Lifestyle Screening and Molecular Profiling for a Healthier Life","Inclusion Criteria:\n\n* 40-, 50-, 60-, and 70-year old men and women\n* Listed at a healthcare center in Skåne county\n\nExclusion Criteria:\n\n\\* Inability to understand the written study information and give informed consent","40 Years","70 Years",{"count":332,"type":20},18000,"The County Council of Region Skåne, Sweden, has recently initiated Targeted Health Dialogues in primary care. The prevention program includes health dialogues provided by specially trained personnel, collection of clinical and laboratory data as well as questionnaire data on, e.g., individual health and health behaviors. So far, it enrolls all 40-year old Swedish and foreign-born inhabitants in the county and it will also include all 50- and 60-year old persons within a near future. A research project will be integrated within the program where the collected data will be linked, on the individual level, to national and regional data on hospital admissions, clinical diagnoses from specialist clinics and primary care, causes of death, and prescriptions. The individual linkages will also include population data on sociodemographic characteristics, neighborhood of residence and family relations. Blood samples will be collected for analyses of molecular biomarkers. The research project will examine associations between potential predictors and future risk of cardiovascular diseases and other serious diseases, such as cancer, and also whether the effect of the prevention program is modified by these potential predictors. The effect of the intervention will be examined, and whether the protocol needs to be modified in order to develop more precise and personalized medicine.",[26,29,335,336,337],"Cardiovascular Diseases","Cancer","Serious Diseases","2025-06-24",{"date":340,"type":40},"2025-06-25",{"date":342,"type":40},"2020-10-01",{"date":344,"type":20},"2040-12-31",{"name":82,"class":47},{"id":347,"slug":348,"hasResults":11,"nctId":349,"briefTitle":350,"officialTitle":351,"acronym":352,"eligibilityCriteria":353,"healthyVolunteers":11,"sex":16,"minAge":56,"maxAge":354,"enrollmentInfo":355,"targetDuration":4,"studyType":21,"phases":357,"briefSummary":358,"conditions":359,"keywords":363,"overallStatus":188,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":376},"100475628","validation-of-a-prognostic-score-for-steroid-therapy-response-in-acute-severe-autoimmune-hepatitis-100475628","NCT05473403","Validation of a Prognostic Score for Steroid Therapy Response in Acute Severe Autoimmune Hepatitis","Validation of a Prognostic Score for Steroid Therapy Response in Acute Severe Autoimmune Hepatitis, a National Prospective Multicentre Study","PRO-SURFASA","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Strong clinical suspicion of severe acute autoimmune hepatitis defined by the presence of increased IgG and\u002For autoantibodies and\u002For histology characteristic of the disease in the absence of other causes of severe acute hepatitis.\n* International Normalized Ratio (INR) ≥ 1.5\n* Informed, written consent\n* Patient having the rights to French social insurance\n\nExclusion Criteria:\n\n* Previous medical history of chronic liver disease including autoimmune liver disease (AIH, Primary Biliary Cholangitis (PBC), Primary Sclerosing Cholangitis (PSC) , alcoholic hepatitis etc.)\n* Other causes of acute severe hepatitis:\n\n  * Hepatitis A Virus (HAV) hepatitis, defined by HAV Immunoglobulin M (IgM) antibodies\n  * Hepatitis B Virus (HBV) hepatitis, defined by HBs antigen and HBV IgM antibodies\n  * Hepatitis E Virus (HEV) hepatitis, defined by HEV IgM antibodies or positive HEV-RNA in immunosuppressed patients\n  * Drug induced hepatitis, histologically proved or induced by well-known hepatotoxic substances\n  * Acute hypoxemic hepatitis, context of shock, hypoxemia or heat shock\n  * Budd-Chiari syndrome, diagnosed by imagery (Doppler ultrasound, CT scan)\n  * Acute hepatitis in the context of a HELLP (Hemolysis, Elevated Liver enzymes and a Low Platelet count) syndrome or acute fatty liver of pregnancy\n* Use of corticosteroids 1 month before inclusion\n* Pregnant or lactating woman\n* Curator or guardianship or patient placed under judicial protection\n* Participation in other interventional research during the study","99 Years",{"count":356,"type":20},150,[23],"Autoimmune hepatitis (AIH) is a chronic liver disease, which is characterized by the increase of immunoglobulin G (IgG) level, the presence of auto-antibodies and a typical histology, in the absence of other liver disease.\n\nDue to the heterogeneity of AIH manifestations, different scoring systems have been validated in order to make a reliable diagnosis. The two most recent scoring systems are: the revised International Autoimmune Hepatitis Group (IAIHG) criteria and the IAIHG simplified criteria. The second one is recommended by the European Association for the Study of the Liver (EASL) clinical practice guidelines (CPGs).\n\nThe EASL clinical practice guidelines suggests that the treatment of ASAIH (Acute Severe AIH) is high doses of corticosteroids (superior to 1mg\u002Fkg\u002Fday) as early as possible and a lack of improvement within seven days should lead to listing for emergency liver transplantation (LT). However, the \"lack of improvement\" is not objectively defined and the grading of recommendation is III (Opinions of respected authorities).\n\nThe hypothesis of the study is that the previously developed decisional score on a retrospective series will prospectively allow the differentiation between patients with ASAIH (Acute Severe AIH) who respond to corticosteroid therapy and should be maintained on treatment and patients who do not respond and should be rapidly evaluated for LT. The score will be computed at day 3 since corticosteroid introduction.",[360,361,362,29],"Liver Failure, Acute","Hepatitis, Autoimmune","Organ Dysfunction Scores",[364,365,366],"Acute Severe AutoImmune Hepatitis (ASAIH)","Decisional score","Prognostic score","2024-03-11",{"date":369,"type":40},"2024-03-13",{"date":371,"type":20},"2024-06-01",{"date":373,"type":20},"2028-06-30",{"name":375,"class":47},"Assistance Publique - Hôpitaux de Paris",26,{"id":378,"slug":379,"hasResults":11,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":383,"eligibilityCriteria":384,"healthyVolunteers":11,"sex":16,"minAge":385,"maxAge":386,"enrollmentInfo":387,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":388,"conditions":389,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":83},"100499869","invasive-group-a-streptococcal-infection-100499869","NCT05788861","Invasive Group A Streptococcal Infection","French Pediatric Nationwide Observatory of Invasive Group A Streptococcal Infection (in Childen for 0 to 18 Ages)","ISAI","Inclusion Criteria:\n\n* Age\\\u003C18 years\n* Documented invasive Group A Streptococcus infection (identification of GAS in a normally sterile site or from another site in case of toxin shock or necrotizing dermo-hypodermatitis)\n\nExclusion Criteria:\n\n* Opposition of the patient or his\u002Fher legal representative","1 Day","17 Years",{"count":255,"type":20},"This study is observational, retrospective and prospective study in pediatric patients hospitalized with invasive streptococcal A infection",[390,29,391,392,393,394,395,396,397],"Sepsis Due to Streptococcus, Group A","Severe Infection","Medical Care","Medical Complications","Outcome, Fatal","Therapy","Strain","Virulence Factors","2024-02-07",{"date":400,"type":40},"2024-02-08",{"date":402,"type":40},"2022-09-01",{"date":404,"type":20},"2026-09-01",{"name":406,"class":47},"Association Clinique Thérapeutique Infantile du val de Marne",{"id":408,"slug":409,"hasResults":11,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":92,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":414,"targetDuration":4,"studyType":21,"phases":415,"briefSummary":416,"conditions":417,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":421,"lastUpdatePostDateStruct":422,"startDateStruct":424,"completionDateStruct":426,"leadSponsor":428,"locationsCount":83},"100509658","family-inheritance-gene-gene-and-gene-environment-interactions-in-the-field-of-cardiovascular-and-renal-diseases-fifth-visit-of-the-stanislas-cohort-100509658","NCT05916287","FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort","HÉRITABILITÉ FAMILIALE, INTERACTIONS GÈNE-GÈNE ET GÈNE-ENVIRONNEMENT DANS LE DOMAINE DES MALADIES CARDIOVASCULAIRES ET RENALES. Cinquième Visite de la Cohorte STANISLAS","Inclusion Criteria:\n\n* aged over 18\n* Person who participated in the Stanislas Cohort\n* Person affiliated to a social security scheme or beneficiary of such a scheme\n* Person having received complete information on the organization of the research and having signed an informed consent\n\nExclusion Criteria:\n\n* Persons deprived of their liberty by a judicial or administrative decision, persons undergoing psychiatric treatment under Articles L. 3212-1 and L. 3213-1\n* Person referred to in Articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code:\n\n  * Pregnant woman, parturient or nursing mother\n  * Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice)\n  * Person of full age unable to express consent",{"count":58,"type":20},[23],"The Stanislas Cohort is a monocentric familial longitudinal cohort originally comprised of 1006 families consisting of two parents and at least two biological children and deemed healthy, recruited in 1993-1995 at the Centre for Preventive Medicine of Nancy. This cohort was established with the primary objective of investigating gene-gene and gene-environment interactions in the field of cardiovascular diseases. The 5th visit of the STANISLAS Cohort will allow a better evaluation of the cardiovascular ageing of the population and the transition toward cardiovascular or renal diseases in relation with their genetic profile and environment.",[335,418,419,29,420],"Cohort Studies","Genotype","Nutrition","2023-08-11",{"date":423,"type":40},"2023-08-15",{"date":425,"type":40},"2023-07-13",{"date":427,"type":20},"2027-07-13",{"name":429,"class":47},"Central Hospital, Nancy, France"]