[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"risky-substance-use\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:risky-substance-use":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":5},"100592267","web-based-mind-body-program-to-improve-resilience-among-risky-substance-users-with-persistent-upper-extremity-pain-100592267",false,"NCT06991205","Web-based Mind-body Program to Improve Resilience Among Risky Substance Users With Persistent Upper Extremity Pain","Feasibility RCT of Web-based Mind-body Treatment to Enhance Resilience Among Patients With Painful Nontraumatic Upper-extremity Conditions and Commorbid Risky Substance Use","Inclusion Criteria:\n\n1. Outpatient adults seeking care in the Hand and Arm Center\n2. Diagnosed with a non-traumatic painful upper-extremity condition (NPUC)\n3. Pain score \\> 4 on the Numerical Rating Scale (NRS)\n4. Risky substance use (scores \\>10 and \\\u003C27 for alcohol, and \\>3 and \\\u003C27 for cannabis, cocaine, amphetamine-type stimulants, inhalants, sedatives, hallucinogens, opioids, tobacco products, and e-cigarette on The World Health Organization's - Alcohol, Smoking and Substance Involvement Screening Test \\[WHO-ASSIST\\])\n5. Owns a smartphone, laptop, or computer with internet access\n6. Age ≥18yr\n7. English fluency\n8. Ability and willingness to participate in a live video focus group and the following asynchronous Web-based intervention\n\nExclusion Criteria:\n\n1. Participation in mind-body or specialized substance abuse treatment in the past 3 months\n2. Practice of mindfulness \\>45 minutes\u002Fweek in the past 3 months\n3. Psychotropic medications (e.g. antidepressants) changed in the past 3 months\n4. Serious untreated mental illness (e.g., Schizophrenia)\n5. Suicidal ideation with intent or plan\n6. Pregnancy\n7. Secondary gains that may bias motivation (e.g., pending disability claim),\n8. Moderate to severe cognitive impairment (score ≥4 on the Short Portable Mental Status Questionnaire (SPMSQ))\n9. History of surgery for the presented NPUC within the past 6 months OR future plans for surgery.","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","The investigator aims to conduct a feasibility randomized controlled trial (RCT) (N=50) to test the feasibility, acceptability, and credibility of an asynchronous web-based mind-body intervention (Toolkit for Resilient Life beyond Pain and Substance Use; Web-TIRELESS) versus web-based minimally enhanced usual care (Web-MEUC) among adult patients with a painful non-traumatic upper-extremity condition(s) (PNUC) and commorbid risky substance use.\n\nDeliverables: \\[1\\] Adapt and refine open pilot protocol, patient recruitment, and other study materials. \\[2\\] Assess the feasibility, acceptability, and credibility of Web-TIRELESS and Web-MEUC in preparation for future research.",[26,27,28,29],"Orthopedic Disorder","Nontraumatic Injury","Upper Extremity Pain","Risky Substance Use",[31,32,33,34,35,36,37,38],"Upper Extremity Problem","Risky substance use","Randomized Controlled Trial (RCT)","Mindfulness","Nontraumatic conditions","Chronic pain","Psychiatry","Feasibility","RECRUITING","2026-03-11",{"date":42,"type":43},"2026-03-13","ACTUAL",{"date":45,"type":43},"2025-09-15",{"date":47,"type":20},"2027-03-01",{"name":49,"class":50},"Jafar Bakhshaie","OTHER"]