[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"root-canal-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:root-canal-infection":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,49,79,109,132,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644596","antibacterial-efficacy-of-bioceramic-and-calcium-hydroxide-intracanal-medicaments-100644596",false,"NCT07671326","Antibacterial Efficacy of Bioceramic and Calcium Hydroxide Intracanal Medicaments","Antibacterial Efficacy of Bioceramic and Calcium Hydroxide-Based Intracanal Medicaments in Endodontic Treatment","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Being systemically healthy (ASA I or ASA II)\n* Mandibular molar teeth with a radiographically detectable radiolucent lesion in the periapical region\n* Willingness of the volunteer or their legal representative to participate in the study by signing the Informed Consent Form\n\nExclusion Criteria:\n\n* Patients who have received antibiotics or corticosteroids within the last 3 months\n* Patients with systemic diseases\n* Teeth that cannot be properly isolated with a rubber dam\n* Teeth with periodontal pockets \\>4 mm and teeth with crown\u002Froot fractures\n* Individuals who are undergoing or planning to start orthodontic treatment during the study period\n* Pregnant or breastfeeding individuals",true,"ALL","18 Years","65 Years",{"count":21,"type":22},24,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study evaluates the antibacterial effectiveness of two different intracanal medicaments, Bio-C Temp and UltraCal XS , in mandibular molar teeth with chronic apical periodontitis. Intracanal bacterial load is assessed before and after root canal preparation, after intracanal medicament removal, and after final irrigation using droplet digital PCR.",[28,29,30],"Periapical Periodontitis","Root Canal Infection","Intracanal Medicaments",[32,33,34,35],"intracanal medicament","bioceramic medicament","ultrasonic activation","ddPCR","RECRUITING","2026-06-25",{"date":39,"type":40},"2026-06-29","ACTUAL",{"date":42,"type":40},"2025-10-15",{"date":44,"type":22},"2026-12",{"name":46,"class":47},"Medipol University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":58,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":48},"100632839","phase-4-nanozymes-in-endodontics-100632839","NCT07518901","Nanozymes in Endodontics","Ferumoxytol Nanozymes for Biofilm Disruption: A Clinical Study","Inclusion Criteria:\n\n1. Patients willing to participate in the study.\n2. Patients are 18 years or above.\n3. Non-contributory medical history (Patient can be seen for regular dental appointment in PDM; ASA classes I and II).\n4. Tooth requiring root canal treatment with radiographic presence of periapical radiolucency and\n\n   1. responding to thermal sensitivity testing negatively (Difluordichlormethane at 50 °C, Endo-Ice,\n   2. Coltène\u002FWhaledent Inc., Cuyahoga Falls, Ohio) or a negative response to EPT testing.\n5. Tooth with adequate remaining tooth structure for proper isolation with rubber dam.\n6. No history of previous endodontic treatment on the tooth.\n7. Teeth with single roots or multirooted teeth.\n\nExclusion Criteria:\n\n1. Self-reported pregnancy.\n2. Patients requiring antibiotic premedication prior to dental treatment.\n3. Patients with multiple drug allergies.\n4. Patients with known hypersensitivity to Ferumoxytol nanoparticles or any iron products.\n5. Patients who are scheduled for MRI for the head region within three months after Ferumoxytol nanoparticles application.\n6. Periodontal changes (pockets 3 mm, mobility Grade I, or gingival edema).\n7. Patients who cannot return for a subsequent appointment or follow-ups.\n8. Radiographic presence of resorptive processes.\n9. Cracked and fractured teeth.",{"count":57,"type":22},72,[59],"PHASE4","The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment. Building on prior protocols that demonstrated ferumoxytol nanozymes antimicrobial activity as a root canal irrigant, ferumoxytol solution will be applied topically, assessment of clinical and radiographical findings will determine its potential as a novel disinfection and its long-term outcome.",[62,63,29],"Apical Periodontitis","Endodontic Disease",[65,66,67,68],"Nanozymes","Root canal irrigants","Nanotechnology","iron oxide nanoparticles","NOT_YET_RECRUITING","2026-04-01",{"date":72,"type":40},"2026-04-09",{"date":74,"type":22},"2026-06",{"date":76,"type":22},"2028-06",{"name":78,"class":47},"University of Pennsylvania",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":88,"briefSummary":89,"conditions":90,"keywords":93,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":48},"100608788","clinical-trial-of-modified-endocrown-and-personalized-post-core-and-crown-for-large-area-tooth-defects-after-root-canal-treatment-100608788","NCT07206108","Clinical Trial of Modified Endocrown and Personalized Post-core and Crown for Large-area Tooth Defects After Root Canal Treatment","A Multicenter, Randomized Controlled, Single-blind, Non-inferiority Clinical Trial of Modified Endocrown and Personalized Post Core Combined With Full Crown for Large-area Tooth Defects After Root Canal Treatment","Inclusion Criteria:\n\n* 1: The affected tooth was a premolar that had undergone complete root canal treatment for two weeks. Both imaging and clinical examinations indicated no abnormal periapical reactions.\n\n  2: The oral hygiene condition is good. There is no periodontitis or combined periodontal and endodontic lesions with a probing depth greater than 4mm. There are no severe oral bad habits (such as smoking more than 20 cigarettes per day, chewing betel nuts, etc.)\n\n  3: At least 50% of the crown structure should be retained, or at least two crown walls should be retained, and the tooth defect should not be located under the gums or can be aligned with the gums or located above the gums through crown lengthening surgery.\n\n  4: The affected tooth has sufficient root length to ensure a pedicle-crown ratio of at least 1:1 and a root tip closure of at least 3 mm.\n\n  5: The occlusal function is normal.\n\n  6: Treated premolars will not be used as abutments for FPD or RPD restoration.\n\nExclusion Criteria:\n\n* 1: Root canal retreatment of the affected tooth.\n\n  2: Loosening \\> I °, alveolar bone resorption exceeds 1\u002F3 of the root length.\n\n  3: Loss of adjacent teeth and occlusal teeth.\n\n  4: The patient is in the preconception period and the pregnancy period.\n\n  5: Patients with night bruxism, deep overbite, tight occlusion or severe limited mouth opening, and temporomandibular joint diseases.\n\n  6: Patients who have a history of chemotherapy or radiotherapy in the head and neck region within 5 years, suffer from severe systemic and organic diseases, have physical disabilities or mental illnesses that affect oral hygiene care, or have received drug treatment that may affect or promote bone metabolism within the past 3 months.\n\n  7: The affected tooth has imaging manifestations of absorption inside and outside the root, or the anatomical morphology of the root and root canal is poor, such as short and small roots, curved root canals, small roots or residual roots that cannot meet the cord-to-root ratio standard for pile-core crown restoration.\n\n  8: The researchers consider other situations that are not suitable for participation.",{"count":87,"type":22},246,[25],"This study intends to adopt a multicenter, randomized controlled, single-blind, non-inferiority clinical trial design. 246 premolars that meet the inclusion criteria after complete root canal treatment will be selected from the clinical practice and randomly divided into two groups. One group will be restored with the modified endocrown, and the other group will be restored with personalized post and core combined with full crown. Follow-up visits were conducted at 6 months, 1 year and 2 years after the operation respectively. Through clinical and imaging examinations, the survival rates of the two different restorations were evaluated and used as the main evaluation indicators to fill the gap in efficacy data of the modified endocrown in clinical applications, providing a strong evidence-based medical basis for subsequent restoration improvement and standardized application.",[29,91,92],"Tooth Defect","Post and Core Technique",[94,95,96,97,98,99],"Modified endocrown","endocrown","personalized post and core combined with full crown","CAD\u002FCAM","Teeth defect","Restoration of large-area defective teeth after root canal treatment","2025-09-25",{"date":102,"type":40},"2025-10-03",{"date":104,"type":40},"2025-08-04",{"date":106,"type":22},"2029-12-31",{"name":108,"class":47},"Nanfang Hospital, Southern Medical University",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":48},"100596635","chitosan-irrigation-in-premolar-root-canal-therapy-randomized-trial-100596635","NCT07048028","Chitosan Irrigation in Premolar Root Canal Therapy (Randomized Trial)","Evaluation of the Antibacterial Efficacy of Chitosan as an Irrigation Solution: A Randomized Controlled Clinical Trial","CHITO-PRE RCT","Inclusion Criteria:\n\n* Patients who agreed to participate in the study\n* Systemically healthy patient\n* Mandibular premolar teeth\n* Teeth that respond negatively to thermal tests and EPT\n* Patients who have not used antibiotics for at least 2 weeks\n\nExclusion Criteria:\n\n* Teeth with previous primary root-canal treatment\n* Pregnant patients\n* Severely curved roots (\\>25° curvature)\n* Canals with instrument separation during preparation\n* Calcified (obliterated) canals",{"count":118,"type":22},90,[25],"The goal of this clinical trial is to learn which of three common root-canal rinsing (irrigation) methods removes bacteria most effectively in adult patients who need root-canal treatment. The main questions it will answer are:\n\nHow much does a chitosan solution used alone lower the number of bacteria inside the root canal? Do the combinations sodium hypochlorite + chitosan or sodium hypochlorite + EDTA lower bacteria even more than chitosan alone? Researchers will compare the three irrigation methods to see which one achieves the greatest bacterial reduction.\n\nWhat participants will do\n\nBe randomly assigned to one of three groups:\n\nGroup 1: Chitosan only Group 2: Sodium hypochlorite followed by chitosan Group 3: Sodium hypochlorite followed by EDTA\n\nAttend two clinic visits:\n\nVisit 1:\n\nReceive standard root-canal treatment under local anesthesia. Provide tiny paper-point samples from inside the canal before and after the assigned rinse (painless; takes seconds).\n\nVisit 2 (about 1 week later):\n\nReturn for a check-up and final filling of the tooth. Record any pain or discomfort for the first three days after treatment in a simple diary (or by phone).\n\nAbout 90 adults will take part. All procedures are routine in dental care, and there is no cost to participate. Participants may withdraw at any time and can ask the study dentist any questions throughout the trial.",[62,122,29],"Dental Pulp Necrosis","2025-07-01",{"date":125,"type":40},"2025-07-04",{"date":127,"type":40},"2025-05-05",{"date":129,"type":22},"2025-12-12",{"name":131,"class":47},"ESRA DAĞCI",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":4,"eligibilityCriteria":138,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":139,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":142,"briefSummary":143,"conditions":144,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":48},"100555916","effectiveness-of-gentlewave-system-in-endodontic-treatment-100555916","NCT06518304","Effectiveness of GentleWave System in Endodontic Treatment","Randomized Controlled Trial: Effectiveness of GentleWave System in Endodontic Treatment and Its Impact on Reducing Post- Operative Pain.","Inclusion Criteria:\n\n* Male and female patients from 18 years age or older (maximum of 80 years of age), both genders.\n* The patients in need of an endodontic intervention.\n* All dental groups in both arches were eligible.\n* Patients who do or do not experience symptoms after the endodontic intervention.\n* Patient-signed informed consent\u002Fassent form\n\nExclusion Criteria:\n\n* Patients\\\u003C 18 years old.\n* fractured teeth.\n* Patients who were recommended extraction after the endodontic evaluation.","80 Years",{"count":141,"type":22},70,[25],"This study aims to evaluate the efficacy of the GentleWave® System compared to conventional methods in reducing postoperative pain in patients with necrotic pulp or requiring endodontic retreatment.",[145,29,146],"Pain, Postoperative","Endodontically Treated Teeth","2024-08-19",{"date":149,"type":40},"2024-08-21",{"date":151,"type":22},"2024-08-20",{"date":153,"type":22},"2024-09-20",{"name":155,"class":47},"University of Salamanca",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":23,"phases":166,"briefSummary":167,"conditions":168,"keywords":169,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":174,"lastUpdatePostDateStruct":175,"startDateStruct":177,"completionDateStruct":179,"leadSponsor":181,"locationsCount":48},"100403008","outcome-of-endodontic-retreatment-in-one-or-two-visits-100403008","NCT04527705","Outcome of Endodontic Retreatment in One or Two Visits","Clinical and Radiographic Outcome of Endodontic Retreatment in One or Two Visits: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Patients that demonstrate understanding of the study and willingness to participate as evidenced by signing the voluntary informed consent and received a signed and dated copy of the informed consent form.\n* Understands and is willing to comply with all study procedures and restrictions.\n* Not presence of clinically significant and relevant abnormalities of clinical history or oral examination.\n* Retreatment cases due to an endodontic failure.\n* Diagnosis of apical periodontitis.\n* Single or bi-radicular teeth.\n\nExclusion Criteria:\n\n* General: Patients with systemic diseases, diabetes, immunocompromised and pregnant women, or any clinically significant or relevant oral abnormalities.\n* Specific: root resorption, root fractures, impossibility of restoration and cases were secondary root canal treatment is not the treatment of choice.","75 Years",{"count":165,"type":22},110,[25],"This study is a prospective randomized controlled study of patients who come to the University and non-surgical root canal retreatment is considered as the election of choice in presence of periapical disease. The aim is to evaluate the success rate of non-surgical retreatment performed in one compared to two visit treatment up to 10 years of follow-up. The null hypothesis is that there will be no statistically significant differences in rates of success, when performing root canal non-surgical retreatment in one or two visits.",[63,146,29],[170,171,172,173],"Primary root canal treatment","Secondary root canal treatment","Periapical healing","Outcome","2020-08-23",{"date":176,"type":40},"2020-08-26",{"date":178,"type":40},"2018-09-20",{"date":180,"type":22},"2031-07-20",{"name":182,"class":47},"Universitat Internacional de Catalunya"]