[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"root-canal-therapy\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:root-canal-therapy":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100629630","mineral-trioxide-aggregate-mta-vs-gutta-percha-for-non-surgical-endodontic-retreatment-in-teeth-with-apical-lesions-100629630",false,"NCT07477171","Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions","Comparison of Two Root Canal Filling Materials in Non-Surgical Endodontic Retreatment: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nPatients ≥18 years old American Society of Anesthesiologists (ASA) physical status I and II Teeth requiring non-surgical endodontic retreatment Periapical lesion ≤10 mm in maximum diameter on periapical radiograph Apical canal diameter ≤ size 50 Teeth without periodontal defects or mobility\n\nExclusion Criteria:\n\nSmokers Teeth with insufficient remaining tooth structure Teeth requiring surgical retreatment Primary endodontic treatment complications (fractured instrument, perforation, ledge or apical transportation)","ALL","18 Years",{"count":19,"type":20},58,"ESTIMATED","INTERVENTIONAL",[23],"NA","The main objective of this study is to compare the healing rate of periapical lesions after non-surgical endodontic retreatment in teeth obturated with gutta-percha versus those obturated with mineral trioxide aggregate (MTA), with a 12-month follow-up. Secondary objectives include evaluating differences between groups in healing time, postoperative pain, and tooth discoloration.",[26,27,28],"Periapical Diseases","Root Canal Therapy","Mineral Trioxide Aggregate (MTA)",[30,31,32],"non-surgical endodontic retreatment","bioceramic","gutta-percha","NOT_YET_RECRUITING","2026-03-18",{"date":36,"type":37},"2026-03-23","ACTUAL",{"date":39,"type":20},"2026-03",{"date":41,"type":20},"2027-04",{"name":43,"class":44},"University of Santiago de Compostela","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100590823","comparison-of-endodontic-flare-up-in-single-visit-root-canal-treatment-versus-multiple-visit-root-canal-treatment-in-patients-visiting-scd-swat-100590823","NCT06972433","Comparison of Endodontic Flare up in Single Visit Root Canal Treatment Versus Multiple Visit Root Canal Treatment in Patients Visiting Scd, Swat.","Inclusion Criteria:\n\n* Children in the age group \\>10 years with deep caries approximating pulp on radiograph and indicated for a root canal treatment.\n* Proper bone support.\n* No evidence of severe mobility\u002Fdischarge of frank pus\n* Radiographically tooth indicated for root canal treatment.\n* Permanent first molars with periapical radiolucency not exceeding 3 mm × 3 mm in size.\n* Complete root formation.\n* Teeth in which the initial master file (K-File)binds at the apex were of ISO size 45 or less.\n\nExclusion Criteria:\n\n* Tooth\u002Fteeth with extensive periodontal pathology\u002F periapical radiolucency.\n* Teeth with evidence of internal or external root resorption involving more than one third of the root length.\n* Children with facial cellulitis or significant extraoral swelling.\n* Patients with any systemic diseases.\n* Patients who had been taking Antibiotics ,nonsteroidal anti-inflammatory drugs, corticosteroids at time of treatment.\n* Pregnant patients","10 Years","60 Years",{"count":55,"type":20},344,[23],"This randomized controlled trial aims to compare the incidence of endodontic flare-ups in patients undergoing single-visit versus multiple-visit root canal treatment (RCT) at Saidu College of Dentistry, Swat. The study will recruit 344 patients aged above 10 and below 60 years, with permanent first molars indicated for RCT and meeting specific clinical and radiographic criteria. Participants will be randomly allocated into two groups: one receiving single-visit RCT and the other receiving multiple-visit RCT. Pain and flare-up incidence will be evaluated using the Visual Analog Scale (VAS) and swelling grading criteria at 6, 24, and 48 hours post-treatment. The primary outcome is the frequency of endodontic flare-ups requiring additional intervention. The study also examines the role of occlusal reduction in managing postoperative discomfort. Data will be analyzed using SPSS v23 with chi-square and Fisher's exact tests to compare outcomes. The findings aim to inform evidence-based protocols for endodontic treatment in the local population.",[59,27,60],"Postoperative Complication","Pulpitis - Irreversible",[62],"enddoontic flare-ups, root canal therapy, single visit root canal treatment, multiple visit root canal treatment","2025-05-13",{"date":65,"type":37},"2025-05-15",{"date":67,"type":20},"2026-01-01",{"date":69,"type":20},"2026-06-30",{"name":71,"class":44},"College of Physicians and Surgeons Pakistan"]