[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"root-canal-treatment\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:root-canal-treatment":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,41,70,102],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100642378","clinical-performance-of-ah-plus-jet-root-canal-sealers-in-single-cone-protocols-100642378",false,"NCT07642284","Clinical Performance of AH Plus Jet® Root Canal Sealers in Single-cone Protocols","A Prospective, Parallel-group, Randomized Clinical Investigation Evaluating Performance and Safety of the AH Plus Jet® Sealing Materials Used in Single-cone Technique for Single Visit Endodontic Treatment. A 2-year Follow-up Study","Inclusion Criteria:\n\n1. Adult aged 18-75 at time of informed consent.\n2. Subject willing to participate in the clinical investigation and able to understand the content of the clinical investigation.\n3. Subject willing to return for follow-up visits.\n4. Subject has signed and dated the informed consent form.\n5. Subject in need of one or two primary root canal treatment on mature permanent anterior (incisor or canine) or premolar tooth.\n6. Planned study tooth has a favorable prognosis for the next 2 years.\n\nExclusion Criteria:\n\n1. History of allergic reaction to epoxy resins or amines or any of the other product components.\n2. Subject has significant systemic health issues or chronic conditions (American Society of Anesthesiologists (ASA) class 3-6).\n3. Known pregnancy or is breastfeeding at time of enrolment or at the RCT visit.\n4. Subject unlikely to comply with investigational procedures, as judged by the Investigator.\n5. Sign of sinus tract or gingival swelling in the planned study position.\n6. Previous enrolment in the present clinical investigation.\n7. Involvement in the planning and conduct of the clinical investigation (applies to both Dentsply Sirona personnel and the clinical investigation site).\n8. Participation in another clinical investigation that may interfere with the present clinical investigation.\n9. Subject experiencing an intraoperative condition that may interfere with the evaluation of the investigational root canal sealer.","ALL","18 Years","75 Years",{"count":20,"type":21},130,"ESTIMATED","INTERVENTIONAL",[24],"NA","A prospective, parallel-group, randomised, post-market clinical follow-up investigation evaluating the performance and safety of the modified formula of the AH Plus Jet® Endodontic Sealer (also referred to as ES) and the predicate AH Plus Jet® Root Canal Sealing material (also referred to as RCS). Around 150 teeth will be randomly assigned to receive either ES or RCS root canal treatment using the single-cone technique. A maximum of 2 teeth per participant will be included and \"tooth\" will be considered the statistical unit and hence considered independent even if the teeth are in the same participant. Participants will be followed up for a period of 24 months to assess the outcomes.",[27],"Root Canal Treatment","NOT_YET_RECRUITING","2026-06-15",{"date":31,"type":32},"2026-06-16","ACTUAL",{"date":34,"type":21},"2026-05-30",{"date":36,"type":21},"2029-03-30",{"name":38,"class":39},"Dentsply Sirona Implants and Consumables","INDUSTRY",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100637105","postoperative-pain-following-root-canal-treatment-with-bioceramic-sealers-100637105","NCT07574801","Postoperative Pain Following Root Canal Treatment With Bioceramic Sealers","Postoperative Pain and Sealer Extrusion Following Root Canal Treatment With Neosealer Flo and Ceraseal Bioceramic Sealers; a Randomized Clinical Trial","Inclusion Criteria:\n\n1. Molar teeth requiring root canal treatment\n2. Diagnosed with symptomatic irreversible pulpitis,\n3. Patients able to understand and use the VAS scale\n\nExclusion Criteria:\n\n1. Patients with systemic diseases affecting pain perception\n2. Use of analgesics within 12 hours before treatment\n3. Previously treated teeth\n4. Teeth with periapical abscess or swelling","60 Years",{"count":50,"type":21},30,[24],"To evaluate and compare postoperative pain and extrusion of sealers following root canal treatment using NeoSealer Flo and CeraSeal bioceramic sealers",[27,54],"Irreversible Acute Pulpitis",[56,57,58,59],"postoperative pain","bioceramic sealer","extrusion","root canal treatment","2026-05-03",{"date":62,"type":32},"2026-05-08",{"date":64,"type":21},"2026-05-01",{"date":66,"type":21},"2026-09-08",{"name":68,"class":69},"Cairo University","OTHER",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":80,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":40},"100613303","this-clinical-trial-aims-to-compare-the-effectiveness-of-two-intra-pulpal-cryotherapy-techniques-endo-ice-and-ice-sticks-in-decreasing-intra-operative-pain-and-enhancing-the-success-of-local-anesthesia-during-pulpectomy-of-mandibular-molars-with-symptomatic-irreversible-pulpitis-100613303","NCT07264829","This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis.","Comparative Analysis of Intra-pulpal Cryotherapy Methods During Pulpectomy in Molars With Symptomatic Irreversible Pulpitis: A Randomized Control Trial","Inclusion Criteria:\n\n1. Individuals (Male and Female) aged 18 to 40 years.\n2. Healthy individuals with no significant present and past medical findings.\n3. Mandibular molars.\n4. Symptomatic irreversible pulpitis (moderate to severe pain according to VAS 4-10).\n5. Periapical index (PAI) Score: 1-3 on periapical radiograph.\n6. DAS-R: 4-14( mild to moderate anxiety)\n\nExclusion Criteria:\n\n1. Immature teeth with open apices.\n2. Calcified pulp chamber and canals.\n3. Periodontally compromised teeth.\n4. Individuals who had taken steroids, analgesics, or antibiotics within the last 48 hours.","40 Years",{"count":79,"type":21},90,[24],"The goal of this clinical trail is to compare the analgesic effect of endo-ice and ice-sticks in reducing intra-operative pain during pulpectomy in molars with Symptomatic Irreversible Pulpitis. Principal Investigator will perform the procedure and outcome assessor will interview the participants as well as fill the pre-operative questionnaire. The patient will be instructed beforehand on how to score their pre-operative, intra-operative and post-operative intensity of pain according to Visual Analogue Scale.The Anxiety level of patient will also be recorded according to the Corah's Dental Anxiety Scale questionnaire and their level of anxiety before and after the intervention will be recorded by the outcome assessor.\n\nThe principal investigator will perform all endodontic procedures, with the outcome assessor blinded to the cryotherapy method. Prior to administering IANB, a topical anesthetic gel will be applied. A 27-gauge needle will deliver 1.8 ml of 2% lidocaine with 1:100,000 epinephrine at a rate of 1 ml\u002Fmin. After a 5-minute wait, anesthesia effectiveness will be confirmed through electric pulp testing (EPT) on a neighboring tooth, with two consecutive negative responses confirming success. Once adequate anesthesia is confirmed, an access opening will be made under rubber dam isolation for the procedure.\n\n1. CONTROL GROUP: After access opening and complete de-roofing of the pulp chamber, pulpectomy of the inflamed pulp will be performed under the given effective IANB with no additional intervention to control intra-operative pain.\n2. ENDO-ICE GROUP: After access opening, pulp will be exposed and de-roofing will be performed. Endo-ice with the help of cotton pellet will be applied inside the pulp chamber for 2min (8 consecutive applications, 15sec each) and pulpectomy of the inflammed pulp will be performed immediately.\n3. ICE-STICKS GROUP: Following the access opening and complete de-roofing of pulp chamber, four ice sticks will be placed inside the pulp chamber for 2 minutes (30 seconds each, using tweezer). Subsequently, pulpectomy of the inflamed pulp will be performed immediately.\n\nPatients will be asked to rate their level of pain to the outcome assessor at four specific intervals during the trial, i.e., pre-operative (before local anesthesia), pre-operative (after local anesthesia), during pulpectomy and immediately after pulp extirpation and it will be recorded in a proforma by the blinded outcome assessor.\n\nPain and Anxiety Scores will be compared to asses either cryotherapy or which method of cryotherapy found to be effective in reducing intra-operative pain.",[27,83,84,85],"Intra-operative Pain","Symptomatic Irreversible Pulpitis","Cryotherapy Effect",[87,88,89,90,91,92,84],"Cryotherapy","Endodontic treatment","Intra-operative pain","Pulpectomy","Endo-ice","Ice-sticks","2026-03-11",{"date":95,"type":32},"2026-03-13",{"date":97,"type":21},"2026-04-15",{"date":99,"type":21},"2026-10-30",{"name":101,"class":69},"Dow University of Health Sciences",{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":40},"100370634","histological-evaluation-in-the-efficacy-of-gentlewave-in-root-canal-pulp-tissue-debridement-and-disinfection-of-difficult-to-reach-areas-in-mandibular-human-molars-ii-an-in-vivo-study-100370634","NCT04105907","Histological Evaluation in the Efficacy of GentleWave in Root Canal Pulp Tissue Debridement and Disinfection of Difficult to Reach Areas in Mandibular Human Molars II. An In-vivo Study.","Inclusion Criteria:\n\n* Only teeth that patient decided to have the extraction done instead of having any other type of dental treatment and teeth extracted at patient's petition.\n\nExclusion Criteria:\n\n* Teeth with root fractures or previously root canal treated teeth.\n* Teeth with severe loss of structure\n* Children","70 Years",{"count":110,"type":21},50,[24],"The purpose of this study is to understand and learn better the efficacy of GentleWave and obtain histological evidence of the efficacy of this new technology done in-vivo",[27],[115,116,117],"GentleWave","Multisonication","Sonendo","2025-09-05",{"date":120,"type":32},"2025-09-12",{"date":122,"type":21},"2025-11-01",{"date":124,"type":21},"2026-11-01",{"name":126,"class":69},"The University of Texas Health Science Center, Houston"]