[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rotator-cuff-disease\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rotator-cuff-disease":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,40,61,82,113],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100639431","umbilical-cord-derived-mesenchymal-stem-cell-injectables-for-the-regeneration-of-partial-thickness-rotator-cuff-tears-100639431",false,"NCT07605559","Umbilical Cord-derived Mesenchymal Stem Cell Injectables for the Regeneration of Partial-thickness Rotator Cuff Tears","A Multi-center Study on Umbilical Cord-derived Mesenchymal Stem Cell Injectables for the Regeneration of Partial-thickness Rotator Cuff Tears","Inclusion Criteria:\n\n* Adults aged 19 years or older\n* Shoulder pain lasting for at least 3 months\n* A pain visual analogue scale (VAS) score of 4 or greater\n* Inadequate response to sufficient conservative treatment for at least 3 months, such as medication, injection therapy, physical therapy, or exercise therapy\n* Partial-thickness rotator cuff tear confirmed by ultrasonography or magnetic resonance imaging (MRI)\n* No restrictions on participation in clinical trial procedures, including hospitalization\n\nExclusion Criteria:\n\n* Receipt of subacromial injection therapy in the affected shoulder within the past 3 months\n* History of rotator cuff surgery on the affected shoulder within the past 6 months\n* Previous treatment with a stem cell therapy for the shoulder\n* Presence of any of the following shoulder conditions: full-thickness rotator cuff tear, obvious isolated acromioclavicular joint arthropathy, or a clear history of trauma to the shoulder joint within the past 3 months\n* Radiologic findings suggestive of or consistent with any of the following: malignancy, severe glenohumeral osteoarthritis, bony abnormalities causing narrowing of the subacromial space, or clear evidence of acute traumatic rotator cuff injury\n* Presence of symptomatic cervical spine disease\n* Patients with polyarthritis, infectious arthritis, rheumatoid arthritis, or fibromyalgia\n* Clinical trial subjects with neurological deficits\n* Pregnant or breastfeeding women\n* Unwillingness to use an effective method of contraception during participation in the clinical trial\n* Presence of any serious disease that may affect participation in this clinical trial, including cardiovascular, renal, hepatic, endocrine, or neoplastic disease\n* Inability to understand the questions used to assess the subject's condition, including the visual analogue scale (VAS), or communication difficulties due to psychiatric illness\n* Unwillingness to participate in the clinical trial or difficulty in complying with follow-up visits according to the study schedule\n* Participation in another clinical trial within 3 months prior to enrollment in this clinical trial\n* Any other condition that, in the opinion of the investigator, makes the subject unsuitable for participation in this clinical trial","ALL","19 Years",{"count":19,"type":20},38,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to evaluate umbilical cord-derived mesenchymal stem cell injectables for the regeneration of partial-thickness rotator cuff tears",[26],"Rotator Cuff Disease","NOT_YET_RECRUITING","2026-05-18",{"date":30,"type":31},"2026-05-26","ACTUAL",{"date":33,"type":20},"2026-05-01",{"date":35,"type":20},"2028-12-31",{"name":37,"class":38},"Kyoung Hwan Koh","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":4,"briefSummary":50,"conditions":51,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":53,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":39},"100621750","long-term-follow-up-study-to-evaluate-long-term-safety-and-efficacy-of-allogenic-umbilical-cord-derived-mesenchymal-stem-cell-in-patients-with-rotator-cuff-disease-100621750","NCT07374679","Long-Term Follow-up Study to Evaluate Long-Term Safety and Efficacy of Allogenic Umbilical Cord-derived Mesenchymal Stem Cell in Patients With Rotator Cuff Disease","A Single Center, Open Label, Long-Term Follow-up Study to Evaluate Long-Term Safety and Efficacy of Allogenic Umbilical Cord-derived Mesenchymal Stem Cell in Patients With Rotator Cuff Disease","Inclusion Criteria:\n\n* Subjects who received the investigational medicinal product in the Phase 1\u002F2a clinical trial (ASB-IP-001).\n* Subjects who voluntarily agreed to participate in this long-term follow-up study and provided written informed consent.\n\nExclusion Criteria:\n\n* Subjects who cannot be contacted by any means, including telephone, mail, or e-mail, and for whom follow-up assessment is therefore not feasible.\n* Subjects deemed inappropriate for participation in this long-term follow-up study at the investigator's discretion, including:\n\n  * Cases in which participation in the study may pose a significant risk to the subject's health or safety; ② Cases in which long-term follow-up visits or assessments are practically impossible due to cognitive impairment, communication difficulties, or similar conditions; ③ Cases in which continued participation in follow-up is unlikely due to difficulty adhering to the study schedule (e.g., prolonged hospitalization, long-term residence abroad).",{"count":48,"type":20},21,"OBSERVATIONAL","The purpose of this study is to evaluate Long-Term Safety and Efficacy of Allogenic Umbilical Cord-derived Mesenchymal Stem Cell in Patients with Rotator Cuff Disease",[26],"RECRUITING",{"date":54,"type":31},"2026-05-22",{"date":56,"type":31},"2026-01-27",{"date":58,"type":20},"2032-01-30",{"name":60,"class":38},"Seoul National University Hospital",{"id":62,"slug":63,"hasResults":11,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":4,"eligibilityCriteria":67,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":68,"targetDuration":4,"studyType":21,"phases":69,"briefSummary":72,"conditions":73,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":39},"100577130","phase-1-effects-of-allogenic-umbilical-cord-derived-mesenchymal-stem-cells-on-patients-with-rotator-cuff-disease-100577130","NCT06794294","Effects of Allogenic Umbilical Cord-Derived Mesenchymal Stem Cells on Patients With Rotator Cuff Disease","A Single Center, Open Label, Phase 1\u002F2a Study to Evaluate Safety and Exploratory Efficacy of Allogenic Umbilical Cord Derived Mesenchymal Stem Cell Treatment in Patients With Rotator Cuff Disease","Inclusion Criteria:\n\n* Male or female 19 years of age and older.\n* Patients with unilateral shoulder pain lasting for at least 3months\n* Patients who do not respond to conservative treatment.\n* Patients who have not responded to sufficient non-surgical treatments, including medication, injection therapy, physical therapy, or exercise therapy, for more than 3 months\n* Patients who have a partial-thickness rotator cuff tear confirmed with magnetic resonance imaging (MRI) or ultrasonography (US).\n* Patients without any restrictions on clinical trial procedures, including hospitalization.\n\nExclusion Criteria:\n\n* Patients who have received subacromial injection therapy on the affected shoulder within the past 3 months.\n* Patients who have undergone rotator cuff surgery on the affected shoulder within the past 6 months\n* Patients with a history of receiving stem cell therapy for the shoulder.\n* Patients with the following shoulder conditions: complete rotator cuff tear, adhesive capsulitis, or isolated acromioclavicular joint arthropathy.\n* Patients showing or suspected of having the following radiological findings: malignancy, severe osteoarthritis of the glenohumeral joint, or skeletal abnormalities decreasing the subacromial space.\n* Patients presenting with symptomatic cervical spine disorders.\n* Patients with concurrent bilateral shoulder pain\n* Patients with polyarthritis, infectious arthritis, rheumatoid arthritis, or fibromyalgia.\n* Patients with neurological deficit\n* Pregnant women or lactating mothers.\n* Patients unwilling to use effective contraception during the clinical trial period.\n* Patients with current HBV, HCV, or HIV infections, or those with a positive RPR test.\n* Patients with severe diseases that may affect the clinical trial, including cardiovascular disease, renal disease, liver disease, endocrine disorders, or malignancies.\n* Patients who are unable to understand the questionnaires used for assessing their clinical status, including the Visual Analogue Scale (VAS), or those with psychiatric disorders impairing communication.\n* Patients who do not wish to participate in the clinical trial or are unable to comply with follow-up schedules.\n* Patients who have participated in another clinical trial within the last 3 months.\n* Patients deemed unsuitable for participation in this clinical trial at the investigator's discretion",{"count":48,"type":20},[70,71],"PHASE1","PHASE2","The purpose of this study is to evaluate safety and efficacy of Allogenic Umbilical Cord-derived Mesenchymal Stem Cell in Patients with Rotator Cuff Disease",[26],"2026-04-28",{"date":76,"type":31},"2026-04-29",{"date":78,"type":31},"2025-01-17",{"date":80,"type":20},"2027-01",{"name":60,"class":38},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":4,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":16,"minAge":89,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":49,"phases":4,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":111,"locationsCount":39},"100568138","establishing-clinical-significance-in-rotator-cuff-disease-100568138","NCT06677320","Establishing Clinical Significance in Rotator Cuff Disease","Establishing the Clinical Significance Values of Scales Used in Rotator Cuff Disease","Inclusion Criteria:\n\n* to be over 18 years old\n* to be a rotator cuff patient\n\nExclusion Criteria:\n\n* to have another pathology in the affected shoulder area\n* to have a neurological, rheumatological, or oncological disease\n* to have radiculopathy\n* to have had a previous fracture or operation in the affected shoulder area\n* to be not cooperative enough for what will be done within the scope of the study","18 Years",{"count":91,"type":20},69,"The goal of this observational study is to learn about rotator cuff patients. The main questions it aims to answer are:\n\n* What is the minimal clinically important difference value of the Shoulder Disability Questionnaire, the short version of the Western Ontario Rotator Cuff Index, the Shoulder Rating Questionnaire, and the University of California-Los Angeles Shoulder Scale?\n* What is the substantial clinical benefit value of the Shoulder Disability Questionnaire, the short version of the Western Ontario Rotator Cuff Index, the Shoulder Rating Questionnaire, and the University of California-Los Angeles Shoulder Scale?\n* What is the patient-acceptable symptomatic state value of the Shoulder Disability Questionnaire, the short version of the Western Ontario Rotator Cuff Index, the Shoulder Rating Questionnaire, and the University of California-Los Angeles Shoulder Scale?\n* What is the maximal outcome improvement value of the Shoulder Disability Questionnaire, the short version of the Western Ontario Rotator Cuff Index, the Shoulder Rating Questionnaire, and the University of California-Los Angeles Shoulder Scale?\n* What are the risk factors that prevent rotator cuff patients from reaching the minimal clinically important difference value?\n* What are the risk factors that prevent rotator cuff patients from reaching the substantial clinical benefit value?\n* What are the risk factors that prevent rotator cuff patients from reaching the patient-acceptable symptomatic state value?\n* What are the risk factors that prevent rotator cuff patients from reaching the maximal outcome improvement value?",[26],[95,96,97,98,99,100,101,102,103,104],"rotator cuff","clinical significance","minimal important chance","substantial clinical benefit","patient acceptable symptomatic state","maximal outcome improvement","Shoulder Disability Questionnaire","Western Ontario Rotator Cuff Index","Shoulder Rating Questionnaire","University of California-Los Angeles Shoulder Scale","2025-03-03",{"date":107,"type":31},"2025-03-04",{"date":105,"type":31},{"date":110,"type":20},"2026-06",{"name":112,"class":38},"Kırklareli University",{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":21,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":52,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":129,"leadSponsor":131,"locationsCount":39},"100578924","arthroscopic-rotator-cuff-repair-with-uc-mscs-for-large-to-massive-tears-100578924","NCT06817616","Arthroscopic Rotator Cuff Repair with UC-MSCs for Large to Massive Tears","Arthroscopic Rotator Cuff Repair with Umbilical Cord-derived Mesenchymal Stem Cells for Large to Massive Rotator Cuff Tears","Inclusion Criteria:\n\n* Male or female 19 years of age and older\n* Unilateral shoulder pain with a pain score of 4 or higher.\n* patients with a symptom duration of at least three months who have not responded to conventional treatments, including analgesics.\n* patients diagnosed with massive or extensive full-thickness rotator cuff tears confirmed by computed tomography arthrography or magnetic resonance imaging.\n\nExclusion Criteria:\n\n* patients diagnosed with small or medium full-thickness rotator cuff tears among study participants with full-thickness rotator cuff tears.\n* patients who have received subacromial injection therapy in the affected shoulder within the past three months.\n* patients who have undergone rotator cuff surgery on the affected shoulder within the past six months.\n* patients exhibiting or suspected of having the following radiological findings: malignant tumors, severe glenohumeral osteoarthritis, or bony abnormalities causing subacromial space narrowing.\n* patients presenting with symptomatic cervical spine disorders.\n* patients experiencing bilateral shoulder pain.\n* patients diagnosed with multiple arthritis, infectious arthritis, rheumatoid arthritis, or fibromyalgia.\n* patients with neurological deficits.\n* Pregnant or breastfeeding patients\n* patients unwilling to use effective contraception during the study period.\n* patients currently infected with HBV, HCV, or HIV, or those with a positive RPR test result.\n* patients with severe conditions that may affect the study, including cardiovascular diseases, renal diseases, hepatic diseases, endocrine disorders, or malignancies.\n* patients who are unable to comprehend the questionnaires used for study assessments, including the Visual Analog Scale (VAS), or those with communication difficulties due to psychiatric disorders.\n* Any other cases deemed inappropriate for study participation by the investigator.",{"count":121,"type":20},15,[23],"Safety Analysis of Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells in Patients Undergoing Rotator Cuff Repair for Massive or Large Rotator Cuff Tears",[26],"2025-02-17",{"date":127,"type":31},"2025-02-18",{"date":78,"type":31},{"date":130,"type":20},"2026-04",{"name":132,"class":38},"Korea University Anam Hospital"]