[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rotator-cuff-related-shoulder-pain\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rotator-cuff-related-shoulder-pain":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,44,67,95,115,148,174,206,229,255,283,316,345,374],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":4},"100617928","effects-of-a-4-week-low-intensity-training-with-blood-flow-restriction-in-people-with-rotator-cuff-related-shoulder-pain-100617928",false,"NCT07324993","Effects of a 4-week Low-intensity Training With Blood Flow Restriction in People With Rotator Cuff-related Shoulder Pain","Analysis of the Effects of a 4-week Low-intensity Training With and Without Blood Flow Restriction in People With Rotator Cuff-related Shoulder Pain","Inclusion Criteria:\n\n* Age between 18 and 65.\n* Shoulder symptoms lasting at least 3 months.\n* Pain in the proximal anterolateral aspect of the shoulder, aggravated by abduction.\n* At least two of the following tests positive: Jobe test, resisted external rotation test, Hawkins-Kennedy test, Neer test, painful arc between 60 and 120 degrees of shoulder abduction.\n\nExclusion Criteria:\n\n* Pain of an intensity that prevents performance of the proposed exercises.\n* Active arm elevation less than 90 degrees.\n* Clinical signs of a complete tear (positive delayed external and internal rotation sign and positive drop arm test).\n* Suspected frozen shoulder (50% reduction or more than 30° loss of passive shoulder external rotation).\n* Primary diagnosis of shoulder instability or acromioclavicular pathology.\n* Shoulder pain due to primary involvement in the cervical or thoracic region\n* Corticosteroid injection within the last 6 weeks.\n* Presence of diseases such as inflammatory arthritis, neurological diseases, fibromyalgia, malignant tumors, or polymyalgia rheumatica.\n* Presence of comorbidities that increase cardiovascular risk, such as hypertension, diabetes, or heart failure.\n* Presence of more than one thromboembolism risk factor (obesity, history of thrombosis, prolonged immobilization, recent surgery, use of contraceptives, etc.).\n* Presence of active skin lesions in the area where the sleeve will be placed, recent scars or burns, or chronic dermatological diseases that compromise skin integrity,\n* Participation in upper limb exercise programs in the last month.","ALL","18 Years","65 Years",{"count":20,"type":21},34,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to analyze the effects of 4 weeks of low-intensity exercise with and without blood flow restriction (BFR) on pain, fear of movement, catastrophizing about pain, strength, and disability in a population with rotator cuff-related shoulder pain. There are two modalities corresponding to the same exercises under different blood flow restriction conditions: 1) 3 low-intensity exercises (30% 1RM) with BFR (50% AOP); 2) 3 low-intensity exercises (30% 1RM) without BFR.\n\nParticipants will be randomly assigned to one of two groups and will undergo a 4-week intervention. The variables of interest will be assessed in each group for subsequent analysis and comparison.",[27],"Rotator Cuff Related Shoulder Pain",[29,30,31],"blood flow restriction","exercise","rotator cuff-related shoulder pain","NOT_YET_RECRUITING","2026-06-08",{"date":35,"type":36},"2026-06-09","ACTUAL",{"date":38,"type":21},"2026-09",{"date":40,"type":21},"2028-06",{"name":42,"class":43},"University of Valencia","OTHER",{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":56,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},"100610817","exercise-induced-hypoalgesia-effects-of-blood-flow-restriction-in-people-with-rotator-cuff-related-shoulder-pain-100610817","NCT07232511","Exercise-induced Hypoalgesia Effects of Blood Flow Restriction in People With Rotator Cuff-related Shoulder Pain","Differences in Exercise-induced Hypoalgesia After a Session With Different Blood Flow Restriction Protocols in People With Rotator Cuff-related Shoulder Pain","Inclusion Criteria:\n\n* Age between 18 and 65\n* Shoulder symptoms lasting at least 3 months\n* Pain in the proximal anterolateral aspect of the shoulder, aggravated by abduction\n* At least two of the following tests positive: Jobe test, resisted external rotation test, Hawkins-Kennedy test, Neer test, painful arc between 60 and 120 degrees of shoulder abduction\n\nExclusion Criteria:\n\n* History of shoulder trauma or surgery\n* Pain of such intensity that it is impossible to perform the proposed exercises\n* Active arm elevation less than 90 degrees\n* Clinical signs of a complete tear (positive delayed external and internal rotation sign and positive arm drop test)\n* Suspected frozen shoulder (50% reduction or more than 30° loss in passive shoulder external rotation)\n* Primary diagnosis of shoulder instability or acromioclavicular pathology\n* Shoulder pain due to primary involvement in the cervical or thoracic region\n* Corticosteroid injections in the last 6 weeks\n* Presence of diseases such as inflammatory arthritis, neurological diseases, fibromyalgia, malignant tumors, or polymyalgia rheumatica\n* Presence of more than one risk factor for thromboembolism\n* Participation in upper limb exercise programs in the last month",{"count":52,"type":21},30,[24],"This study aims to compare the effects of blood flow restricted (BFR) exercise and to examine the differences between various BFR protocols on acute pain reduction in individuals with rotator cuff-related shoulder pain, as well as the exercise tolerance at each intensity and occlusion setting. There are four exercise modalities corresponding to different combinations of intensity (%RM) and percentage of occlusion (%AOP): 1) 30% RM and 30% AOP; 2) 30% RM and 50% AOP; 3) 30% RM and 70% AOP; 4) 30% RM and BFR placebo (cuff without pressure).\n\nAll participants will complete one session of each of the four exercise modalities, analyzing the variables studied in each for subsequent analysis and comparison.",[27],[29,30,31],"RECRUITING","2026-04-28",{"date":60,"type":36},"2026-05-04",{"date":62,"type":36},"2026-03-05",{"date":64,"type":21},"2026-12",{"name":42,"class":43},1,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":66},"100634930","the-effect-of-an-exercise-program-based-on-attentional-focus-shifting-on-clinical-outcomes-in-rotator-cuff-related-shoulder-pain-100634930","NCT07546084","The Effect of an Exercise Program Based on Attentional Focus Shifting on Clinical Outcomes in Rotator Cuff Related Shoulder Pain","Inclusion Criteria:\n\n* Having symptoms persisting for at least 3 months\n* Experiencing pain intensity of at least 3 on the Numeric Pain Rating Scale (NPRS) during activity\n* Presence of a painful arc during shoulder flexion or abduction\n* Positive Neer test or Hawkins-Kennedy test\n* Pain provoked by resisted external rotation\u002Fabduction of the humerus, or a positive Jobe (Empty Can) test\n* Having a clinical diagnosis of subacromial pain syndrome, rotator cuff tendinopathy, subacromial bursitis, or symptomatic partial\u002Ffull-thickness rotator cuff tear\n* Being able to understand and complete questionnaires in Turkish\n\nExclusion Criteria:\n\n* Presence of adhesive capsulitis (≥30% limitation in passive range of motion)\n* Advanced osteoarthritis of the shoulder\n* History of fracture or dislocation affecting the shoulder region\n* Advanced acromioclavicular joint pathology\n* Massive rotator cuff tear (positive lag signs)\n* Previous shoulder surgery\n* Presence of neurological disorders\n* Diagnosis of rheumatoid arthritis\n* History of cancer\n* Symptomatic cervical spine pathology\n* Corticosteroid injection to the shoulder within the past 6 weeks\n* Cognitive impairments that may interfere with the ability to perform clinical tasks or execute attention shift-based exercises",{"count":74,"type":21},46,[24],"The aim of this clinical trial is to investigate the effects of an attention shift-based rehabilitation program on clinical outcomes in individuals with rotator cuff-related shoulder pain (RCRSP). The study will evaluate the effects of an attention shift approach, in which motor tasks targeting regions outside the shoulder are performed concurrently with standard shoulder exercises, on pain, functional status, and pain catastrophizing. These results will be compared with those of a standard shoulder rehabilitation program.\n\nThe main questions this study aims to answer are:\n\nIs there a difference in pain levels between individuals with RCRSP who participate in an attention shift-based rehabilitation program and those who participate in a standard exercise program? Is there a difference between these two rehabilitation approaches in terms of shoulder function and pain catastrophizing?\n\nParticipants will:\n\nBe randomly assigned to either an attention shift-based rehabilitation group or a standard shoulder rehabilitation group Participate in supervised exercise sessions twice per week for 6 weeks Attend sessions lasting approximately 60-75 minutes Undergo clinical assessments at baseline and at week 6",[27,78,79,80,81],"Subacromial Pain Syndrome","Shoulder Bursitis","Shoulder Tendinopathy","Rotator Cuff Tears of the Shoulder",[83,84,85],"Rotator cuff","Shoulder pain","attention shift","2026-04-20",{"date":88,"type":36},"2026-04-22",{"date":90,"type":21},"2026-05-15",{"date":92,"type":21},"2027-06-15",{"name":94,"class":43},"Istanbul University",{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":102,"briefSummary":103,"conditions":104,"keywords":106,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":66},"100624925","the-effect-of-a-dual-task-technique-based-exercise-program-on-clinical-outcomes-in-rotator-cuff-related-shoulder-pain-100624925","NCT07415967","The Effect of a Dual-Task Technique-Based Exercise Program on Clinical Outcomes in Rotator Cuff Related Shoulder Pain","Inclusion Criteria:\n\n* Aged between 18 and 65 years\n* Diagnosis of impingement syndrome, subacromial bursitis, rotator cuff tendinopathy, or partial rotator cuff tear\n* Shoulder pain level ≥3 according to the Numeric Pain Rating Scale (NPRS)\n* Shoulder pain persisting for at least 3 months\n\nExclusion Criteria:\n\n* Diagnosis of shoulder instability, adhesive capsulitis, or full-thickness or massive rotator cuff tear\n* Presence of musculoskeletal, neurological, and\u002For psychological conditions that would prevent participation in an exercise program\n* History of shoulder surgery\n* Having received physiotherapy or corticosteroid injection treatment for shoulder pain within the past 6 months\n* Presence of cognitive impairment that would prevent participation in dual-task exercise activities",{"count":74,"type":21},[24],"The aim of this clinical trial is to investigate the effects of a dual-task-based exercise program on clinical outcomes in individuals with rotator cuff-related shoulder pain. The study will evaluate the effects of a dual-task exercise approach, in which physical exercises are performed concurrently with cognitive tasks, on pain, functional status, pain catastrophizing and kinesiophobia. These results will be compared with those of a standard shoulder rehabilitation program. The main questions this study aims to answer are:\n\n* Is there a difference in pain levels between individuals with rotator cuff-related shoulder pain who participate in a dual-task-based exercise program and those who participate in a standard exercise program?\n* Is there a difference between these two exercise approaches in terms of shoulder function and psychosocial factors?\n\nParticipants will:\n\n* Participate in either a dual-task-based shoulder exercise program or a standard shoulder exercise program twice per week for 6 weeks.\n* Undergo clinical assessments at baseline, at week 6, and at week 12.",[27,105,78],"Shoulder Pain Syndrome",[83,84,107],"Dual-task exercise","2026-04-15",{"date":86,"type":36},{"date":111,"type":36},"2026-02-16",{"date":113,"type":21},"2027-06-16",{"name":94,"class":43},{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":66},"100625856","contextually-enriched-individualized-exercise-versus-contextually-fixed-exercise-for-rotator-cuff-related-shoulder-pain-100625856","NCT07428070","Contextually Enriched Individualized Exercise Versus Contextually Fixed Exercise for Rotator Cuff-Related Shoulder Pain","Comparison of the Effectiveness of Contextually Enriched Exercise Programs in Rotator Cuff-related Shoulder Pain","CONTEXT-RCRSP","Inclusion Criteria:\n\n* Age between 18 and 75 years\n* Clinical diagnosis of rotator cuff-related shoulder pain\n* Shoulder pain duration longer than 3 months\n* Painful arc during shoulder flexion or abduction\n* Positive Neer or Hawkins-Kennedy test\n* Pain during resisted external rotation or abduction, or positive Jobe test\n* Ability to understand and speak Turkish\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Clinical signs of a large rotator cuff tear characterized by marked weakness without pain\n* Other shoulder conditions (e.g., frozen shoulder defined as at least 30 percent passive glenohumeral restriction in two or more directions, advanced osteoarthritis, fracture, dislocation, or severe acromioclavicular joint pathology)\n* Previous shoulder surgery\n* Neurological disorders or significant systemic diseases such as rheumatoid arthritis\n* Current or past history of malignancy\n* Physical or cognitive impairments preventing participation in assessments or intervention sessions\n* Reproduction of shoulder symptoms with active cervical spine movements indicating symptomatic cervical pathology\n* Corticosteroid injection within the previous 6 weeks\n* Participation in other concurrent shoulder treatments during the study","75 Years",{"count":125,"type":21},72,[24],"The goal of this clinical trial is to learn whether adding personalized contextual factors to an exercise program can improve pain and function in people with rotator cuff-related shoulder pain. This condition is a common cause of shoulder pain and can limit daily activities.\n\nThe main questions this study aims to answer are:\n\n1. Does a contextually enriched and individualized exercise program lead to greater improvement in upper-limb disability (measured by the QuickDASH questionnaire) compared with a contextually fixed program?\n2. Does it lead to greater reductions in pain intensity (measured by the Numeric Pain Rating Scale) and greater improvements in autonomic nervous system regulation (measured by heart rate variability)?\n3. Does it result in more favorable changes in psychosocial outcomes, exercise adherence, and therapeutic alliance?\n\nResearchers will compare two exercise programs to determine whether adding personalized contextual features enhances treatment effectiveness.\n\nOne group will receive a standardized, evidence-based exercise program delivered in a fixed and neutral manner.\n\nThe other group will receive the same exercise program with added personalized contextual elements, such as:\n\n* Preferred music and lighting\n* Choice between equivalent exercises (without changing exercise type or dosage)\n* Motivational feedback and supportive communication\n* Personalized progress tracking\n\nBoth groups will:\n\n* Attend supervised exercise sessions twice per week for 12 weeks\n* Follow a structured home exercise program\n* Complete questionnaires assessing pain, function, and psychological factors\n* Undergo heart rate variability assessment to evaluate autonomic regulation\n* Be followed for 12 months after treatment\n\nThe researchers expect that integrating personalized contextual elements into exercise therapy may enhance recovery, increase motivation, and improve long-term outcomes.",[27,129,130],"Shoulder Pain","Rotator Cuff Injuries",[130,129,132,133,134,135,136,137,138],"Contextual Healing","Placebo Effect","Exercise Therapy","Therapeutic Alliance","Treatment Adherence","Pain Catastrophizing","Kinesiophobia","2026-04-06",{"date":141,"type":36},"2026-04-09",{"date":143,"type":21},"2026-05-06",{"date":145,"type":21},"2028-05-06",{"name":147,"class":43},"Istanbul Nisantasi University",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":154,"targetDuration":156,"studyType":157,"phases":4,"briefSummary":158,"conditions":159,"keywords":161,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":66},"100620686","profiling-patients-with-rotator-cuff-related-shoulder-pain-what-factors-influence-outcomes-with-non-operative-care-in-a-secondary-care-specialist-shoulder-clinic-100620686","NCT07360847","Profiling Patients With Rotator Cuff Related Shoulder Pain: What Factors Influence Outcomes With Non-operative Care in a Secondary Care Specialist Shoulder Clinic?","Inclusion Criteria:\n\n* Adults\n* Clinically diagnosed Rotator Cuff Related Shoulder Pain (disorder of the rotator cuff muscles and\u002For sub acromial space).\n* Being referred to primary care physiotherapy or other non-surgical management.\n\nExclusion Criteria:\n\n* Under 18\n* Non-rotator cuff related pathologies of the shoulder such as fractures, frozen shoulder, concomitant neck pain.\n* Person undergoing shoulder surgery.\n* Neither the patient nor carer can communicate in English sufficiently to complete consent or baseline assessment.",{"count":155,"type":21},150,"6 Months","OBSERVATIONAL","Shoulder pain from rotator cuff disorders is common, affecting function and quality of life. Many patients in orthopaedic clinics are diagnosed with these conditions. Most do not need surgery and are treated with pain relief and physiotherapy. However, long physiotherapy waitlists cause delays, and some patients do not achieve good outcomes. There is limited evidence to predict who will recover well with non-surgical care.\n\nA cohort study at Croom Orthopaedic Hospital is proposed to explore this. Patients assessed as suitable for non-surgical care by the shoulder physiotherapist will provide consent and complete questionnaires on pain, disability, quality of life, and personal factors like age and gender. They will continue with prescribed care and repeat the questionnaires after six months.\n\nThis study will identify factors predicting successful outcomes, improving treatment programs to better meet patients' needs. It is funded by the Irish Research Council and led by Professors Karen McCreesh and Rose Galvin, UL, and Mr. Tristan Cassidy, Orthopaedic Consultant. Collaborators include Catriona Foley, shoulder specialist physiotherapist at Croom.",[27,160],"RCRSP",[160,27,162,163,164],"Non-operative","Prognosis","Prognostic Factor","2026-03-23",{"date":167,"type":36},"2026-03-27",{"date":169,"type":36},"2026-01-05",{"date":171,"type":21},"2027-11-01",{"name":173,"class":43},"University of Limerick",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":181,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":182,"targetDuration":4,"studyType":22,"phases":183,"briefSummary":184,"conditions":185,"keywords":189,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":66},"100614097","hiit-for-inflammatory-driven-shoulder-pain-100614097","NCT07275164","HIIT for Inflammatory-driven Shoulder Pain.","Revolutionizing Musculoskeletal Shoulder Pain Management: High-intensity Interval Training as a Systemic Intervention. A Feasibility Study.","Inclusion Criteria:\n\nShoulder pain group\n\n* Shoulder pain \\> 3 months\n* Diagnosis of rotator cuff related shoulder pain or frozen shoulder\n* Understanding Dutch in speaking and writing.\n\nControl group\n\no Understanding Dutch in speaking and writing\n\nExclusion Criteria:\n\nShoulder pain group\n\n* \\\u003C18 years\n* Shoulder surgery or trauma in past year\n* Neurological, cancer, or neuromuscular disease\n* Osteoarthritis, cervical or AC joint pathology\n* Heavy physical exertion \\\u003C48h before testing\n\nControl group\n\n* \\\u003C18 years\n* recent or recurrent neck\u002Fshoulder pain\n* systemic or neurological disease\n* psychiatric disorders\n* pregnancy\u002Fbreastfeeding\n* pain medication \\\u003C48h before test",true,{"count":52,"type":21},[24],"This feasibility study investigates whether high-intensity interval training (HIIT) is feasible and acceptable for individuals with long-term shoulder pain where low-grade inflammation is suspected. Many patients do not recover fully with current local treatments, and systemic factors such as inflammation, and metabolic changes, additionally disturbances in the functioning of the nervous system often seem to play a role. HIIT is a time-efficient form of exercise that has been shown to improve inflammation and metabolic values and positively influence the balance of the nervous system. In this feasibility study, the investigators are enrolling 15 individuals with persistent shoulder pain (diagnosed with rotator cuff-related shoulder pain or frozen shoulder) with \\>3 months of symptoms, and 15 individuals without shoulder complaints. All participants will undergo measurements of inflammatory levels, glycosylated hemoglobin (HbA1c), blood pressure, body composition, pain sensitivity tests, and complete questionnaires about autonomic complaints and quality of life. Participants with shoulder pain will also perform one personalized HIIT session on a cycle ergometer. The investigators will assess whether participants accept a systemic intervention for their shoulder pain, if they are cooperative, and how they feel about the session; additionally, any side effects will be recorded. The aim is to determine whether HIIT is practically feasible and safe for this group and whether there are indications that systemic factors such as inflammation and nervous system function are associated with persistent shoulder pain. The outcome will determine whether follow-up research with a larger study is worthwhile.",[186,27,187,188,129],"Chronic Shoulder Pain","Frozen Shoulder","Shoulder Adhesive Capsulitis",[190,191,192,193,194,195,196],"low-grade inflammation","chronic shoulder pain","autonomic dysfunction","metabolic syndrome","frozen shoulder","rotator cuff related shoulder pain","high intensity interval training","2026-02-10",{"date":199,"type":36},"2026-02-13",{"date":201,"type":36},"2025-12-10",{"date":203,"type":21},"2026-10",{"name":205,"class":43},"Universiteit Antwerpen",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":212,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":218,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":220,"lastUpdatePostDateStruct":221,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":66},"100617878","which-patient-group-shows-greater-improvement-with-patient-education-alone-in-rotator-cuff-related-shoulder-pain---a-cohort-study-100617878","NCT07324343","Which Patient Group Shows Greater Improvement With Patient Education Alone in Rotator Cuff-Related Shoulder Pain? - A Cohort Study","Inclusion Criteria:\n\n* Individuals aged 18-65 years\n* Shoulder pain persisting for at least 4 weeks\n* Diagnosed by an orthopedic physician with impingement, subacromial bursitis, rotator cuff (RC) tendinopathy, or partial tear\n* Activity-related pain ≥3 on the NPRS\n* Cognitively able to understand the education and provide written informed consent\n\nExclusion Criteria:\n\n* History of shoulder surgery\n* Diagnosis of frozen shoulder, full-thickness or massive rotator cuff (RC) tear, or instability\n* Presence of neurological or psychiatric conditions that prevent exercise\n* History of physical therapy-rehabilitation or injection treatment within the past 6 months\n* Pain persisting for more than 12 months",{"count":213,"type":21},116,[24],"The primary aim of this study is to determine the clinical effectiveness of patient education alone in individuals with rotator cuff-related shoulder pain and to identify which patient subgroups benefit more from this approach. In addition, the translation and cultural adaptation of the \"Patient Knowledge Questionnaire (PKQ-RCRSP)\" into Turkish will be carried out to measure the level of patient knowledge regarding patient education.",[105,78,27,217],"Patient Education",[219,27],"patient education","2025-12-24",{"date":222,"type":36},"2026-01-07",{"date":224,"type":36},"2025-09-01",{"date":226,"type":21},"2026-12-01",{"name":228,"class":43},"Istanbul University - Cerrahpasa",{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":236,"targetDuration":4,"studyType":22,"phases":237,"briefSummary":238,"conditions":239,"keywords":240,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":66},"100615492","optimizing-the-use-of-virtual-reality-in-rehabilitation-for-individuals-with-persistent-shoulder-pain-100615492","NCT07293312","Optimizing the Use of Virtual Reality in Rehabilitation for Individuals With Persistent Shoulder Pain","Optimizing the Use of Virtual Reality in Rehabilitation for Individuals With Persistent Rotator Cuff-related Shoulder Pain","Inclusion Criteria:\n\n* Rotator cuff-related shoulder pain (screen by phone and then confirmed by the physiotherapist at the initial evaluation: pain over the deltoid and\u002For upper arm region, pain associated with arm movement \\[painful arc of movement\\], and familiar pain reproduced with loading or resisted testing during external rotation of the arm) for at least 6 months\n* Minimum score of 15\u002F100 on the shortened version of the Disabilities of the Arm, Shoulder, and Hand (1.5 times the minimally clinically important difference)\n\nExclusion Criteria:\n\n* Unavailable for the 4 weeks intervention\n* Cannot understand or read French\n* Have a diagnosis of rheumatoid, inflammatory or neurodegenerative diseases\n* Have received a corticosteroid injection or any other type of injection (e.g., platelet-rich plasma, prolotherapy, hyaluronic acid) in the past three months for their current condition\n* Have bilateral shoulder pain\n* Have pain in another upper limb joint\n* Have signs of upper (e.g., bilateral paresthesia, hyperreflexia, or spasticity) or lower (e.g., decreased sensation or strength in dermatomes and myotomes, hypotonia, or hyporeflexia) motor neuron lesions\n* History of shoulder surgery, dislocation, or fracture\n* Presence of severe osteoarthritis, symptomatic acromioclavicular joint pathology, or adhesive capsulitis (defined as restriction of passive glenohumeral movement of at least 30% for two or more directions)\n* Full thickness rotator cuff tear, identified by imaging or clinical tests (lag signs and gross weakness)",{"count":52,"type":21},[24],"The primary objective of this clinical trial is to investigate the effect of a block of four specific virtual reality (VR) exercises on upper limb function, pain, kinesiophobia, and pain catastrophizing in individuals with rotator cuff-related shoulder pain (RCRSP). The secondary objective is to examine participants' tolerability of different VR interventions.\n\nStudy Procedures:\n\nParticipants will:\n\n* Attend a face-to-face assessment to confirm eligibility and receive a standardized pain neurophysiology education session (week 0).\n* Visit the clinic once weekly for four weeks to undergo the VR interventions and review pain education concepts (Weeks 5 to 8).\n* Complete online questionnaires evaluating upper limb function, kinesiophobia, pain, sense of presence, and cybersickness.\n\nInterventions\n\nFour VR interventions will be tested:\n\n* Unimanual distraction task with normal visual feedback\n* Bimanual distraction task with normal visual feedback\n* Unimanual reaching task with augmented visual feedback\n* Unimanual reaching task with diminished visual feedback\n\nFindings will guide clinicians in selecting the most effective VR interventions for shoulder impairment and assess the feasibility of implementing VR in a private physiotherapy clinic for individuals with RCRSP.",[27],[241,242,243,244,245],"Musculoskeletal Disorders","Virtual reality","Education","Shoulder","chronic pain intervention","2025-12-07",{"date":248,"type":36},"2025-12-19",{"date":250,"type":21},"2026-01-15",{"date":252,"type":21},"2026-12-31",{"name":254,"class":43},"Laval University",{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":267,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":4},"100597834","predictive-model-for-pens-response-in-subacromial-pain-syndrome-100597834","NCT07063641","Predictive Model for PENS Response in Subacromial Pain Syndrome","Development of a Predictive Model to Identify Clinical Factors Associated With Response to Percutaneous Electrical Nerve Stimulation in Patients With Subacromial Pain Syndrome","Inclusion Criteria:\n\nAdults aged between 18 and 65 years.\n\nClinical diagnosis of subacromial pain syndrome (SAPS), based on the following clinical criteria:\n\n* Pain localized to the anterolateral shoulder region.\n* Symptoms present for more than 6 weeks.\n* Painful arc during shoulder abduction.\n* Positive Neer or Hawkins-Kennedy impingement signs.\n* Positive Jobe (empty can) test or external rotation resistance test.\n\nVisual Analogue Scale (VAS) for shoulder pain ≥ 3\u002F10 in the previous week.\n\nAble to understand study procedures and sign informed consent.\n\nExclusion Criteria:\n\n* Bilateral shoulder pain.\n* History of fracture, dislocation, or surgical intervention on the affected shoulder.\n* Presence of other shoulder pathologies such as adhesive capsulitis (frozen shoulder), glenohumeral instability, or full-thickness rotator cuff tear.\n* Medical contraindications for PENS application (e.g., active anticoagulation, pregnancy, or decompensated psychiatric condition).\n* Diagnosed cervical radiculopathy or myelopathy.\n* Neurological or cognitive disorders interfering with study participation.\n* Presence of chronic widespread pain syndromes, such as fibromyalgia.\n* Belonephobia (severe needle phobia) that prevents intervention.",{"count":263,"type":21},269,[24],"Subacromial pain syndrome (SPS) is one of the most common causes of shoulder pain, leading to significant disability and socioeconomic burden. Although percutaneous electrical nerve stimulation (PENS) targeting the suprascapular nerve (SN) has shown positive therapeutic outcomes, individual response to the intervention varies considerably. This study aims to develop a multivariable predictive model to estimate clinical response to SN-targeted PENS in patients with SPS. The model will be built using clinical, psychological, and neural mechanosensitivity variables. The goal is to enhance patient selection and guide personalized treatment strategies.",[78,27],[268,269,270,271,272,273],"Percutaneous Electrical Nerve Stimulation","Suprascapular Nerve","Neural Mechanosensitivity","Musculoskeletal Pain","Ultrasound-Guided Interventions","Subacromial pain syndrome","2025-07-03",{"date":276,"type":36},"2025-07-14",{"date":278,"type":21},"2025-09-20",{"date":280,"type":21},"2026-11-10",{"name":282,"class":43},"Néstor Requejo Salinas",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":298,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":66},"100569379","could-a-feedback-device-help-manage-work-related-shoulder-disorders-100569379","NCT06693479","Could a Feedback Device Help Manage Work-related Shoulder Disorders?","Could a Feedback Device Help Manage Work-related Shoulder Disorders? - Protocol of a Mixed Methods Pilot Study","Inclusion Criteria:\n\n1. Adult (≧ 18 years) employed full-time (minimum of 30 hours per week).\n2. Experiencing work-related shoulder disorders (WRSDs), with minimal score of 14 points on the for the abbreviated version of the Disability of the Arm Shoulder and Hand questionnaire (QuickDASH), stemming from a diagnosis of rotator cuff-related shoulder pain (RCRSP), shoulder osteoarthritis (SOA) or rheumatoid arthritis (RA) involving the shoulder.\n3. Symptoms persisting for more than 6 weeks.\n\nDiagnosis-specific criteria:\n\n1. RCRSP: diagnosis requires meeting three positive criteria, including the presence of a painful arc in abduction, a positive Neer sign, Hawkins-Kennedy test, or Jobe Test, pain with resisted humeral external rotation;\n2. SOA: diagnosis based on clinical findings (e.g., activity-related pain, reduced range of motion particularly external rotation and function, worsening night\u002Frest pain) and radiologic findings (e.g., osteophytes, joint space narrowing, subchondral sclerosis, cyst formations, and humeral head deformities);\n3. RA involving the shoulder: confirmed diagnosis according to the American College of Rheumatology criteria.\n\nBoth SOA and RA diagnoses will be confirmed by a physician.\n\nExclusion Criteria:\n\n1. clinical signs of a massive rotator cuff tear (e.g., pseudoparesis or pseudoparalysis, passive elevation intact but active limited to \\\u003C90°, without neurologic deficit);\n2. acute traumatic rotator cuff tears, fractures, adhesive capsulitis (characterized by night pain, pain with sudden or unexpected movements, global loss of active and passive range of motion), or shoulder instability (evidenced by a combination of orthopaedic tests such as apprehension and relocation tests, Jerk, Kim and posterior tests, along with and clinical signs like neuromuscular function impairment, history of instability, lesion mechanisms, worries that their shoulder could dislocate during activities);\n3. distal neurovascular symptoms (e.g., thoracic outlet syndrome, venous thromboembolism);\n4. previous shoulder surgery;\n5. corticosteroid injection administered within the past 3 months;\n6. symptomatic acromioclavicular joint pathology;\n7. currently receiving conservative management for their shoulder pain (excluding medication for RA and OA),\n8. absenteeism from work (unable to work at least 30 hours per week or on sick leave).",{"count":291,"type":21},42,[24],"Work-related shoulder pain is a common problem with significant socio-economic repercussions. The impact of these disorders on workers is considerable, particularly in terms of pain, disability and reduced quality of life. Several occupational factors may explain the onset of these disorders, such as changes in the work environment, physical demands, psychosocial factors specific to the occupational context and the age of workers. The lack of quantitative measurement tools to assess the physical demands of work over an extended period of time is sorely felt. Recently, our team developed a wearable feedback device, similar to a watch worn on the arm, which measures shoulder movements and muscle activity, transforming this real-time data into clinical indicators. These indicators provide immediate feedback to workers, enabling them to better understand the physical demands of their tasks and adapt accordingly. If this device proves effective in reducing physical demands, it could become a valuable tool for guiding workplace assessments and interventions. However, this device has not yet been tested on workers with shoulder pain. For this reason, a two-part pilot study is needed to understand user needs, assess ease of use and the feasibility of implementing the device. The first component will consist of a pilot clinical trial involving 42 workers suffering from shoulder pain, divided into two groups: one group will use the feedback device for 2 weeks, while the other group will continue to work without intervention. The second phase will analyze the experience of participants who have used the device.",[295,296,297],"Rotator Cuff-related Shoulder Pain","Shoulder Osteoarthritis","Rheumatoid Arthritis (RA)",[299,84,300,301,302,303,304,305,306,307],"Technology","Feasibility","Workers","Feedback","Pilot","Randomized controlled trial","Focus group","Device","Mixed methods study","2025-05-05",{"date":310,"type":36},"2025-05-08",{"date":312,"type":36},"2025-03-01",{"date":314,"type":21},"2026-07",{"name":254,"class":43},{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":322,"eligibilityCriteria":323,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":324,"targetDuration":4,"studyType":157,"phases":4,"briefSummary":326,"conditions":327,"keywords":329,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":4},"100584787","assessing-shoulder-pathways-involving-the-cuff-100584787","NCT06893900","Assessing Shoulder Pathways Involving the Cuff","Description of Care Pathways in Non-Traumatic Rotator Cuff Related Shoulder Pain Syndrome","ASPIC","Inclusion Criteria:\n\n* Rotator cuff related shoulder pain\n* Consultation with a general practitionner for this disorder in the 6 weeks prior to the inclusion\n\nExclusion Criteria:\n\n* History of upper limb trauma associated with the current episode of shoulder pain\n* Neurologic or rheumatismal shoulder disorder\n* Frozen shoulder (current or past)\n* History of advanced glenohumeral athritis\n* History of shoulder surgery (on the affected side)",{"count":325,"type":21},160,"New recommendations regarding care pathways for the management of shoulder pain syndromes have recently been published. We aim to analyze and compare the existing care pathways and identify the most appropriate approaches for different patient profiles.\n\nOur primary objective is to compare pain levels and shoulder function one year after your initial consultation with your general practitioner for this episode. We also seek to assess which healthcare professionals you consult for your shoulder management, the treatments you receive (e.g., analgesics), and any imaging studies you undergo (if prescribed).\n\nWe will send you notifications to remind you of the survey completion schedule and provide the link to access the questionnaire.\n\nParticipation in this study requires your commitment and adherence to the timeline, as missing data may compromise the analysis of results.\n\nNon-participation in the study will not affect your current medical care.",[328,27],"Rotator Cuff Shoulder Syndrome and Allied Disorders",[330,331,332,333,334,335],"rotator cuff","health economics","cost utility","incapacity","shoulder","non-traumatic","2025-04-29",{"date":338,"type":36},"2025-04-30",{"date":340,"type":21},"2025-05-12",{"date":342,"type":21},"2027-03-27",{"name":344,"class":43},"University Hospital, Grenoble",{"id":346,"slug":347,"hasResults":11,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":351,"eligibilityCriteria":352,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":353,"targetDuration":4,"studyType":22,"phases":355,"briefSummary":356,"conditions":357,"keywords":362,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":373,"locationsCount":66},"100580096","which-model-of-care-is-the-most-cost-effective-in-the-treatment-of-musculoskeletal-disorders-100580096","NCT06832852","Which Model of Care is the Most Cost-effective in the Treatment of Musculoskeletal Disorders?","Is a Stepped Model of Care Cost-effective Compared to Usual Care for Musculoskeletal Disorders? a Randomized Controlled Trial","Edu1st","Inclusion Criteria:\n\n* present with one of the four targeted MSKDs (low back pain, neck pain, anterior knee pain, rotator cuff-related shoulder pain).\n* have had pain for at least 6 weeks.\n* For low back pain (LBP): 1) non-specific LBP with or without radiation to the lower limbs, 2) minimal score of 15 on the ODI.\n* For neck pain : 1) non-specific neck pain with or without radiation to the upper limbs, 2) minimal score of 21 on the NDI.\n* For anterior knee pain : 1) anterior knee pain during walking, running or going up or down stairs, or during at least two activities among: kneeling, squatting, and resisted knee extension, 2) maximum score of 79 on the KOS-ADL.\n* For rotator cuff-related shoulder pain : 1) minimal score of 15 on the QuickDASH, and 2) shoulder pain attributed to a rotator cuff-related shoulder pain using diagnostic guidelines of the British Elbow and Shoulder Society.\n\nExclusion Criteria:\n\n* Unavailable to participate during the 24 weeks of the study.\n* Do not understand French or English.\n* Diagnosis of rheumatoid, inflammatory or neurodegenerative diseases.\n* Received a corticosteroid injection in the previous 3 months.\n* Cognitive problems interfering (Mini-Mental State Examination ≥ 24).\n* Received a corticosteroid injection in the previous 3 months.\n* Less than 6 weeks since an intervention for their condition (including performing prescribed condition-specific exercises or taking prescribed medication).\n* For low back pain (LBP): 1) LBP related to specific conditions (e.g., vertebral fracture, infections, neuropathic pain \\[\\>4 at the DN4 questionnaire\\]), 2) history of spine surgery or signs of upper motor neuron lesions (bilateral paresthesia, hyperreflexia or spasticity)..\n* For neck pain : 1) neck pain related to specific conditions (e.g.; vertebral fracture, infections, neuropathic pain \\[\\>4 at the DN4 questionnaire\\]), 2) history of spine surgery or signs of upper motor neuron lesions.\n* For anterior knee pain : 1) history of knee surgery or patellar dislocation, 2) pain believed to originate either from meniscus or from any knee ligament.\n* For rotator cuff-related shoulder pain : 1) history of shoulder surgery, dislocations, fractures or capsulitis, 2) full thickness rotator cuff tear identified by imagery or clinical tests (lag signs and gross weakness).",{"count":354,"type":21},369,[24],"As musculoskeletal disorders (MSKDs) reach epidemic proportions in Canada, access to the public health system for those who suffer from them is increasingly difficult. One of the main barriers is the delays to see a publicly funded health professional. New models of care must therefore be developed to ensure better access. We have previously shown that not all patients with a MSKD need to be closely followed by a health professional as for a large proportion of patients simply educating them is enough to resolve their MSKD. A stepped care model where education would be given first before deciding if patients need a more extensive follow-up should be explored. This project will compare the effectiveness of a Stepped Care Model to that of the two most widely used models of care: Usual Medical Care and Usual Rehabilitation Care. We think that a Stepped Care Model will be as effective to reduce functional limitations, but will lead to lower healthcare costs.\n\nAdults (n=369) with a MSKD will be randomly assigned to one of the intervention groups: Stepped Care, Usual Medical Care (physician-led intervention: e.g., advice\u002Feducation, pharmacological pain management), or Usual Rehabilitation Care (physiotherapist-led intervention: e.g., advice\u002Feducation, exercises). Participants in the Stepped Care Group will take part in two education sessions during the first 6 weeks. After 6 weeks, those who still have clinically important symptoms will receive follow-up rehabilitation interventions, while those who don't will be considered recovered and will have no further intervention. Primary (functional limitations) and secondary (e.g., pain, quality of life) outcomes will be assessed at baseline, and at 6, 12 and 24 weeks, and costs estimate will be established for each model of care. Knowing the urgent need for an overhaul of services to reduce wait times, the Stepped Care Model proposed could be a solution to improve access to health services without compromising quality of care.",[358,359,360,361],"Low Back Pain","Neck Pain","Anterior Knee Pain Syndrome","Rotator-cuff Related Shoulder Pain",[363,364,241,243,365],"Stepped-Care","Rehabilitation","Medical Care","2025-02-11",{"date":368,"type":36},"2025-02-18",{"date":370,"type":36},"2025-01-31",{"date":372,"type":21},"2028-07-31",{"name":254,"class":43},{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":16,"minAge":381,"maxAge":4,"enrollmentInfo":382,"targetDuration":4,"studyType":22,"phases":384,"briefSummary":385,"conditions":386,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":4},"100579354","effects-of-movement-representation-techniques-with-sensorimotor-training-for-rotator-cuff-related-shoulder-pain-100579354","NCT06823206","Effects of Movement Representation Techniques with Sensorimotor Training for Rotator Cuff Related Shoulder Pain","Effects of Movement Representation Techniques with Sensorimotor Training for Rotator Cuff Related Shoulder Pain: a Randomised Controlled Trial","Inclusion Criteria:\n\n* Aged 50 or above\n* Presence of shoulder pain for more than three months\n* Clinical test showed 3\u002F5 positive tests (painful arc, resisted external rotation, Neer test, Kennedy-Hawkins test, and Jobe test), and the intensity of pain being provoked should be ≥ 3\u002F10 on an 11-point numeric pain rating scale (NPRS)\n* Structural changes of rotator cuff tendons using MRI or ultrasound imaging\n\nExclusion Criteria:\n\n* History of trauma\n* Shoulder fracture, glenohumeral osteoarthritis, or arthritis in the acromioclavicular joint\n* Clinically suspected labrum lesion\n* Previous shoulder surgery or dislocation\n* Clinical signs of anterior shoulder instability\n* Clinical signs of frozen shoulders\n* Previous clinical treatment or corticosteroid injection for a shoulder injury within the last 12 months\n* Symptoms referred from or related to the spine; and (9) other competing diagnoses (i.e., rheumatoid arthritis, cancer, neurological disorders, fibromyalgia, or psychiatric illness).","50 Years",{"count":383,"type":21},122,[24],"The aim of this study is to evaluate the efficacy of 12 weeks of sensorimotor training with movement representation techniques for reducing pain intensity in people with rotator cuff related shoulder pain, relative to standard care. Besides, the secondary aim of this study is to explore the mechanisms underlying the effects of central mechanism treatment in people with rotator cuff related shoulder pain. A total of 122 older adults aged 50 or above with the presence of shoulder pain for more than three months will be recruited and randomized into 12-weeks of movement representation techniques with sensorimotor training vs. standard care. Shoulder pain and disability Index (SPADI), changes in primary motor cortex (M1) using brain MRI, changes in subacromial space using ultrasound imaging, Widespread Pain Index (WPI), Pain Catastrophising Scale (PCS), and Fear-avoidance Beliefs questionnaires (FABQ) will be assessed at baseline and 12-week post intervention.",[27],"2025-02-07",{"date":389,"type":36},"2025-02-12",{"date":391,"type":21},"2025-03",{"date":393,"type":21},"2027-12",{"name":395,"class":43},"The Hong Kong Polytechnic University"]