[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rotator-cuff-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rotator-cuff-syndrome":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,40,62,90,120,143,170,201,226,252,275,295,325],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":23,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100644406","forearm-muscle-and-tendon-thickness-in-rotator-cuff-related-shoulder-pain-100644406",false,"NCT07662772","Forearm Muscle and Tendon Thickness in Rotator Cuff-Related Shoulder Pain","Ultrasonographic Assessment of Forearm Muscle and Tendon Thickness According to Symptom Duration in Individuals With Rotator Cuff-Related Shoulder Pain","Inclusion Criteria:\n\nRCRSP Group Adults aged 18-65 years. Clinical diagnosis of rotator cuff-related shoulder pain (RCRSP). Unilateral shoulder pain lasting at least 6 weeks. Pain localized around the anterolateral shoulder, aggravated by arm elevation and\u002For overhead activities.\n\nPositive findings on at least three clinical tests suggestive of RCRSP (e.g., painful arc, Hawkins-Kennedy test, Neer test, Jobe\u002FEmpty Can test, resisted external rotation).\n\nAbility to understand the study procedures and provide written informed consent.\n\nHealthy Control Group Adults aged 18-65 years. No current shoulder pain. No history of shoulder pain, shoulder surgery, or upper extremity musculoskeletal disorders during the previous 12 months.\n\nAbility to provide written informed consent.\n\nExclusion Criteria:\n\nPrevious shoulder surgery on either upper extremity. History of shoulder fracture, shoulder dislocation, or major upper extremity trauma.\n\nFull-thickness rotator cuff tear or other shoulder pathology requiring surgical management.\n\nClinical signs of adhesive capsulitis. Cervical radiculopathy or other neurological disorders affecting the upper extremity.\n\nSystemic inflammatory, rheumatologic, or neuromuscular diseases. Peripheral nerve entrapment (e.g., carpal tunnel syndrome, cubital tunnel syndrome).\n\nPrevious surgery or significant injury involving the forearm, wrist, or hand. Corticosteroid injection into the affected shoulder within the previous 3 months.\n\nCurrent pregnancy. Inability to complete study assessments or provide informed consent.",true,"ALL","18 Years","65 Years",{"count":21,"type":22},90,"ESTIMATED","1 Day","OBSERVATIONAL","Rotator cuff-related shoulder pain (RCRSP) is one of the most common musculoskeletal disorders affecting the shoulder and is frequently associated with pain, reduced muscle strength, and impaired upper extremity function. Although previous studies have primarily focused on structural and functional changes around the shoulder, little is known about the potential adaptations occurring in the distal upper extremity, particularly the forearm muscles and tendons.\n\nAltered upper extremity use, pain-related muscle inhibition, and compensatory movement patterns associated with prolonged shoulder pain may lead to morphological changes in the forearm musculature and tendons. However, the relationship between symptom duration and these structural adaptations has not yet been investigated.\n\nThe aim of this cross-sectional study is to evaluate forearm muscle and tendon thickness using portable ultrasonography in individuals with RCRSP and to investigate whether these parameters differ according to symptom duration. In addition, hand grip strength, pain intensity, and upper extremity function will be assessed to explore their associations with ultrasonographic findings.\n\nThe findings of this study are expected to provide new insights into distal upper extremity adaptations associated with RCRSP and may contribute to the development of more comprehensive rehabilitation strategies that address not only the shoulder but also the forearm musculature.",[27],"Rotator Cuff Syndrome","NOT_YET_RECRUITING","2026-06-17",{"date":31,"type":32},"2026-06-23","ACTUAL",{"date":34,"type":22},"2026-07-18",{"date":36,"type":22},"2026-12-19",{"name":38,"class":39},"Kirsehir Ahi Evran Universitesi","OTHER",{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":4},"100641498","mobilization-with-movement-in-rotator-cuff-tendinopathy-100641498","NCT07656441","Mobilization With Movement in Rotator Cuff Tendinopathy","Effects of Mobilization With Movement on Tendon Morphology, Pain, and Function in Patients With Rotator Cuff Tendinopathy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Clinical diagnosis of rotator cuff tendinopathy (supraspinatus involvement) confirmed by musculoskeletal ultrasound\n* Shoulder pain duration of at least 3 months\n* Pain intensity ≥ 3\u002F10 on the Visual Analog Scale (VAS)\n* Ability to understand and follow instructions and complete questionnaires\n\nExclusion Criteria:\n\n* Full-thickness or large rotator cuff tear confirmed by ultrasound or MRI\n* History of shoulder surgery on the affected side\n* Diagnosis of adhesive capsulitis (frozen shoulder)\n* Shoulder instability or dislocation history\n* Cervical radiculopathy or referred neck-related shoulder pain\n* Inflammatory rheumatic diseases (e.g., rheumatoid arthritis, ankylosing spondylitis)\n* Neurological disorders affecting upper extremity function\n* Corticosteroid injection in the shoulder within the last 6 months\n* Ongoing physiotherapy or manual therapy treatment for shoulder pain in the last 3 months\n* Severe systemic or psychiatric conditions that may interfere with participation",{"count":48,"type":22},60,"INTERVENTIONAL",[51],"NA","This randomized controlled trial aims to investigate the effects of Mobilization With Movement (MWM) combined with exercise therapy on tendon morphology, pain, and functional outcomes in individuals with rotator cuff tendinopathy. A total of approximately 60 participants diagnosed with supraspinatus tendinopathy will be randomly assigned to either an exercise-only group or an exercise plus MWM group.\n\nAll participants will undergo a standardized rehabilitation program for 8 weeks. Clinical outcomes, including pain intensity (Visual Analog Scale), shoulder function (SPADI and QuickDASH), range of motion, muscle strength, proprioception, and psychosocial status (Tampa Scale of Kinesiophobia, Pain Catastrophizing Scale, and Central Sensitization Inventory), will be assessed at baseline and post-intervention. In addition, ultrasound imaging will be used to evaluate tendon morphology, including tendon thickness, subacromial bursa thickness, acromiohumeral distance, echogenicity, and vascularity.\n\nThe primary objective is to determine whether MWM produces superior improvements in clinical outcomes and whether it is associated with measurable changes in tendon structure as assessed by ultrasound. The findings are expected to contribute to a better understanding of the biomechanical and neurophysiological mechanisms underlying manual therapy in rotator cuff tendinopathy and to provide evidence for its role in musculoskeletal rehabilitation.",[27],"2026-06-15",{"date":56,"type":32},"2026-06-18",{"date":58,"type":22},"2026-07-08",{"date":60,"type":22},"2026-12-13",{"name":38,"class":39},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":49,"phases":73,"briefSummary":74,"conditions":75,"keywords":76,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":89},"100642382","effects-of-myofascial-trigger-point-release-versus-neil-asher-technique-oin-patients-with-rotator-cuff-syndrome-100642382","NCT07645963","Effects of Myofascial Trigger Point Release Versus Neil Asher Technique Oin Patients With Rotator Cuff Syndrome","Effects of Myofascial Trigger Point Release Versus Neil Asher Technique on Pain, Range of Motion, and Disability in Patients With Rotator Cuff Syndrome","Inclusion Criteria:\n\n* Age 40-60 years\n* Positive Neer's and Hawkins Kennedy test (27)\n* Grade 1 or 2 rotator cuff syndrome (non-surgical)\n\nExclusion Criteria:\n\n* Cardiac issues (e.g., myocardial infarction)\n* Fibromyalgia\n* Pregnancy\n* Trauma-related shoulder pain\n* History of shoulder surgery\n* Numbness, tingling\n* Corticosteroid injections","40 Years","60 Years",{"count":72,"type":22},36,[51],"Rotator cuff syndrome is a common cause of shoulder pain and functional limitation, often associated with myofascial trigger points. Myofascial Trigger Point Release (MFTR) and the Neil Asher Technique (NAT) are manual therapies aimed at reducing pain and improving mobility. This study compares their effects on pain, range of motion, and disability in individuals with rotator cuff syndrome.",[27],[77,78,79],"pain","functional disability","range of motion","2026-06-08",{"date":82,"type":32},"2026-06-12",{"date":84,"type":22},"2026-06-30",{"date":86,"type":22},"2026-10-30",{"name":88,"class":39},"Riphah International University",1,{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":98,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":49,"phases":103,"briefSummary":105,"conditions":106,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":4},"100540558","phase-2-estradiol-supplementation-and-rotator-cuff-repair-100540558","NCT06318403","Estradiol Supplementation and Rotator Cuff Repair","Estradiol Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial","ESTRCR","Inclusion Criteria\n\n1. A plan for a primary rotator cuff repair\n2. Female sex (assigned sex at birth)\n3. \\>1 cm tear width, full thickness supraspinatus\u002Finfraspinatus tear\n4. Post-menopausal, as defined by at least twelve months since last menses\n5. Age 50-80\n\nExclusion Criteria\n\n1. Active infection\n2. Baseline serum estradiol \\>20 pg\u002FmL\n3. Infraspinatus or supraspinatus muscle atrophy of greater than or equal to Goutallier grade 3\n4. Pre-operative systemic estradiol supplementation\n5. Medically unfit for operative intervention\n6. Revision surgery\n7. Unwillingness to participate in the study, including post-operative imaging\n8. Inability to read or comprehend written instructions\n9. Prisoner\n10. Concomitant patch augmentation or tendon-transfer\n11. Breast cancer or a history of breast cancer or other estradiol-dependent neoplasia\n12. Liver disease as documented in the medical record\n13. Active venous thromboembolic disease, such as deep venous thrombosis, pulmonary embolism, a history of these conditions, or a known predisposition to these disorders (such as Protein C, protein S, or antithrombin deficiency)\n14. Active arterial thromboembolic disease, such as stroke, myocardiac infarction, a history of these conditions, or a known predisposition to these disorders\n15. Isolated subscapularis tears\n16. Known anaphylactic reaction or hypersensitivity to estradiol, adhesive, or transdermal patches","FEMALE","50 Years","80 Years",{"count":102,"type":22},58,[104],"PHASE2","Rotator cuff tears in the shoulder are common causes of pain and disability, often fail to heal with surgery, and tears, worse outcomes after surgery, and failure of healing are associated with estradiol deficiency. In this study, post-menopausal women will be randomized to either estradiol patches or placebo patches after repair of the rotator cuff. The purpose of this study is to determine whether estradiol patches show promise in improving shoulder pain, strength, muscle volumes, and function when given with rotator cuff repair.",[107,108,27,109,110],"Rotator Cuff Tears","Rotator Cuff Injuries","Menopause Related Conditions","Menopause","2026-03-17",{"date":113,"type":32},"2026-03-19",{"date":115,"type":22},"2028-03",{"date":117,"type":22},"2030-12",{"name":119,"class":39},"University of Utah",{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":49,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":133,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":89},"100600162","study-comparing-two-anesthetics-for-arthroscopic-rotator-cuff-repair-100600162","NCT07093905","Study Comparing Two Anesthetics for Arthroscopic Rotator Cuff Repair","Prospective, Randomized Study Comparing General Anesthesia Combined With Locoregional Anesthesia to Locoregional Anesthesia Alone for Arthroscopic Rotator Cuff Repair.","ALRAGA","Inclusion Criteria:\n\n* Age ≥ 18 years;\n* Patients with surgically repairable complete or partial rotator cuff tears;\n* American Society of Anesthesiologists Class I to III;\n* Patient able to understand study information;\n* Patient willing to accept study evaluations and follow-up visits;\n* Affiliation with a social insurance plan;\n* Patient having been informed and having agreed to participate in the study by signing an informed consent form.\n\nExclusion Criteria:\n\n* Contraindication to general or locoregional anesthesia;\n* Chronic opioid use;\n* Patient unable to understand study information (linguistic, psychological, cognitive, etc.);\n* Patient unable to answer a self-questionnaire;\n* Patient participating in or being excluded from another interventional research study;\n* Pregnant or breast-feeding women;\n* Protected patient (under legal protection, guardianship or deprived of liberty by judicial or administrative decision).",{"count":129,"type":22},34,[51],"The purpose of this study is to to compare the post-anesthetic recovery time to awake consciousness and hemodynamic and ventilatory capacities for discharge from the Post-Interventional Monitoring Room in patients admitted for shoulder rotator cuff arthroscopy (using local anesthesia versus general anesthesia + local anesthesia).",[27],"RECRUITING","2026-03-13",{"date":136,"type":32},"2026-03-16",{"date":138,"type":32},"2026-03-12",{"date":140,"type":22},"2026-12",{"name":142,"class":39},"GCS Ramsay Santé pour l'Enseignement et la Recherche",{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":149,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":49,"phases":152,"briefSummary":153,"conditions":154,"keywords":157,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":89},"100622946","virtual-reality-intervention-in-patients-with-persistent-shoulder-pain-100622946","NCT07390227","Virtual Reality Intervention in Patients With Persistent Shoulder Pain","Inclusion Criteria:\n\n* General inclusion criteria:\n\n  * Unilateral shoulder pain NPRS ≥ 4\u002F10, persisting longer than 3 months\n  * Adults ≥ 16 years old\n  * Willing and able to comply with study protocol\n  * Diagnosis of rotator cuff related shoulder pain, or shoulder instability, or frozen shoulder, confirmed according to international clinical guidelines\n\n    1\\. RC related shoulder pain\n  * shoulder pain and\u002For weakness during active or resisted shoulder external rotation, and or, shoulder elevation and\u002For\n  * Presence of Painful arc during elevation\n\n    2\\. shoulder instability\n  * Radiographically, computed tomography scans, magnetic resonance imaging scans confirmed dislocation or\n  * Documented history of manual or surgical relocation of the shoulder\n  * Traumatic onset with persistent symptoms\n  * Positive apprehension sign (fear of imminent dislocation when the arm is placed in abduction and external rotation during clinical examination)\n\n    3\\. frozen shoulder\n  * Restricted active and passive range of shoulder movement in all directions\n  * Restricted active and passive shoulder external rotation of 50 percent compared to non-painful arm\n  * Nothing abnormal detected on radiograph of shoulder\n\nExclusion Criteria:\n\n* Neurological disease affecting the shoulder\n* Shoulder stiffness not consistent to frozen shoulder\n* Pain in the shoulder that is elicited by movements of the head and neck.\n* history of motion-sickness\n* history of seizures\n* severe vertigo or vestibular impairment.","16 Years",{"count":151,"type":22},30,[51],"Shoulder pain is very common and can make daily activities difficult. Many people have shoulder pain for a long time, even after treatment. Common shoulder problems include pain from the shoulder muscles and tendons, a frozen shoulder, or an unstable shoulder. Unfortunately, both surgery and physiotherapy often help only a little. This can be due to many reasons, such as people not continuing their exercises, fear of moving the shoulder, incorrect beliefs about pain, other health problems, or lifestyle factors.\n\nVirtual Reality (VR) is a new and promising technology that is already being used to help people with long-lasting pain. By using a VR headset, people can exercise in a motivating and engaging virtual environment. VR may help reduce fear of movement, improve how people feel about their body, make movement easier, and help people stick to their exercises. However, there is still very little research on using VR for long-lasting shoulder pain.\n\nThe goal of this study is to find out whether a home-based VR exercise program for people with ongoing shoulder complaints is practical and acceptable. The investigators want to know if people are willing and able to use VR at home, whether they continue the treatment, and whether it shows early signs of reducing pain and limitations. They also want to understand who benefits most from VR, in which situations it works best, and why it may or may not help.\n\nPeople aged 16 years and older who have had shoulder pain and limitations for more than three months can take part. This includes people with shoulder tendon-related pain, frozen shoulder, or shoulder instability.\n\nThe study lasts six weeks and includes three parts. First, participants receive online educational videos about shoulder pain and movement. Second, they take part in three physiotherapy sessions: one in person and two online. Third, participants use a VR headset at home every day for about 15 minutes to perform guided shoulder and whole-body exercises, such as reaching or aiming tasks. The exercises gradually become more challenging. Participants receive clear written and video instructions, and technical support is available if needed.\n\nDuring the study, participants will complete questionnaires and the VR system will record basic usage data. At the end of the study, group interviews will be held with participants and physiotherapists to talk about their experiences with VR and how it influenced pain, movement, and daily activities.\n\nUsing VR is considered safe. Some people may experience mild and short-lasting side effects, such as dizziness, but serious problems are not expected. The main effort for participants is the time spent on exercises and completing questionnaires.\n\nThe results of this study will help determine whether VR is a useful and realistic treatment option for people with long-lasting shoulder pain and will guide future, larger studies.",[27,155,156],"Shoulder Instability","Frozen Shoulder",[158,159,160],"Virtual reality","Shoulder","persitent shoulder pain","2026-02-05",{"date":163,"type":32},"2026-02-09",{"date":165,"type":22},"2026-01-12",{"date":167,"type":22},"2026-12-01",{"name":169,"class":39},"HAN University of Applied Sciences",{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":4,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":177,"targetDuration":4,"studyType":49,"phases":179,"briefSummary":180,"conditions":181,"keywords":184,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":89},"100621914","effect-of-sleeping-posture-guidance-on-sleep-quality-in-patients-with-rotator-cuff-syndrome-100621914","NCT07376811","Effect Of Sleeping Posture Guidance On Sleep Quality In Patients With Rotator Cuff Syndrome","Effect Of Sleeping Posture Guidance On Sleep Quality In Patients With Rotator Cuff Syndrome Undergoing Physical Therapy: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Clinical and\u002For radiological diagnosis of Rotator Cuff Syndrome (RCS).\n* Presence of shoulder pain for at least 3 months (chronic pain).\n* Patients aged between 18 and 65 years.\n* Patients referred for conservative physical therapy treatment.\n* Ability to understand and answer the assessment questionnaires (PSQI, MSQ, ASES, and VAS).\n* Voluntarily signing the Informed Consent Form (ICF).\n\nExclusion Criteria:\n\n* History of surgical procedures on the affected shoulder.\n* Presence of fractures or recent acute trauma in the shoulder or upper limb.\n* Associated neurological disorders, inflammatory systemic diseases (e.g., Rheumatoid Arthritis), or adhesive capsulitis (frozen shoulder).\n* Previous diagnosis of primary sleep disorders unrelated to pain (e.g., severe obstructive sleep apnea) already under clinical treatment.\n* Recent history of corticosteroid injections in the shoulder (within the last 3 months).",{"count":178,"type":22},64,[51],"This study investigates sleep quality in patients with Rotator Cuff Syndrome (RCS) undergoing physical therapy treatment. Existing literature presents a gap regarding longitudinal studies evaluating the impact of physical therapy and different sleeping positions on sleep quality within this specific population. The central hypothesis is that physical therapy, combined with guidance on the best sleeping positions, reduces pain, improves shoulder function, and consequently promotes an improvement in sleep quality for RCS patients over time. The justification for this research lies in the need to better understand the relationship between physical therapy and sleep quality in RCS patients, aiming for the development of more effective and less invasive interventions. Previous studies have demonstrated that chronic pain, a common symptom of RCS, is intrinsically linked to sleep disturbances, which can lead to deleterious effects such as dopamine reduction, alterations in the descending pain modulation system, and central sensitization. Improvements in sleep quality have been observed after surgical procedures such as shoulder arthroscopy and arthroplasty, often associated with improved function and pain reduction. Thus, this study seeks to longitudinally evaluate whether physical therapy is capable of promoting a sustained improvement in sleep quality for patients with RCS",[27,182,183],"Rotator Cuff Injury","Sleep Disorder (Disorder)",[185,186,187,188,189,190,191],"rotator cuff syndrome","sleep quality","sleeping position","physical therapy","randomized controlled trial","shoulder pain","rehabilitation","2026-01-25",{"date":194,"type":32},"2026-01-29",{"date":196,"type":22},"2026-03-01",{"date":198,"type":22},"2029-11-01",{"name":200,"class":39},"Federal University of São Paulo",{"id":202,"slug":203,"hasResults":11,"nctId":204,"briefTitle":205,"officialTitle":205,"acronym":4,"eligibilityCriteria":206,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":207,"enrollmentInfo":208,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":210,"conditions":211,"keywords":214,"overallStatus":133,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":89},"100607070","does-sarcopenia-influence-rotator-cuff-tear-patterns-radiological-insights-from-patients-with-rotator-cuff-syndrome-100607070","NCT07183774","Does Sarcopenia Influence Rotator Cuff Tear Patterns? Radiological Insights From Patients With Rotator Cuff Syndrome","Inclusion Criteria:\n\n1. Patients with rotator cuff syndrome\n2. Aged between 40 and 75 years\n\nExclusion Criteria:\n\n1. History of previous shoulder surgery\n2. Presence of shoulder pathology other than rotator cuff syndrome\n3. History of surgical intervention involving the hip or thigh region\n4. Being wheelchair-bound or bedridden\n5. Presence of an oncologic disease\n6. Diagnosis of any neurological disorder\n7. Presence of cognitive impairment","75 Years",{"count":209,"type":22},104,"Sarcopenia is the loss of muscle mass due to aging, which consequently leads to a decline in muscle function. It is considered an independent risk factor for falls and fractures, disability, postoperative complications, and mortality. Rotator cuff tears are known to be influenced by systemic diseases such as diabetes, hypercholesterolemia, thyroid disorders, and osteoporosis. The aim of our study is to investigate whether there is a relationship between sarcopenia and rotator cuff tears, and if so, to determine the location and type of the tear.",[107,212,213,27],"Sarcopenia","Shoulder Pain",[215,216,212],"Rotator cuff syndrome","Rotator cuff tear","2025-11-19",{"date":219,"type":32},"2025-11-26",{"date":221,"type":32},"2025-01-01",{"date":223,"type":22},"2025-12-30",{"name":225,"class":39},"Haydarpasa Numune Training and Research Hospital",{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":19,"enrollmentInfo":232,"targetDuration":4,"studyType":49,"phases":234,"briefSummary":235,"conditions":236,"keywords":237,"overallStatus":133,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":89},"100533654","comparison-of-rehabilitative-game-exercise-and-body-awareness-therapy-in-rotator-cuff-syndrome-100533654","NCT06228625","Comparison of Rehabilitative Game Exercise and Body Awareness Therapy in Rotator Cuff Syndrome","Inclusion Criteria:\n\n* Diagnosis of partial supraspinatus rupture by an Orthopedics and Traumatology specialist placement.\n* Unilateral shoulder pain,\n* Not having been involved in any physiotherapy program before due to shoulder problem,\n* Body mass index (BMI) ≤ 30 kg\u002Fm²\n* Cooperation of individuals\n\nExclusion Criteria:\n\n* Having had previous shoulder surgery,\n* Having received local corticosteroid injection\u002Fcorticosteroid treatment in the last three months,\n* Presence of a disease that will affect the neurological, cardiac, systemic, cognitive and visual systems,",{"count":233,"type":22},66,[51],"Rotator cuff syndrome is one of the most common problems in the shoulder, starting as acute tendinopathy and progressing to partial and full thickness tears. Shoulder pain causes a decrease in shoulder joint movement, joint position sense, upper extremity function and quality of life. Among the most commonly used conservative treatment methods; Joint range of motion exercises, stretching exercises, strengthening exercises, mobilization and electrotherapy method are included.\n\nNowadays, with the widespread use of technology in rehabilitation, video-based games have begun to be used for rehabilitative purposes in addition to conservative approaches. Although the effectiveness of video-based games has been extensively studied in diseases such as cerebral palsy, stroke and parkinsonism, there are a limited number of studies in the field of orthopedic rehabilitation, especially in shoulder rehabilitation.\n\nBasic body awareness therapy is used to treat chronic musculoskeletal-related painful conditions. In the literature, basic body awareness therapy has been studied in patient groups such as mental health, stroke patient groups, chronic musculoskeletal problems, chronic waist and neck pain, scoliosis and knee osteoarthritis. Studies have shown that the TBFT method provides improvements in individuals' body awareness, mobility in daily living activities, health-related quality of life, body image and pain intensity. However, no studies have been found in which basic body awareness therapy was used in the field of shoulder rehabilitation.\n\nOur study aims to compare the effectiveness of a rehabilitative game exercise program and body awareness training in terms of pain, joint range of motion, shoulder functionality, proprioception, body awareness, shoulder-related quality of life, kinesiophobia and patient satisfaction in individuals with Rotator cuff syndrome.",[27],[238,239,240,241,242],"Body Awareness","Body İmage","Exergame","Rotator cuff","Videogames","2025-09-26",{"date":245,"type":32},"2025-10-01",{"date":247,"type":32},"2024-12-02",{"date":249,"type":22},"2025-12-02",{"name":251,"class":39},"Medipol University",{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":11,"sex":17,"minAge":69,"maxAge":19,"enrollmentInfo":259,"targetDuration":4,"studyType":49,"phases":260,"briefSummary":261,"conditions":262,"keywords":263,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":272,"leadSponsor":273,"locationsCount":89},"100514249","exercise-vs-supplements-in-rotator-cuff-related-shoulder-pain-100514249","NCT05976035","Exercise vs. Supplements in Rotator Cuff-Related Shoulder Pain","Do Taking Supplements Provide Additional Benefits in Rotator Cuff-Related Shoulder Pain?","Inclusion Criteria:\n\n* Being over the age of 40\n* Diagnosing with rotator cuff-related shoulder pain confirming through clinical examination (Hawkins Kennedy and Empty Can tests) and MRI imaging\n* Having shoulder pain for at least three months\n\nExclusion Criteria:\n\n* Having full-thickness or massive rotator cuff tear,\n* Having a history of symptoms onset due to trauma,\n* Having a history of surgery on the same shoulder,\n* Having shoulder passive external rotation \\\u003C30° and flexion \\\u003C120°,\n* Having shoulder instability,\n* Having an allergy to any supplement,\n* Having psychological, emotional, or cognitive problems\n* Presence of shoulder problems caused by systemic diseases,\n* Presence of diabetes, presence of pregnancy or breastfeeding,\n* Malignancy.",{"count":102,"type":22},[51],"Rotator cuff-related shoulder pain is a pathology characterized by pain and functional impairment originating from one or more rotator cuff tendons. The lifetime incidence of rotator cuff-related shoulder pain is around 67%, with an annual incidence exceeding 1%. Many patients continue to experience pain and functional loss for up to one year, and more than half of the patients report shoulder pain persisting for over three years.\n\nThe pathophysiology underlying rotator cuff-related shoulder pain continues to be a subject of ongoing research and uncertainty, with many aspects yet to be fully elucidated. The most common belief regarding its pathogenesis involves the role of inflammation. This hypothesis is supported by the accumulation of inflammatory cells in tendons, oxidative stress, and increased levels of pro-inflammatory cytokines. In tendon pathologies with inflammatory cell accumulation and increased cytokine levels, the use of antioxidants and anti-inflammatory agents in addition to conservative treatment contributes to tendon healing. Anti-oxidants and anti-inflammatories are substances capable of preventing or delaying certain cell damage.The use of anti-inflammatory and antioxidant supplements such as Vitamin C (Vit-C), Vitamin D (Vit-D), Omega-3, and Magnesium (Mg) is recommended. Despite indicating exercise as the gold standard for managing rotator cuff-related shoulder pain and the demonstrated anti-inflammatory and anti-oxidant properties of the mentioned supplements, there are still gaps in the understanding of their effectiveness in rotator cuff-related shoulder pain.\n\nBased on these gaps, the goal of this study is to investigate the effects of supplements (Vit-C, Vit-D, Omega-3, and Mg) given in addition to exercise on patients' blood parameters (TNF-a, IL-6, and CRP levels), pain, functional status, quality of life, and patient satisfaction in individuals with rotator cuff-related shoulder pain.",[27],[264,265,266,267],"Exercise","Physical Therapy","Anti-oxidant","Anti-Inflammatory","2025-03-21",{"date":270,"type":32},"2025-03-24",{"date":245,"type":22},{"date":167,"type":22},{"name":274,"class":39},"Istanbul University - Cerrahpasa",{"id":276,"slug":277,"hasResults":11,"nctId":278,"briefTitle":279,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":281,"targetDuration":4,"studyType":49,"phases":283,"briefSummary":284,"conditions":285,"keywords":4,"overallStatus":133,"whyStopped":4,"lastUpdateSubmitDate":286,"lastUpdatePostDateStruct":287,"startDateStruct":289,"completionDateStruct":291,"leadSponsor":293,"locationsCount":89},"100571705","additional-effects-of-mobilization-with-movement-with-upper-quadrant-core-strengthening-in-rotator-cuff-related-paina-randomized-controlled-trail-100571705","NCT06723730","ADDITIONAL EFFECTS OF MOBILIZATION WITH MOVEMENT WITH UPPER QUADRANT CORE STRENGTHENING IN ROTATOR CUFF RELATED PAIN:A RANDOMIZED CONTROLLED TRAIL","Inclusion Criteria:\n\n* Age 18-65 years\n* Both genders\n* Unilateral shoulder pain of traumatic origin\n* Scoring should be less than 8 on numeric pain rating scale\n* Symptoms lasting more than 6 weeks\n* Pain on active shoulder movement\n* Pain provoked by atleast three of the following tests. A. Neer test B. Hawkins-Kennedy test C. Empty Can test D. Full Can test E. Painfull Arc test F. Resisted external rotation test\n* Patients reffered by a rehabilitation and orthopedic specialistwith diagnosis of rotator cuff injury, subacromial impingement syndrome, subacromial pain\n\nExclusion Criteria:\n\n* History and Clinical presentation compatible with complete rotator cuff or bicep brachia rupture\n* Adhesive capsulitis\n* History of dislocation\n* Glenohumeral osteoarthritis\n* Cancer\n* Auto-immune inflammatory conditions and infection\n* Positive joint integrity tests ( Ant. and Post. Drawer tests)\n* Hill sachs lesions\n* Bankarts lesions\n* Cervical rib\n* Previous shoulder or neck surgery or fracture\n* Familiar pain provoked by neck movements\n* Presence of radicular sign\n* Diagnosis of fibromyalgia\n* Clinical depression\n* Rheumatoid arthritis\n* Poor bone quality ( osteoporosis)\n* Vertobrobasilar insufficiency test",{"count":282,"type":22},40,[51],"This study is a randomised control trial and the purpose of this study is to determine the additional effects of mobilization with movement with upper quadrant core strengthening in rotator cuff related pain\n\n.",[27],"2024-12-04",{"date":288,"type":32},"2024-12-09",{"date":290,"type":32},"2024-07-18",{"date":292,"type":22},"2025-06-20",{"name":294,"class":39},"Foundation University Islamabad",{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":301,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":303,"targetDuration":4,"studyType":49,"phases":305,"briefSummary":306,"conditions":307,"keywords":309,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":316,"lastUpdatePostDateStruct":317,"startDateStruct":319,"completionDateStruct":321,"leadSponsor":323,"locationsCount":89},"100537312","digital-physiotherapy-treatment-for-patients-with-subacromial-pain-compared-to-usual-physiotherapy-in-primary-care-100537312","NCT06276192","Digital Physiotherapy Treatment for Patients With Subacromial Pain Compared to Usual Physiotherapy in Primary Care","Digital Physiotherapy Treatment for Patients With Subacromial Pain Compared to Traditional Physiotherapy Treatment in Primary Care - a Non-Inferiority Randomised Controlled Trial","diSAID","Inclusion Criteria:\n\n* \\>18 years old\n* Pain duration \\>2 weeks\n* Lateral shoulder pain (C5 dermatome)\n\nAt least three positive tests as follows:\n\n* Painful arc\n* External rotation resistance test\n* Jobe's test\n* Neer's impingement sign\n* Hawkin's-Kennedy's impingement test\n\nExclusion Criteria:\n\n* Symptoms are related to a traumatic event in the last 6 months with suspected rotator cuff tear, dislocation or fracture.\n* Clinical features of cervical radiculopathy\n* Clinical features of Adhesive capsulitis\n* The patient does not understand or can not read Swedish\n* The patient has no access to BankID",{"count":304,"type":22},120,[51],"The goal of this clinical trial is to test a digital treatment for patients with subacromial pain using the digital Shoulder Aid (diSAID) strategy. The participants in this study will be randomly assigned to digital treatment (diSAID) or to receive the treatment that is currently available in primary care, i.e. continue according to usual practice.\n\nThe main question this clinical trial aims to answer are:\n\n\\- Can the diSAID improve shoulder function and reduce pain for patients with subacromial pain in primary care?",[308,213,27],"Subacromial Pain Syndrome",[310,311,312,313,314,315],"Shoulder pain","Subacromial pain","Digital care","Digital health intervention","Physiotherapy","Primary care","2024-02-18",{"date":318,"type":32},"2024-02-23",{"date":320,"type":22},"2024-02-26",{"date":322,"type":22},"2028-03-26",{"name":324,"class":39},"Region Östergötland",{"id":326,"slug":327,"hasResults":11,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":100,"enrollmentInfo":332,"targetDuration":4,"studyType":49,"phases":334,"briefSummary":335,"conditions":336,"keywords":337,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":352,"completionDateStruct":354,"leadSponsor":356,"locationsCount":4},"100517353","outcomes-of-massive-rotator-cuff-tendon-tear-treatment-100517353","NCT06016439","Outcomes of Massive Rotator Cuff Tendon Tear Treatment.","Outcomes of Different Treatment Modalities for Massive Rotator Cuff Tendon Tear.","Inclusion Criteria:\n\n* Massive rotator cuff tendon tear: grade III according to Davidson and Burkhart 2010 classification, diagnosed on MRI, and LHBB tendon is intact.\n* Primary rotator cuff pathology AND\n* Symptoms have not lasted more than 6 months.\n* In case of trauma, traumatic event no more than 6 months ago.\n* Aged between 50 and 80 at the time of enrollment.\n* Subject is able and willing to give informed consent AND\n* Subject is physically and mentally willing and able to comply with the post-operative rehabilitation protocol, questionnaires, and scheduled clinical and radiographic visits.\n\nExclusion Criteria:\n\n* Previous rotator cuff surgery of the index shoulder.\n* Acute or chronic osteomyelitis.\n* Inflammatory joint disease (rheumatoid arthritis\u002F (pseudo)gout arthritis).\n* Uncontrolled diabetes.\n* Active oncological disease.\n* Radiologically stage IV shoulder joint arthrosis (rotator cuff arthropathy).\n* Systemic or intra-articular corticosteroid therapy less than 60 days prior to planned operation date.\n* Intramuscular or peroral corticosteroid treatment less than 30 days prior to planned operation date.\n* Acute or chronic conditions that are contraindications for functional testing.\n* MRI contraindicated.\n* Substance or alcohol abuse.\n* Refusal or withdrawal of consent.",{"count":333,"type":22},80,[51],"Rotator cuff tear is the leading cause of shoulder pain in the elderly. There isn't enough evidence nor clinical guidelines to guide the treatment of massive rotator cuff tears, specially irreparable tears. Arthroscopic partial repair has been widely used and superior capsular reconstruction (SCR), either with allograft, autograft or augmentation with long head biceps brachii tendon (LHBBT), has been recently added. It is showing promising results, but lacking high quality evidence.\n\nThis is a prospective clinical study to compare the outcomes of different surgical methods for massive rotator cuff tendon tears. Minimal follow-up time will be two years. In this trial, massive rotator cuff tears will be anatomically repaired if possible. For irreparable tears a method will be randomly assigned intra-operatively once a tear is determined to be irreparable - either partial repair or partial repair with superior capsular reconstruction using the long head biceps brachii (LHBB) tendon. Patients who are eligible for the study but refuse operative treatment, will serve as conservative study group.\n\nThe hypothesis is that massive rotator cuff tears that are reparable will have the best functional outcomes. For irreparable tears, augmentation with LHBBT will give superior results over partial repair.",[107,27],[338,339,340,341,342,343,344,345,346,347,348],"rotator cuff injury","rotator cuff tears","massive","shoulder","shoulder injuries","superior capsular reconstruction","long head of biceps tendon","irreparable","tear","rupture","partial repair","2023-11-22",{"date":351,"type":32},"2023-11-24",{"date":353,"type":22},"2024-01",{"date":355,"type":22},"2033-12",{"name":357,"class":39},"Tartu University Hospital"]