[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rotator-cuff-tears\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rotator-cuff-tears":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,46,0,25,[9,43,65,94,122,151,174,196,223,248,272,298,327,352,378,395,420,440,463,489,514,542,567,590,619],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100053385","phase-4-rotator-cuff-repairs-with-or-without-bioenthesis-augmentation-100053385",false,"NCT06289686","Rotator Cuff Repairs With or Without BioEnthesis™ Augmentation","Inclusion Criteria:\n\n* DEERS-eligible\n* Adults, between the ages of 18-65 (inclusive)\n* Presenting with a rotator cuff tear that is reparable surgically (a reparable tear is defined as tear of the RC where it is possible to bring the retracted tendon edge back to the greater tuberosity of the humerus under minimal tension)\n* Ability to undergo surgery to repair rotator cuff tear\n* Willingness to commit to study procedures including study intervention and a 12-month follow-up\n* Fluency in speaking, reading, comprehending English\n* 1-2 tendon full thickness reparable RC tear (full thickness tear is defined as a tear that involves the majority of supraspinatus and less than half of the infraspinatus under minimal tension, with no subscapularis involvement beyond the upper border)\n* Patients who have high-grade partial thickness tears where the surgeon elects to complete the tear during surgery before repairing the tendon(s)\n\nExclusion Criteria:\n\n* Previous shoulder surgery (excluding acromioplasty or diagnostic arthroscopy)\n* Inability to receive an MRI\n* Current (within the past 6 months) tobacco user\n* Unwilling to remain tobacco free for the duration of the study\n* Current lower limb injuries requiring walking assist devices such as crutches and walkers\n* Diagnosed with systemic arthritis\n* Significant neck pathology\n* Active joint or systemic infection\n* Currently enrolled, or plans to enroll, in another clinical trial during this study (that would affect the patient's safety or results of this trial)\n* Significant muscle paralysis of the shoulder girdle\n* Currently pregnant or plans to become pregnant during this study\n* Inability of the surgeon to repair the tear with remaining defect no greater than 10 mm in diameter\n* Inability of the surgeon to repair the tear with less than 1cm of medialization\n* Evidence of other significant shoulder pathology (such as Grade III osteoarthritis)\n* Has a history of alcohol abuse, illicit drug use, significant mental illness, physical dependence to any opioid, or drug abuse or addiction\n* Major medical illness that would preclude undergoing surgery\n* Major psychiatric illness or developmental handicap\n* Goutallier III classification and above","ALL","18 Years","65 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Rotator cuff (RC) injuries are particularly prevalent, difficult to repair, and attachment between the bone and tendon is notoriously difficult to achieve. The most common method and current standard of care (SOC) for reattaching connective tissues (e.g., ligaments, tendons) to bone typically involves suture anchor-based techniques, but this is fraught with problems. More specifically, re-tearing of the connective tissue after this procedure occurs in 30-60% of cases, and can be even higher in patients who engage in smoking, have a diagnosis of diabetes, etc. To address these clinical challenges, Sparta Biopharma Inc. (Sparta) developed a unique technology, called BioEnthesis, to improve the connection between the tendon and bone. Pre-clinical in vivo studies demonstrated that the biphasic bovine cancellous matrix regenerated at the bone-soft tissue interface-thereby leading to high structural integrity and will likely lead to reduced re-tear rates over time. The investigators hypothesize that patients in this interventional cohort will experience enhanced mobility, reduced pain, and less re-tears after RC procedures versus a standard suture anchor-based repair.",[27,28,29],"Rotator Cuff Tears","Rotator Cuff Injuries","Surgery","RECRUITING","2026-07-10",{"date":33,"type":34},"2026-07-13","ACTUAL",{"date":36,"type":34},"2023-07-28",{"date":38,"type":21},"2027-08",{"name":40,"class":41},"Brooke Army Medical Center","FED",5,{"id":44,"slug":45,"hasResults":12,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":4},"100644233","effect-of-central-sensitization-on-response-to-physical-therapy-in-patients-with-partial-supraspinatus-tear-100644233","NCT07664137","Effect of Central Sensitization on Response to Physical Therapy in Patients With Partial Supraspinatus Tear","Inclusion Criteria:\n\nAdults aged 18 to 65 years. Diagnosis of supraspinatus partial-thickness tear confirmed by clinical examination and magnetic resonance imaging (MRI).\n\nPresence of shoulder pain for at least 6 weeks. Candidates for a standardized physical therapy and rehabilitation program. Ability to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\nFull-thickness rotator cuff tear or history of previous shoulder surgery on the affected side.\n\nAcute fracture, shoulder dislocation, or other major traumatic injury involving the affected shoulder.\n\nInflammatory rheumatic diseases, active infection, or malignancy affecting the musculoskeletal system.\n\nNeurological disorders that may influence pain perception or upper extremity function (e.g., stroke, cervical myelopathy, peripheral neuropathy).\n\nSevere glenohumeral or acromioclavicular osteoarthritis requiring surgical treatment.\n\nReceipt of corticosteroid injection or any invasive shoulder intervention within the previous 3 months.\n\nParticipation in another structured rehabilitation program for the affected shoulder within the previous 3 months.\n\nPregnancy or inability to comply with the study protocol or complete the required questionnaires.",{"count":50,"type":21},60,"OBSERVATIONAL","This prospective observational study aims to investigate whether central sensitization influences the response to physical therapy in patients with partial supraspinatus tendon tears. Participants will undergo standardized clinical evaluation before treatment and after a 6-week physical therapy program. Pain intensity, shoulder function, disability, and central sensitization-related symptoms will be assessed using validated outcome measures. The study seeks to determine the relationship between baseline central sensitization status and treatment outcomes, thereby identifying factors that may predict rehabilitation success and support individualized treatment strategies for patients with partial supraspinatus tears.",[27],"NOT_YET_RECRUITING","2026-06-17",{"date":57,"type":34},"2026-06-24",{"date":59,"type":21},"2026-06-30",{"date":61,"type":21},"2026-11-30",{"name":63,"class":64},"Kanuni Sultan Suleyman Training and Research Hospital","OTHER",{"id":66,"slug":67,"hasResults":12,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":12,"sex":16,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":4,"studyType":22,"phases":76,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":4},"100642907","phase-1-repeated-injections-of-adipose-derived-stem-cells-in-rotator-cuff-tears-100642907","NCT07592936","Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears","Effects and Benefits of Repeated Injections of Adipose-derived Stem Cells on Shoulder Function in Rotator Cuff Tears: A Randomized Controlled Study","Inclusion Criteria:\n\n* Clinical signs and symptoms compatible with a traumatic RCT\n* MR verified supraspinatus tear\n* Reparable lesion with tendon retraction \\\u003C 2 cm.\n* Fatty infiltration level 0-2 according to Fuchs or out of 5 based on Goutalliers classification\n* No history of inflammatory disease\n* Negative infectious disease marker tests Signed consent to the study\n\nExclusion Criteria:\n\n* Former surgery in the affected shoulder\n* Signs of infection\n* Immunosuppression (due to clinical condition or medical therapy)\n* Any malignancy within 5 years prior to screening\n* Previous radiotherapy to the shoulder\n* BMI under 18\n* BMI above 35\n* Allergy to antibiotics such as penicillin\n* Coagulopathy","30 Years","69 Years",{"count":75,"type":21},30,[77,78],"PHASE1","PHASE2","The aim of the project is to investigate whether repeated implantations of micro-fragmented adipose tissue (MFAT), into the shoulder muscle can improve the outcome of standard surgical treatment for rotator cuff tears (RCT). The investigators hypothesize that combining surgery with repeated implantations of micro-fragmented adipose tissue (MFAT) into the muscle provides a more effective treatment for patients with rotator cuff tears compared to standard surgical treatment. The result would be better outcomes such as improved shoulder functioning and reduced pain.",[27,28,81],"Stem Cells",[83,84],"Adipose derived stem cells","ADSC","2026-06-09",{"date":87,"type":34},"2026-06-12",{"date":89,"type":21},"2026-08",{"date":91,"type":21},"2028-08",{"name":93,"class":64},"University of Southern Denmark",{"id":95,"slug":96,"hasResults":12,"nctId":97,"briefTitle":98,"officialTitle":99,"acronym":4,"eligibilityCriteria":100,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":101,"targetDuration":4,"studyType":22,"phases":103,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":121},"100622393","effect-of-mobilization-with-movement-in-patients-with-rotator-cuff-lesions-100622393","NCT07383038","Effect of Mobilization With Movement in Patients With Rotator Cuff Lesions","The Effect of Mobilization With Movement on Function, Disability, and Pain in Patients With Rotator Cuff Lesions: A Double-Blind Randomized Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 65 years\n* Clinical and\u002For imaging-confirmed diagnosis of rotator cuff lesion (e.g., tendinopathy or partial tear)\n* Presence of shoulder pain for at least 3 months\n* Pain and functional limitation during shoulder movements\n* Ability to actively perform shoulder movements required for assessment and intervention\n* No physiotherapy or manual therapy treatment for the affected shoulder within the last 3 months\n\nExclusion Criteria:\n\n* History of shoulder surgery on the affected side\n* Full-thickness rotator cuff tear or shoulder instability\n* Shoulder fracture, dislocation, or acute trauma within the past 6 months\n* Neurological disorders affecting the upper extremity (e.g., cervical radiculopathy, peripheral neuropathy)\n* Systemic inflammatory or rheumatologic diseases\n* Severe shoulder osteoarthritis or adhesive capsulitis\n* Current participation in another clinical trial\n* Use of corticosteroid injection in the affected shoulder within the last 3 months\n* Pregnancy\n* Inability to comply with the study protocol or assessment procedures",{"count":102,"type":21},75,[104],"NA","This randomized controlled trial aims to investigate the effects of Mobilization with Movement (MWM) on pain and functional status in individuals with rotator cuff lesions. Rotator cuff pathology is a common cause of shoulder pain and functional limitation, and impairments in proprioception may further compromise shoulder motor control and recovery.\n\nEligible participants with rotator cuff lesions will be randomly allocated into three groups: (1) Mobilization with Movement (MWM), (2) conventional physiotherapy, and (3) control group. All participants will be evaluated before and after the intervention period. Outcome measures will include shoulder-related functional disability assessed by the QuickDASH questionnaire, pain intensity, and shoulder joint position sense evaluated using an active repositioning test with a laser pointer during shoulder flexion.\n\nThe study is designed to determine whether MWM provides additional benefits over conventional treatment or task oriented training intervention in improving pain, function, and proprioceptive accuracy. The findings are expected to contribute to evidence-based conservative rehabilitation strategies for patients with rotator cuff lesions.",[27,107],"Physical Disability",[109,110,111],"rotator cuff lesions","Mulligan mobilization","joint position sense","2026-06-05",{"date":114,"type":34},"2026-06-08",{"date":116,"type":34},"2025-08-25",{"date":118,"type":21},"2026-08-28",{"name":120,"class":64},"Kirsehir Ahi Evran Universitesi",1,{"id":123,"slug":124,"hasResults":12,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":4,"eligibilityCriteria":127,"healthyVolunteers":12,"sex":16,"minAge":128,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":141,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":146,"leadSponsor":148,"locationsCount":121},"100508867","post-market-clinical-follow-up-pmcf-study-of-the-pitch-patch-for-the-augmentation-or-reinforcement-of-the-rotator-cuff-100508867","NCT05906004","Post-Market Clinical Follow-up (PMCF) Study of the Pitch-Patch for the Augmentation or Reinforcement of the Rotator Cuff","Inclusion Criteria:\n\n* Patient has been treated using a Pitch-Patch device for augmentation or reinforcement of the rotator cuff 2-2.5years prior to enrolment.\n* Patient has a baseline Constant Murley Score (CMS), assessed within 30 days prior to implantation of the device.\n* Patient must be 16 years old or above.\n* Patient is willing to participate in the study, and having been informed of the nature of the study, has provided written informed consent as approved by the Ethics Committee (EC).\n\nExclusion Criteria:\n\n\\- The Pitch-Patch has been used outside its intended use.","16 Years",{"count":130,"type":21},37,"This is a clinical investigation study. It will verify the long-term safety and performance of the Pitch-Patch when implanted to reinforce partially repairable rotator cuff tears and used as described by the manufacturer's instructions.\n\nThe medical device in this study is already on the market and is manufactured by Xiros Ltd.\n\nThe Pitch-Patch is a single-use polyester prosthesis available in two sizes (30x20mm and 35x25mm). It is reinforced around the perimeter and around each eyelet to provide strength and stability to the device and repair.\n\nThe study will collect data on patients who meet the entry criteria and have received the device.\n\nThis is a single-armed study, meaning all patients will have a Pitch-Patch. The total length of the study is expected to be 3 years.\n\nA minimum of 37 patients will be enrolled into the study. Patients will be enrolled at a study specific follow up visit 2-2.5 years after implant, and data for baseline, procedure, and other time points prior to 2 years (3month, 6month, and 1 year post surgery) will be collected retrospectively from medical records if available.",[133,27,134,28],"Rotator Cuff Tear","Rotator Cuff Tears of the Shoulder",[136,137,138,139,140],"Rotator Cuff Reinforcement","Rotator Cuff Repair","Pitch-Patch","Xiros","Rotator Cuff Augmentation","2026-05-12",{"date":143,"type":34},"2026-05-15",{"date":145,"type":21},"2026-05",{"date":147,"type":21},"2029-12",{"name":149,"class":150},"Xiros Ltd","INDUSTRY",{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":155,"acronym":156,"eligibilityCriteria":157,"healthyVolunteers":12,"sex":16,"minAge":158,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":22,"phases":162,"briefSummary":163,"conditions":164,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":121},"100437385","phase-4-rotator-cuff-tears-repair-with-or-without-dermal-patch-augmentation-100437385","NCT04975581","Rotator Cuff Tears Repair With or Without Dermal Patch Augmentation","CUFFPATCH","Inclusion Criteria:\n\n1. Patient aged at least 50 years to 75 years.\n2. Degenerative cuff tear.\n3. Large Full thickness rotator cuff tear (≥ 3cm and \\\u003C 5 cm ) that is fully repairable.\n4. Tears diagnosed using MRI scan.\n5. Ability to consent.\n6. Agreement to use of human dermal matrix allograft as augmentative patch\n\nExclusion Criteria:\n\n1. Previous surgery on the affected shoulder.\n2. Osteoarthritic changes.\n3. Unable to have MRI Scans.\n4. Significant neck pathology.\n5. Cognitive problems or language issue.\n6. Systemic arthritis\n7. Significant dual pathology in the involved shoulder\n8. Acute Traumatic tears (\\\u003C 6 months since injury).","50 Years","75 Years",{"count":161,"type":21},40,[24],"The Investigators are planning to conduct a Pilot study of 40 patients of Pragmatic randomised controlled trial comparing rotator cuff tendons repair (small tendons around the shoulder ) with or without augmentative patch. It includes patients between age groups 50 to 75 years with large (≥ 3cm and \\\u003C 5 cm ) rotator cuff tear that can be fully repaired using open or mini open repair with or without an augmentation with a human dermal matrix allograft (processed skin graft from a human donor ). The main aim is to examine whether the addition of the patch helps to reduce the rate of re-tear of the rotator cuff tendons at one year following surgery. Patients are randomized to receive either a repair with addition of an augmentative patch or a repair without a patch and have an identical follow-up after surgery. Patients are followed up in outpatient at 6 weeks , 3 months and 12 months after randomization and receive an Magnetic Resonant Imaging (MRI) scan 12 months after surgery. The primary outcome measure is to assess the Re-tear rate of rotator cuff at 12 months after surgery. The secondary outcome measure is to assess functional scores of the shoulder at 12 months . The tertiary outcome measures are to check the cost effectiveness of each procedure.",[27],"2026-05-06",{"date":167,"type":34},"2026-05-11",{"date":169,"type":34},"2021-12-03",{"date":171,"type":21},"2026-12-31",{"name":173,"class":64},"University Hospitals, Leicester",{"id":175,"slug":176,"hasResults":12,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":22,"phases":184,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":192,"leadSponsor":194,"locationsCount":4},"100636646","arthroscopic-rotator-cuff-repair-trial-100636646","NCT07568392","Arthroscopic Rotator Cuff Repair Trial","A Prospective Randomized Controlled Trial Comparing Arthroscopic Rotator Cuff Repair With and Without Biceps Tendon Autograft Patch Augmentation","Inclusion Criteria:\n\n* Patients \\> 18 years of age who speak English, indicated for arthroscopic rotator cuff repair and open subpectoral biceps tenodesis.\n* Supraspinatus (+\u002F- anterior infraspinatus tendon) full thickness tears.\n* Medium (1-3cm) and large (3-5) cm tears. Classification according to anterior to posterior dimensions: small \\\u003C1cm, medium 1-3 cm, large 3-5 cm, massive \\>5cm or 2 tendons.\n* Patte Grade 1 and 2. Patte Classification: grade 1, tear at insertion; grade 2, retracted to humeral head; grade 3, retracted to glenoid or medial to glenoid.\n* Goutallier grade 0-2 fatty infiltration on pre-operative MRI.\n* Repairable upper border subscapularis tendon tear.\n* Patients undergoing concomitant biceps tenodesis.\n\nExclusion Criteria:\n\n* Pregnant women, non-English speakers and prisoners.\n* Patients with prior surgery on the ipsilateral shoulder.\n* Worker's compensation status.\n* Adhesive capsulitis.\n* Patient with glenohumeral osteoarthritis, as graded by the modified Samilson and Prieto Classification (grades 1-3).\n* Partial thickness rotator cuff tears.\n* Any cuff tears requiring medialization of the footprint\n* Patients undergoing concomitant distal clavicle resection.","99 Years",{"count":183,"type":21},80,[104],"This study aims to assess post-operative outcomes and healing rates following arthroscopic rotator cuff repair with and without biceps tendon autograft patch augmentation in patients with medium to large rotator cuff tears. This will be a single center, parallel arm randomized trial within the Orthopedics Shoulder Surgery Department at University of Iowa Hospitals and Clinics (UIHC). Eligible patients indicated for arthroscopic rotator cuff repair and open subpectoral biceps tenodesis will be enrolled, consented and randomized, in a 1:1 scheme, into 2 study arms. Arm 1 will consist of arthroscopic rotator cuff repair without biceps tendon autograft. Arm 2 will consist of arthroscopic rotator cuff repair with biceps tendon autograft patch augmentation. Outcomes of interest are American Shoulder and Elbow Surgeons Score (ASES), at 1 year and 2 years postoperatively. Exploratory outcomes are SANE, VAS Pain and active shoulder range of motion, and healing signs on MRI imaging studies at minimum 6-months postoperatively.",[27],"2026-04-30",{"date":189,"type":34},"2026-05-05",{"date":191,"type":21},"2026-06-01",{"date":193,"type":21},"2027-09-30",{"name":195,"class":64},"Joseph W. Galvin",{"id":197,"slug":198,"hasResults":12,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":12,"sex":16,"minAge":72,"maxAge":203,"enrollmentInfo":204,"targetDuration":4,"studyType":22,"phases":205,"briefSummary":206,"conditions":207,"keywords":208,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":121},"100636638","the-effectiveness-of-high-intensity-laser-therapy-after-arthroscopic-shoulder-rotator-cuff-repair-100636638","NCT07568288","The Effectiveness of High-intensity Laser Therapy After Arthroscopic Shoulder Rotator Cuff Repair.","The Effectiveness of High-intensity Laser Therapy After Arthroscopic Shoulder Rotator Cuff Repair. A Randomized Controlled Trial","Inclusion Criteria:\n\n* Arthroscopic rotator cuff repair of one shoulder for partial or full-thickness tear\n* Willingness to provide written informed consent\n* Age between 30 and 70 years\n* Pain intensity greater than 40\u002F100 on the Visual Analog Scale\n\nExclusion Criteria:\n\n* Psychiatric disorders\n* Cognitive impairment\n* Rheumatic diseases or Fibromyalgia\n* Vascular diseases\n* Neoplastic diseases\n* Infectious diseases\n* Neurological disorders\n* Hemophilia or bleeding diathesis\n* Use of anticoagulant therapy\n* Presence of a pacemaker\n* History of epileptic seizures\n* Pregnancy or breastfeeding\n* Skin lesions or abrasions at the laser application site\n* Known hypersensitivity to laser therapy or photosensitization\n* Use of photosensitizing medications\n* Tattoo in the treatment area\n* Steroid injections in the target area within the previous 2-3 weeks\n* Recent trauma or injury\n* Suspected conditions in which deep tissue heating is contraindicated\n* Use of analgesic or anti-inflammatory medications during the study period\n* Positive status for human immunodeficiency virus infection","70 Years",{"count":5,"type":21},[104],"This randomized controlled trial aims to evaluate the effectiveness of high-intensity laser therapy (HILT) as an adjunct to conventional rehabilitation in patients undergoing arthroscopic rotator cuff repair.\n\nDespite surgical repair, patients frequently experience postoperative pain, limited range of motion, and delayed functional recovery. Conventional physiotherapy represents the standard of care; however, additional strategies may be needed to optimize outcomes. High-intensity laser therapy has been proposed as a non-invasive intervention with potential analgesic and anti-inflammatory effects, but its effectiveness in the postoperative setting remains unclear.\n\nParticipants will be randomly allocated to one of two groups: an experimental group receiving HILT in addition to conventional physiotherapy, and a control group receiving sham laser therapy combined with the same rehabilitation program. Both groups will undergo standardized rehabilitation sessions including therapeutic exercise.\n\nThe primary outcome is pain intensity, measured using the Visual Analog Scale. Secondary outcomes include shoulder range of motion (active and passive), muscle strength, functional status assessed with the Constant-Murley Score, and patient-reported disability and quality of life measured using the Shoulder Pain and Disability Index and the Quick Disabilities of the Arm, Shoulder and Hand.\n\nAssessments will be conducted at baseline (at the start of rehabilitation), during the intervention period after the fourth (T1), seventh (T2), and tenth (T3) physiotherapy sessions, and at follow-up at 4 months.",[27],[209,210,211,212,213,214],"Arthroscopic rotator cuff repair","Rotator cuff repair","laser therapy","High intensity laser therapy","Rehabilitation","Shoulder pain","2026-04-28",{"date":189,"type":34},{"date":218,"type":21},"2026-09",{"date":220,"type":21},"2029-09",{"name":222,"class":64},"Istituto Ortopedico Rizzoli",{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":22,"phases":233,"briefSummary":234,"conditions":235,"keywords":236,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":121},"100507966","prospective-study-to-determine-the-safety-and-effectiveness-of-a-connective-tissue-allograft-active-matrix-am-vs-standard-of-care-in-arthroscopic-rotator-cuff-repair-100507966","NCT05894265","Prospective Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft Active Matrix (AM) vs. Standard of Care in Arthroscopic Rotator Cuff Repair","Prospective Pilot Study to Determine the Safety and Effectiveness of a Connective Tissue Allograft (Active Matrix) vs. Standard of Care in Arthroscopic Rotator Cuff Repair","Inclusion Criteria:\n\n* Provision of signed and dated informed consent form\n* Stated willingness to comply with all study procedures and availability for the duration of the study\n* 1-2 tendon full thickness reparable rotator cuff tendon tear(s)\n\nReparable tear defined as:\n\na tear of the rotator cuff where it is possible to bring the retracted tendon edge back to the greater tuberosity of the humerus under minimal tension.\n\nFull-thickness tear defined as:\n\na tear that involves the majority of supraspinatus and less than half of the infraspinatus under minimal tension, with no subscapularis involvement beyond the upper border\n\n* Failed conservative medical management of the rotator cuff tendon tear defined as: 4-6 weeks of formal physical therapy or guided home exercises and activity modification\n* Have no contraindications or allergies to the treatment administered\n* Have current imaging studies (plain radiographs and MRI exams) of the shoulder to rule out other etiologic diagnoses\n* Able and willing to comply with the post-operative physical therapy and study follow-up schedule\n\nExclusion Criteria:\n\n* Prior surgery on the index shoulder within 12 months of enrollment, including Latarjet procedures, superior labral treat from anterior to posterior (SLAP), and (failed) primary rotator cuff surgery,\n* Prior surgery for bone defects requiring bone implantation in the index shoulder,\n* Steroid injection into the index shoulder within 6 weeks of enrollment.\n* Subscapularis tear greater than 1\u002F3 of tendon involvement requiring repair,\n* Calcific tendonitis in the index shoulder,\n* Fatty infiltration of the index shoulder rotator cuff muscle, i.e. Goutallier classification ≥ Grade 3,\n* Contralateral shoulder injury that may interfere with the post-operative rotator cuff repair rehab guidelines,\n* History of advanced osteoarthritis of glenohumeral joint (AC joint can have advanced OA) i.e. Samilson-Prieto classification ≥ Grade 2\n* History of malignant tumor and osseous metastatic disease,\n* History of heterotopic ossification,\n* History of chronic pain disorders (i.e., fibromyalgia),\n* Current substance abuse (drug or alcohol), by the investigator's judgment,\n* For females of child-bearing potential: unable or unwilling to take adequate contraceptive precautions during the study, known to be pregnant at enrollment, breastfeeding an infant at enrollment or during the study, or planning to become pregnant during the study,\n* Currently participating in, or have been recently exited from (within 30 days from enrollment in this study), or plan to enroll in another clinical study for a bone allograft or drug that may impact participation or outcomes of this study,\n* Currently involved in any injury litigation or workers compensation claims,\n* has a condition, disorder or other factor that, in the investigator's opinion, would interfere with study participation.","80 Years",{"count":232,"type":21},72,[104],"The purpose of this study is to see how well the ActiveMatrix® graft works at improving healing and function of the shoulder following rotator cuff repair surgery",[27],[237,238],"musculoskeletal injuries","rotator cuff repair","2026-04-27",{"date":241,"type":34},"2026-04-29",{"date":243,"type":34},"2023-06-14",{"date":245,"type":21},"2026-08-01",{"name":247,"class":64},"The University of Texas Health Science Center, Houston",{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":255,"targetDuration":4,"studyType":22,"phases":256,"briefSummary":257,"conditions":258,"keywords":259,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":266,"completionDateStruct":268,"leadSponsor":270,"locationsCount":121},"100583405","effect-of-motor-imagery-training-on-pain-functionality-proprioception-and-kinesiophobia-in-partial-rotator-cuff-tear-100583405","NCT06875895","Effect of Motor Imagery Training on Pain, Functionality, Proprioception and Kinesiophobia in Partial Rotator Cuff Tear","Effect of Motor Imagery Training on Pain, Functionality, Proprioception and Kinesiophobia in Patients With Partial Rotator Cuff Tears","Inclusion Criteria:\n\n* Partial rotator cuff tear diagnosis.\n* Between the ages of 18-65\n* Patients experiencing pain for at least 4 weeks.\n* Having a valid score on the Mini Mental Test (\\>24)\n* Those without a history of any neurological or serious psychological illness.\n* Those who have not participated in a previous study on motor imagery training\n\nExclusion Criteria:\n\n* Complete rotator cuff tear or conditions requiring surgical intervention,\n* Participants who have received treatment with corticosteroids by any means in the previous 6 months,\n* Participants who have a rotator cuff tear due to acute traumatic conditions (proximal humerus fracture).",{"count":183,"type":21},[104],"The aim of this study is to investigate the effects of motor imagery training on pain, functionality, proprioception and kinesiophobia in patients with partial rotator cuff tears. Participants will be randomly assigned to traditional physiotherapy and motor imagery groups. Interventions will be performed with a physiotherapist for a total of 20 sessions for 4 weeks, 5 days a week. The intervention program will be determined by the Specialist Physical Therapy Physician. Data will be collected before the study, at the end of the training in the 4th week and at the 8th week (follow-up evaluation). Motor imagery ability will be assessed with the Movement Imagery Questionnaire (MIQ-R), pain will be assessed with the Numerical Assessment Scale for functionality with the DASH, proprioception will be assessed with the inclinometer and kinesiophobia will be assessed with the Tampa Kinesiophobia Scale.",[27],[260,261,262],"Rotator Cuff","Exercise therapy","Imagery","2026-04-20",{"date":265,"type":34},"2026-04-23",{"date":267,"type":34},"2025-01-16",{"date":269,"type":21},"2026-05-03",{"name":271,"class":64},"Kutahya Health Sciences University",{"id":273,"slug":274,"hasResults":12,"nctId":275,"briefTitle":276,"officialTitle":277,"acronym":278,"eligibilityCriteria":279,"healthyVolunteers":280,"sex":16,"minAge":281,"maxAge":203,"enrollmentInfo":282,"targetDuration":4,"studyType":22,"phases":284,"briefSummary":285,"conditions":286,"keywords":287,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":291,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":121},"100515889","biobrace-implant-for-arthroscopic-repair-of-full-thickness-rotator-cuff-tears-100515889","NCT05997381","BioBrace® Implant for Arthroscopic Repair of Full Thickness Rotator Cuff Tears","REinForce: A Prospective, Single Blind, Multi-Center, Randomized, Controlled, Pivotal Study to Evaluate the Safety and Effectiveness of the BioBrace® Implant During Arthroscopic Repair of Full Thickness Rotator Cuff Tears","REinForce","Inclusion Criteria:\n\n1. Male or female 40 to 70 years old\n2. Positive diagnostic imaging by MRI within 6 months of enrollment of the index shoulder indicating a full thickness rotator cuff tear (RCT):\n\n   1. Tear of the supraspinatus and\u002For infraspinatus tendons\n   2. Tear size ≥ 2 cm and \\\u003C 5 cm\n3. Chronic shoulder pain ≥ 3 months\n4. Failed non-operative treatment of the index shoulder to include one or all of the following:\n\n   1. Oral analgesics\n   2. Nonsteroidal anti-inflammatory medications (NSAIDs)\n   3. Corticosteroid injections\n   4. Activity modifications\n   5. Physical therapy or home-guided exercises\n5. Able to read and understand the study REB\u002FIRB approved Informed Consent Form (ICF)\n6. Willing to be available to attend each protocol-required follow-up examination\n\nIntraoperative Inclusion Criteria:\n\n1. Full thickness tear of the supraspinatus and\u002For infraspinatus tendons\n2. Tear size ≥ 2 cm and \\\u003C 5 cm\n3. Able to reapproximate the tendons to cover \\> 50% of the footprint on the greater tuberosity\n\nExclusion Criteria:\n\n1. Previous surgery of the index shoulder one year prior to the study surgery excluding diagnostic arthroscopy\n2. Fatty infiltration of the index shoulder rotator cuff muscle ≥ Grade 3 (Goutallier Score)\n3. Major medical condition that could affect quality of life and influence the results of the study as determined by the Investigator\n4. Oral steroid use or steroid injection within 6 weeks prior to surgery\n5. Active smoker\n6. History of insulin-dependent diabetes\n7. Documented evidence of a history (e.g., liver testing) of drug\u002Falcohol abuse within 12 months of enrollment\n8. Hypersensitivity to any investigational device materials including collagen of animal origin (bovine type-I), poly-L-lactic acid (PLLA) or polyethylene glycol (PEG)\n9. Presence of an implanted metallic device or other implants that would contraindicate acquisition or inhibit radiologist review of an MRI of the index shoulder\n10. History of claustrophobia that would prevent an MRI of the index shoulder\n11. Females of child-bearing potential who are either pregnant or breastfeeding or plan to become pregnant during the course of the study\n12. Currently participating, or plans to enroll in another clinical trial during this study that would affect the outcomes of this study as determined by the Investigator\n13. History of non-compliance with medical treatment or clinical trial participation\n14. The subject is physically or mentally compromised (e.g., currently being treated for a psychiatric disorder, senile dementia, Alzheimer's disease, etc.), to the extent that the Investigator judges the subject to be unable or unlikely to remain compliant with protocol required follow-up\n15. Any comorbidity or condition that renders the patient a poor surgical candidate as determined by the Investigator\n16. The subject is receiving prescription narcotic pain medication\n17. The subject currently has an acute infection in the area surrounding the surgical site\n18. Contralateral shoulder condition where rotator cuff repair is scheduled or to be scheduled over the course of this study\n19. The subject's condition represents a worker's compensation case\n\nIntraoperative Exclusion Criteria:\n\n1\\. Subject requires subscapularis repair other than a repair with a single anchor",true,"40 Years",{"count":283,"type":21},268,[104],"This study aims to evaluate the safety and effectiveness of arthroscopic rotator cuff repair augmented with the BioBrace® Implant vs. arthroscopic rotator cuff repair alone in subjects requiring surgical intervention for a full-thickness rotator cuff tear.",[27],[288,289,290],"Rotator cuff tear","Full thickness tear","BioBrace",{"date":265,"type":34},{"date":293,"type":34},"2024-01-05",{"date":295,"type":21},"2027-06",{"name":297,"class":150},"CONMED Corporation",{"id":299,"slug":300,"hasResults":12,"nctId":301,"briefTitle":302,"officialTitle":303,"acronym":304,"eligibilityCriteria":305,"healthyVolunteers":12,"sex":16,"minAge":281,"maxAge":159,"enrollmentInfo":306,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":308,"conditions":309,"keywords":314,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":318,"lastUpdatePostDateStruct":319,"startDateStruct":321,"completionDateStruct":323,"leadSponsor":325,"locationsCount":121},"100584253","pain-education-after-rotator-cuff-surgery-100584253","NCT06886932","Pain Education After Rotator Cuff Surgery","The Effect of Pain Neuroscience Education on Patients Undergoing Surgical Repair of Moderate-Sized Rotator Cuff Tears","PNE-RCS","Eligibility Criteria\n\nInclusion Criteria:\n\nDiagnosis of a medium-sized rotator cuff tear (1-3 cm) confirmed by Magnetic Resonance Imaging (MRI) and scheduled for surgical repair Age between 40 and 75 years Sufficient Turkish language proficiency to understand and complete the informed consent form and assessment scales Mini-Mental State Examination (MMSE) score ≥ 24, indicating adequate cognitive function for study participation\n\nExclusion Criteria:\n\nCorticosteroid injection received within the last 6 weeks Adhesive capsulitis, defined as loss of passive external rotation greater than 50% or 30° History of previous cervical, thoracic, or shoulder surgery Presence of cervical radiculopathy, characterized by pain and tingling radiating to the arm due to nerve root involvement Acromioclavicular joint pathology or shoulder instability causing shoulder pain Full-thickness rotator cuff tear Calcific tendinitis Systemic diseases (e.g., inflammatory arthritis, malignancy) or neurological disorders (e.g., fibromyalgia, other neurological deficits) Fracture, labral lesion, or biceps tendon injury in the affected shoulder Prior participation in a chronic pain psychological management program or presence of generalized body pain",{"count":307,"type":21},45,"Study Title: The Effect of Pain Neuroscience Education Combined with Conventional Rehabilitation on Pain Management and Functional Outcomes in Patients Undergoing Mini-Open Rotator Cuff Repair\n\nPurpose: This study aims to investigate whether adding Pain Neuroscience Education (PNE) to a conventional rehabilitation program improves pain management, physical function, and psychosocial outcomes in patients who have undergone mini-open surgery for rotator cuff tears (RCT). The study will also compare the effects of PNE when delivered before versus after surgery.\n\nWho Can Participate: Adults aged 40-75 who have been diagnosed with a medium-sized rotator cuff tear and are scheduled for mini-open surgical repair. Participants must meet specific health criteria and be willing to participate in the rehabilitation program.\n\nStudy Details:\n\nParticipants will be randomly assigned to one of three groups:\n\nGroup 1: Conventional rehabilitation only. Group 2: Conventional rehabilitation + PNE before surgery. Group 3: Conventional rehabilitation + PNE after surgery. PNE involves educational sessions that explain the biology of pain, how the nervous system processes pain, and strategies to reduce fear and catastrophizing related to pain.\n\nThe study will last approximately 12 weeks, with regular assessments of pain levels, physical function, and psychosocial factors (e.g., fear of movement, depression, sleep quality).\n\nPotential Benefits:\n\nParticipants may experience reduced pain, improved shoulder function, and better overall recovery.\n\nThe study may provide valuable insights into how PNE can enhance rehabilitation outcomes for patients with rotator cuff tears.\n\nPotential Risks:\n\nSome participants may find the educational sessions time-consuming or mentally challenging.\n\nThere is a small risk of discomfort during physical assessments or rehabilitation exercises.\n\nWhy is this study important?:\n\nRotator cuff tears are a common cause of shoulder pain and disability, especially in older adults. Post-surgical pain and fear of movement can slow recovery and reduce quality of life. This study will help determine whether PNE, when combined with conventional rehabilitation, can improve recovery outcomes and provide a better understanding of how timing (before or after surgery) affects its effectiveness.",[27,310,311,312,313],"Postoperative Pain Management","Shoulder Dysfunction","Kinesiophobia (Fear of Movement)","Postoperative Rehabilitation",[315,313,133,316,317,310],"Pain Neuroscience Education","Kinesiophobia","Shoulder Surgery Outcomes","2026-04-18",{"date":320,"type":34},"2026-04-22",{"date":322,"type":34},"2025-04-01",{"date":324,"type":21},"2026-09-30",{"name":326,"class":64},"Elif Dilara Durmaz",{"id":328,"slug":329,"hasResults":12,"nctId":330,"briefTitle":331,"officialTitle":331,"acronym":4,"eligibilityCriteria":332,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":333,"enrollmentInfo":334,"targetDuration":4,"studyType":22,"phases":336,"briefSummary":337,"conditions":338,"keywords":341,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":350,"locationsCount":121},"100572454","innovating-physical-therapy-a-pilot-study-on-band-connects-impact-on-compliance-satisfaction-and-revenue-100572454","NCT06733480","Innovating Physical Therapy: A Pilot Study on Band Connect's Impact on Compliance, Satisfaction, and Revenue","Inclusion Criteria:\n\n* Age range: from 18 to 89 years old\n* Surgery performed by Dr. Robert Gillespie and will be undergoing post-op physical therapy rehabilitation at University Hospitals\n* Patients undergoing primary anatomic total shoulder shoulder arthroplasty (aTSA) or primary reverse total shoulder arthroplasty (rTSA)\n* Patients undergoing primary rotator cuff repair\n* Prescribed outpatient physical therapy for post-operative rehabilitation\n\nChart Review Inclusion Criteria:\n\n* Age range: from 18 to 89 years old\n* Surgery performed by Dr. Robert Gillespie who underwent post-op physical therapy rehabilitation at University Hospitals\n* Patients who underwent primary anatomic total shoulder shoulder arthroplasty (aTSA) or primary reverse total shoulder arthroplasty (rTSA)\n* Patients who underwent primary rotator cuff repair\n* Prescribed outpatient physical therapy for post-operative rehabilitation\n\nExclusion Criteria:\n\n* Patients undergoing hemiarthroplasty or revision TSA\n* Patients undergoing revision rotator cuff repair\n* TSA performed for proximal humerus fractures\n* Length of stay in hospital following shoulder surgery greater than 3 days\n* Shoulder injuries related to workers compensation or involved in any pending litigation\n* Pregnant individuals\n\nChart Review Exclusion Criteria:\n\n* Patients undergoing hemiarthroplasty or revision TSA\n* Patients undergoing revision rotator cuff repair\n* TSA performed for proximal humerus fractures\n* Length of stay in hospital following shoulder surgery greater than 3 days\n* Shoulder injuries related to workers compensation or involved in any pending litigation\n* Pregnant individuals","89 Years",{"count":335,"type":21},499,[104],"Participants are being invited to take part in this research study because you will be undergoing total shoulder replacement or rotator cuff repair and will be participating in physical therapy rehabilitation following the procedure. The purpose of this research is to investigate the effectiveness of Band Connect, a connected health platform, in enhancing compliance with home exercise programs among patients undergoing physical therapy. This study aims to evaluate the implications of increased compliance on improving patient engagement and increasing satisfaction for both patients and clinicians. Additionally, the study will analyze the economic implications of implementing Band Connect's hybrid care model on driving increased revenue per patient.",[27,339,340],"Anatomic Total Shoulder Arthroplasty","Reverse Total Shoulder Arthroplasty",[342,343],"physical therapy compliance","home-based physical therapy","2026-03-31",{"date":346,"type":34},"2026-04-02",{"date":348,"type":34},"2025-02-04",{"date":191,"type":21},{"name":351,"class":64},"University Hospitals Cleveland Medical Center",{"id":353,"slug":354,"hasResults":12,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":360,"minAge":158,"maxAge":230,"enrollmentInfo":361,"targetDuration":4,"studyType":22,"phases":363,"briefSummary":364,"conditions":365,"keywords":4,"overallStatus":54,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":374,"leadSponsor":376,"locationsCount":4},"100540558","phase-2-estradiol-supplementation-and-rotator-cuff-repair-100540558","NCT06318403","Estradiol Supplementation and Rotator Cuff Repair","Estradiol Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial","ESTRCR","Inclusion Criteria\n\n1. A plan for a primary rotator cuff repair\n2. Female sex (assigned sex at birth)\n3. \\>1 cm tear width, full thickness supraspinatus\u002Finfraspinatus tear\n4. Post-menopausal, as defined by at least twelve months since last menses\n5. Age 50-80\n\nExclusion Criteria\n\n1. Active infection\n2. Baseline serum estradiol \\>20 pg\u002FmL\n3. Infraspinatus or supraspinatus muscle atrophy of greater than or equal to Goutallier grade 3\n4. Pre-operative systemic estradiol supplementation\n5. Medically unfit for operative intervention\n6. Revision surgery\n7. Unwillingness to participate in the study, including post-operative imaging\n8. Inability to read or comprehend written instructions\n9. Prisoner\n10. Concomitant patch augmentation or tendon-transfer\n11. Breast cancer or a history of breast cancer or other estradiol-dependent neoplasia\n12. Liver disease as documented in the medical record\n13. Active venous thromboembolic disease, such as deep venous thrombosis, pulmonary embolism, a history of these conditions, or a known predisposition to these disorders (such as Protein C, protein S, or antithrombin deficiency)\n14. Active arterial thromboembolic disease, such as stroke, myocardiac infarction, a history of these conditions, or a known predisposition to these disorders\n15. Isolated subscapularis tears\n16. Known anaphylactic reaction or hypersensitivity to estradiol, adhesive, or transdermal patches","FEMALE",{"count":362,"type":21},58,[78],"Rotator cuff tears in the shoulder are common causes of pain and disability, often fail to heal with surgery, and tears, worse outcomes after surgery, and failure of healing are associated with estradiol deficiency. In this study, post-menopausal women will be randomized to either estradiol patches or placebo patches after repair of the rotator cuff. The purpose of this study is to determine whether estradiol patches show promise in improving shoulder pain, strength, muscle volumes, and function when given with rotator cuff repair.",[27,28,366,367,368],"Rotator Cuff Syndrome","Menopause Related Conditions","Menopause","2026-03-17",{"date":371,"type":34},"2026-03-19",{"date":373,"type":21},"2028-03",{"date":375,"type":21},"2030-12",{"name":377,"class":64},"University of Utah",{"id":379,"slug":380,"hasResults":12,"nctId":381,"briefTitle":382,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":12,"sex":384,"minAge":281,"maxAge":230,"enrollmentInfo":385,"targetDuration":4,"studyType":22,"phases":386,"briefSummary":387,"conditions":388,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":389,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":121},"100435025","phase-2-sex-hormone-supplementation-and-rotator-cuff-repair-a-preliminary-randomized-trial-100435025","NCT04944836","Sex Hormone Supplementation and Rotator Cuff Repair: A Preliminary Randomized Trial","Inclusion Criteria\n\n1. A plan for a primary rotator cuff repair\n2. Male sex\n3. \\>1 cm tear width, full thickness supraspinatus\u002Finfraspinatus tear\n\nExclusion Criteria\n\n1. Active infection\n2. Pre-operative testosterone supplementation\n3. Known diagnosis of secondary testicular failure or testosterone deficiency\n4. Medically unfit for operative intervention\n5. Revision surgery\n6. Unwillingness to participate in the study, including post-operative imaging\n7. Inability to read or comprehend written instructions\n8. Prisoner\n9. Concomitant patch augmentation or tendon-transfer\n10. Untreated prostate cancer\n11. Liver disease\n12. Pituitary or hypothalamic dysfunction","MALE",{"count":362,"type":21},[78],"Shoulder tendon tears are a common cause of shoulder pain and disability and after surgery the repaired tendon often does not heal. In this pilot study, men with low sex hormone levels will be randomly assigned to receive sex hormone therapy or placebo pills while healing from tendon repair surgery in their shoulder. Sex hormone therapy increases sex hormone levels, and the investigators will test whether these increased sex hormone levels show promise in improving tendon healing and patient shoulder function and pain.",[27],{"date":371,"type":34},{"date":391,"type":34},"2023-03-09",{"date":393,"type":21},"2029-01-01",{"name":377,"class":64},{"id":396,"slug":397,"hasResults":12,"nctId":398,"briefTitle":399,"officialTitle":400,"acronym":4,"eligibilityCriteria":401,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":402,"targetDuration":4,"studyType":22,"phases":404,"briefSummary":405,"conditions":406,"keywords":408,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":411,"lastUpdatePostDateStruct":412,"startDateStruct":414,"completionDateStruct":416,"leadSponsor":418,"locationsCount":121},"100473050","phase-4-bioinductive-patch-for-full-thickness-rotator-cuff-tears-100473050","NCT05439850","Bioinductive Patch for Full-Thickness Rotator Cuff Tears","Arthroscopic Rotator Cuff Repair Augmented With Bioinductive Implant for Full-Thickness Tears: A Randomized Controlled Study","Inclusion Criteria:\n\n* Indicated and scheduled for arthroscopic rotator cuff repair.\n* Full-thickness medium (1-3 cm), large (3-5 cm), and massive (\\>5 cm) rotator cuff tears involving the supraspinatus and\u002For infraspinatus tendons demonstrated on magnetic resonance or ultrasound imaging.\n* Chronic, degenerative rotator cuff tears.\n* Ability to read and understand English.\n* Age ≥18 years\n* Patient failed ≥6 weeks of conservative treatment, which included structured, in-person physical therapy or documented home therapy\n\nExclusion Criteria:\n\n* Patient scheduled for open or mini-open rotator cuff repair\n* Prior surgery of affected shoulder (except diagnostic arthroscopy)\n* Partial-thickness rotator cuff tears\n* Small (\\\u003C1 cm) rotator cuff tears\n* Rotator cuff tears involving the subscapularis tendon\n* Acute and traumatic rotator cuff tears\n* Active infection\n* Cancer\n* Autoimmune and rheumatologic disorders, including rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus",{"count":403,"type":21},78,[24],"The purpose of this randomized-controlled study is to compare outcomes of arthroscopic rotator cuff repair augmented with a Bioinductive Implant (study group) to standard arthroscopic rotator cuff repair (control group). The primary outcome of this study is rotator cuff repair integrity (absence of full- or partial-thickness defect) demonstrated on ultrasound at 1-year postoperatively. The investigators hypothesize that the study group will have higher rates of repair integrity demonstrated on ultrasound at 1-year postoperatively.",[27,407],"Rotator Cuff Tear Arthropathy",[133,409,410,407],"Bioinductive","Arthroscopic Rotator Cuff Repair","2026-02-24",{"date":413,"type":34},"2026-02-27",{"date":415,"type":34},"2022-08-16",{"date":417,"type":21},"2029-07-01",{"name":419,"class":64},"Henry Ford Health System",{"id":421,"slug":422,"hasResults":12,"nctId":423,"briefTitle":424,"officialTitle":425,"acronym":426,"eligibilityCriteria":427,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":428,"targetDuration":4,"studyType":22,"phases":429,"briefSummary":430,"conditions":431,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":121},"100505009","acellular-matrix-from-human-dermis-in-combination-with-orthobiologic-stimuli-for-augmentation-of-massive-rotator-cuff-tears-100505009","NCT05855759","Acellular Matrix From Human Dermis in Combination With Orthobiologic Stimuli for Augmentation of Massive Rotator Cuff Tears","Acellular Matrix Homologous From Human Dermis in Combination With Orthobiologic Stimuli,Subacromial Bursa and Humeral Bone Marrow Concentrate, for Augmentation of Massiverotator Cuff Tears: Therapeutic Efficacy and Improvements for the Development of a Costeffective and Ready to Use Product","MODA","Inclusion Criteria:\n\n* patients affected by large to massive lesion according to Gerber involving supraspinatus and infraspinatus tendons\n* tendon retraction \\\u003C=3 according to Thomazeau\n* fatty degeneration \\\u003C=3 according to Goutallier\n* possibility to obtain tendon reduction,\n* pre-operative Magnetic Resonance Imaging,\n* ability to read, understand and complete outcome scores\n\nExclusion Criteria:\n\n* patients affected by osteoarthritic degeneration,\n* frozen shoulder,\n* symptomatic acromioclavicular arthritis,\n* revision surgeries,\n* inability to cope with post-operative rehabilitation regimen,\n* autoimmune connective tissue disease,\n* current or past hematologicaldisorders,\n* comorbidities affecting healing,\n* active infections,\n* cancers,\n* pregnancy and lactation",{"count":232,"type":21},[104],"The use of biologic acellular matrices for the surgical augmentation of rotator cuff lesions has greatly expanded inrecent years. The study team patented a method for removing cells from human dermis (Acellular Dermal Matrix), maintaining unaltered biological and structural integrity. Acellular Dermal Matrix has been succesfully used for rotator cuff surgical repair augmentation beside in a limited number of patients. The aim of the project is to demonstrate the therapeutical efficacy of this strategy in patients affected by rotator cuff massive tears. Acellular Dermal Matrix will be also combined with autologous orthobiologics.",[27],"2026-02-17",{"date":434,"type":34},"2026-02-19",{"date":436,"type":34},"2023-12-18",{"date":438,"type":21},"2026-05-30",{"name":222,"class":64},{"id":441,"slug":442,"hasResults":12,"nctId":443,"briefTitle":444,"officialTitle":444,"acronym":4,"eligibilityCriteria":445,"healthyVolunteers":280,"sex":16,"minAge":17,"maxAge":333,"enrollmentInfo":446,"targetDuration":4,"studyType":22,"phases":448,"briefSummary":449,"conditions":450,"keywords":451,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":455,"lastUpdatePostDateStruct":456,"startDateStruct":458,"completionDateStruct":460,"leadSponsor":461,"locationsCount":462},"100419494","comparison-of-partial-rotator-cuff-repair-vs-superior-capsular-reconstruction-for-irreparable-rotator-cuff-tears-100419494","NCT04742452","Comparison of Partial Rotator Cuff Repair vs. Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears","Inclusion Criteria:\n\n* Age range: ≥18 years\n* Irreparable rotator cuff tear suspected on pre-operative MRI\n\nExclusion Criteria:\n\n* Pregnant, illiterate, or non-English speaking individuals\n* Rotator cuff pathology amenable to a complete repair intraoperatively\n* Moderate to severe rotator cuff arthropathy (Hamada grade ≥3)\n* Presence of glenohumeral arthritis on radiographs\n* Irreparable subscapularis muscle intraoperatively\n* Active infection within the ipsilateral glenohumeral joint\n* Neurologic pathology limiting shoulder function\n* Current smoker\n* Workers' compensation claim",{"count":447,"type":21},105,[104],"The primary objective of this prospective randomized controlled trial is to compare pain and functional outcomes between two surgical modalities for irreparable rotator cuff tears as measured by the pain visual analog scale (VAS), simple shoulder test (SST), American Shoulder and Elbow Surgery shoulder score (ASES), and Patient Reported Outcomes Measurement Information System (PROMIS) 29 score at 6 weeks, 3, 6, 12, and 24 months post-operatively. The two surgical modalities of interest are partial rotator cuff repair alone and partial rotator cuff repair with superior capsule reconstruction (SCR). The secondary objective of this study is determine the failure rate of partial repair alone vs. partial repair with SCR via magnetic resonance imaging (MRI) at 12 months post-operatively. The information gained from this investigation will be useful to discern if SCR provides any benefit to patients with irreparable rotator cuff tears. The investigators hypothesize that there is no statistically significant difference in pain and functional outcomes between partial rotator cuff repair alone versus partial rotator cuff repair with SCR. In addition, the investigators hypothesize that the failure rate will be significantly higher in patients undergoing partial rotator cuff repair with SCR.",[27],[452,453,454],"Superior capsular reconstruction","Partial rotator cuff repair","Magnetic resonance imaging","2026-02-09",{"date":457,"type":34},"2026-02-12",{"date":459,"type":34},"2020-11-24",{"date":191,"type":21},{"name":351,"class":64},3,{"id":464,"slug":465,"hasResults":12,"nctId":466,"briefTitle":467,"officialTitle":467,"acronym":4,"eligibilityCriteria":468,"healthyVolunteers":12,"sex":16,"minAge":281,"maxAge":469,"enrollmentInfo":470,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":472,"conditions":473,"keywords":474,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":488},"100426296","genetic-epidemiology-of-rotator-cuff-tears-the-cuffgen-study-100426296","NCT04831164","Genetic Epidemiology of Rotator Cuff Tears: The cuffGEN Study","Inclusion Criteria:\n\n* Aged ≥40 years to \\\u003C 85 years\n* Confirmed diagnosis of partial or full-thickness cuff tear on MRI (Cases) OR absence of rotator cuff tear on shoulder MRI (Controls)\n* Ability and willingness to provide informed consent\n* Ability to complete questionnaires in English (to maintain scientific integrity since standardized questionnaires are extensively validated in English)\n\nExclusion Criteria:\n\n* Acute rotator cuff tear caused by a severe trauma","85 Years",{"count":471,"type":21},3500,"Rotator cuff tear is one of the most common reasons to seek musculoskeletal care, and cuff repair is one of the fastest growing ambulatory surgery procedures. However, the etiology of cuff tears, reasons for variability treatment success, and causes of FI are poorly understood. A large-scale genome-wide association studies (GWAS) using imaging-verified rotator cuff tear cases and controls can address limitations in rigor of prior research and assess the genetic basis of FI and functional outcomes of cuff tear treatments.\n\nPrimary Objective: To conduct a case-control GWAS of imaging-verified symptomatic rotator cuff tear in approximately 3000-6000 individuals and replicate findings in an independent set of 3000-6000 or more imaging-verified individuals to identify common variants in several genetic loci that increase risk for rotator cuff tears.\n\nHypothesis: Common variants in several genetic loci increase risk for rotator cuff tears.\n\nSecondary Objectives:\n\n1. To perform an imputed transcriptome-wide association study (TWAS) to identify and prioritize gene targets associated with rotator cuff tear by integrating GWAS summary statistics and gene-expression weights from muscle and adipose tissue available in the GTEx project.\n\n   Hypothesis: Genetically predicted gene expression of multiple genes in muscle and adipose tissue are associated with rotator cuff tear.\n2. To identify if single nucleotide polymorphisms (SNPs) associated with rotator cuff tear and their genetic risk score (GRS) predict improved pain and function as measured by American Shoulder and Elbow Surgeons Standardized Form (ASES) and other outcome measures.\n\n   Hypothesis: Select SNPs and GRS predict ASES outcome.\n3. To identify genetic variants associated with Fatty Infiltration (FI) in patients with cuff tears in a two stage GWAS of imaged rotator cuffs and to prioritize gene targets through an imputed-TWAS in muscle and adipose tissue.\n\nHypothesis: Multiple genetic variants are associated with FI and some exert their influence by altering gene expression in the muscle and adipose tissue.",[27],[475,476,477,478],"rotator cuff","shoulder","GWAS","musculoskeletal","2026-02-05",{"date":481,"type":34},"2026-02-10",{"date":483,"type":34},"2021-03-04",{"date":485,"type":21},"2031-12-31",{"name":487,"class":64},"University of Michigan",10,{"id":490,"slug":491,"hasResults":12,"nctId":492,"briefTitle":493,"officialTitle":494,"acronym":4,"eligibilityCriteria":495,"healthyVolunteers":12,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":496,"targetDuration":4,"studyType":22,"phases":497,"briefSummary":498,"conditions":499,"keywords":500,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":512,"locationsCount":121},"100572584","phase-1-tuberoplasty-versus-balloon-spacer-100572584","NCT06735170","Tuberoplasty Versus Balloon Spacer","Tuberoplasty Versus Balloon Spacer in Treatment of Rotator Cuff Tears","Inclusion Criteria:\n\n* Massive irreparable rotator cuff tear involving the supraspinatus and infraspinatus.\n* No involvement of the subscapularis.\n* Centered humeral head on X-ray examination.\n* Primary complaint of pain.\n* History of prior surgery, including failed rotator cuff repair.\n\nExclusion Criteria:\n\n* Involvement of the subscapularis.\n* Acromiohumeral distance less than 7 mm on upright anterior-posterior (AP) radiograph.\n* Rotator cuff deemed repairable at the time of surgery.\n* Patients younger than 65 years due to FDA clearance of the subacromial balloon spacer only for patients over 65",{"count":161,"type":21},[77,78],"The purpose of this study is to examine bone-to-bone contact between the tuberosity as compared to a subacromial balloon spacer procedure. Using biplanar fluoroscopy to determine the three-dimensional (3D) motion of the shoulder compared pre-procedure to post-procedure, the investigators will be able to assess 1) the bone-to-bone contact of the tuberosity and acromion in the setting of a massive posterior superior rotator cuff tear 2) if the placement of a dermal allograft over the tuberosity does indeed decrease bone contact and 3) if the placement of a subacromial balloon spacer decreases bone-to-bone contact. Doing so will allow assessment of the relative contribution of the implant for arm elevation versus potential compensatory motion of increased scapulothoracic motion. The investigators will also be able to correlate this to patient-reported outcomes of pain and shoulder function.",[27],[501,502,503,504],"rotator cuff tear","shoulder surgery","tuberoplasty","subacromial balloon spacer","2026-01-05",{"date":507,"type":34},"2026-01-07",{"date":509,"type":34},"2024-12-02",{"date":511,"type":21},"2026-11-26",{"name":513,"class":64},"University of Minnesota",{"id":515,"slug":516,"hasResults":12,"nctId":517,"briefTitle":518,"officialTitle":519,"acronym":4,"eligibilityCriteria":520,"healthyVolunteers":12,"sex":16,"minAge":521,"maxAge":4,"enrollmentInfo":522,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":524,"conditions":525,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":536,"completionDateStruct":538,"leadSponsor":539,"locationsCount":541},"100485642","exactech-shoulder-post-market-clinical-follow-up-study-100485642","NCT05603728","Exactech Shoulder Post Market Clinical Follow-up Study","An Open Label, Multi-Center, Retrospective and Prospective Evaluation of Shoulder Arthroplasty Clinical and Radiographic Outcomes","Inclusion Criteria:\n\n* Patient is indicated for shoulder arthroplasty (or has previously undergone shoulder arthroplasty)\n* Patient is skeletelly mature\n* Patient is expected to survive at least 2 years beyond surgery\n* Patient is willing to participate by complying with pre- and postoperative visit requirements\n* Patient is willing and able to read and sign a study informed consent form\n\nExclusion Criteria:\n\n* Osteomyelitis of the proximal humerus or scapula; if a systemic infection or a secondary remote infection is suspected or confirmed, implantation should be delayed until infection is resolved\n* Inadequate or malformed bone that precludes adequate support or fixation of the prosthesis\n* Medial humeral bone loss resulting in compromised humeral stem fixation\n* Proximal humeral bone loss extending distal to the surgical neck where there is compromised humeral stem fixation\n* Neuromuscular disorders that do not allow control of the joint\n* Significant injury to the brachial plexus\n* Non-functional deltoid muscles\n* Patient's age, weight, or activity level would cause the surgeon to expect early failure of the system\n* The patient is unwilling or unable to comply with the post-operative care instructions\n* Alcohol, drug, or other subtance abuse\n* Any disease state that could adversaly affect the function or longevity of the implant\n* Patient is pregnant\n* Patient is a prisoner\n* Patient is contraindicated for the surgery\n* Revision cases in which a stemmed humeral component was used (Stemless Shoulder System)\n* Metal allergy or sensitivity to the implants materials (Stemless Shoulder System)\n* Acute fracture of the proximal humerus and displacement of the tuberosities, displaced three or four part fractures of the proximal humerus (hemi-arthroplasty), or acture fracture of the proximal humerus with failure of the glenohumeral joint (total anatomic shoulder arthroplasty) (Stemless Shoulder System)\n* Acute fracture of the proximal humerus in combination with degenerative diseases of the glenohumeral joint and a grossly deficient, irreparable rotator cuff resulting in superior migration of the humeral head (reverse total shoulder arthroplasty) (Stemless Shoulder System)","21 Years",{"count":523,"type":21},20000,"The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time. This study will follow subjects long-term for a minimum of 10-years, without an early-term restriction on the amount of time they will be followed.",[526,527,27,407,528,529,530,531,532],"Osteo Arthritis Shoulders","Osteonecrosis","Ankylosing Spondylitis","Post-traumatic Osteoarthritis","Rheumatoid Arthritis","Fracture","Infections","2025-12-09",{"date":535,"type":34},"2025-12-15",{"date":537,"type":34},"2007-07-19",{"date":485,"type":21},{"name":540,"class":150},"Exactech",38,{"id":543,"slug":544,"hasResults":12,"nctId":545,"briefTitle":546,"officialTitle":546,"acronym":4,"eligibilityCriteria":547,"healthyVolunteers":12,"sex":16,"minAge":72,"maxAge":203,"enrollmentInfo":548,"targetDuration":4,"studyType":22,"phases":549,"briefSummary":550,"conditions":551,"keywords":552,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":558,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":566},"100586643","fiberlocker-system-augmentation-of-rotator-cuff-repairs-100586643","NCT06918041","FiberLocker® System Augmentation of Rotator Cuff Repairs","Inclusion Criteria:\n\n1. The Subject is between the ages of 30 and 70 years.\n2. Subject is planning to undergo arthroscopic surgery for full-thickness rotator cuff tear (RCT)\n3. Tear size ≥ 2 cm\n4. Primary rotator cuff repair\n5. Subject preoperative MRI obtained within 1 year prior to surgery\n\nExclusion Criteria:\n\n1. The Subject is unable or unwilling to sign the Patient Informed Consent, approved by the Institutional Review Board.\n2. The Subject objects to the use of the FiberLocker® System\n3. History or known allergy or intolerance to polyester\n4. Complete full-thickness subscapularis tears of \\> than the superior 1\u002F3 of the tendon (Lafosse grade 3 and above)\n5. Hamada grade III and above\n6. Less than 2 mm joint space of the glenohumeral joint on either an anteroposterior or axillary radiograph\n7. Recurrent shoulder instability\n8. Corticosteroid injection in the operative shoulder within three months before surgery\n9. Subjects with inflammatory or auto-immune based joint diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus)\n10. Subjects with current acute infection in the area surrounding the surgical site\n11. Revision rotator cuff repair\n12. Pregnant or planning to become pregnant during the study period\n13. Subject is breastfeeding during the study period\n14. Subject has conditions or circumstances that would interfere with study requirements\n\nIntraoperative Exclusion Criteria:\n\n1. Partial rotator cuff repairs\n2. Lafosse grade 3 or higher subscapularis tears\n3. Limited space for implant delivery\n4. FiberLocker® System cannot be used as indicated",{"count":50,"type":21},[104],"The purpose of this study is to prospectively evaluate healing, functional clinical outcomes, and safety of arthroscopic rotator cuff repairs augmented with the FiberLocker® System (encompassing the SpeedPatch® PET and the FiberLocker® Instrument SN).\n\nThe primary outcome measure is healing evaluation based on Magnetic Resonance Imaging (MRI) at a minimum of 6 months post-operatively.\n\nThe secondary outcome measures are the Sugaya classification, Goutallier Stage and tendon quality based on MRI as well as objective scores and patient-reported outcome measures (PROMs) from validated outcome scoring systems.",[133,27,134],[27,137,553,554,555,556],"Augmentation","Reinforcement","Mechanical Augmentation","Rotator Cuff Degeneration","2025-11-27",{"date":559,"type":34},"2025-12-01",{"date":561,"type":34},"2025-08-05",{"date":563,"type":21},"2028-04-01",{"name":565,"class":150},"ZuriMED Technologies Inc.",4,{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":571,"acronym":4,"eligibilityCriteria":572,"healthyVolunteers":12,"sex":16,"minAge":281,"maxAge":159,"enrollmentInfo":573,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":575,"conditions":576,"keywords":579,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":581,"lastUpdatePostDateStruct":582,"startDateStruct":584,"completionDateStruct":586,"leadSponsor":588,"locationsCount":121},"100607070","does-sarcopenia-influence-rotator-cuff-tear-patterns-radiological-insights-from-patients-with-rotator-cuff-syndrome-100607070","NCT07183774","Does Sarcopenia Influence Rotator Cuff Tear Patterns? Radiological Insights From Patients With Rotator Cuff Syndrome","Inclusion Criteria:\n\n1. Patients with rotator cuff syndrome\n2. Aged between 40 and 75 years\n\nExclusion Criteria:\n\n1. History of previous shoulder surgery\n2. Presence of shoulder pathology other than rotator cuff syndrome\n3. History of surgical intervention involving the hip or thigh region\n4. Being wheelchair-bound or bedridden\n5. Presence of an oncologic disease\n6. Diagnosis of any neurological disorder\n7. Presence of cognitive impairment",{"count":574,"type":21},104,"Sarcopenia is the loss of muscle mass due to aging, which consequently leads to a decline in muscle function. It is considered an independent risk factor for falls and fractures, disability, postoperative complications, and mortality. Rotator cuff tears are known to be influenced by systemic diseases such as diabetes, hypercholesterolemia, thyroid disorders, and osteoporosis. The aim of our study is to investigate whether there is a relationship between sarcopenia and rotator cuff tears, and if so, to determine the location and type of the tear.",[27,577,578,366],"Sarcopenia","Shoulder Pain",[580,288,577],"Rotator cuff syndrome","2025-11-19",{"date":583,"type":34},"2025-11-26",{"date":585,"type":34},"2025-01-01",{"date":587,"type":21},"2025-12-30",{"name":589,"class":64},"Haydarpasa Numune Training and Research Hospital",{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":594,"acronym":4,"eligibilityCriteria":595,"healthyVolunteers":12,"sex":16,"minAge":17,"maxAge":230,"enrollmentInfo":596,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":597,"conditions":598,"keywords":605,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":610,"lastUpdatePostDateStruct":611,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":617,"locationsCount":121},"100378588","evaluating-hemidiaphragmatic-paralysis-with-prolonged-neural-blockade-from-an-interscalene-brachial-plexus-block-100378588","NCT04209504","Evaluating Hemidiaphragmatic Paralysis With Prolonged Neural Blockade From an Interscalene Brachial Plexus Block","Inclusion Criteria:\n\n* English speaking 18-80 year old ASA 1-3 patients\n* Primary shoulder surgery\n* Must live within a 25 mile radius\n\nExclusion Criteria:\n\n* ASA 4 or 5\n* Revision shoulder surgery\n* Diagnosis of chronic pain\n* Daily chronic opioid use (over 3 months of continuous opioid use)\n* Inability to communicate pain scores or need for analgesia\n* Infection at the site of block placement\n* Age under 18 years old or greater than 80 years old\n* Pregnant women (as determined by point-of-care serum bHCG)\n* Intolerance\u002Fallergy to local anesthetics\n* Weight \\\u003C50 kg\n* BMI \\> 40\n* severe pulmonary disease including chronic obstructive pulmonary disease and restrictive lung disease\n* Suspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years.\n* Uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, may interfere with study assessments or compliance.\n* Current or historical evidence of any clinically significant disease or condition that, in the opinion of the investigator, may increase the risk of surgery or complicate the subject's postoperative course.",{"count":50,"type":21},"This prospective observational study aims to evaluate the incidence of hemidiaphragmatic paralysis in patients receiving interscalene brachial plexus nerve block with prolonged neural blockade. English speaking American Society of Anesthesiologists (ASA) 1-3 patients ages 18-80 receiving prolonged interscalene nerve block will be randomized into 3 groups: first group receiving a perineural catheter infusing 0.2% ropivacaine; the second group receiving a single shot injection of 10mL liposomal bupivacaine (Exparel; n=20) plus 5 mL 0.5% bupivacaine and the third receiving 20mL liposomal bupivacaine plus 5mL bupivacaine (to be determined by the attending anesthesiologist).Primary outcome will be incidence of hemidiaphragmatic paralysis postoperative day 1 as measured by point of care (POCUS) ultrasound.",[599,578,600,601,602,27,28,603,604,137],"Shoulder Surgery","Shoulder Injuries","Shoulder Arthritis","Shoulder Disease","Rotator Cuff Arthropathy of Left Shoulder","Rotator Cuff Arthropathy of Right Shoulder",[137,599,606,607,608,609],"Hemidiaphragmatic paralysis","Interscalene Block","Interscalene Catheter","Interscalene Liposomal Bupivacaine","2025-09-29",{"date":612,"type":34},"2025-10-01",{"date":614,"type":34},"2021-10-12",{"date":616,"type":21},"2026-08-31",{"name":618,"class":64},"Duke University",{"id":620,"slug":621,"hasResults":12,"nctId":622,"briefTitle":623,"officialTitle":624,"acronym":4,"eligibilityCriteria":625,"healthyVolunteers":12,"sex":16,"minAge":626,"maxAge":18,"enrollmentInfo":627,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":629,"conditions":630,"keywords":631,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":121},"100593063","the-impact-of-cervical-radiculopathy-on-functionality-in-patients-undergoing-rotator-cuff-repair-100593063","NCT07001566","The Impact of Cervical Radiculopathy on Functionality in Patients Undergoing Rotator Cuff Repair","The Impact of Cervical Radiculopathy on Functionality and Quality of Life in Patients Undergoing Rotator Cuff Repair","Inclusion Criteria:\n\n* Patients who have undergone rotator cuff repair\n* Patients under the age of 65\n\nExclusion Criteria:\n\n* Patients who have undergone shoulder surgery other than rotator cuff repair\n* Patients with a history of cervical spine surgery\n* Patients with any neurological disorders\n* Patients with a history of pathological fractures\n* Patients with oncological diseases\n* Patients with a history of infection\n* Patients who were deceased at the time of retrospective screening","41 Years",{"count":628,"type":21},50,"The aim of the study is to evaluate the impact of cervical radiculopathy on functional status and quality of life outcomes in patients who have undergone rotator cuff repair, comparing the group with a history of cervical radiculopathy to the group without cervical radiculopathy.\n\nStudy topic: The participants of the study were selected from patients who underwent rotator cuff repair at the Orthopedics and Traumatology clinic of Kartal Dr. Lütfi Kırdar City Hospital between 2018 and 2023. The first group consisted of patients without cervical radiculopathy, while the second group included patients with a previously diagnosed cervical radiculopathy. The study will examine the effect of the presence of cervical radiculopathy on functional outcomes and quality of life in patients who underwent rotator cuff repair.",[27],[632,633,634],"pain","functionality","quality of life","2025-06-01",{"date":637,"type":34},"2025-06-03",{"date":639,"type":34},"2025-03-20",{"date":641,"type":21},"2025-09-30",{"name":643,"class":64},"Biruni University"]