[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rumination---thoughts\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rumination---thoughts":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100637591","nlp-analysis-of-weekly-narratives-for-dynamic-clinical-assessment-in-sud-100637591",false,"NCT07595614","NLP Analysis of Weekly Narratives for Dynamic Clinical Assessment in SUD","Analysis of Weekly Narratives Using Natural Language Processing in Patients Undergoing Residential Rehabilitation: A Hybrid Approach for the Dynamic Assessment of Clinical Processes","DYNA-NLP","Inclusion Criteria:\n\n1. Clinical diagnosis of severe substance use disorder (polydrug use, including cocaine, methamphetamines, alcohol, and\u002For cannabis), confirmed by the center's admission assessment.\n2. Male sex (all participants in the center's residential program are male).\n3. Age 18 years or older.\n4. Current resident of the participating residential rehabilitation center in Mexico.\n5. Completed at least four weeks of residential treatment at the time of study enrollment.\n6. Able to write coherent weekly narratives in Spanish (no severe cognitive impairment or active psychosis).\n7. Willing to provide written informed consent.\n\nExclusion Criteria:\n\n1. Presence of acute psychotic symptoms that interfere with the ability to write or understand the study procedures.\n2. Severe cognitive impairment (e.g., due to traumatic brain injury, intellectual disability) that prevents meaningful narrative production.\n3. Inability to comply with weekly narrative writing (e.g., illiteracy, severe visual impairment).\n4. Planned discharge from the residential program within less than 4 weeks from enrollment.\n5. Enrollment in another interventional clinical trial that could confound the interpretation of outcomes.","MALE","18 Years",{"count":20,"type":21},35,"ESTIMATED","20 Weeks","OBSERVATIONAL","This prospective observational study follows adults undergoing residential rehabilitation for severe substance use disorders at a specialized treatment center in Mexico. Participants provide weekly written narratives describing their emotions, challenges, coping strategies, and treatment experiences, and complete validated psychological questionnaires every two weeks, including the Generalized Anxiety Disorder-7 (GAD-7), Environmental Reward Observation Scale (EROS), Automatic Thoughts Questionnaire-8 (ATQ-8), and Behavioral Activation for Depression Scale (BADS).\n\nThe study applies natural language processing (NLP) and machine learning methods to analyze participants' narratives and identify emotional, cognitive, and behavioral patterns associated with clinical change over time. Narrative-derived features are combined with questionnaire scores to generate a dynamic clinical risk representation that may help detect early signs of psychological worsening or improvement during residential treatment.\n\nParticipants continue receiving standard residential care, and the study does not modify treatment decisions or clinical interventions. Up to 35 participants with sufficient longitudinal follow-up data will be included in the primary analysis. Data collection is expected to continue through September 2026.",[26,27,28,29,30],"Substance Use Disorder (SUD)","Addiction","Anxiety","Emotional Dysregulation","Rumination - Thoughts",[32,33,34,35,36],"Natural Language Processing","Machine Learning","Behavioral Activation","Automatic Thoughts","Residential Rehabilitation","RECRUITING","2026-05-14",{"date":40,"type":41},"2026-05-19","ACTUAL",{"date":43,"type":41},"2025-05-25",{"date":45,"type":21},"2026-09",{"name":47,"class":48},"Lauro Gutiérrez Castro","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":57,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":74,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":49},"100637117","calming-minds-study-100637117","NCT07577401","Calming Minds Study","Understanding the Mechanisms Driving the Reduction of Repetitive Negative Thought","Inclusion Criteria:\n\n* Aged 18+ years\n* Able to provide a valid Imperial Valley College email address\n* Access to a suitable smartphone\u002Fdevice (iPhone 8+ running iOS 16.4 or higher, or Android version 8 or higher)\n* Access to internet\n* Elevated repetitive negative thought (RNT) based on scores from Ruminative Response Scale Brood subscale (RSS-brood) and Penn State Worry Questionnaire (PSWQ)\n\nExclusion Criteria:\n\n* Concurrent psychotherapy\n* Self-reported current or past diagnosis or treatment for Psychosis\n* Self-reported current or past diagnosis or treatment for Bipolar disorder\n* Self-reported current or past diagnosis or currently receiving, or waiting to receive, treatment for substance abuse\u002Fdependence\n* Self-reported current diagnosis or currently receiving, or waiting to receive, treatment for alcohol abuse\u002Fdependence\n* Antidepressant\u002Fanxiolytic medication that has changed in dose or nature in last 6 weeks\n* Current severe PTSD defined as measured by the adapted International Trauma Questionnaire\n* Active suicidal thoughts or self-harm","ALL",{"count":59,"type":21},500,"INTERVENTIONAL",[62],"NA","The goal of this study is to understand why certain treatments help people reduce repetitive negative thinking (RNT), which is common in many mental health problems. We want to:\n\n1. Figure out what actually causes repetitive negative thinking to decrease when people use cognitive-behavioral therapy (CBT).\n2. Find out which parts of RNT-focused CBT are the most important - the parts that truly make a difference in reducing RNT.\n\nThe main result we will look at is how much a person's repetitive negative thought patterns change from the start of the study to the end of treatment (16 weeks). We will measure this using the Perseverative Thinking Questionnaire at baseline and week 16.",[28,65,66,67,30],"Anxiety Depression","Worry","Depression",[69,70,67,66,28,71,72,73],"Imperial Valley College","Community College","Mental Health","STAND","Calming Minds","NOT_YET_RECRUITING","2026-05-03",{"date":77,"type":41},"2026-05-11",{"date":79,"type":21},"2026-06-08",{"date":81,"type":21},"2028-06-14",{"name":83,"class":48},"University of California, Los Angeles"]