[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"rumination\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:rumination":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,51,73,100,129,156,184,228,255,284,305,333,356],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100631623","pilot-study-of-sensor-informed-smartphone-based-mental-health-interventions-for-mood-in-early-psychosis-100631623",false,"NCT07503093","Pilot Study of Sensor-Informed Smartphone-based Mental Health Interventions for Mood in Early Psychosis","Development of Sensor-Informed Smartphone-Based Mental Health Intervention for Early Psychosis","Inclusion Criteria:\n\n* Age 18-50 years\n* History of DSM-5 psychotic disorder (e.g., schizophrenia, schizoaffective disorder, psychosis not otherwise specified)\n* Current elevated mood symptoms, defined as mild or greater depressive symptoms (Patient Health Questionnaire-8 score ≥5) or anxiety symptoms (Generalized Anxiety Disorder-7 score ≥5)\n* Own a personal iPhone or Android smartphone\n* Willing and able to provide informed consent\n* English-speaking\n\nExclusion Criteria:\n\n* Active suicidal ideation with both intent and a specific plan.\n* Current substance use disorder requiring acute treatment\n* Diagnosis of neurodevelopmental disorder that would impair ability to use smartphone app or complete study procedures\n* Traumatic brain injury with significant cognitive impairment","ALL","18 Years","50 Years",{"count":20,"type":21},10,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of this trial is to evaluate the feasibility and preliminary efficacy of using passive smartphone sensors to detect moments of heightened negative mood and inform the timing of brief mental health interventions, such as mindfulness exercises and psychoeducation, in adults with early psychosis.",[27,28,29,30],"Psychosis","Anxiety","Depression","Rumination",[32,33,27,34,35,36,37],"Mirco-Randomized Study","Mobile Health","Digital Mental Health","Negative Mood","Digital Phenotyping","Passive Sensors","NOT_YET_RECRUITING","2026-06-22",{"date":41,"type":42},"2026-06-25","ACTUAL",{"date":44,"type":21},"2026-08-01",{"date":46,"type":21},"2027-06-01",{"name":48,"class":49},"Mclean Hospital","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":58,"maxAge":17,"enrollmentInfo":59,"targetDuration":4,"studyType":22,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":50},"100416077","mechanisms-and-predictors-of-change-in-app-based-mindfulness-training-for-adolescents-100416077","NCT04697966","Mechanisms and Predictors of Change in App-Based Mindfulness Training for Adolescents","Inclusion Criteria:\n\n* Both genders, all ethnicities (see Section: Inclusion of Women and Minorities)\n* Ages 13-18 years\n* Written informed assent\u002Fconsent from adolescent and parent\u002Fguardian\n* English as a first language or English fluency\n* Right-handed\n* Personal iPhone or Android smartphone\n* CRSQ rumination subscale score\n* If on psychotropic medication, must be on stable dose for at least 2 months\n\nExclusion Criteria:\n\n* History or current diagnosis of any of the following DSM-5 disorders: schizophrenia spectrum or other psychotic disorder, bipolar disorder, substance\u002Falcohol use disorder within the past 12 months or lifetime severe substance\u002Falcohol use disorder.\n* Systemic medical or neurological illness that could impact fMRI measures of cerebral blood flow\n* Failure to meet standard exclusion criteria for fMRI scanning (e.g. pregnancy, claustrophobia, cardiac or neural pacemakers, surgically implanted metal devices, cochlear implants, metal objects in the body)\n* History of seizure disorder, or head trauma with loss of consciousness \\> 2 mins\n* Serious or unstable medical illness (e.g., cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease)\n* Participants with active suicidal ideation will be immediately referred to appropriate clinical treatment.\n* Current or past treatment with mindfulness-based psychotherapy (e.g., MBCT, DBT or ACT)\n* Exposure to in-person or app-based mindfulness\u002Fmeditation course (at least 300 mins of past practice)",true,"13 Years",{"count":60,"type":21},158,[24],"A growing body of research implicates rumination as being a transdiagnostic risk factor involved in the development of depression and anxiety in youth. Critically, mindfulness meditation has shown significant promise in targeting rumination, and ultimately improving depressive and anxiety symptoms. Mindfulness apps offer a convenient and cost-effective means for accessing mindfulness training, while being interactive and engaging for youth. Despite their growing popularity among teens, strikingly little research has been conducted on these apps. Two critical questions have yet to be addressed: (1) what are the underlying neural and cognitive mechanisms that account for the beneficial effects of these apps and (2) for whom is app-based mindfulness well-suited. To address these gaps, adolescents (ages 13-18) will be randomly assigned to an app-delivered mindfulness course vs. a control condition and will complete pre- and post-intervention resting state functional magnetic resonance imaging (fMRI) scans to probe static and dynamic functional connectivity within - and between - brain networks strongly implicated in mindfulness training and rumination. In addition, cognitive tasks will be administered at pre- and post-intervention to assess attentional control abilities putatively enhanced by mindfulness training. Finally, mindfulness skills and changes in rumination will be assessed via smartphone-based ecological momentary assessment (EMA). First, the investigators will test whether changes in (1) brain functional connectivity, (2) attentional control and (3) acquisition and use of mindfulness skills mediate between-group (i.e., app vs. control) differences in the reduction of rumination. Second, the investigators will test whether a machine learning model incorporating baseline clinical, demographic, and psychosocial characteristics can be used to identify which adolescents are predicted to benefit from app-based mindfulness training.",[30],"RECRUITING","2026-06-15",{"date":67,"type":42},"2026-06-17",{"date":69,"type":42},"2021-11-16",{"date":71,"type":21},"2027-09-30",{"name":48,"class":49},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":80,"enrollmentInfo":81,"targetDuration":4,"studyType":22,"phases":83,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100638590","metacognitive-bibliotherapy-for-anxiety-depression-and-metacognitions-in-university-students-100638590","NCT07627139","Metacognitive Bibliotherapy for Anxiety, Depression, and Metacognitions in University Students","The Effects of a Metacognitive Bibliotherapy Intervention on Anxiety, Depression, and Metacognitions Among University Students: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Active enrollment in the Faculties of Medicine, Nursing, Pharmacy, Dentistry, or Psychology at Istanbul Nisantasi University\n* Aged between 18 and 25 years\n* Provision of voluntary digital informed consent\n\nExclusion Criteria:\n\n* Currently receiving active psychiatric treatment (psychotherapy or pharmacotherapy)\n* Change in psychopharmacological medication within the past 6 months\n* Prior reading of either of the study books\n* Presence of acute psychotic symptoms or suicidal risk","25 Years",{"count":82,"type":21},110,[24],"The goal of this clinical trial is to learn if a self-help reading program, called metacognitive bibliotherapy, can reduce anxiety and depression in university students studying medicine and health sciences. It will also examine whether the program changes unhelpful thinking patterns about worry and rumination.\n\nThe main questions it aims to answer are:\n\nDoes metacognitive bibliotherapy lower anxiety and depression symptoms in university students? Does it reduce unhelpful thinking patterns, such as excessive worry and rumination?\n\nResearchers will compare two different self-help books with a waiting list group to see if reading these books helps reduce anxiety and depression.\n\nParticipants will:\n\n* Be randomly assigned to one of three groups: read The Art of Letting Go - How to Stop Rumination, read Anchored: How to Befriend Your Nervous System Using Polyvagal Theory, or join a waiting list\n* Read the assigned book at their own pace over 8 weeks\n* Complete online questionnaires at the start of the study, after 4 weeks, and after 8 weeks\n* Participants in the waiting list group will receive both books for free after the 8-week study period ends",[28,29,86,30],"Stress (Psychology)",[88,89,90,91],"Metacognition","Psychological Distress","self-help","rumination","2026-05-30",{"date":94,"type":42},"2026-06-04",{"date":65,"type":21},{"date":97,"type":21},"2026-10-31",{"name":99,"class":49},"Istanbul Nisantasi University",{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":107,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":115,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":128},"100636440","optimization-of-late-imagery-rescripting-research-using-generative-artificial-intelligence-100636440","NCT07565714","Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence","ImRs_LLM_DeanG","Inclusion Criteria:\n\n* Age 18-35\n* Score ≥ 8 on GAD-7 (Plummer et al., 2016)\n* Ability to recall at least two childhood memories involving parental criticism\n\nExclusion Criteria:\n\n* History of prolonged physical or sexual abuse\n* Current psychotherapy or psychopharmacology\n* PTSD diagnosis (DSM-5 screening)\n* Substance abuse (TAPS tool)","35 Years",{"count":109,"type":21},40,[24],"The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs). Intervention will involve the prior presentation of the most aversive fragment of the memory, the so-called 'hotspot.' This intervention will allow for the replication of the effect described by Dibbets and Arntz (2016), according to which the prior activation of the most emotional element of a memory enhances the effectiveness of ImRs.\n\nThe study is also significant due to another ongoing study in which a substantial number of participants have already been examined; however, due to the exhaustion of funds, it was not possible to utilize the remainder of the recruited sample. Investigating an additional condition will allow for a more complete utilization of the available participant pool and significantly increase the project's scientific value by comparing the traditional ImRs mechanism with its AI-generated version.",[113,114,30],"Generalized Anxiety","Fear of Failure",[114,116,113,117,118],"Intrusive Autobiographical Memories","Imagery Rescripting","AI","2026-05-03",{"date":121,"type":42},"2026-05-07",{"date":123,"type":21},"2026-04",{"date":125,"type":21},"2026-07",{"name":127,"class":49},"University of Social Sciences and Humanities, Warsaw",2,{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":135,"eligibilityCriteria":136,"healthyVolunteers":11,"sex":16,"minAge":58,"maxAge":17,"enrollmentInfo":137,"targetDuration":4,"studyType":22,"phases":139,"briefSummary":140,"conditions":141,"keywords":143,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":128},"100486701","mindfulness-based-fmri-neurofeedback-for-depression-100486701","NCT05617495","Mindfulness-Based fMRI Neurofeedback for Depression","Targeting Adolescent Depression Symptoms Using Network-based Real-time fMRI Neurofeedback and Mindfulness Meditation (NIMH); Mindfulness-Based Real-Time fMRI Neurofeedback for Depression (IRB)","mbNF","Inclusion Criteria:\n\n* Ages 13-18 years-old\n* Written informed assent\u002Fconsent and parental\u002Fguardian permission for 13-17 year-olds or informed consent for 18 year-olds\n* Tanner puberty stage ≥3\n* Meets current diagnostic criteria for MDD\n* English fluency\n\nExclusion Criteria:\n\n* Lifetime history of primary psychotic disorders, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorders\n* Substance use disorder, moderate or severe in past 6 months\n* Active suicidal ideation with a specific plan\n* History of seizure disorder\n* Medical or neurological illness (e.g., severe head injury)\n* MRI contraindications\n* Current psychotropic medication use other than antidepressant medication\n* Intelligence quotient (IQ) \\\u003C80.",{"count":138,"type":21},90,[24],"In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.",[142,30],"Depression in Adolescence",[144,145,30,146],"Real-time fMRI Neurofeedback","Mindfulness","Major Depressive Disorder","2026-04-24",{"date":149,"type":42},"2026-04-29",{"date":151,"type":42},"2024-04-10",{"date":153,"type":21},"2027-06-30",{"name":155,"class":49},"Columbia University",{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":160,"acronym":4,"eligibilityCriteria":161,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":162,"enrollmentInfo":163,"targetDuration":4,"studyType":22,"phases":165,"briefSummary":166,"conditions":167,"keywords":171,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":50},"100629724","readiness-and-progress-in-emotion-regulation-therapy-100629724","NCT07478393","Readiness and Progress in Emotion Regulation Therapy","Inclusion Criteria:\n\n* Between the ages of 18 and 65\n* Fluent in English (and therefore able to provide consent)\n* Currently living in New York State\n* Access to at least one device with internet and video-conferencing capabilities\n* High self-reported worry, rumination, and\u002For self-criticism\n* Meet Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-5) criteria for at least one, current psychological disorder\n\nExclusion Criteria:\n\n* Active suicidal ideation or intent\n* Substance dependence disorder, schizophrenia, bipolar-I disorder, or a primary DSM-5 diagnosis of borderline or narcissistic personality disorder\n* Currently in therapy or receiving any type of psychosocial treatment\n* Individuals taking psychotropic mediation that has not been stabilized for a period of at least 3 months\n* Current students at Teachers College, Columbia University","65 Years",{"count":164,"type":21},36,[24],"This study is an open trial designed to examine individual changes that occur before, during, and after 6 modules of Emotion Regulation Therapy (ERT) delivered via telehealth for individuals in New York State who are experiencing elevated worry, rumination, or self-criticism.",[30,168,169,28,29,170],"Worry","Self-Criticism","Distress, Emotional",[168,30,169,172,173,174],"Emotion Regulation Therapy","Emotion Regulation","Treatment Mechanisms","2026-03-12",{"date":177,"type":42},"2026-03-17",{"date":179,"type":42},"2025-10-24",{"date":181,"type":21},"2028-09-01",{"name":183,"class":49},"Teachers College, Columbia University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":190,"eligibilityCriteria":191,"healthyVolunteers":11,"sex":16,"minAge":192,"maxAge":193,"enrollmentInfo":194,"targetDuration":4,"studyType":22,"phases":196,"briefSummary":197,"conditions":198,"keywords":210,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":50},"100579744","culturally-adapted-i-cbt-for-farsidari-speaking-migrants-100579744","NCT06828276","Culturally Adapted i-CBT for Farsi\u002FDari Speaking Migrants","Culturally and Language-Adapted i-CBT for Common Mental Health Problems: A Randomized Controlled Study With Farsi\u002FDari-Speaking Migrants","i-CBT","Inclusion Criteria:\n\n* Between the ages of 15 and 29.\n* A score above the cut-off 1.75 on HSCL-25\n* Has a refugee or migrant background\n* Has a good and stable internet connection\n* Has access to a computer, tablet or smartphone\n* Is fluent in reading and writing Arabic\n* Has the ability to dedicate time to take part in the intervention for 6-10 weeks.\n\nExclusion Criteria:\n\n* Is suffering from a severe mental illness, such as psychosis or severe depression.\n* Is suffering from substance abuse\n* Is undergoing a psychological treatment\n* Has a high risk of suicide","15 Years","29 Years",{"count":195,"type":21},128,[24],"The aim of this randomized controlled trial (RCT) is to investigate the effectiveness of a culturally adapted internet-based cognitive behavioral therapy (i-CBT) intervention in reducing symptoms of common mental health issues among Farsi\u002FDari-speaking youth migrants and refugees. Investigator hypothesizes that there will be a significant decrease in psychological symptoms after participants receive the intervention compared to a control group.",[199,200,201,202,203,204,205,206,207,208,209,30],"Depressive Symptoms","Anxiety Symptoms","Grief","Psychological Trauma","Insomnia","Resilience","Stress","Psychological Well Being","Marital Relationship","Wellbeing","Common Mental Health Problems",[211,212,213,214,215,216,217,204,218],"Refugee","Cognitive behavioral therapy","Psychological problems","Persian speaking","Psychological well-being","Youth","Mental problems","Asylum seeker","2025-12-05",{"date":221,"type":42},"2025-12-12",{"date":223,"type":42},"2025-03-25",{"date":225,"type":21},"2026-12-31",{"name":227,"class":49},"Karolinska Institutet",{"id":229,"slug":230,"hasResults":11,"nctId":231,"briefTitle":232,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":162,"enrollmentInfo":235,"targetDuration":4,"studyType":237,"phases":4,"briefSummary":238,"conditions":239,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":254},"100557024","barretts-esophagitis-in-anorexia-nervosa-bingepurge-subtype-100557024","NCT06532734","Barrett's Esophagitis in Anorexia Nervosa Binge\u002FPurge Subtype","Presence of Barrett's Esophagitis in a Cohort of People With Eating Disorders Who Engage in Purging Behaviors: A Pilot Study","Inclusion Criteria:\n\n* Patients diagnosed with an eating disorder diagnosis that includes purging history\n* Ages 18-65\n* Purging history =\\>5 years\n* Purging or rumination at a minimum of once daily upon admission.\n* Admission to the ACUTE Center for Eating Disorders and Severe Malnutrition\n\nExclusion Criteria:\n\n* Any eating disorder diagnosis that does not include purging behaviors\n* Ages under 18 and over 65\n* Patients who otherwise meet the current ACG screening guidelines (chronic GERD and 3 or more risk factors for Barrett's mentioned in the Background)\n* Received mandated care at time of enrollment\n* Inability to consent to participate in the research",{"count":236,"type":21},25,"OBSERVATIONAL","To better define the presence of Barrett's esophagus (BE) via non-endoscopic testing in an eating disorder cohort with purging (vomiting\u002Frumination) behaviors",[240,241,30,242,243,244],"Barrett Esophagus","Anorexia Nervosa, Binge Eating\u002FPurging Type","Vomiting","Eating Disorders","Esophageal Adenocarcinoma","2025-12-03",{"date":247,"type":42},"2025-12-10",{"date":249,"type":42},"2024-11-12",{"date":251,"type":21},"2026-11",{"name":253,"class":49},"Denver Health and Hospital Authority",3,{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":57,"sex":16,"minAge":17,"maxAge":262,"enrollmentInfo":263,"targetDuration":4,"studyType":237,"phases":4,"briefSummary":265,"conditions":266,"keywords":269,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":50},"100573645","modulation-of-cortical-brain-activity-during-attentional-control-100573645","NCT06748976","Modulation of Cortical Brain Activity During Attentional Control","EEG Alpha Rhythm Modulation Using Sham Neurofeedback During Attentional Control in a Virtual Reality Environment","Inclusion Criteria:\n\n* Adults aged between 18 and 60 years.\n* Normal or corrected vision.\n* Ability to provide written informed consent.\n\nExclusion Criteria:\n\n* Diagnosed with photosensitive epilepsy.\n* Significant hearing loss or diagnosed hearing impairment.\n* Current psychiatric illness or disorder.\n* History of migraines or chronic headaches.\n* History of substance or alcohol abuse.\n* Currently pregnant.\n* Discomfort with using a virtual reality headset, assessed during a pilot session.","60 Years",{"count":264,"type":21},35,"The goal of this study is to determine whether an open-loop sham neurofeedback system can effectively modulate EEG alpha rhythms, which are associated with attentional control. The main questions it aims to answer are:\n\nDoes positive sham neurofeedback lead to a decrease in relative EEG alpha power compared to a control condition without feedback?\n\nResearchers will compare the effects of positive and negative sham-neurofeedback conditions to a control condition without feedback to assess the system's impact on alpha rhythm modulation. Participants will:\n\nExperience three conditions (positive sham-neurofeedback, negative sham-neurofeedback, and no feedback) within a virtual reality environment.\n\nUndergo EEG recordings to measure changes in alpha power as a marker of attentional resource allocation.\n\nProvide written informed consent and complete the study following ethical guidelines.\n\nThis study seeks to explore the potential of open-loop feedback systems to enhance attentional control by modulating alpha rhythm.",[30,267,268],"Chronic Pain","Fibromyalgia",[270,91,271,272,273],"operant conditioning","metacognition","neurofeedback","selective attention","2025-09-22",{"date":276,"type":42},"2025-09-25",{"date":278,"type":42},"2025-07-01",{"date":280,"type":21},"2025-11",{"name":282,"class":283},"National Council of Scientific and Technical Research, Argentina","OTHER_GOV",{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":107,"enrollmentInfo":291,"targetDuration":4,"studyType":22,"phases":293,"briefSummary":294,"conditions":295,"keywords":296,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":50},"100607527","optimization-of-imagery-rescripting-research-using-generative-artificial-intelligence-100607527","NCT07189715","Optimization of Imagery Rescripting Research Using Generative Artificial Intelligence","A Randomized Controlled Pilot Study on AI-Based Imagery Rescripting for Childhood Criticism Memories","FRBN",{"count":292,"type":21},80,[24],"This pilot randomized controlled trial will investigate the feasibility and effectiveness of using generative artificial intelligence to create personalized therapeutic scripts for imagery rescripting (ImRs). Eighty participants will listen to autobiographical scenarios based on their own memories of childhood criticism and neutral events. The scenarios will be generated by the Gemini large language model and reviewed by trained experimenters. On Day 1, all participants will be exposed to both critical and neutral scenarios and randomly assigned to either an experimental group receiving an ImRs intervention or a control group receiving no therapeutic modification. Skin conductance and subjective emotional ratings will be collected during the session, with follow-up questionnaires administered one week later. In addition, cognitive-behavioral therapists will evaluate the quality of the generated scripts. The study aims to assess emotional and physiological responses to AI-generated content, compare outcomes between groups, and explore the potential of large language models in scalable psychological interventions.",[113,114,30],[114,116,113,117,118],"2025-09-15",{"date":299,"type":42},"2025-09-24",{"date":301,"type":42},"2025-06-01",{"date":303,"type":21},"2025-12-31",{"name":127,"class":49},{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":310,"acronym":4,"eligibilityCriteria":311,"healthyVolunteers":11,"sex":16,"minAge":162,"maxAge":4,"enrollmentInfo":312,"targetDuration":4,"studyType":22,"phases":314,"briefSummary":315,"conditions":316,"keywords":320,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":331,"locationsCount":50},"100603644","the-effect-of-cognitive-behavioral-therapy-cbt-based-psychoeducation-on-cognitive-flexibility-and-rumination-in-the-elderly-100603644","NCT07139197","The Effect of Cognitive Behavioral Therapy (CBT)-Based Psychoeducation on Cognitive Flexibility and Rumination in the Elderly","The Effect of a Cognitive Behavioral Approach-Based Psychoeducation Program on Cognitive Flexibility and Rumination in Elderly Individuals Living in Nursing Homes","Inclusion Criteria:\n\n* Be 65 years of age or older,\n* Be willing to participate in the study,\n* Not have hearing or vision problems that would prevent understanding the training to be provided,\n* Have communication and comprehension skills,\n* Be literate,\n* Have a Standardized Mini Mental Test score between 25 and 30 points.\n\nExclusion Criteria:\n\n* Having any hearing or vision problems.\n* Having physical, neurological, or psychological health problems that could disrupt group harmony and integrity.\n* Having an illness or problem that could prevent them from responding to the measurement tools used in the study.\n* Having a Standardized Mini Mental Test score below 25.",{"count":313,"type":21},38,[24],"This study aimed to investigate the effect of psychoeducation on rumination and cognitive flexibility in elderly individuals residing in nursing homes. Cognitive Behavioral Therapy (CBT)-based psychoeducation has recently been applied to multiple specific groups around the world and in our country. In general, executive functioning skills and, more specifically, cognitive flexibility appear to be important for the ability to use certain CBT techniques; however, considering that these skills naturally decline with age, further research is needed. It is anticipated that the results of this study will contribute to applications in the field of psychiatric nursing.",[317,30,318,319],"Cognitive Flexibility","Elderly (People Aged 65 or More)","Psychoeducation",[321,322,323,91,324],"elderly","psychoeducation","cognitive flexibility","cognitive behavioral therapy","2025-08-27",{"date":327,"type":42},"2025-09-04",{"date":329,"type":21},"2025-09-01",{"date":65,"type":21},{"name":332,"class":49},"Ataturk University",{"id":334,"slug":335,"hasResults":11,"nctId":336,"briefTitle":337,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":162,"enrollmentInfo":339,"targetDuration":4,"studyType":22,"phases":340,"briefSummary":341,"conditions":342,"keywords":343,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":347,"lastUpdatePostDateStruct":348,"startDateStruct":350,"completionDateStruct":352,"leadSponsor":354,"locationsCount":50},"100472885","decoding-and-modulating-affective-brain-states-100472885","NCT05437705","Decoding and Modulating Affective Brain States","Inclusion criteria:\n\n1. 18-65 years old\n2. Patient Health Questionnaire (PHQ-9 score) = or \\> than 10\n3. Comprehension of instructions in the English language.\n4. Capacity to provide informed consent and follow study procedures.\n5. Availability for the duration of the study.\n\nExclusion Criteria:\n\n1. Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder\n2. Recent use of psychoactive medications or substances as determined by investigators\n3. History of neurological disorder or traumatic brain injury (other than mild)\n4. Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data\n5. Unable to receive or tolerate TMS\n6. Implanted devices, such as an aneurysm clip or cardiac pacemaker\n7. History of stroke, epilepsy, or brain scarring\n8. Pregnant, nursing, or trying to become pregnant (self-attestation alone)\n\nDuring this study, participants are asked to:\n\n1. Refrain from substance use (including marijuana and illicit drugs) for duration of the study (self-attestation alone).\n2. Abstain from alcohol for 24 hours before the MRI scans (self-attestation alone).\n3. Abstain from increasing caffeine intake or begin taking any new medications (self-attestation alone).",{"count":109,"type":21},[24],"The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation (TMS). First, the investigators will use functional Magnetic Resonance Imaging (fMRI) data to generate a negative affect map for each participant. Then, the investigators will apply a variety of repetitive transcranial magnetic stimulation (rTMS) sequences while the participant is inside the MRI scanner to determine the optimal and least optimal rTMS frequencies at changing negative affect brain states. Finally, these two frequencies will be tested over two 3-day rTMS neuromodulation sessions to assess whether they can reduce negative emotions.",[30,146,28],[344,91,345,346],"TMS","depression","anxiety","2025-08-26",{"date":349,"type":42},"2025-09-03",{"date":351,"type":42},"2023-02-21",{"date":353,"type":21},"2028-12-01",{"name":355,"class":49},"University of Pennsylvania",{"id":357,"slug":358,"hasResults":11,"nctId":359,"briefTitle":360,"officialTitle":361,"acronym":4,"eligibilityCriteria":362,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":363,"targetDuration":4,"studyType":22,"phases":365,"briefSummary":366,"conditions":367,"keywords":368,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":4},"100559942","rct-protocol-for-overthinking-a-mobile-emi-for-reducing-experiential-avoidance-100559942","NCT06570694","RCT Protocol for 'OverThinking': A Mobile EMI for Reducing Experiential Avoidance","A Mobile Ecological Momentary Intervention for Reducing Experiential Avoidance in the Context of Rumination: Protocol for a Randomised-Controlled Trial","Inclusion Criteria:\n\n\\- Self-reporting problems with repetitive negative thinking.\n\nExclusion Criteria:\n\n* Aged below 18 years at the commencement of the trial.\n* Currently in receipt of any form of psychotherapy.\n* Currently in receipt of any form of psychiatric medication.\n\nNote: Participants who hold a psychiatric diagnosis will not be excluded from the trial provided they meet the inclusion criterion and do not meet any of the exclusion criteria listed above.",{"count":364,"type":21},60,[24],"The goal of this trial is to examine whether a mobile app intervention for rumination can modify a maladaptive feature of repetitive negative thinking (RNT) - this is understood by the link between daily RNT and well-being, depressive and anxiety symptoms.\n\nThe main questions it aims to answer are:\n\n1. If the intervention can modify the maladaptive feature of repetitive negative thinking - the investigators anticipate the link between daily rumination and maladaptive outcomes (poorer wellbeing, higher depressive\u002Fanxious symptoms) will be weaker in the intervention groups.\n2. By examining (1) above, to confirm the role played by avoidance in repetitive negative thinking.\n3. By splitting the intervention condition into two groups (one receiving concurrent support from a therapist, one not), to evaluate if interventions such as these might be enhanced by therapist support.\n4. To examine if the impact of the intervention on depressive and anxious symptoms might be mediated by changes in beliefs regarding emotions (e.g. the valuation of negative emotions).\n\nResearchers will compare across four groups to examine the above effects:\n\n(1) intervention condition (therapist support); (2) intervention condition (no therapist support); (3) Partial intervention (daily sampling and emotion valuation questions); (4) Control group (only daily sampling questions).\n\nParticipants will:\n\n* Be requested to participate in a four-week intervention, providing daily assessments of depressive and anxiety symptoms, affect, repetitive negative thinking, and rumination outcomes.\n* Use a mobile application during the intervention period, which has been designed by the research team (intervention groups), or provide daily assessment scores only (control groups).\n* Be assessed at pre-intervention (all groups), post-intervention (all groups), 1-month follow-up (all groups), and 3-month follow-up (intervention groups only).",[29,28,30],[30,369,29,28,370],"Experiential Avoidance","Ecological momentary intervention","2025-04-29",{"date":373,"type":42},"2025-05-02",{"date":375,"type":21},"2025-05-01",{"date":377,"type":21},"2025-07-30",{"name":127,"class":49}]