[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"safety-and-effectiveness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:safety-and-effectiveness":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,50,86,114],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100606768","phase-1-safety-and-feasibility-of-temporal-interference-brain-stimulation-for-treatment-in-psychiatric-disorders-100606768",false,"NCT07179848","Safety and Feasibility of Temporal Interference Brain Stimulation for Treatment in Psychiatric Disorders","Phase I Clinical Trial of a New Non-invasive Deep Brain Stimulation Technique","Inclusion Criteria:\n\n* Healthy adults from the community\n* Age between 20 and 65 years old\n* No diagnosis of severe psychiatric disorders\n* No family history of psychiatric diseases\n\nExclusion Criteria:\n\n* Age below 20 years old or above 65 years old\n* Currently prescribed any medication\n* Diagnosis of psychiatric disorders (e.g., Major Depressive Disorder, Bipolar Disorder, Schizophrenia)\n* Diagnosis of neurological disorders (e.g., Dementia, Stroke, Parkinson's disease)\n* History of substance abuse\n* Diagnosis of cancer or malignant tumors\n* Chronic kidney failure or undergoing hemodialysis\n* Pregnant or breastfeeding\n* Severe arrythmia, presence of pacemaker, or metal implants in the brain\n* Claustrophobia\n* History or family history of seizure\n* History of syncope\n* Organic brian disease, brian trauma, or history of neurosurgery\n* Received electroconvulsive therapy or repetitive transcranial magnetic stimulation within the past month\n* Skin disorders (e.g., dermatitis, psoriasis, eczema)\n* Currently participating in other clinical interventional trials\n* Presence of any metal implants or devices affected by electromagnetic fields",true,"ALL","20 Years","65 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"PHASE1","The goal of this clinical trial is to validate if temporal interference brain stimulation (TIBS) is safe in healthy volunteers aged 20 to 65. The main questions it aims to answer are:\n\n* Is it safe to apply TIBS intervention to the left hippocampus in healthy participants?\n* Is it safe to apply TIBS intervention to the left insula in healthy participants?\n* Is it safe to apply TIBS intervention to the left anterior cingulate cortex in healthy participants?\n* Is it safe to apply TIBS intervention to the right inferior frontal cortex in healthy participants?\n\nParticipants will:\n\n* Be Randomly allocated to either sham-first group or treat first-group, stratified by stimulated brain region, following a crossover-controlled experimental design\n* Complete baseline cognitive evaluations and mental status assessments, and undergo a baseline MRI scan on the same day\n* Receive stimulation for 5 consecutive days, followed by a 2-days washout period, then complete the remaining 5 days of stimulation.\n* Complete post-intervention cognitive evaluations and mental status assessments, and undergo a post-intervention MRI scan on the same day",[28,29,30,31],"Health Adults","Temporal Interference Stimulation","Safety and Effectiveness","Crossover Study",[33,29,34,35,36],"Hippocampus","Insula","Anterior Cingulate Cortex","Inferior Frontal Cortex","RECRUITING","2026-02-05",{"date":40,"type":41},"2026-02-09","ACTUAL",{"date":43,"type":41},"2025-02-26",{"date":45,"type":22},"2026-10",{"name":47,"class":48},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":16,"sex":17,"minAge":58,"maxAge":19,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":49},"100621148","feasibility-and-safety-of-sciatic-nerve-paraneural-sheath-block-using-a-mid-femoral-lateral-approach-100621148","NCT07366853","Feasibility and Safety of Sciatic Nerve Paraneural Sheath Block Using a Mid-Femoral Lateral Approach","Feasibility and Safety of Intraneural Sciatic Nerve Block Via Lateral Mid-femoral Approach: A Clinical Study","iSNB-LF","Inclusion Criteria:\n\n1. Patients scheduled for elective unilateral surgery below the knee (e.g., internal fixation for ankle, metatarsal, or calcaneal fractures; hallux valgus correction; flatfoot reconstruction).\n2. American Society of Anesthesiologists (ASA) physical status class I or II.\n3. Aged 18 to 65 years.\n4. Ability to understand the study procedure and provide written informed consent.\n\nExclusion Criteria:\n\n1. Contraindications to peripheral nerve block:\n\n   * Known allergy or history of toxicity to local anesthetics.\n   * Pre-existing neuropathy in the operative limb.\n   * Severe coagulopathy.\n   * Infection at the intended needle puncture site.\n   * Systemic infection.\n2. Requirement for simultaneous surgery at a site other than the unilateral lower limb below the knee.\n3. Previous surgery or significant scarring in the area of the planned needle insertion for the sciatic nerve block.\n4. Body mass index (BMI) \\> 35 kg\u002Fm².\n5. Patients receiving chronic pain therapy or with a history of opioid abuse.\n6. Inability to communicate or cooperate with the study assessments (e.g., due to cognitive impairment, language barrier, or psychiatric disorder).\n7. Pregnancy or lactation.","18 Years",{"count":60,"type":22},200,[62],"NA","This study is designed as a randomized controlled trial aiming to evaluate the feasibility and safety of ultrasound-guided mid-femoral lateral approach sciatic nerve paraneural sheath block, in order to provide a new sciatic nerve block approach for clinical practice that offers greater patient comfort and higher precision, thereby facilitating its use for specific patient populations and less experienced operators.",[65,66,30],"Adverse Effect","Feasibility Study",[68,69,70,71,72,73,74],"Sciatic Nerve Block","Subparaneural Block","Lateral Mid-femoral Approach","Popliteal Approach","Ultrasound-guided","Feasibility","Safety","NOT_YET_RECRUITING","2026-01-16",{"date":78,"type":41},"2026-01-26",{"date":80,"type":22},"2026-01-01",{"date":82,"type":22},"2026-10-01",{"name":84,"class":85},"General Hospital of Ningxia Medical University","OTHER",{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":16,"sex":17,"minAge":92,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":49},"100600180","clinical-and-radiographic-outcomes-of-the-jointmedica-custom-made-resurfacing-device-100600180","NCT07094139","Clinical and Radiographic Outcomes of the JointMedica Custom-Made Resurfacing Device","Inclusion Criteria:\n\n* Age 21 or above at the time of the surgery.\n* Have had the JointMedica Custom-Made Hip Resurfacing device implanted between September 2020 to January 2025\n* Written informed consent given by subject\n\nExclusion Criteria:\n\n* There is no exclusion criteria for this study","21 Years",{"count":94,"type":22},41,"OBSERVATIONAL","The Custom Resurfacing (CR) Implants are indicated for use for the reduction or relief of pain and\u002For improved hip function all skeletally mature patients where a total joint replacement is indicated, and where there is no other suitable, commercially distributed device available.\n\nThe Resurfacing System is a metal-on-polyethylene hip resurfacing device consisting of a metallic femoral component and an acetabular component made of Vitamin E HXLPE with a titanium coating on its bone-contacting surface.\n\nThe custom-Made Hip Resurfacing System is a single use device intended for hybrid fixation: cemented femoral head component and cementless acetabular component.\n\nThe goal of this observational study is to generate Real World Evidence (RWE) on the device performance of the Polymotion Hip Resurfacing (PHR) system and its use in patients who have been implanted with the device for the treatment of hip osteoarthritis.\n\nThis study will assess the following endpoints:\n\n* The survivorship of the Acetabular Cup (Kaplan-Meier estimate) through 2 years of follow-up.\n* Radiographic success of the implanted cups, through quantitative motion analysis to assess migration of the acetabular cups.\n* Absence of subsequent surgical intervention at the acetabulum of there operated hip.\n* Absence of serious, device-related adverse events.\n* Patient reported outcomes through Harris Hip Score and SUSHI - UCLA Hip Score questionnaires.",[98,99,30,100],"Healthy","Real World Data","Patient Reported Outcome (PRO)",[102,103,104],"Custom-Made Hip Resurfacing","Hip Resurfacing","Hip Arthroplasty","2025-07-23",{"date":107,"type":41},"2025-07-30",{"date":109,"type":22},"2025-08",{"date":111,"type":22},"2026-12",{"name":113,"class":85},"JointMedica Inc.",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":118,"acronym":4,"eligibilityCriteria":119,"healthyVolunteers":16,"sex":17,"minAge":92,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":122,"conditions":123,"keywords":124,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":135},"100599144","clinical-and-radiographic-outcomes-of-the-jointmedica-polymotion-resurfacing-phr-device-100599144","NCT07080671","Clinical and Radiographic Outcomes of the JointMedica Polymotion Resurfacing (PHR) Device","Inclusion Criteria:\n\n* Age 21 or above at the time of the surgery.\n* Have had the Polymotion Hip Resurfacing (PHR) (implanted between September 2020 to January 2025\n* Written informed consent given by subject\n\nExclusion Criteria:\n\n* There is no exclusion criteria for this study",{"count":121,"type":22},105,"The goal of this observational study is to generate Real World Evidence (RWE) on the device performance of the Polymotion Hip Resurfacing (PHR) system and its use in patients who have been implanted with the device for the treatment of hip osteoarthritis.\n\nThis study will assess the following endpoints:\n\n* The survivorship of the Acetabular Cup (Kaplan-Meier estimate) through 2 years of follow-up.\n* Radiographic success of the implanted cups, through quantitative motion analysis to assess migration of the acetabular cups.\n* Absence of subsequent surgical intervention at the acetabulum of there operated hip.\n* Absence of serious, device-related adverse events.\n* Patient reported outcomes through Harris Hip Score and SUSHI - UCLA Hip Score questionnaires.",[98,99,30,100],[125,126,127],"PHR","Polymotion Hip Resurfacing","Polymotion","2025-07-15",{"date":105,"type":41},{"date":131,"type":22},"2025-07-25",{"date":133,"type":22},"2026-12-31",{"name":113,"class":85},3]